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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for NFIA
Z-value: 1.01
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Transcription factors associated with NFIA
Network of associatons between targets according to the STRING database.
First level regulatory network of NFIA
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 23.2 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
| 1.5 | 19.6 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 2.3 | 18.2 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 0.9 | 16.8 | GO:0010457 | centriole-centriole cohesion(GO:0010457) |
| 2.5 | 12.7 | GO:0015688 | iron chelate transport(GO:0015688) siderophore transport(GO:0015891) |
| 0.5 | 12.6 | GO:0001502 | cartilage condensation(GO:0001502) |
| 0.8 | 12.3 | GO:0015671 | oxygen transport(GO:0015671) |
| 3.9 | 11.8 | GO:1902528 | regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530) |
| 0.1 | 11.3 | GO:0050796 | regulation of insulin secretion(GO:0050796) |
| 1.1 | 11.2 | GO:0051791 | medium-chain fatty acid metabolic process(GO:0051791) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 26.1 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.1 | 20.9 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.2 | 20.7 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.2 | 20.3 | GO:0005814 | centriole(GO:0005814) |
| 2.3 | 18.2 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.1 | 17.4 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.8 | 16.9 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.6 | 16.7 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.9 | 12.3 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.1 | 11.7 | GO:0035578 | azurophil granule lumen(GO:0035578) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 24.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 21.9 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 1.9 | 18.9 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.3 | 15.8 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.5 | 13.4 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.1 | 12.7 | GO:0002020 | protease binding(GO:0002020) |
| 0.2 | 12.6 | GO:0070063 | RNA polymerase binding(GO:0070063) |
| 0.9 | 12.3 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.1 | 11.5 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 2.2 | 11.2 | GO:0004771 | sterol esterase activity(GO:0004771) methylumbelliferyl-acetate deacetylase activity(GO:0047374) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 40.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 37.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 23.9 | SIG BCR SIGNALING PATHWAY | Members of the BCR signaling pathway |
| 0.3 | 22.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.8 | 18.2 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.6 | 14.8 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.3 | 13.1 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.2 | 12.6 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.4 | 11.8 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.2 | 11.1 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 24.1 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.3 | 15.4 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.6 | 10.0 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.4 | 8.9 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.2 | 7.9 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.1 | 7.3 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.5 | 7.1 | REACTOME ANDROGEN BIOSYNTHESIS | Genes involved in Androgen biosynthesis |
| 0.1 | 7.0 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.4 | 6.8 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.4 | 6.8 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |