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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for NKX2-2
Z-value: 1.24
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Transcription factors associated with NKX2-2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NKX2-2 | hg19_v2_chr20_-_21494654_21494678 | -0.22 | 1.2e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX2-2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 74.2 | GO:0045143 | homologous chromosome segregation(GO:0045143) |
| 2.0 | 58.0 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 1.2 | 47.4 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.6 | 45.7 | GO:0070126 | mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126) |
| 0.8 | 38.5 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 2.9 | 37.3 | GO:0070986 | left/right axis specification(GO:0070986) |
| 9.3 | 37.1 | GO:0044111 | development involved in symbiotic interaction(GO:0044111) |
| 7.3 | 36.4 | GO:0006436 | tryptophanyl-tRNA aminoacylation(GO:0006436) |
| 4.2 | 33.8 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 5.6 | 33.7 | GO:0042780 | tRNA 3'-end processing(GO:0042780) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 63.7 | GO:0005811 | lipid particle(GO:0005811) |
| 1.8 | 58.0 | GO:1902562 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
| 2.2 | 47.8 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
| 1.1 | 45.7 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.3 | 39.8 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.7 | 38.5 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.2 | 36.6 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 1.6 | 35.8 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.2 | 33.7 | GO:0000784 | nuclear chromosome, telomeric region(GO:0000784) |
| 2.0 | 32.2 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 94.0 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.9 | 68.9 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 2.5 | 63.8 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 0.2 | 61.5 | GO:0003924 | GTPase activity(GO:0003924) |
| 5.5 | 38.5 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 7.3 | 36.4 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
| 0.3 | 36.1 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.7 | 34.5 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 5.6 | 33.8 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 7.7 | 31.0 | GO:0004310 | farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 46.4 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.7 | 39.7 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.3 | 35.5 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.3 | 29.7 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.2 | 28.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.3 | 26.8 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.5 | 23.8 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.7 | 23.6 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.2 | 21.1 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.3 | 19.1 | PID RAC1 PATHWAY | RAC1 signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 68.9 | REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS | Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins |
| 1.7 | 42.3 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 1.1 | 38.7 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 1.0 | 36.4 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.9 | 34.0 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 1.3 | 33.8 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 1.1 | 33.7 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 1.7 | 32.9 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 1.0 | 31.0 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 1.3 | 29.0 | REACTOME SIGNALLING TO P38 VIA RIT AND RIN | Genes involved in Signalling to p38 via RIT and RIN |