Project
GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for NFATC4
Z-value: 0.50
Motif logo
Transcription factors associated with NFATC4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFATC4 | hg19_v2_chr14_+_24837226_24837547 | 0.32 | 9.9e-07 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFATC4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.3 | 31.7 | GO:0052565 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
| 2.9 | 29.3 | GO:0051612 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 5.9 | 23.7 | GO:0006210 | pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859) |
| 7.5 | 22.6 | GO:0007412 | axon target recognition(GO:0007412) |
| 2.5 | 22.4 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 6.8 | 20.4 | GO:2000777 | positive regulation of oocyte maturation(GO:1900195) negative regulation of NLRP3 inflammasome complex assembly(GO:1900226) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777) |
| 0.5 | 19.8 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.5 | 18.2 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.1 | 17.1 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.3 | 16.6 | GO:0071377 | cellular response to glucagon stimulus(GO:0071377) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 34.8 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 1.3 | 31.7 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 1.1 | 22.4 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 2.3 | 20.4 | GO:0072687 | meiotic spindle(GO:0072687) |
| 1.0 | 17.8 | GO:0098563 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.4 | 16.0 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 3.1 | 15.4 | GO:0098843 | postsynaptic endocytic zone(GO:0098843) |
| 0.3 | 14.9 | GO:0031430 | M band(GO:0031430) |
| 0.3 | 14.1 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 1.0 | 13.4 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 31.7 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.6 | 29.2 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.9 | 23.7 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 5.7 | 22.6 | GO:0031694 | alpha-2A adrenergic receptor binding(GO:0031694) |
| 6.8 | 20.4 | GO:0034739 | histone deacetylase activity (H4-K16 specific)(GO:0034739) |
| 0.4 | 20.3 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.7 | 18.5 | GO:0005521 | lamin binding(GO:0005521) |
| 4.3 | 17.1 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
| 0.1 | 17.0 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 1.0 | 16.6 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 41.2 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.5 | 32.5 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.3 | 21.1 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.6 | 20.4 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.3 | 15.4 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.3 | 13.4 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.2 | 10.8 | ST GA13 PATHWAY | G alpha 13 Pathway |
| 0.1 | 8.6 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.2 | 8.5 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.2 | 8.5 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 38.6 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.6 | 30.5 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.8 | 20.8 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.2 | 20.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.5 | 17.7 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.7 | 16.6 | REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.6 | 15.4 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.2 | 14.3 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.7 | 13.5 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.2 | 12.5 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |