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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for NKX2-5

Z-value: 0.34

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Transcription factors associated with NKX2-5

Gene Symbol Gene ID Gene Info
NKX2-5
ENSG00000183072.9 NK2 homeobox 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-5hg19_v2_chr5_-_172662303_172662360-0.111.1e-01Click!

Activity profile of NKX2-5 motif

Sorted Z-values of NKX2-5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_-_13835147 15.12 ENST00000493677.1
ENST00000355135.2
GPM6B
glycoprotein M6B
chr3_+_125694347 11.37 ENST00000505382.1
ENST00000511082.1
ROPN1B
rhophilin associated tail protein 1B
chr15_+_42696992 9.68 ENST00000561817.1
CAPN3
calpain 3, (p94)
chr15_+_42697018 9.56 ENST00000397204.4
CAPN3
calpain 3, (p94)
chr5_-_149792295 9.33 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr9_+_17579084 8.81 ENST00000380607.4
SH3GL2
SH3-domain GRB2-like 2
chr8_-_120651020 8.79 ENST00000522826.1
ENST00000520066.1
ENST00000259486.6
ENST00000075322.6
ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr3_+_125687987 8.10 ENST00000514116.1
ENST00000251776.4
ENST00000504401.1
ENST00000513830.1
ENST00000508088.1
ROPN1B
rhophilin associated tail protein 1B
chr3_-_123710893 8.08 ENST00000467907.1
ENST00000459660.1
ENST00000495093.1
ENST00000460743.1
ENST00000405845.3
ENST00000484329.1
ENST00000479867.1
ENST00000496145.1
ROPN1
rhophilin associated tail protein 1
chr15_+_42696954 7.56 ENST00000337571.4
ENST00000569136.1
CAPN3
calpain 3, (p94)
chr17_-_29624343 6.69 ENST00000247271.4
OMG
oligodendrocyte myelin glycoprotein
chr22_-_38577782 6.42 ENST00000430886.1
ENST00000332509.3
ENST00000447598.2
ENST00000435484.1
ENST00000402064.1
ENST00000436218.1
PLA2G6
phospholipase A2, group VI (cytosolic, calcium-independent)
chr6_-_112115074 6.13 ENST00000368667.2
FYN
FYN oncogene related to SRC, FGR, YES
chr22_-_38577731 6.07 ENST00000335539.3
PLA2G6
phospholipase A2, group VI (cytosolic, calcium-independent)
chr7_+_99775520 5.51 ENST00000317296.5
ENST00000422690.1
ENST00000439782.1
STAG3
stromal antigen 3
chr7_+_99775366 5.47 ENST00000394018.2
ENST00000416412.1
STAG3
stromal antigen 3
chr22_-_50523760 5.44 ENST00000395876.2
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr22_-_50524298 5.31 ENST00000311597.5
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr7_-_37488834 4.98 ENST00000310758.4
ELMO1
engulfment and cell motility 1
chr2_-_175499294 4.81 ENST00000392547.2
WIPF1
WAS/WASL interacting protein family, member 1
chr19_+_16999654 4.77 ENST00000248076.3
F2RL3
coagulation factor II (thrombin) receptor-like 3
chr21_+_44313375 4.76 ENST00000354250.2
ENST00000340344.4
NDUFV3
NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa
chr15_-_81282133 4.53 ENST00000261758.4
MESDC2
mesoderm development candidate 2
chr14_-_21516590 4.37 ENST00000555026.1
NDRG2
NDRG family member 2
chr17_-_29641084 4.24 ENST00000544462.1
EVI2B
ecotropic viral integration site 2B
chr5_-_74062930 4.24 ENST00000509430.1
ENST00000345239.2
ENST00000427854.2
ENST00000506778.1
GFM2
G elongation factor, mitochondrial 2
chr15_-_42840961 4.19 ENST00000563454.1
ENST00000397130.3
ENST00000570160.1
ENST00000323443.2
LRRC57
leucine rich repeat containing 57
chr10_+_111967345 3.98 ENST00000332674.5
ENST00000453116.1
MXI1
MAX interactor 1, dimerization protein
chr17_-_19771216 3.84 ENST00000395544.4
ULK2
unc-51 like autophagy activating kinase 2
chr3_-_187388173 3.77 ENST00000287641.3
SST
somatostatin
chr8_+_133879193 3.74 ENST00000377869.1
ENST00000220616.4
TG
thyroglobulin
chrX_-_49965663 3.73 ENST00000376056.2
ENST00000376058.2
ENST00000358526.2
AKAP4
A kinase (PRKA) anchor protein 4
chr17_-_29641104 3.61 ENST00000577894.1
ENST00000330927.4
EVI2B
ecotropic viral integration site 2B
chr14_-_106963409 3.51 ENST00000390621.2
IGHV1-45
immunoglobulin heavy variable 1-45
chr3_-_15374659 3.40 ENST00000426925.1
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr11_+_108093839 3.39 ENST00000452508.2
ATM
ataxia telangiectasia mutated
chr5_+_140729649 3.27 ENST00000523390.1
PCDHGB1
protocadherin gamma subfamily B, 1
chr4_+_113970772 3.25 ENST00000504454.1
ENST00000394537.3
ENST00000357077.4
ENST00000264366.6
ANK2
ankyrin 2, neuronal
chr16_+_57769635 3.24 ENST00000379661.3
ENST00000562592.1
ENST00000566726.1
KATNB1
katanin p80 (WD repeat containing) subunit B 1
chr15_+_81589254 3.23 ENST00000394652.2
IL16
interleukin 16
chr13_-_41240717 2.98 ENST00000379561.5
FOXO1
forkhead box O1
chr17_+_27055798 2.98 ENST00000268766.6
NEK8
NIMA-related kinase 8
chr20_+_57226284 2.98 ENST00000458280.1
ENST00000355957.5
ENST00000361770.5
ENST00000312283.8
ENST00000412911.1
ENST00000359617.4
ENST00000371141.4
STX16
syntaxin 16
chr16_-_30134266 2.96 ENST00000484663.1
ENST00000478356.1
MAPK3
mitogen-activated protein kinase 3
chr12_+_123717458 2.90 ENST00000253233.1
C12orf65
chromosome 12 open reading frame 65
chr14_-_106830057 2.79 ENST00000390616.2
IGHV4-34
immunoglobulin heavy variable 4-34
chr2_-_201936302 2.75 ENST00000453765.1
ENST00000452799.1
ENST00000446678.1
ENST00000418596.3
FAM126B
family with sequence similarity 126, member B
chr17_+_58755184 2.66 ENST00000589222.1
ENST00000407086.3
ENST00000390652.5
BCAS3
breast carcinoma amplified sequence 3
chr15_+_42841008 2.55 ENST00000260372.3
ENST00000568876.1
ENST00000568846.2
ENST00000562398.1
HAUS2
HAUS augmin-like complex, subunit 2
chr10_-_81320151 2.51 ENST00000372325.2
ENST00000372327.5
ENST00000417041.1
SFTPA2
surfactant protein A2
chr17_+_40811283 2.50 ENST00000251412.7
TUBG2
tubulin, gamma 2
chr17_+_46048376 2.49 ENST00000338399.4
CDK5RAP3
CDK5 regulatory subunit associated protein 3
chr11_+_17756279 2.41 ENST00000265969.6
KCNC1
potassium voltage-gated channel, Shaw-related subfamily, member 1
chr17_+_48624450 2.33 ENST00000006658.6
ENST00000356488.4
ENST00000393244.3
SPATA20
spermatogenesis associated 20
chr19_+_5681011 2.30 ENST00000581893.1
ENST00000411793.2
ENST00000301382.4
ENST00000581773.1
ENST00000423665.2
ENST00000583928.1
ENST00000342970.2
ENST00000422535.2
ENST00000581521.1
ENST00000339423.2
HSD11B1L
hydroxysteroid (11-beta) dehydrogenase 1-like
chr10_-_49813090 2.30 ENST00000249601.4
ARHGAP22
Rho GTPase activating protein 22
chr14_-_106406090 2.26 ENST00000390593.2
IGHV6-1
immunoglobulin heavy variable 6-1
chr4_+_156680518 2.26 ENST00000513437.1
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr19_-_5680499 2.26 ENST00000587589.1
C19orf70
chromosome 19 open reading frame 70
chr8_-_10588010 2.25 ENST00000304501.1
SOX7
SRY (sex determining region Y)-box 7
chr4_-_2264015 2.25 ENST00000337190.2
MXD4
MAX dimerization protein 4
chr6_+_33378738 2.24 ENST00000374512.3
ENST00000374516.3
PHF1
PHD finger protein 1
chr1_+_154301264 2.17 ENST00000341822.2
ATP8B2
ATPase, aminophospholipid transporter, class I, type 8B, member 2
chr12_+_4918342 2.11 ENST00000280684.3
ENST00000433855.1
KCNA6
potassium voltage-gated channel, shaker-related subfamily, member 6
chr10_-_101841588 1.98 ENST00000370418.3
CPN1
carboxypeptidase N, polypeptide 1
chr16_+_77233294 1.96 ENST00000378644.4
SYCE1L
synaptonemal complex central element protein 1-like
chr12_+_93772402 1.92 ENST00000546925.1
NUDT4
nudix (nucleoside diphosphate linked moiety X)-type motif 4
chr1_+_211433275 1.87 ENST00000367005.4
RCOR3
REST corepressor 3
chr5_-_171615315 1.87 ENST00000176763.5
STK10
serine/threonine kinase 10
chr16_-_30134524 1.86 ENST00000395202.1
ENST00000395199.3
ENST00000263025.4
ENST00000322266.5
ENST00000403394.1
MAPK3
mitogen-activated protein kinase 3
chr20_-_44485835 1.85 ENST00000457981.1
ENST00000426915.1
ENST00000217455.4
ACOT8
acyl-CoA thioesterase 8
chr19_+_41313017 1.72 ENST00000595621.1
ENST00000595051.1
EGLN2
egl-9 family hypoxia-inducible factor 2
chr11_-_118436606 1.66 ENST00000530872.1
IFT46
intraflagellar transport 46 homolog (Chlamydomonas)
chr18_+_42260861 1.61 ENST00000282030.5
SETBP1
SET binding protein 1
chr11_-_111175739 1.56 ENST00000532918.1
COLCA1
colorectal cancer associated 1
chr15_-_72563585 1.51 ENST00000287196.9
ENST00000260376.7
PARP6
poly (ADP-ribose) polymerase family, member 6
chr4_+_2470664 1.51 ENST00000314289.8
ENST00000541204.1
ENST00000502316.1
ENST00000507247.1
ENST00000509258.1
ENST00000511859.1
RNF4
ring finger protein 4
chrX_-_30326445 1.48 ENST00000378963.1
NR0B1
nuclear receptor subfamily 0, group B, member 1
chr11_-_118436707 1.46 ENST00000264020.2
ENST00000264021.3
IFT46
intraflagellar transport 46 homolog (Chlamydomonas)
chr5_+_140810132 1.40 ENST00000252085.3
PCDHGA12
protocadherin gamma subfamily A, 12
chr12_+_111051832 1.40 ENST00000550703.2
ENST00000551590.1
TCTN1
tectonic family member 1
chr10_-_99531709 1.40 ENST00000266066.3
SFRP5
secreted frizzled-related protein 5
chrX_+_11777671 1.39 ENST00000380693.3
ENST00000380692.2
MSL3
male-specific lethal 3 homolog (Drosophila)
chr13_-_95364389 1.39 ENST00000376945.2
SOX21
SRY (sex determining region Y)-box 21
chr10_+_76586348 1.39 ENST00000372724.1
ENST00000287239.4
ENST00000372714.1
KAT6B
K(lysine) acetyltransferase 6B
chr4_-_168155730 1.33 ENST00000502330.1
ENST00000357154.3
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr12_-_371994 1.30 ENST00000343164.4
ENST00000436453.1
ENST00000445055.2
ENST00000546319.1
SLC6A13
solute carrier family 6 (neurotransmitter transporter), member 13
chr5_+_140345820 1.30 ENST00000289269.5
PCDHAC2
protocadherin alpha subfamily C, 2
chr9_+_116263778 1.27 ENST00000394646.3
RGS3
regulator of G-protein signaling 3
chr9_-_117692697 1.23 ENST00000223795.2
TNFSF8
tumor necrosis factor (ligand) superfamily, member 8
chr17_+_53342311 1.20 ENST00000226067.5
HLF
hepatic leukemia factor
chr13_-_53422640 1.17 ENST00000338862.4
ENST00000377942.3
PCDH8
protocadherin 8
chr12_+_111051902 1.16 ENST00000397655.3
ENST00000471804.2
ENST00000377654.3
ENST00000397659.4
TCTN1
tectonic family member 1
chr20_+_57226841 1.11 ENST00000358029.4
ENST00000361830.3
STX16
syntaxin 16
chr8_-_95220775 1.10 ENST00000441892.2
ENST00000521491.1
ENST00000027335.3
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr9_+_116263639 1.04 ENST00000343817.5
RGS3
regulator of G-protein signaling 3
chr14_+_22963806 1.04 ENST00000390493.1
TRAJ44
T cell receptor alpha joining 44
chr3_+_42201653 1.03 ENST00000341421.3
ENST00000396175.1
TRAK1
trafficking protein, kinesin binding 1
chr1_-_11907829 1.02 ENST00000376480.3
NPPA
natriuretic peptide A
chr3_+_108321623 1.02 ENST00000497905.1
ENST00000463306.1
DZIP3
DAZ interacting zinc finger protein 3
chr20_-_41818373 1.02 ENST00000373187.1
ENST00000356100.2
ENST00000373184.1
ENST00000373190.1
PTPRT
protein tyrosine phosphatase, receptor type, T
chr11_+_118754475 1.02 ENST00000292174.4
CXCR5
chemokine (C-X-C motif) receptor 5
chr3_-_47950745 1.02 ENST00000429422.1
MAP4
microtubule-associated protein 4
chr1_-_22109682 1.00 ENST00000400301.1
ENST00000532737.1
USP48
ubiquitin specific peptidase 48
chr12_-_51422017 0.97 ENST00000394904.3
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
chr2_+_219646462 0.95 ENST00000258415.4
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr1_+_22962948 0.92 ENST00000374642.3
C1QA
complement component 1, q subcomponent, A chain
chr4_-_168155700 0.91 ENST00000357545.4
ENST00000512648.1
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr14_+_81421355 0.87 ENST00000541158.2
TSHR
thyroid stimulating hormone receptor
chr17_-_46667594 0.83 ENST00000476342.1
ENST00000460160.1
ENST00000472863.1
HOXB3
homeobox B3
chr17_+_29421987 0.82 ENST00000431387.4
NF1
neurofibromin 1
chr9_-_138393580 0.78 ENST00000371791.1
C9orf116
chromosome 9 open reading frame 116
chr7_+_129906660 0.77 ENST00000222481.4
CPA2
carboxypeptidase A2 (pancreatic)
chr7_+_129007964 0.75 ENST00000460109.1
ENST00000474594.1
ENST00000446212.1
AHCYL2
adenosylhomocysteinase-like 2
chr3_-_194072019 0.74 ENST00000429275.1
ENST00000323830.3
CPN2
carboxypeptidase N, polypeptide 2
chrX_-_14047996 0.74 ENST00000380523.4
ENST00000398355.3
GEMIN8
gem (nuclear organelle) associated protein 8
chrX_-_154299501 0.74 ENST00000369476.3
ENST00000369484.3
MTCP1
CMC4
mature T-cell proliferation 1
C-x(9)-C motif containing 4
chr7_-_81399411 0.73 ENST00000423064.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr17_-_46667628 0.73 ENST00000498678.1
HOXB3
homeobox B3
chr16_+_33006369 0.69 ENST00000425181.3
IGHV3OR16-10
immunoglobulin heavy variable 3/OR16-10 (non-functional)
chr1_+_32671236 0.68 ENST00000537469.1
ENST00000291358.6
IQCC
IQ motif containing C
chr1_-_202858227 0.67 ENST00000367262.3
RABIF
RAB interacting factor
chr22_+_40322623 0.67 ENST00000399090.2
GRAP2
GRB2-related adaptor protein 2
chr2_-_85895295 0.66 ENST00000428225.1
ENST00000519937.2
SFTPB
surfactant protein B
chr16_+_68344877 0.64 ENST00000566657.1
ENST00000565745.1
ENST00000569571.1
ENST00000569047.3
ENST00000449359.3
PRMT7
protein arginine methyltransferase 7
chr22_+_40322595 0.62 ENST00000420971.1
ENST00000544756.1
GRAP2
GRB2-related adaptor protein 2
chr9_+_134065506 0.57 ENST00000483497.2
NUP214
nucleoporin 214kDa
chr16_+_765092 0.54 ENST00000568223.2
METRN
meteorin, glial cell differentiation regulator
chr12_-_49259643 0.50 ENST00000309739.5
RND1
Rho family GTPase 1
chr4_-_168155577 0.50 ENST00000541354.1
ENST00000509854.1
ENST00000512681.1
ENST00000421836.2
ENST00000510741.1
ENST00000510403.1
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr1_+_114472222 0.47 ENST00000369558.1
ENST00000369561.4
HIPK1
homeodomain interacting protein kinase 1
chr7_-_81399329 0.47 ENST00000453411.1
ENST00000444829.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr6_-_41715128 0.46 ENST00000356667.4
ENST00000373025.3
ENST00000425343.2
PGC
progastricsin (pepsinogen C)
chr7_+_130020180 0.44 ENST00000481342.1
ENST00000011292.3
ENST00000604896.1
CPA1
carboxypeptidase A1 (pancreatic)
chr2_+_152214098 0.43 ENST00000243347.3
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr17_-_7493390 0.41 ENST00000538513.2
ENST00000570788.1
ENST00000250055.2
SOX15
SRY (sex determining region Y)-box 15
chr4_-_74853897 0.41 ENST00000296028.3
PPBP
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
chr1_-_149982624 0.40 ENST00000417191.1
ENST00000369135.4
OTUD7B
OTU domain containing 7B
chr16_-_67997947 0.39 ENST00000537830.2
SLC12A4
solute carrier family 12 (potassium/chloride transporter), member 4
chr5_+_78407602 0.38 ENST00000274353.5
ENST00000524080.1
BHMT
betaine--homocysteine S-methyltransferase
chr1_-_23520755 0.36 ENST00000314113.3
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
chr6_-_27279949 0.36 ENST00000444565.1
ENST00000377451.2
POM121L2
POM121 transmembrane nucleoporin-like 2
chr14_+_81421861 0.33 ENST00000298171.2
TSHR
thyroid stimulating hormone receptor
chr5_+_75699040 0.32 ENST00000274364.6
IQGAP2
IQ motif containing GTPase activating protein 2
chr17_+_66521936 0.32 ENST00000592800.1
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr16_+_68344981 0.30 ENST00000441236.1
ENST00000348497.4
ENST00000339507.5
PRMT7
protein arginine methyltransferase 7
chr17_+_45973516 0.29 ENST00000376741.4
SP2
Sp2 transcription factor
chr16_+_8814563 0.29 ENST00000425191.2
ENST00000569156.1
ABAT
4-aminobutyrate aminotransferase
chr7_-_87342564 0.27 ENST00000265724.3
ENST00000416177.1
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr14_+_21467414 0.26 ENST00000554422.1
ENST00000298681.4
SLC39A2
solute carrier family 39 (zinc transporter), member 2
chr7_-_128415844 0.25 ENST00000249389.2
OPN1SW
opsin 1 (cone pigments), short-wave-sensitive
chr12_+_14518598 0.25 ENST00000261168.4
ENST00000538511.1
ENST00000545723.1
ENST00000543189.1
ENST00000536444.1
ATF7IP
activating transcription factor 7 interacting protein
chr10_+_73156664 0.22 ENST00000398809.4
ENST00000398842.3
ENST00000461841.3
ENST00000299366.7
CDH23
cadherin-related 23
chrX_+_86772707 0.13 ENST00000373119.4
KLHL4
kelch-like family member 4
chr14_+_81421710 0.11 ENST00000342443.6
TSHR
thyroid stimulating hormone receptor
chrX_+_115567767 0.06 ENST00000371900.4
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr14_+_81421921 0.04 ENST00000554263.1
ENST00000554435.1
TSHR
thyroid stimulating hormone receptor
chr1_+_154300217 0.02 ENST00000368489.3
ATP8B2
ATPase, aminophospholipid transporter, class I, type 8B, member 2
chr3_+_45984947 0.02 ENST00000304552.4
CXCR6
chemokine (C-X-C motif) receptor 6

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 26.8 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
3.1 12.5 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
1.9 9.3 GO:0002906 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
1.5 15.1 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
1.1 3.4 GO:1904884 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
1.1 3.2 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
1.1 19.5 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
1.0 8.8 GO:0016191 synaptic vesicle uncoating(GO:0016191)
1.0 4.8 GO:0000189 MAPK import into nucleus(GO:0000189)
0.9 3.8 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
0.8 3.2 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.8 11.0 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.8 12.9 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.8 2.3 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.6 2.6 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.6 6.1 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.6 3.0 GO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947)
0.6 4.8 GO:0060155 platelet dense granule organization(GO:0060155)
0.6 8.8 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.5 1.1 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.5 3.8 GO:0075071 autophagy of host cells involved in interaction with symbiont(GO:0075044) autophagy involved in symbiotic interaction(GO:0075071)
0.5 4.2 GO:0032790 ribosome disassembly(GO:0032790)
0.5 3.4 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.4 3.7 GO:0015705 iodide transport(GO:0015705)
0.4 0.4 GO:0014717 regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014717) positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718) satellite cell activation involved in skeletal muscle regeneration(GO:0014901)
0.4 2.0 GO:0030070 insulin processing(GO:0030070)
0.4 1.5 GO:0090234 regulation of kinetochore assembly(GO:0090234)
0.4 2.2 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.3 1.4 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.3 1.3 GO:1904588 cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229)
0.3 0.9 GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918)
0.3 1.6 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.3 2.5 GO:0071569 protein ufmylation(GO:0071569)
0.3 4.4 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.3 0.8 GO:0061534 gamma-aminobutyric acid secretion, neurotransmission(GO:0061534)
0.3 3.0 GO:0035330 regulation of hippo signaling(GO:0035330)
0.2 4.1 GO:0090161 Golgi ribbon formation(GO:0090161)
0.2 1.7 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.2 1.0 GO:0015692 lead ion transport(GO:0015692)
0.2 1.0 GO:0051012 microtubule sliding(GO:0051012)
0.1 2.7 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 3.2 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.1 1.2 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 1.8 GO:0016559 peroxisome fission(GO:0016559)
0.1 1.5 GO:0033327 Leydig cell differentiation(GO:0033327)
0.1 5.0 GO:0016601 Rac protein signal transduction(GO:0016601)
0.1 0.6 GO:1901911 diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.1 3.3 GO:0044458 motile cilium assembly(GO:0044458)
0.1 4.0 GO:0042994 cytoplasmic sequestering of transcription factor(GO:0042994)
0.1 3.4 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.1 0.7 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 1.0 GO:0019896 axonal transport of mitochondrion(GO:0019896)
0.1 1.6 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.1 2.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 6.5 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 2.2 GO:0045332 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.1 6.5 GO:0050771 negative regulation of axonogenesis(GO:0050771)
0.1 3.1 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.1 0.5 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.1 1.2 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 2.5 GO:0007020 microtubule nucleation(GO:0007020)
0.1 4.5 GO:0034394 protein localization to cell surface(GO:0034394)
0.1 0.4 GO:0031335 regulation of sulfur amino acid metabolic process(GO:0031335) regulation of homocysteine metabolic process(GO:0050666)
0.1 2.3 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 1.9 GO:2000401 regulation of lymphocyte migration(GO:2000401)
0.1 0.5 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.1 1.0 GO:0048535 lymph node development(GO:0048535)
0.1 8.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.4 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 1.4 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 6.8 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.0 0.4 GO:0014827 intestine smooth muscle contraction(GO:0014827)
0.0 0.8 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.0 1.0 GO:0070646 protein deubiquitination(GO:0016579) protein modification by small protein removal(GO:0070646)
0.0 3.2 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.0 2.9 GO:0070126 mitochondrial translational termination(GO:0070126)
0.0 0.5 GO:0016322 neuron remodeling(GO:0016322)
0.0 2.2 GO:0001706 endoderm formation(GO:0001706)
0.0 0.4 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 2.0 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.7 GO:0050821 protein stabilization(GO:0050821)
0.0 0.9 GO:0010039 response to iron ion(GO:0010039)
0.0 0.3 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 1.0 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.0 1.3 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 1.4 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 0.4 GO:0006884 cell volume homeostasis(GO:0006884)
0.0 0.7 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.2 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.4 GO:0030728 ovulation(GO:0030728)
0.0 0.9 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 1.0 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 0.2 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.3 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 0.6 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 11.0 GO:0030893 meiotic cohesin complex(GO:0030893)
1.3 9.3 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.4 4.7 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.4 30.0 GO:0030315 T-tubule(GO:0030315)
0.3 3.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.3 2.6 GO:0070652 HAUS complex(GO:0070652)
0.2 1.0 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836)
0.2 1.4 GO:0072487 MSL complex(GO:0072487)
0.2 1.0 GO:0070826 paraferritin complex(GO:0070826)
0.2 0.6 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.2 0.9 GO:0005602 complement component C1 complex(GO:0005602)
0.2 2.6 GO:0036038 MKS complex(GO:0036038)
0.2 3.8 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.2 4.8 GO:0031143 pseudopodium(GO:0031143)
0.2 3.2 GO:0042599 lamellar body(GO:0042599)
0.2 22.6 GO:0031514 motile cilium(GO:0031514)
0.1 1.4 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 1.5 GO:0042788 polysomal ribosome(GO:0042788)
0.1 8.8 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.1 6.5 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 2.5 GO:0000242 pericentriolar material(GO:0000242)
0.1 10.7 GO:0005901 caveola(GO:0005901)
0.1 2.7 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 0.7 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.1 2.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 3.3 GO:0097546 ciliary base(GO:0097546)
0.1 2.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 2.4 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1 11.3 GO:0005884 actin filament(GO:0005884)
0.1 2.9 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 0.3 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
0.1 2.0 GO:0000795 synaptonemal complex(GO:0000795)
0.1 3.4 GO:1990391 DNA repair complex(GO:1990391)
0.1 4.1 GO:0031201 SNARE complex(GO:0031201)
0.0 0.8 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.4 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 1.0 GO:0042629 mast cell granule(GO:0042629)
0.0 2.0 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 5.7 GO:0030426 growth cone(GO:0030426)
0.0 1.8 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 5.8 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 1.0 GO:1904115 axon cytoplasm(GO:1904115)
0.0 41.6 GO:0005615 extracellular space(GO:0005615)
0.0 2.1 GO:0043679 axon terminus(GO:0043679)
0.0 1.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 1.9 GO:0035579 specific granule membrane(GO:0035579)
0.0 3.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 1.2 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.4 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 0.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.2 GO:0032420 stereocilium(GO:0032420)
0.0 1.0 GO:0072686 mitotic spindle(GO:0072686)
0.0 4.8 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 1.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 8.8 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
1.9 26.8 GO:0031432 titin binding(GO:0031432)
1.9 9.3 GO:0042289 MHC class II protein binding(GO:0042289)
1.4 12.5 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
1.0 6.1 GO:0042610 CD8 receptor binding(GO:0042610)
1.0 2.9 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.9 2.7 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.8 4.8 GO:0015057 thrombin receptor activity(GO:0015057)
0.6 3.4 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.5 3.2 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.5 19.5 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.5 1.5 GO:0032184 SUMO polymer binding(GO:0032184)
0.3 0.9 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.3 1.1 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.3 4.8 GO:0005522 profilin binding(GO:0005522)
0.2 4.8 GO:0004707 MAP kinase activity(GO:0004707)
0.2 1.3 GO:0015185 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.2 3.2 GO:0042609 CD4 receptor binding(GO:0042609)
0.2 1.0 GO:0070097 delta-catenin binding(GO:0070097)
0.2 1.0 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.2 1.3 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.2 2.5 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.2 1.7 GO:0019826 oxygen sensor activity(GO:0019826)
0.2 1.8 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.2 4.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.2 4.2 GO:0003746 translation elongation factor activity(GO:0003746)
0.2 4.5 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 3.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.4 GO:0047150 betaine-homocysteine S-methyltransferase activity(GO:0047150)
0.1 0.7 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 0.6 GO:0052842 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.1 6.5 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 3.0 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 2.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 1.0 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.1 2.3 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 4.1 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 1.0 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 11.3 GO:0008565 protein transporter activity(GO:0008565)
0.1 2.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.3 GO:0032145 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
0.1 4.0 GO:0051018 protein kinase A binding(GO:0051018)
0.1 8.5 GO:0005179 hormone activity(GO:0005179)
0.1 0.8 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.1 1.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 8.4 GO:0017124 SH3 domain binding(GO:0017124)
0.1 2.6 GO:0030507 spectrin binding(GO:0030507)
0.1 1.0 GO:0050811 GABA receptor binding(GO:0050811)
0.1 3.6 GO:0035064 methylated histone binding(GO:0035064)
0.0 1.5 GO:0000217 DNA secondary structure binding(GO:0000217)
0.0 1.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.4 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 2.0 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.4 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.4 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 1.2 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 1.0 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 8.3 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.4 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 1.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.2 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.7 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 1.4 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.5 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 1.6 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 1.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.0 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.8 PID S1P S1P4 PATHWAY S1P4 pathway
0.3 4.8 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.2 11.1 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 8.8 PID RHOA PATHWAY RhoA signaling pathway
0.1 3.4 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 3.0 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 1.5 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 5.5 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 1.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 4.3 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 2.7 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 2.3 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.1 3.4 PID BCR 5PATHWAY BCR signaling pathway
0.1 2.5 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 2.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 3.1 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.6 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.8 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 2.3 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.0 PID AP1 PATHWAY AP-1 transcription factor network
0.0 4.2 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 12.0 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.4 8.8 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.4 6.1 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.3 4.8 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.3 3.4 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.2 2.5 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 4.1 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 5.0 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.1 2.8 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.1 4.8 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.1 9.5 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 4.3 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.3 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 0.9 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 8.9 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 2.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 6.7 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.1 1.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.7 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 1.3 REACTOME CD28 CO STIMULATION Genes involved in CD28 co-stimulation
0.0 2.6 REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES Genes involved in Recruitment of mitotic centrosome proteins and complexes
0.0 0.5 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 1.6 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 0.4 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 1.0 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 5.0 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 2.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.3 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 2.3 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.3 REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION Genes involved in Glucagon signaling in metabolic regulation
0.0 1.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.3 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.6 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein