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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for NFAT5
Z-value: 0.65
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Transcription factors associated with NFAT5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFAT5 | hg19_v2_chr16_+_69600209_69600254 | 0.27 | 3.9e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_60097524 Show fit | 21.11 |
ENST00000342503.4
|
reticulon 1 |
|
| chr11_-_111794446 Show fit | 20.92 |
ENST00000527950.1
|
crystallin, alpha B |
|
| chr14_-_60097297 Show fit | 20.11 |
ENST00000395090.1
|
reticulon 1 |
|
| chr12_+_10365404 Show fit | 16.11 |
ENST00000266458.5
ENST00000421801.2 ENST00000544284.1 ENST00000545047.1 ENST00000543602.1 ENST00000545887.1 |
GABA(A) receptor-associated protein like 1 |
|
| chr13_-_67804445 Show fit | 15.50 |
ENST00000456367.1
ENST00000377861.3 ENST00000544246.1 |
protocadherin 9 |
|
| chr1_-_57045228 Show fit | 14.85 |
ENST00000371250.3
|
phosphatidic acid phosphatase type 2B |
|
| chr22_+_23243156 Show fit | 14.25 |
ENST00000390323.2
|
immunoglobulin lambda constant 2 (Kern-Oz- marker) |
|
| chr22_+_23248512 Show fit | 13.11 |
ENST00000390325.2
|
immunoglobulin lambda constant 3 (Kern-Oz+ marker) |
|
| chr8_-_27469196 Show fit | 12.88 |
ENST00000546343.1
ENST00000560566.1 |
clusterin |
|
| chr7_+_149570049 Show fit | 12.47 |
ENST00000421974.2
ENST00000456496.2 |
ATPase, H+ transporting V0 subunit e2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFAT5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 27.7 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 26.3 | GO:0002250 | adaptive immune response(GO:0002250) |
| 0.5 | 21.3 | GO:0006536 | glutamate metabolic process(GO:0006536) |
| 1.2 | 20.9 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.6 | 19.1 | GO:0007035 | vacuolar acidification(GO:0007035) |
| 1.6 | 17.8 | GO:2000582 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 0.9 | 16.1 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 1.1 | 16.0 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 2.7 | 13.4 | GO:1904578 | response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579) |
| 2.1 | 12.9 | GO:1902998 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 41.2 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.2 | 36.3 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.8 | 23.8 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 1.4 | 22.6 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 20.9 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 20.9 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 1.4 | 19.1 | GO:0033179 | proton-transporting V-type ATPase, V0 domain(GO:0033179) |
| 0.5 | 16.1 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.0 | 15.2 | GO:0005615 | extracellular space(GO:0005615) |
| 0.6 | 14.5 | GO:0032982 | myosin filament(GO:0032982) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 29.6 | GO:0003823 | antigen binding(GO:0003823) |
| 4.3 | 21.3 | GO:0047820 | D-glutamate cyclase activity(GO:0047820) |
| 0.7 | 20.9 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.9 | 17.8 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 1.2 | 16.1 | GO:0030957 | Tat protein binding(GO:0030957) |
| 1.1 | 16.0 | GO:0031432 | titin binding(GO:0031432) |
| 0.0 | 16.0 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.2 | 15.8 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.6 | 12.9 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.5 | 12.5 | GO:0036442 | hydrogen-exporting ATPase activity(GO:0036442) proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 36.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 16.4 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 14.5 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.2 | 12.2 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.1 | 7.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 6.5 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 5.9 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 5.1 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.1 | 4.7 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.2 | 4.3 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.8 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.3 | 17.7 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.5 | 17.5 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 13.8 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.8 | 12.2 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.2 | 9.8 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 7.5 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.2 | 6.7 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.2 | 6.7 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.1 | 6.5 | REACTOME AMYLOIDS | Genes involved in Amyloids |