ISMARA results: NKX2-4

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for NKX2-4

Z-value: 0.65

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Transcription factors associated with NKX2-4

Gene Symbol	Gene ID	Gene Info
NKX2-4 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000125816.4	NK2 homeobox 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NKX2-4	hg19_v2_chr20_-_21378666_21378666	-0.11	1.0e-01	Click!

Activity profile of NKX2-4 motif

Sorted Z-values of NKX2-4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_49066811 Show fit	10.35	ENST00000442157.1 ENST00000326739.4	IMPDH2 Ensembl NCBI GeneCards UniProt NextProt Show fit	IMP (inosine 5'-monophosphate) dehydrogenase 2
chr10_-_28571015 Show fit	7.60	ENST00000375719.3 ENST00000375732.1	MPP7 Ensembl NCBI GeneCards UniProt NextProt Show fit	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr2_-_225434538 Show fit	7.02	ENST00000409096.1	CUL3 Ensembl NCBI GeneCards UniProt NextProt Show fit	cullin 3
chr1_-_153643442 Show fit	6.46	ENST00000368681.1 ENST00000361891.4	ILF2 Ensembl NCBI GeneCards UniProt NextProt Show fit	interleukin enhancer binding factor 2
chr7_-_96339132 Show fit	6.39	ENST00000413065.1	SHFM1 Ensembl NCBI GeneCards UniProt NextProt Show fit	split hand/foot malformation (ectrodactyly) type 1
chr7_-_93519471 Show fit	6.34	ENST00000451238.1	TFPI2 Ensembl NCBI GeneCards UniProt NextProt Show fit	tissue factor pathway inhibitor 2
chr7_+_116139424 Show fit	6.18	ENST00000222693.4	CAV2 Ensembl NCBI GeneCards UniProt NextProt Show fit	caveolin 2
chr11_+_62439126 Show fit	6.07	ENST00000377953.3	C11orf83 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 11 open reading frame 83
chr7_+_75932863 Show fit	6.04	ENST00000429938.1	HSPB1 Ensembl NCBI GeneCards UniProt NextProt Show fit	heat shock 27kDa protein 1
chr17_-_38574169 Show fit	5.91	ENST00000423485.1	TOP2A Ensembl NCBI GeneCards UniProt NextProt Show fit	topoisomerase (DNA) II alpha 170kDa

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	11.0	GO:0035666	TRIF-dependent toll-like receptor signaling pathway(GO:0035666)
1.7	10.3	GO:0006177	GMP biosynthetic process(GO:0006177)
0.1	8.9	GO:0051965	positive regulation of synapse assembly(GO:0051965)
1.1	7.6	GO:0071896	protein localization to adherens junction(GO:0071896)
1.8	7.0	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.3	6.9	GO:0006144	purine nucleobase metabolic process(GO:0006144) purine-containing compound salvage(GO:0043101)
0.1	6.7	GO:0036498	IRE1-mediated unfolded protein response(GO:0036498)
0.3	6.3	GO:0003334	keratinocyte development(GO:0003334)
1.0	6.2	GO:0044791	modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.2	6.2	GO:0071498	cellular response to fluid shear stress(GO:0071498)

Showing 1 to 10 of 175 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	12.3	GO:1904813	ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.1	12.1	GO:0031903	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0	10.4	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.0	9.3	GO:0010008	endosome membrane(GO:0010008)
0.0	8.6	GO:0009986	cell surface(GO:0009986)
1.3	8.1	GO:1902560	GMP reductase complex(GO:1902560)
0.6	7.6	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.2	7.3	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	7.1	GO:0030027	lamellipodium(GO:0030027)
0.8	7.0	GO:0005827	polar microtubule(GO:0005827)

Showing 1 to 10 of 106 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	15.2	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.1	11.7	GO:0032947	protein complex scaffold(GO:0032947)
0.2	11.0	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)
2.6	10.3	GO:0003938	IMP dehydrogenase activity(GO:0003938)
0.0	8.4	GO:0003735	structural constituent of ribosome(GO:0003735)
1.3	8.1	GO:0016657	GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
1.8	7.0	GO:0031208	POZ domain binding(GO:0031208)
0.2	6.9	GO:0023026	MHC class II protein complex binding(GO:0023026)
0.0	6.7	GO:0030246	carbohydrate binding(GO:0030246)
0.1	6.3	GO:0008307	structural constituent of muscle(GO:0008307)

Showing 1 to 10 of 133 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	11.6	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	9.3	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	8.7	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.1	8.6	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.1	7.4	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	7.3	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.2	7.0	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.1	6.0	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.1	5.5	PID ATR PATHWAY	ATR signaling pathway
0.1	5.3	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development

Showing 1 to 10 of 32 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	10.3	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.3	10.0	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.2	9.9	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	8.1	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.2	7.7	REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE	Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0	7.6	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.3	6.9	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	5.7	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.3	5.1	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.2	5.0	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins

Showing 1 to 10 of 69 entries

Results for NKX2-4

Z-value: 0.65

Motif logo

Transcription factors associated with NKX2-4

Activity-expression correlation:

Activity profile of NKX2-4 motif

Sorted Z-values of NKX2-4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: