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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for NKX2-2

Z-value: 1.24

Motif logo

Transcription factors associated with NKX2-2

Gene Symbol Gene ID Gene Info
ENSG00000125820.5 NK2 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-2hg19_v2_chr20_-_21494654_21494678-0.221.2e-03Click!

Activity profile of NKX2-2 motif

Sorted Z-values of NKX2-2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr9_+_91926103 38.52 ENST00000314355.6
CDC28 protein kinase regulatory subunit 2
chr1_-_54405773 35.85 ENST00000371376.1
heat shock protein family B (small), member 11
chr5_+_159848807 35.25 ENST00000352433.5
pituitary tumor-transforming 1
chr9_+_131447342 34.53 ENST00000409104.3
SET nuclear oncogene
chr2_+_170655322 33.68 ENST00000260956.4
ENST00000417292.1
Sjogren syndrome antigen B (autoantigen La)
chr5_+_159848854 33.62 ENST00000517480.1
ENST00000520452.1
ENST00000393964.1
pituitary tumor-transforming 1
chr17_+_48823896 26.43 ENST00000511974.1
LUC7-like 3 (S. cerevisiae)
chr8_-_121457332 26.41 ENST00000518918.1
mitochondrial ribosomal protein L13
chr15_-_60690163 25.26 ENST00000558998.1
ENST00000560165.1
ENST00000557986.1
ENST00000559780.1
ENST00000559467.1
ENST00000559956.1
ENST00000332680.4
ENST00000396024.3
ENST00000421017.2
ENST00000560466.1
ENST00000558132.1
ENST00000559113.1
ENST00000557906.1
ENST00000558558.1
ENST00000560468.1
ENST00000559370.1
ENST00000558169.1
ENST00000559725.1
ENST00000558985.1
ENST00000451270.2
annexin A2
chr8_-_101962777 24.93 ENST00000395951.3
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr12_+_69004619 24.57 ENST00000250559.9
ENST00000393436.5
ENST00000425247.2
ENST00000489473.2
ENST00000422358.2
ENST00000541167.1
ENST00000538283.1
ENST00000341355.5
ENST00000537460.1
ENST00000450214.2
ENST00000545270.1
ENST00000538980.1
ENST00000542018.1
ENST00000543393.1
RAP1B, member of RAS oncogene family
chr10_-_121296045 24.55 ENST00000392865.1
regulator of G-protein signaling 10
chr19_-_18433910 24.25 ENST00000594828.3
ENST00000593829.1
LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr3_+_158991025 23.85 ENST00000337808.6
IQCJ-SCHIP1 readthrough
chr5_+_34757309 22.74 ENST00000397449.1
retinoic acid induced 14
chr22_-_42086477 22.72 ENST00000402458.1
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
chr19_+_47634039 21.80 ENST00000597808.1
ENST00000413379.3
ENST00000600706.1
ENST00000540850.1
ENST00000598840.1
ENST00000600753.1
ENST00000270225.7
ENST00000392776.3
SUMO1 activating enzyme subunit 1
chr17_+_48823975 21.40 ENST00000513969.1
ENST00000503728.1
LUC7-like 3 (S. cerevisiae)
chr10_-_36813162 20.92 ENST00000440465.1
nicotinamide phosphoribosyltransferase-like
chr14_-_100841670 20.60 ENST00000557297.1
ENST00000555813.1
ENST00000557135.1
ENST00000556698.1
ENST00000554509.1
ENST00000555410.1
tryptophanyl-tRNA synthetase
chr5_+_135394840 19.90 ENST00000503087.1
transforming growth factor, beta-induced, 68kDa
chr1_-_75198940 19.56 ENST00000417775.1
crystallin, zeta (quinone reductase)
chr2_-_151344172 19.43 ENST00000375734.2
ENST00000263895.4
ENST00000454202.1
Rho family GTPase 3
chr15_+_65843130 19.23 ENST00000569894.1
protein tyrosine phosphatase-like A domain containing 1
chr2_+_219110149 19.13 ENST00000456575.1
actin related protein 2/3 complex, subunit 2, 34kDa
chr8_-_121457608 18.80 ENST00000306185.3
mitochondrial ribosomal protein L13
chr11_-_11374904 18.79 ENST00000528848.2
casein kinase 2, alpha 3 polypeptide
chr7_+_2394445 18.67 ENST00000360876.4
ENST00000413917.1
ENST00000397011.2
eukaryotic translation initiation factor 3, subunit B
chr3_+_23847432 18.42 ENST00000346855.3
ubiquitin-conjugating enzyme E2E 1
chrX_-_70474910 18.26 ENST00000373988.1
ENST00000373998.1
zinc finger, MYM-type 3
chr8_+_26150628 18.17 ENST00000523925.1
ENST00000315985.7
protein phosphatase 2, regulatory subunit B, alpha
chr19_-_14945933 17.98 ENST00000322301.3
olfactory receptor, family 7, subfamily A, member 5
chr3_+_152017181 17.85 ENST00000498502.1
ENST00000324196.5
ENST00000545754.1
ENST00000357472.3
muscleblind-like splicing regulator 1
chr8_+_71485681 17.79 ENST00000391684.1
AC120194.1
chr8_+_11666649 17.24 ENST00000528643.1
ENST00000525777.1
farnesyl-diphosphate farnesyltransferase 1
chr19_+_39138320 17.21 ENST00000424234.2
ENST00000390009.3
ENST00000589528.1
actinin, alpha 4
chr8_-_49834299 17.17 ENST00000396822.1
snail family zinc finger 2
chr6_-_150067632 17.16 ENST00000460354.2
ENST00000367404.4
ENST00000543637.1
nucleoporin 43kDa
chr11_-_107729887 17.12 ENST00000525815.1
solute carrier family 35, member F2
chr18_+_29671812 16.50 ENST00000261593.3
ENST00000578914.1
ring finger protein 138, E3 ubiquitin protein ligase
chr1_-_115259337 16.35 ENST00000369535.4
neuroblastoma RAS viral (v-ras) oncogene homolog
chr5_-_43557791 15.94 ENST00000338972.4
ENST00000511321.1
ENST00000515338.1
poly(A) binding protein interacting protein 1
chr15_+_79165372 15.84 ENST00000558502.1
mortality factor 4 like 1
chr14_-_100841930 15.80 ENST00000555031.1
ENST00000553395.1
ENST00000553545.1
ENST00000344102.5
ENST00000556338.1
ENST00000392882.2
ENST00000553934.1
tryptophanyl-tRNA synthetase
chr9_-_139361503 15.63 ENST00000453963.1
SEC16 homolog A (S. cerevisiae)
chr1_+_53480598 15.53 ENST00000430330.2
ENST00000408941.3
ENST00000478274.2
ENST00000484100.1
ENST00000435345.2
ENST00000488965.1
sterol carrier protein 2
chrX_-_23761317 15.51 ENST00000492081.1
ENST00000379303.5
ENST00000336430.7
acyl-CoA thioesterase 9
chr3_+_23847394 15.35 ENST00000306627.3
ubiquitin-conjugating enzyme E2E 1
chr11_-_77850629 15.16 ENST00000376156.3
ENST00000525870.1
ENST00000530454.1
ENST00000525755.1
ENST00000527099.1
ENST00000525761.1
ENST00000299626.5
ALG8, alpha-1,3-glucosyltransferase
chr6_-_150067696 15.01 ENST00000340413.2
ENST00000367403.3
nucleoporin 43kDa
chr9_-_86593238 14.69 ENST00000351839.3
heterogeneous nuclear ribonucleoprotein K
chr5_+_82767583 14.65 ENST00000512590.2
ENST00000513960.1
ENST00000513984.1
ENST00000502527.2
versican
chr12_-_49582978 14.61 ENST00000301071.7
tubulin, alpha 1a
chrX_+_123095546 14.44 ENST00000371157.3
ENST00000371145.3
ENST00000371144.3
stromal antigen 2
chr18_+_9103957 14.42 ENST00000400033.1
NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
chr5_+_82767487 14.16 ENST00000343200.5
ENST00000342785.4
versican
chrX_-_70474499 14.00 ENST00000353904.2
zinc finger, MYM-type 3
chr8_-_141810634 13.78 ENST00000521986.1
ENST00000523539.1
ENST00000538769.1
protein tyrosine kinase 2
chr8_-_49833978 13.44 ENST00000020945.1
snail family zinc finger 2
chr22_-_36220420 13.27 ENST00000473487.2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr12_-_120315074 13.23 ENST00000261833.7
ENST00000392521.2
citron (rho-interacting, serine/threonine kinase 21)
chr15_+_79165296 13.15 ENST00000558746.1
ENST00000558830.1
ENST00000559345.1
mortality factor 4 like 1
chr1_-_155880672 12.65 ENST00000609492.1
ENST00000368322.3
Ras-like without CAAX 1
chr9_+_71819927 12.47 ENST00000535702.1
tight junction protein 2
chr8_-_101719159 12.46 ENST00000520868.1
ENST00000522658.1
poly(A) binding protein, cytoplasmic 1
chr7_+_115862858 12.46 ENST00000393481.2
testis derived transcript (3 LIM domains)
chr20_+_57226841 12.42 ENST00000358029.4
ENST00000361830.3
syntaxin 16
chr9_+_71820057 11.92 ENST00000539225.1
tight junction protein 2
chr2_+_201994208 11.83 ENST00000440180.1
CASP8 and FADD-like apoptosis regulator
chr15_-_56209306 11.82 ENST00000506154.1
ENST00000338963.2
ENST00000508342.1
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
chr19_-_2427536 11.54 ENST00000591871.1
translocase of inner mitochondrial membrane 13 homolog (yeast)
chr18_+_55888767 11.49 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr3_+_183892635 11.47 ENST00000427072.1
ENST00000411763.2
ENST00000292807.5
ENST00000448139.1
ENST00000455925.1
adaptor-related protein complex 2, mu 1 subunit
chr3_+_179280668 11.46 ENST00000429709.2
ENST00000450518.2
ENST00000392662.1
ENST00000490364.1
actin-like 6A
chr1_-_246670519 11.41 ENST00000388985.4
ENST00000490107.1
SET and MYND domain containing 3
chr17_+_52978107 11.19 ENST00000445275.2
target of myb1 (chicken)-like 1
chr19_+_39138271 11.05 ENST00000252699.2
actinin, alpha 4
chr1_-_36615051 10.54 ENST00000373163.1
trafficking protein particle complex 3
chr11_+_9406169 10.42 ENST00000379719.3
ENST00000527431.1
importin 7
chr8_-_101718991 10.34 ENST00000517990.1
poly(A) binding protein, cytoplasmic 1
chr5_-_98262240 10.30 ENST00000284049.3
chromodomain helicase DNA binding protein 1
chr5_+_118812294 10.25 ENST00000509514.1
hydroxysteroid (17-beta) dehydrogenase 4
chr3_-_33686743 9.98 ENST00000333778.6
ENST00000539981.1
cytoplasmic linker associated protein 2
chr6_-_55739542 9.44 ENST00000446683.2
bone morphogenetic protein 5
chr1_-_36615065 8.98 ENST00000373166.3
ENST00000373159.1
ENST00000373162.1
trafficking protein particle complex 3
chr10_+_13628921 8.70 ENST00000378572.3
pre-mRNA processing factor 18
chr17_+_66521936 8.64 ENST00000592800.1
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr3_-_196911002 8.32 ENST00000452595.1
discs, large homolog 1 (Drosophila)
chr12_+_56546363 8.22 ENST00000551834.1
ENST00000552568.1
myosin, light chain 6B, alkali, smooth muscle and non-muscle
chr8_-_141774467 8.02 ENST00000520151.1
ENST00000519024.1
ENST00000519465.1
protein tyrosine kinase 2
chr14_+_96968707 8.00 ENST00000216277.8
ENST00000557320.1
ENST00000557471.1
poly(A) polymerase alpha
chr11_+_64949899 7.99 ENST00000531068.1
ENST00000527699.1
ENST00000533909.1
ENST00000527323.1
calpain 1, (mu/I) large subunit
chr12_+_20963632 7.98 ENST00000540853.1
ENST00000261196.2
solute carrier organic anion transporter family, member 1B3
chr5_+_140602904 7.97 ENST00000515856.2
ENST00000239449.4
protocadherin beta 14
chr17_+_75315534 7.95 ENST00000590294.1
ENST00000329047.8
septin 9
chr3_+_38206975 7.85 ENST00000446845.1
ENST00000311806.3
oxidative stress responsive 1
chr6_+_158733692 7.81 ENST00000367094.2
ENST00000367097.3
tubby like protein 4
chr12_+_20963647 7.72 ENST00000381545.3
solute carrier organic anion transporter family, member 1B3
chr8_+_110552337 7.58 ENST00000337573.5
estrogen receptor binding site associated, antigen, 9
chr2_+_162087577 7.57 ENST00000439442.1
TRAF family member-associated NFKB activator
chr5_+_167718604 7.30 ENST00000265293.4
WW and C2 domain containing 1
chr5_-_179047881 7.28 ENST00000521173.1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr10_-_112678692 7.27 ENST00000605742.1
BBSome interacting protein 1
chrX_+_11777671 7.26 ENST00000380693.3
ENST00000380692.2
male-specific lethal 3 homolog (Drosophila)
chr13_+_50656307 7.22 ENST00000378180.4
deleted in lymphocytic leukemia 1 (non-protein coding)
chr2_+_189157536 7.16 ENST00000409580.1
ENST00000409637.3
GULP, engulfment adaptor PTB domain containing 1
chr8_+_11660227 7.16 ENST00000443614.2
ENST00000525900.1
farnesyl-diphosphate farnesyltransferase 1
chr2_+_189157498 7.13 ENST00000359135.3
GULP, engulfment adaptor PTB domain containing 1
chr5_+_118812237 7.12 ENST00000513628.1
hydroxysteroid (17-beta) dehydrogenase 4
chr14_-_50154921 7.09 ENST00000553805.2
ENST00000554396.1
ENST00000216367.5
ENST00000539565.2
polymerase (DNA directed), epsilon 2, accessory subunit
chr1_-_31538517 7.09 ENST00000440538.2
ENST00000423018.2
ENST00000424085.2
ENST00000426105.2
ENST00000257075.5
ENST00000373747.3
ENST00000525843.1
ENST00000373742.2
pumilio RNA-binding family member 1
chr1_-_227505289 7.07 ENST00000366765.3
CDC42 binding protein kinase alpha (DMPK-like)
chr15_+_79165151 6.97 ENST00000331268.5
mortality factor 4 like 1
chr10_+_13203543 6.91 ENST00000378714.3
ENST00000479669.1
ENST00000484800.2
minichromosome maintenance complex component 10
chr4_+_41937131 6.91 ENST00000504986.1
ENST00000508448.1
ENST00000513702.1
ENST00000325094.5
transmembrane protein 33
chr16_+_30212378 6.70 ENST00000569485.1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr8_+_11660120 6.60 ENST00000220584.4
farnesyl-diphosphate farnesyltransferase 1
chr2_-_55276320 6.58 ENST00000357376.3
reticulon 4
chr4_-_105416039 6.51 ENST00000394767.2
CXXC finger protein 4
chr2_+_120436733 6.15 ENST00000401466.1
ENST00000424086.1
ENST00000272521.6
transmembrane protein 177
chr1_+_84630053 6.12 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
protein kinase, cAMP-dependent, catalytic, beta
chr13_+_25875785 5.99 ENST00000381747.3
nucleoporin like 1
chr6_+_32936353 5.97 ENST00000374825.4
bromodomain containing 2
chr16_+_30212050 5.81 ENST00000563322.1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr19_-_44174330 5.80 ENST00000340093.3
plasminogen activator, urokinase receptor
chr8_+_110552831 5.71 ENST00000530629.1
estrogen receptor binding site associated, antigen, 9
chr8_-_122653630 5.50 ENST00000303924.4
hyaluronan synthase 2
chr20_-_13765526 5.37 ENST00000202816.1
ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
chrX_+_152953505 5.36 ENST00000253122.5
solute carrier family 6 (neurotransmitter transporter), member 8
chr14_-_20801427 5.31 ENST00000557665.1
ENST00000358932.4
ENST00000353689.4
cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
chr12_-_58240470 4.95 ENST00000548823.1
ENST00000398073.2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr16_-_1821496 4.93 ENST00000564628.1
ENST00000563498.1
NME/NM23 nucleoside diphosphate kinase 3
chr12_-_10955226 4.90 ENST00000240687.2
taste receptor, type 2, member 7
chr5_-_150521192 4.74 ENST00000523714.1
ENST00000521749.1
annexin A6
chr10_-_104262460 4.65 ENST00000446605.2
ENST00000369905.4
ENST00000545684.1
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
chr7_+_79765071 4.61 ENST00000457358.2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
chr13_-_36944307 4.59 ENST00000355182.4
spastic paraplegia 20 (Troyer syndrome)
chr14_+_22962898 4.56 ENST00000390492.1
T cell receptor alpha joining 45
chr17_+_74372662 4.41 ENST00000591651.1
ENST00000545180.1
sphingosine kinase 1
chrX_+_108779004 4.39 ENST00000218004.1
nuclear transport factor 2-like export factor 2
chr8_-_99954788 4.34 ENST00000523601.1
serine/threonine kinase 3
chr12_-_10978957 4.34 ENST00000240619.2
taste receptor, type 2, member 10
chr5_+_125758865 4.26 ENST00000542322.1
ENST00000544396.1
GRAM domain containing 3
chrX_-_70473957 4.25 ENST00000373984.3
ENST00000314425.5
ENST00000373982.1
zinc finger, MYM-type 3
chr8_+_97597148 4.12 ENST00000521590.1
syndecan 2
chr12_-_54689532 4.02 ENST00000540264.2
ENST00000312156.4
nuclear factor, erythroid 2
chr3_-_113897899 3.80 ENST00000383673.2
ENST00000295881.7
dopamine receptor D3
chr4_+_56719782 3.72 ENST00000381295.2
ENST00000346134.7
ENST00000349598.6
exocyst complex component 1
chr12_-_28124903 3.70 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
parathyroid hormone-like hormone
chr13_+_102104980 3.66 ENST00000545560.2
integrin, beta-like 1 (with EGF-like repeat domains)
chr5_+_125758813 3.62 ENST00000285689.3
ENST00000515200.1
GRAM domain containing 3
chr12_-_10875831 3.61 ENST00000279550.7
ENST00000228251.4
Y box binding protein 3
chr22_-_39268308 3.61 ENST00000407418.3
chromobox homolog 6
chr12_-_111926342 3.41 ENST00000389154.3
ataxin 2
chr15_+_79165222 3.30 ENST00000559930.1
mortality factor 4 like 1
chr1_+_224301787 3.25 ENST00000366862.5
ENST00000424254.2
F-box protein 28
chr17_-_42143963 3.24 ENST00000585388.1
ENST00000293406.3
LSM12 homolog (S. cerevisiae)
chr19_-_39881669 3.13 ENST00000221266.7
Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
chr4_+_95376396 3.08 ENST00000508216.1
ENST00000514743.1
PDZ and LIM domain 5
chr9_+_125132803 3.05 ENST00000540753.1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr7_+_150065278 3.02 ENST00000519397.1
ENST00000479668.1
ENST00000540729.1
replication initiator 1
chr4_-_99578776 2.98 ENST00000515287.1
tetraspanin 5
chr14_+_39703084 2.94 ENST00000553728.1
cTAGE family member 5 isoform 4
chr9_+_116263778 2.92 ENST00000394646.3
regulator of G-protein signaling 3
chr6_+_151561506 2.82 ENST00000253332.1
A kinase (PRKA) anchor protein 12
chr10_-_104262426 2.78 ENST00000487599.1
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
chr20_+_57226284 2.64 ENST00000458280.1
ENST00000355957.5
ENST00000361770.5
ENST00000312283.8
ENST00000412911.1
ENST00000359617.4
ENST00000371141.4
syntaxin 16
chr9_+_116263639 2.62 ENST00000343817.5
regulator of G-protein signaling 3
chr2_+_152266392 2.60 ENST00000444746.2
ENST00000453091.2
ENST00000428287.2
ENST00000433166.2
ENST00000420714.3
ENST00000243326.5
ENST00000414861.2
RAP1 interacting factor homolog (yeast)
chr12_-_68696652 2.45 ENST00000539972.1
Mdm1 nuclear protein homolog (mouse)
chr11_-_72432950 2.43 ENST00000426523.1
ENST00000429686.1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr20_+_30697510 2.41 ENST00000217315.5
transmembrane 9 superfamily protein member 4
chr13_+_50570019 2.29 ENST00000442421.1
tripartite motif containing 13
chr20_+_30697298 2.28 ENST00000398022.2
transmembrane 9 superfamily protein member 4
chr19_-_44174305 2.07 ENST00000601723.1
ENST00000339082.3
plasminogen activator, urokinase receptor
chr17_+_7591747 2.04 ENST00000534050.1
WD repeat containing, antisense to TP53
chr12_-_71551652 1.97 ENST00000546561.1
tetraspanin 8
chr6_-_155776966 1.93 ENST00000159060.2
NADPH oxidase 3
chr6_-_11779014 1.88 ENST00000229583.5
androgen-dependent TFPI-regulating protein
chr6_+_151561085 1.87 ENST00000402676.2
A kinase (PRKA) anchor protein 12
chr4_-_111563076 1.62 ENST00000354925.2
ENST00000511990.1
paired-like homeodomain 2
chr5_+_148206156 1.62 ENST00000305988.4
adrenoceptor beta 2, surface
chr16_+_10837643 1.57 ENST00000574334.1
ENST00000283027.5
ENST00000433392.2
nucleotide binding protein 1
chr11_-_26743546 1.53 ENST00000280467.6
ENST00000396005.3
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr17_-_38859996 1.51 ENST00000264651.2
keratin 24
chr3_-_170744498 1.46 ENST00000382808.4
ENST00000314251.3
solute carrier family 2 (facilitated glucose transporter), member 2
chr1_+_171217677 1.37 ENST00000402921.2
flavin containing monooxygenase 1
chr1_-_202936394 1.33 ENST00000367249.4
cytochrome b5 reductase 1
chr17_+_7591639 1.27 ENST00000396463.2
WD repeat containing, antisense to TP53
chr4_-_110723335 1.25 ENST00000394634.2
complement factor I
chr2_-_40739501 1.22 ENST00000403092.1
ENST00000402441.1
ENST00000448531.1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr2_-_214014959 1.16 ENST00000442445.1
ENST00000457361.1
ENST00000342002.2
IKAROS family zinc finger 2 (Helios)
chr11_+_107879459 1.09 ENST00000393094.2
cullin 5
chr8_+_76452097 1.05 ENST00000396423.2
hepatocyte nuclear factor 4, gamma
chr7_-_22234381 1.05 ENST00000458533.1
Rap guanine nucleotide exchange factor (GEF) 5
chr2_-_75938115 1.04 ENST00000321027.3
GC-rich sequence DNA-binding factor 2
chr8_+_77593474 1.02 ENST00000455469.2
ENST00000050961.6
zinc finger homeobox 4
chrX_+_49091920 1.00 ENST00000376227.3
coiled-coil domain containing 22
chr12_-_8803128 0.91 ENST00000543467.1
microfibrillar associated protein 5
chrX_+_107288239 0.90 ENST00000217957.5
V-set and immunoglobulin domain containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
10.2 30.6 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
9.4 28.3 GO:1902396 protein localization to bicellular tight junction(GO:1902396)
9.3 37.1 GO:0044111 development involved in symbiotic interaction(GO:0044111)
7.3 36.4 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
6.2 31.0 GO:0008204 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
5.6 33.7 GO:0042780 tRNA 3'-end processing(GO:0042780)
4.2 33.8 GO:0032020 ISG15-protein conjugation(GO:0032020)
3.7 14.7 GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
3.3 10.0 GO:0071676 negative regulation of mononuclear cell migration(GO:0071676)
3.1 15.5 GO:0032377 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
2.9 17.4 GO:0036111 very long-chain fatty-acyl-CoA metabolic process(GO:0036111)
2.9 37.3 GO:0070986 left/right axis specification(GO:0070986)
2.6 7.8 GO:2000681 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
2.5 22.8 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
2.4 24.4 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
2.4 21.8 GO:0038007 netrin-activated signaling pathway(GO:0038007)
2.4 16.5 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
2.3 18.7 GO:0075525 viral translational termination-reinitiation(GO:0075525)
2.3 6.9 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
2.3 11.5 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
2.2 13.3 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
2.0 58.0 GO:0043968 histone H2A acetylation(GO:0043968)
2.0 7.9 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
1.9 5.8 GO:0071048 nuclear mRNA surveillance of spliceosomal pre-mRNA splicing(GO:0071030) nuclear retention of unspliced pre-mRNA at the site of transcription(GO:0071048)
1.8 12.5 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
1.7 24.9 GO:0090168 Golgi reassembly(GO:0090168)
1.5 74.2 GO:0045143 homologous chromosome segregation(GO:0045143)
1.5 4.4 GO:0046521 sphingoid catabolic process(GO:0046521)
1.4 24.5 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
1.3 14.4 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
1.3 24.6 GO:0032486 Rap protein signal transduction(GO:0032486)
1.3 11.5 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
1.3 32.9 GO:0006337 nucleosome disassembly(GO:0006337)
1.3 7.6 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
1.2 10.0 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
1.2 47.4 GO:0006376 mRNA splice site selection(GO:0006376)
1.2 6.1 GO:0097338 response to clozapine(GO:0097338)
1.2 7.3 GO:0035331 negative regulation of hippo signaling(GO:0035331)
1.2 27.7 GO:0033962 cytoplasmic mRNA processing body assembly(GO:0033962)
1.2 8.3 GO:1903760 regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760)
1.2 28.8 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
1.1 4.6 GO:0048698 negative regulation of collateral sprouting in absence of injury(GO:0048698)
1.1 11.3 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
1.1 3.3 GO:0032203 telomere formation via telomerase(GO:0032203)
1.1 5.5 GO:0070295 renal water absorption(GO:0070295)
1.1 6.5 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
1.0 7.1 GO:1900246 positive regulation of RIG-I signaling pathway(GO:1900246)
1.0 18.2 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.9 3.8 GO:0050883 negative regulation of sodium:proton antiporter activity(GO:0032416) gastric motility(GO:0035482) gastric emptying(GO:0035483) musculoskeletal movement, spinal reflex action(GO:0050883)
0.9 15.2 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.9 19.6 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.9 15.1 GO:0090161 Golgi ribbon formation(GO:0090161)
0.9 19.1 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.9 4.3 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.8 3.3 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.8 38.5 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.7 11.2 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.7 32.2 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.7 6.6 GO:0006999 nuclear pore organization(GO:0006999) nuclear pore complex assembly(GO:0051292) endoplasmic reticulum tubular network assembly(GO:0071787)
0.7 7.3 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.7 11.5 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.6 10.3 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.6 45.7 GO:0070126 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.6 4.1 GO:0008218 bioluminescence(GO:0008218)
0.6 8.6 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.6 8.0 GO:0060056 mammary gland involution(GO:0060056)
0.5 1.6 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.5 16.3 GO:0072600 establishment of protein localization to Golgi(GO:0072600)
0.5 2.6 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.5 5.4 GO:0006600 creatine metabolic process(GO:0006600)
0.5 1.5 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.5 16.0 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.5 4.7 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.5 3.6 GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.4 4.9 GO:0046051 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.4 6.2 GO:0072697 protein localization to cell cortex(GO:0072697)
0.4 8.0 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.4 17.9 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.3 3.1 GO:0016584 nucleosome positioning(GO:0016584)
0.3 3.7 GO:0051601 exocyst localization(GO:0051601)
0.3 4.7 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.3 13.2 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.3 7.9 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.3 12.9 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.3 14.0 GO:0006270 DNA replication initiation(GO:0006270)
0.3 1.9 GO:0048840 otolith development(GO:0048840)
0.2 11.5 GO:0048255 mRNA stabilization(GO:0048255)
0.2 7.8 GO:0061512 protein localization to cilium(GO:0061512)
0.2 19.0 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.2 4.7 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.2 2.5 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.2 3.0 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.2 1.5 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.2 25.1 GO:0043484 regulation of RNA splicing(GO:0043484)
0.2 5.5 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.2 1.2 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.1 15.0 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.1 2.3 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.1 17.4 GO:0006334 nucleosome assembly(GO:0006334)
0.1 4.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 8.0 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 0.7 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.1 7.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 3.1 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 2.5 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.1 7.4 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.1 5.0 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.1 1.0 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.1 6.3 GO:0006810 transport(GO:0006810)
0.1 0.1 GO:0035990 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.1 4.4 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.1 0.5 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1 7.9 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
0.0 0.9 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 5.2 GO:0002062 chondrocyte differentiation(GO:0002062)
0.0 4.4 GO:0051028 mRNA transport(GO:0051028)
0.0 0.3 GO:0042797 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 0.1 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.0 13.3 GO:0001558 regulation of cell growth(GO:0001558)
0.0 0.9 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 2.5 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 2.3 GO:0006606 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744)
0.0 3.7 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 3.0 GO:0006260 DNA replication(GO:0006260)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
6.4 19.1 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
5.5 21.8 GO:0031510 SUMO activating enzyme complex(GO:0031510)
5.1 25.3 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
2.9 14.4 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
2.2 24.2 GO:0005688 U6 snRNP(GO:0005688)
2.2 47.8 GO:0071004 U2-type prespliceosome(GO:0071004)
2.1 18.7 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
2.0 32.2 GO:0031080 nuclear pore outer ring(GO:0031080)
1.9 5.8 GO:0071020 post-spliceosomal complex(GO:0071020)
1.8 58.0 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
1.6 35.8 GO:0030992 intraciliary transport particle B(GO:0030992)
1.6 19.5 GO:0030008 TRAPP complex(GO:0030008)
1.4 11.5 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
1.4 7.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
1.2 7.4 GO:0002177 manchette(GO:0002177)
1.1 45.7 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
1.0 28.3 GO:0031143 pseudopodium(GO:0031143)
1.0 3.0 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
1.0 10.0 GO:0045180 basal cortex(GO:0045180)
0.9 3.7 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.8 7.3 GO:0034464 BBSome(GO:0034464)
0.8 14.9 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.8 6.9 GO:0031298 replication fork protection complex(GO:0031298)
0.7 14.8 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.7 63.7 GO:0005811 lipid particle(GO:0005811)
0.7 7.9 GO:0071438 invadopodium membrane(GO:0071438)
0.7 8.3 GO:0097025 lateral loop(GO:0043219) MPP7-DLG1-LIN7 complex(GO:0097025)
0.7 38.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.7 19.1 GO:0035861 site of double-strand break(GO:0035861)
0.6 11.3 GO:0097342 ripoptosome(GO:0097342)
0.6 11.5 GO:0036020 endolysosome membrane(GO:0036020)
0.5 18.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.5 8.2 GO:0016461 unconventional myosin complex(GO:0016461)
0.5 28.3 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.4 24.6 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.4 6.6 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.4 1.1 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.4 8.0 GO:0031105 septin complex(GO:0031105)
0.4 11.8 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.4 5.3 GO:0000795 synaptonemal complex(GO:0000795)
0.3 3.1 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.3 11.5 GO:0005771 multivesicular body(GO:0005771)
0.3 1.9 GO:0043020 NADPH oxidase complex(GO:0043020)
0.3 39.8 GO:0005795 Golgi stack(GO:0005795)
0.2 14.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 33.7 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.2 28.0 GO:0005923 bicellular tight junction(GO:0005923)
0.2 25.6 GO:0042641 actomyosin(GO:0042641)
0.2 36.6 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.2 2.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.2 4.6 GO:0099738 cell cortex region(GO:0099738)
0.2 19.9 GO:0005604 basement membrane(GO:0005604)
0.2 21.5 GO:0005796 Golgi lumen(GO:0005796)
0.2 16.3 GO:0070821 tertiary granule membrane(GO:0070821)
0.2 24.5 GO:0043679 axon terminus(GO:0043679)
0.1 21.0 GO:0001650 fibrillar center(GO:0001650)
0.1 1.9 GO:0012505 endomembrane system(GO:0012505)
0.1 12.8 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 3.3 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 0.5 GO:0032420 stereocilium(GO:0032420)
0.1 10.4 GO:0005643 nuclear pore(GO:0005643)
0.1 24.4 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.1 14.4 GO:0000775 chromosome, centromeric region(GO:0000775)
0.1 3.6 GO:0031519 PcG protein complex(GO:0031519)
0.1 9.9 GO:0000790 nuclear chromatin(GO:0000790)
0.1 1.3 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 3.8 GO:0030139 endocytic vesicle(GO:0030139)
0.0 0.9 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.0 3.1 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.3 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 4.3 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.2 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.8 GO:0055037 recycling endosome(GO:0055037)
0.0 1.5 GO:0016324 apical plasma membrane(GO:0016324)
0.0 11.0 GO:0005925 focal adhesion(GO:0005925)
0.0 8.6 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 1.3 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 1.3 GO:0005882 intermediate filament(GO:0005882)
0.0 1.3 GO:0005667 transcription factor complex(GO:0005667)
0.0 12.0 GO:0005654 nucleoplasm(GO:0005654)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
7.7 31.0 GO:0004310 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
7.3 36.4 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
5.9 17.8 GO:0001069 regulatory region RNA binding(GO:0001069)
5.6 33.8 GO:0042296 ISG15 transferase activity(GO:0042296)
5.5 38.5 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
5.2 15.5 GO:0070538 oleic acid binding(GO:0070538)
5.1 15.2 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
4.2 25.3 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
3.9 19.6 GO:0070404 NADH binding(GO:0070404)
3.6 21.8 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
2.9 23.3 GO:0019871 sodium channel inhibitor activity(GO:0019871)
2.9 17.4 GO:0033989 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity(GO:0033989) 17-beta-hydroxysteroid dehydrogenase (NAD+) activity(GO:0044594)
2.6 7.9 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
2.5 63.8 GO:0008266 poly(U) RNA binding(GO:0008266)
2.4 24.2 GO:0042731 PH domain binding(GO:0042731)
2.1 12.5 GO:0047685 amine sulfotransferase activity(GO:0047685)
1.9 5.8 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
1.8 5.5 GO:0050501 hyaluronan synthase activity(GO:0050501)
1.3 15.9 GO:0008494 translation activator activity(GO:0008494)
1.3 21.8 GO:0008432 JUN kinase binding(GO:0008432)
1.3 11.4 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
1.3 7.6 GO:0035800 deubiquitinase activator activity(GO:0035800)
1.0 8.0 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
1.0 5.0 GO:0008420 CTD phosphatase activity(GO:0008420)
1.0 15.5 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
1.0 18.2 GO:0048156 tau protein binding(GO:0048156)
1.0 28.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.9 68.9 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.8 9.2 GO:0033038 bitter taste receptor activity(GO:0033038)
0.8 24.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.8 3.0 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.8 8.3 GO:0097016 L27 domain binding(GO:0097016)
0.7 4.4 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.7 34.5 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.7 15.7 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.7 14.4 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.6 11.5 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.6 19.1 GO:0004385 guanylate kinase activity(GO:0004385)
0.6 28.3 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.6 13.3 GO:0016505 peptidase activator activity involved in apoptotic process(GO:0016505)
0.5 3.8 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.5 1.6 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.5 1.5 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.5 16.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.5 6.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.4 18.7 GO:0031369 translation initiation factor binding(GO:0031369)
0.4 8.6 GO:0008603 cAMP-dependent protein kinase inhibitor activity(GO:0004862) cAMP-dependent protein kinase regulator activity(GO:0008603)
0.4 6.9 GO:0003688 DNA replication origin binding(GO:0003688)
0.4 1.2 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.4 11.3 GO:0005123 death receptor binding(GO:0005123) cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.4 4.6 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.4 19.5 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.4 10.0 GO:0051010 microtubule plus-end binding(GO:0051010)
0.4 94.0 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.4 17.9 GO:0004984 olfactory receptor activity(GO:0004984)
0.3 24.6 GO:0019003 GDP binding(GO:0019003)
0.3 15.1 GO:0005484 SNAP receptor activity(GO:0005484)
0.3 5.4 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.3 4.7 GO:0008179 adenylate cyclase binding(GO:0008179)
0.3 3.3 GO:0031702 angiotensin receptor binding(GO:0031701) type 1 angiotensin receptor binding(GO:0031702)
0.3 11.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.3 10.3 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.3 6.9 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.3 7.1 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.3 36.1 GO:0047485 protein N-terminus binding(GO:0047485)
0.2 21.6 GO:0030165 PDZ domain binding(GO:0030165)
0.2 10.4 GO:0008536 Ran GTPase binding(GO:0008536)
0.2 4.9 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.2 61.5 GO:0003924 GTPase activity(GO:0003924)
0.2 0.7 GO:0002113 interleukin-33 binding(GO:0002113)
0.2 3.7 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.2 11.2 GO:0030276 clathrin binding(GO:0030276)
0.2 2.3 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.2 3.7 GO:0017049 GTP-Rho binding(GO:0017049)
0.2 8.0 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 27.5 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.2 6.0 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.2 1.5 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.2 4.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 4.3 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.2 1.9 GO:0070700 BMP receptor binding(GO:0070700)
0.1 14.7 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 3.1 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 3.3 GO:0070034 telomerase RNA binding(GO:0070034)
0.1 7.3 GO:0035064 methylated histone binding(GO:0035064)
0.1 7.3 GO:0032947 protein complex scaffold(GO:0032947)
0.1 1.3 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 1.3 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 0.3 GO:0033149 FFAT motif binding(GO:0033149)
0.1 0.5 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.1 1.9 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.1 14.9 GO:0000287 magnesium ion binding(GO:0000287)
0.1 1.0 GO:0097602 cullin family protein binding(GO:0097602)
0.1 26.7 GO:0045296 cadherin binding(GO:0045296)
0.1 0.8 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 3.6 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 5.1 GO:0008565 protein transporter activity(GO:0008565)
0.1 2.5 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 1.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 6.5 GO:0005178 integrin binding(GO:0005178)
0.0 0.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 4.0 GO:0003774 motor activity(GO:0003774)
0.0 1.3 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 46.4 PID NECTIN PATHWAY Nectin adhesion pathway
0.7 16.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.7 23.6 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.7 39.7 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.5 23.8 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.5 11.5 PID ARF 3PATHWAY Arf1 pathway
0.4 9.0 PID S1P S1P1 PATHWAY S1P1 pathway
0.3 35.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.3 13.2 PID RHOA PATHWAY RhoA signaling pathway
0.3 29.7 PID TGFBR PATHWAY TGF-beta receptor signaling
0.3 11.8 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.3 11.3 PID TRAIL PATHWAY TRAIL signaling pathway
0.3 26.8 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.3 5.5 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.3 5.0 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.3 7.7 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.3 19.1 PID RAC1 PATHWAY RAC1 signaling pathway
0.3 14.6 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.3 8.3 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.3 11.5 PID MYC PATHWAY C-MYC pathway
0.3 16.3 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2 12.0 PID PLK1 PATHWAY PLK1 signaling events
0.2 21.1 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.2 9.2 PID ARF6 PATHWAY Arf6 signaling events
0.2 8.0 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.2 3.7 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.2 3.7 PID INSULIN PATHWAY Insulin Pathway
0.2 28.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 8.1 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 1.2 PID CDC42 PATHWAY CDC42 signaling events
0.0 0.8 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.9 PID NOTCH PATHWAY Notch signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 32.9 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
1.7 42.3 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
1.6 24.2 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
1.3 33.8 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
1.3 24.4 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
1.3 29.0 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
1.1 38.7 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
1.1 33.7 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
1.0 24.9 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
1.0 36.4 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
1.0 31.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
1.0 27.0 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.9 28.3 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.9 34.0 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.9 68.9 REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.8 12.3 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.6 11.6 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.6 11.5 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.6 15.2 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.6 8.0 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.5 14.6 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.5 15.1 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.5 4.6 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.5 22.7 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.4 14.8 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.4 12.1 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.4 7.1 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.4 11.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.4 17.6 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.3 8.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.3 5.5 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.3 18.2 REACTOME G1 PHASE Genes involved in G1 Phase
0.3 7.9 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.3 22.0 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.3 11.8 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.2 18.7 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 7.6 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.2 3.3 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.2 4.1 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.2 6.9 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.2 11.5 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.2 14.4 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 14.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.2 3.7 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 27.0 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 4.7 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 7.1 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 5.0 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.5 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.1 5.0 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 6.9 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 1.2 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 1.3 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.3 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 2.7 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters