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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for NKX1-1

Z-value: 0.23

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Transcription factors associated with NKX1-1

Gene Symbol Gene ID Gene Info
NKX1-1
ENSG00000235608.1 NK1 homeobox 1

Activity profile of NKX1-1 motif

Sorted Z-values of NKX1-1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_8822113 7.70 ENST00000396290.1
ENST00000331129.3
ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr1_-_197115818 3.35 ENST00000367409.4
ENST00000294732.7
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr17_-_8113886 2.74 ENST00000577833.1
ENST00000534871.1
ENST00000583915.1
ENST00000316199.6
ENST00000581511.1
ENST00000585124.1
AURKB
aurora kinase B
chr7_-_86849883 2.69 ENST00000433078.1
TMEM243
transmembrane protein 243, mitochondrial
chr6_+_34204642 2.67 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1
high mobility group AT-hook 1
chr1_+_155278539 2.63 ENST00000447866.1
FDPS
farnesyl diphosphate synthase
chr1_+_155278625 2.56 ENST00000368356.4
ENST00000356657.6
FDPS
farnesyl diphosphate synthase
chr3_-_52567792 2.47 ENST00000307092.4
ENST00000422318.2
ENST00000459839.1
NT5DC2
5'-nucleotidase domain containing 2
chr12_-_102513843 1.89 ENST00000551744.2
ENST00000552283.1
NUP37
nucleoporin 37kDa
chr8_+_98656693 1.81 ENST00000519934.1
MTDH
metadherin
chr8_+_98656336 1.78 ENST00000336273.3
MTDH
metadherin
chr19_-_8070474 1.68 ENST00000407627.2
ENST00000593807.1
ELAVL1
ELAV like RNA binding protein 1
chr9_+_34646624 1.57 ENST00000450095.2
ENST00000556278.1
GALT
GALT
galactose-1-phosphate uridylyltransferase
Uncharacterized protein
chr17_-_61777459 1.53 ENST00000578993.1
ENST00000583211.1
ENST00000259006.3
LIMD2
LIM domain containing 2
chr1_+_174843548 1.47 ENST00000478442.1
ENST00000465412.1
RABGAP1L
RAB GTPase activating protein 1-like
chr12_+_28410128 1.44 ENST00000381259.1
ENST00000381256.1
CCDC91
coiled-coil domain containing 91
chr9_+_34646651 1.41 ENST00000378842.3
GALT
galactose-1-phosphate uridylyltransferase
chr18_+_55888767 1.39 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr19_+_41256764 1.36 ENST00000243563.3
ENST00000601253.1
ENST00000597353.1
ENST00000599362.1
SNRPA
small nuclear ribonucleoprotein polypeptide A
chr19_+_11071546 1.27 ENST00000358026.2
SMARCA4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr3_+_23851928 1.25 ENST00000467766.1
ENST00000424381.1
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr10_-_1095050 1.22 ENST00000381344.3
IDI1
isopentenyl-diphosphate delta isomerase 1
chr3_-_105588231 1.19 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr2_+_187371440 1.17 ENST00000445547.1
ZC3H15
zinc finger CCCH-type containing 15
chr3_+_158519654 1.10 ENST00000415822.2
ENST00000392813.4
ENST00000264266.8
MFSD1
major facilitator superfamily domain containing 1
chr11_-_111741994 1.09 ENST00000398006.2
ALG9
ALG9, alpha-1,2-mannosyltransferase
chr8_+_94929077 1.04 ENST00000297598.4
ENST00000520614.1
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr8_+_94929110 1.03 ENST00000520728.1
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr8_+_94929168 1.01 ENST00000518107.1
ENST00000396200.3
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr4_-_103682145 0.99 ENST00000226578.4
MANBA
mannosidase, beta A, lysosomal
chr7_-_99716952 0.97 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr17_-_27418537 0.94 ENST00000408971.2
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr19_+_45504688 0.78 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
RELB
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr16_-_66864806 0.75 ENST00000566336.1
ENST00000394074.2
ENST00000563185.2
ENST00000359087.4
ENST00000379463.2
ENST00000565535.1
ENST00000290810.3
NAE1
NEDD8 activating enzyme E1 subunit 1
chr6_-_82957433 0.73 ENST00000306270.7
IBTK
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr11_-_71823796 0.72 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
ANAPC15
anaphase promoting complex subunit 15
chr3_+_57261743 0.71 ENST00000288266.3
APPL1
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
chr16_-_11036300 0.70 ENST00000331808.4
DEXI
Dexi homolog (mouse)
chr12_+_102513950 0.68 ENST00000378128.3
ENST00000327680.2
ENST00000541394.1
ENST00000543784.1
PARPBP
PARP1 binding protein
chrX_+_19362011 0.66 ENST00000379806.5
ENST00000545074.1
ENST00000540249.1
ENST00000423505.1
ENST00000417819.1
ENST00000422285.2
ENST00000355808.5
ENST00000379805.3
PDHA1
pyruvate dehydrogenase (lipoamide) alpha 1
chr7_-_99717463 0.66 ENST00000437822.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr4_-_66536057 0.64 ENST00000273854.3
EPHA5
EPH receptor A5
chr17_+_45286387 0.64 ENST00000572316.1
ENST00000354968.1
ENST00000576874.1
ENST00000536623.2
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr17_-_45266542 0.64 ENST00000531206.1
ENST00000527547.1
ENST00000446365.2
ENST00000575483.1
ENST00000066544.3
CDC27
cell division cycle 27
chr2_-_47143160 0.62 ENST00000409800.1
ENST00000409218.1
MCFD2
multiple coagulation factor deficiency 2
chr1_+_62439037 0.61 ENST00000545929.1
INADL
InaD-like (Drosophila)
chr18_-_33709268 0.60 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr10_+_1095416 0.59 ENST00000358220.1
WDR37
WD repeat domain 37
chr7_+_50348268 0.57 ENST00000438033.1
ENST00000439701.1
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr9_+_139780942 0.56 ENST00000247668.2
ENST00000359662.3
TRAF2
TNF receptor-associated factor 2
chrX_+_55026763 0.55 ENST00000374987.3
APEX2
APEX nuclease (apurinic/apyrimidinic endonuclease) 2
chr12_-_6961050 0.54 ENST00000538862.2
CDCA3
cell division cycle associated 3
chr1_-_51796987 0.53 ENST00000262676.5
TTC39A
tetratricopeptide repeat domain 39A
chr14_-_24711470 0.53 ENST00000559969.1
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr11_-_47198380 0.51 ENST00000419701.2
ENST00000526342.1
ENST00000528444.1
ENST00000530596.1
ENST00000525398.1
ENST00000319543.6
ENST00000426335.2
ENST00000527927.1
ENST00000525314.1
ARFGAP2
ADP-ribosylation factor GTPase activating protein 2
chr11_-_71823715 0.51 ENST00000545944.1
ENST00000502597.2
ANAPC15
anaphase promoting complex subunit 15
chr12_+_2921788 0.49 ENST00000228799.2
ENST00000419778.2
ENST00000542548.1
ITFG2
integrin alpha FG-GAP repeat containing 2
chr1_-_221915418 0.47 ENST00000323825.3
ENST00000366899.3
DUSP10
dual specificity phosphatase 10
chr4_-_66536196 0.45 ENST00000511294.1
EPHA5
EPH receptor A5
chr17_+_45286706 0.41 ENST00000393450.1
ENST00000572303.1
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr10_+_5238793 0.38 ENST00000263126.1
AKR1C4
aldo-keto reductase family 1, member C4
chr13_-_36050819 0.37 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chr14_-_24711806 0.37 ENST00000540705.1
ENST00000538777.1
ENST00000558566.1
ENST00000559019.1
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr14_-_24711865 0.36 ENST00000399423.4
ENST00000267415.7
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr16_-_2318373 0.34 ENST00000566458.1
ENST00000320225.5
RNPS1
RNA binding protein S1, serine-rich domain
chr3_+_186560476 0.30 ENST00000320741.2
ENST00000444204.2
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr3_+_186560462 0.29 ENST00000412955.2
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr5_-_22853429 0.27 ENST00000504376.2
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr19_-_6424783 0.26 ENST00000398148.3
KHSRP
KH-type splicing regulatory protein
chr7_+_120628731 0.25 ENST00000310396.5
CPED1
cadherin-like and PC-esterase domain containing 1
chr7_+_12727250 0.24 ENST00000404894.1
ARL4A
ADP-ribosylation factor-like 4A
chr21_-_37914898 0.23 ENST00000399136.1
CLDN14
claudin 14
chr2_-_47142884 0.22 ENST00000409105.1
ENST00000409973.1
ENST00000409913.1
ENST00000319466.4
MCFD2
multiple coagulation factor deficiency 2
chr7_+_6048856 0.20 ENST00000223029.3
ENST00000400479.2
ENST00000395236.2
AIMP2
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
chr17_-_10372875 0.19 ENST00000255381.2
MYH4
myosin, heavy chain 4, skeletal muscle
chr7_-_6048650 0.18 ENST00000382321.4
ENST00000406569.3
PMS2
PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
chr16_-_2318055 0.18 ENST00000561518.1
ENST00000561718.1
ENST00000567147.1
ENST00000562690.1
ENST00000569598.2
RNPS1
RNA binding protein S1, serine-rich domain
chr9_+_116225999 0.16 ENST00000317613.6
RGS3
regulator of G-protein signaling 3
chr11_+_134201768 0.16 ENST00000535456.2
ENST00000339772.7
GLB1L2
galactosidase, beta 1-like 2
chr2_-_167232484 0.16 ENST00000375387.4
ENST00000303354.6
ENST00000409672.1
SCN9A
sodium channel, voltage-gated, type IX, alpha subunit
chr7_+_26331541 0.16 ENST00000416246.1
ENST00000338523.4
ENST00000412416.1
SNX10
sorting nexin 10
chr22_+_22730353 0.13 ENST00000390296.2
IGLV5-45
immunoglobulin lambda variable 5-45
chr4_+_87515454 0.08 ENST00000427191.2
ENST00000436978.1
ENST00000502971.1
PTPN13
protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
chr1_-_51796226 0.07 ENST00000451380.1
ENST00000371747.3
ENST00000439482.1
TTC39A
tetratricopeptide repeat domain 39A
chrX_-_153363188 0.03 ENST00000303391.6
MECP2
methyl CpG binding protein 2 (Rett syndrome)
chr12_-_91451758 0.02 ENST00000266719.3
KERA
keratocan

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX1-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.7 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
1.0 5.2 GO:0033383 geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337)
1.0 3.0 GO:0006258 UDP-glucose catabolic process(GO:0006258) galactose catabolic process via UDP-galactose(GO:0033499)
0.9 2.7 GO:0044878 mitotic cytokinesis checkpoint(GO:0044878)
0.7 2.7 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.6 3.4 GO:0051661 maintenance of centrosome location(GO:0051661)
0.3 1.2 GO:0046490 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
0.3 1.4 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.3 1.3 GO:0007068 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070)
0.2 3.6 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.2 1.3 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836)
0.2 0.6 GO:0097018 renal albumin absorption(GO:0097018) regulation of renal albumin absorption(GO:2000532) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.2 1.2 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 0.7 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.1 0.6 GO:1903721 regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721)
0.1 0.5 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 1.4 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.1 1.7 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
0.1 0.7 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.1 0.8 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.1 1.2 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1 1.1 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 0.2 GO:1903630 regulation of aminoacyl-tRNA ligase activity(GO:1903630)
0.1 1.0 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.1 0.6 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.1 1.4 GO:1900363 regulation of mRNA polyadenylation(GO:1900363)
0.1 0.4 GO:0071395 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.1 1.1 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 0.8 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.0 3.6 GO:0031663 lipopolysaccharide-mediated signaling pathway(GO:0031663)
0.0 0.7 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0 1.9 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 1.1 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.0 0.3 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.0 0.6 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 1.6 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.1 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 1.5 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.5 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.0 0.6 GO:0007091 metaphase/anaphase transition of mitotic cell cycle(GO:0007091)
0.0 0.8 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.7 GO:0090003 regulation of establishment of protein localization to plasma membrane(GO:0090003)
0.0 0.6 GO:0006284 base-excision repair(GO:0006284)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.6 GO:0046581 intercellular canaliculus(GO:0046581)
0.5 3.4 GO:0036449 microtubule minus-end(GO:0036449)
0.3 2.7 GO:0032133 chromosome passenger complex(GO:0032133)
0.2 2.7 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.2 0.6 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.1 1.3 GO:0070187 telosome(GO:0070187)
0.1 1.9 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 0.6 GO:0070545 PeBoW complex(GO:0070545)
0.1 0.7 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.1 0.8 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 1.9 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 0.5 GO:0061574 ASAP complex(GO:0061574)
0.1 1.3 GO:0071564 npBAF complex(GO:0071564)
0.0 0.9 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 1.4 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.6 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.2 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 0.7 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.4 GO:0005771 multivesicular body(GO:0005771)
0.0 1.0 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 1.1 GO:0031672 A band(GO:0031672)
0.0 0.5 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.2 GO:0032982 myosin filament(GO:0032982)
0.0 0.8 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 5.2 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.5 3.1 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.4 1.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.3 2.7 GO:0035174 histone serine kinase activity(GO:0035174)
0.3 3.0 GO:0070569 uridylyltransferase activity(GO:0070569)
0.3 1.1 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.2 2.5 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.2 1.2 GO:0042296 ISG15 transferase activity(GO:0042296)
0.2 1.4 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.2 2.7 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.2 0.6 GO:0005174 CD40 receptor binding(GO:0005174)
0.2 0.6 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.2 0.7 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.2 1.4 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.2 0.7 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.1 1.9 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 1.6 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 1.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 1.3 GO:0030957 Tat protein binding(GO:0030957)
0.1 0.4 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
0.1 3.6 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 1.2 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 0.7 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.1 1.0 GO:0015923 mannosidase activity(GO:0015923)
0.0 0.6 GO:0033691 sialic acid binding(GO:0033691)
0.0 7.1 GO:0044325 ion channel binding(GO:0044325)
0.0 0.7 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) mitogen-activated protein kinase p38 binding(GO:0048273)
0.0 1.3 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.2 GO:0004565 beta-galactosidase activity(GO:0004565)
0.0 0.1 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 0.8 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 3.5 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 13.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 1.3 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 2.7 PID AURORA B PATHWAY Aurora B signaling
0.0 1.4 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.9 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.5 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.4 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 1.3 PID TELOMERASE PATHWAY Regulation of Telomerase

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.7 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.2 3.7 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.2 6.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.9 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.1 0.7 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 1.9 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 1.1 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.4 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.6 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 2.7 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 1.9 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 1.3 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.8 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.6 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.8 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.9 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 1.1 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.9 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.8 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification