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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for NKX1-1
Z-value: 0.23
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Transcription factors associated with NKX1-1
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX1-1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 7.7 | GO:0061030 | epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) |
| 1.0 | 5.2 | GO:0033383 | geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337) |
| 0.2 | 3.6 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.0 | 3.6 | GO:0031663 | lipopolysaccharide-mediated signaling pathway(GO:0031663) |
| 0.6 | 3.4 | GO:0051661 | maintenance of centrosome location(GO:0051661) |
| 1.0 | 3.0 | GO:0006258 | UDP-glucose catabolic process(GO:0006258) galactose catabolic process via UDP-galactose(GO:0033499) |
| 0.9 | 2.7 | GO:0044878 | mitotic cytokinesis checkpoint(GO:0044878) |
| 0.7 | 2.7 | GO:0090402 | oncogene-induced cell senescence(GO:0090402) |
| 0.0 | 1.9 | GO:0071431 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 0.1 | 1.7 | GO:0060965 | negative regulation of gene silencing by miRNA(GO:0060965) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.6 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.5 | 3.4 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.3 | 2.7 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 0.2 | 2.7 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.1 | 1.9 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.1 | 1.9 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.0 | 1.4 | GO:0005685 | U1 snRNP(GO:0005685) |
| 0.0 | 1.4 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.1 | 1.3 | GO:0070187 | telosome(GO:0070187) |
| 0.1 | 1.3 | GO:0071564 | npBAF complex(GO:0071564) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.1 | GO:0044325 | ion channel binding(GO:0044325) |
| 1.0 | 5.2 | GO:0004337 | dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337) |
| 0.1 | 3.6 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.0 | 3.5 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.5 | 3.1 | GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 0.3 | 3.0 | GO:0070569 | uridylyltransferase activity(GO:0070569) |
| 0.3 | 2.7 | GO:0035174 | histone serine kinase activity(GO:0035174) |
| 0.2 | 2.7 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.2 | 2.5 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 0.1 | 1.9 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 2.7 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 1.4 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 1.4 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 1.3 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 1.3 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 0.9 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.5 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.4 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.2 | 3.7 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.3 | 2.7 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.0 | 2.7 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.1 | 1.9 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 0.0 | 1.9 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.0 | 1.9 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| 0.0 | 1.9 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 1.3 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 1.1 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |