Project
GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for NFIX_NFIB
Z-value: 1.33
Motif logo
Transcription factors associated with NFIX_NFIB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFIB | hg19_v2_chr9_-_14308004_14308041 | 0.61 | 3.1e-23 | Click! |
| NFIX | hg19_v2_chr19_+_13106383_13106423, hg19_v2_chr19_+_13134772_13134846, hg19_v2_chr19_+_13135731_13135787 | 0.35 | 9.9e-08 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFIX_NFIB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.3 | 144.6 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.7 | 98.7 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 4.2 | 96.1 | GO:0007597 | blood coagulation, intrinsic pathway(GO:0007597) |
| 1.2 | 73.7 | GO:0030049 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 5.3 | 68.5 | GO:2001135 | regulation of endocytic recycling(GO:2001135) |
| 6.7 | 67.4 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 11.1 | 66.5 | GO:1902847 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 3.5 | 63.6 | GO:0006590 | thyroid hormone generation(GO:0006590) |
| 2.1 | 61.9 | GO:0015695 | organic cation transport(GO:0015695) |
| 4.5 | 58.7 | GO:0070327 | thyroid hormone transport(GO:0070327) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 970.7 | GO:0031224 | intrinsic component of membrane(GO:0031224) |
| 0.5 | 620.5 | GO:0005615 | extracellular space(GO:0005615) |
| 0.8 | 256.3 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.8 | 200.2 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 25.7 | 102.7 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 1.2 | 98.3 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 6.1 | 97.8 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.3 | 73.7 | GO:0043025 | neuronal cell body(GO:0043025) |
| 4.5 | 72.6 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 1.0 | 71.2 | GO:0005796 | Golgi lumen(GO:0005796) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 225.8 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 2.1 | 223.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 12.8 | 167.0 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.7 | 156.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.3 | 140.6 | GO:0005509 | calcium ion binding(GO:0005509) |
| 2.0 | 122.2 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.8 | 92.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 1.1 | 86.1 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 1.0 | 77.7 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 1.6 | 73.2 | GO:0008009 | chemokine activity(GO:0008009) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 426.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 1.4 | 364.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 1.7 | 297.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.6 | 226.6 | NABA MATRISOME | Ensemble of genes encoding extracellular matrix and extracellular matrix-associated proteins |
| 1.5 | 104.6 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 1.8 | 104.3 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 1.1 | 77.3 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 2.1 | 60.8 | PID S1P S1P2 PATHWAY | S1P2 pathway |
| 1.7 | 59.7 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 1.0 | 52.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 214.7 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.4 | 113.4 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 1.2 | 85.1 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 4.2 | 84.9 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 4.6 | 82.8 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.9 | 74.0 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.8 | 70.4 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 1.3 | 69.5 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 2.8 | 67.2 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 2.7 | 66.3 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |