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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for NKX3-1

Z-value: 0.32

Motif logo

Transcription factors associated with NKX3-1

Gene Symbol Gene ID Gene Info
ENSG00000167034.9 NK3 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX3-1hg19_v2_chr8_-_23540402_23540466-0.111.1e-01Click!

Activity profile of NKX3-1 motif

Sorted Z-values of NKX3-1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_14180778 9.59 ENST00000380924.1
ENST00000543693.1
nuclear factor I/B
chr16_+_3068393 9.36 ENST00000573001.1
tumor necrosis factor receptor superfamily, member 12A
chr11_+_114168085 8.20 ENST00000541754.1
nicotinamide N-methyltransferase
chr3_-_81811312 8.11 ENST00000429644.2
glucan (1,4-alpha-), branching enzyme 1
chrX_+_114795489 7.98 ENST00000355899.3
ENST00000537301.1
ENST00000289290.3
plastin 3
chr16_-_69760409 7.24 ENST00000561500.1
ENST00000439109.2
ENST00000564043.1
ENST00000379046.2
ENST00000379047.3
NAD(P)H dehydrogenase, quinone 1
chr8_-_49834299 6.25 ENST00000396822.1
snail family zinc finger 2
chr8_+_30300119 6.03 ENST00000520191.1
RNA binding protein with multiple splicing
chr9_+_706842 6.02 ENST00000382293.3
KN motif and ankyrin repeat domains 1
chr19_-_44174330 5.93 ENST00000340093.3
plasminogen activator, urokinase receptor
chr9_+_90341024 5.73 ENST00000340342.6
ENST00000342020.5
cathepsin L
chr8_-_49833978 5.39 ENST00000020945.1
snail family zinc finger 2
chr17_-_76870126 5.28 ENST00000586057.1
TIMP metallopeptidase inhibitor 2
chr17_-_76870222 5.19 ENST00000585421.1
TIMP metallopeptidase inhibitor 2
chr2_-_27545921 5.11 ENST00000402310.1
ENST00000405983.1
ENST00000403262.2
ENST00000428910.1
ENST00000402722.1
ENST00000399052.4
ENST00000380044.1
ENST00000405076.1
MpV17 mitochondrial inner membrane protein
chr9_+_36572851 4.59 ENST00000298048.2
ENST00000538311.1
ENST00000536987.1
ENST00000545008.1
ENST00000536860.1
ENST00000536329.1
ENST00000541717.1
ENST00000543751.1
maternal embryonic leucine zipper kinase
chr3_+_158991025 4.18 ENST00000337808.6
IQCJ-SCHIP1 readthrough
chr3_+_100428188 4.03 ENST00000418917.2
ENST00000490574.1
TRK-fused gene
chr1_-_6445809 3.88 ENST00000377855.2
acyl-CoA thioesterase 7
chr11_+_101983176 3.86 ENST00000524575.1
Yes-associated protein 1
chr6_+_63921399 3.76 ENST00000356170.3
FK506 binding protein 1C
chr5_+_176873446 3.64 ENST00000507881.1
proline rich 7 (synaptic)
chr12_-_53298841 3.53 ENST00000293308.6
keratin 8
chr3_+_100428316 3.51 ENST00000479672.1
ENST00000476228.1
ENST00000463568.1
TRK-fused gene
chr5_-_176889381 3.49 ENST00000393563.4
ENST00000512501.1
drebrin 1
chr3_+_100428268 3.48 ENST00000240851.4
TRK-fused gene
chr3_+_98482175 3.19 ENST00000485391.1
ENST00000492254.1
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
chr1_-_77685084 3.10 ENST00000370812.3
ENST00000359130.1
ENST00000445065.1
ENST00000370813.5
phosphatidylinositol glycan anchor biosynthesis, class K
chr2_+_102456277 3.04 ENST00000421882.1
mitogen-activated protein kinase kinase kinase kinase 4
chr20_-_56285595 3.04 ENST00000395816.3
ENST00000347215.4
prostate transmembrane protein, androgen induced 1
chr1_+_151372010 2.88 ENST00000290541.6
proteasome (prosome, macropain) subunit, beta type, 4
chr16_+_69373323 2.78 ENST00000254940.5
NIP7, nucleolar pre-rRNA processing protein
chr7_+_100303676 2.69 ENST00000303151.4
processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)
chr12_-_54978086 2.48 ENST00000553113.1
protein phosphatase 1, regulatory (inhibitor) subunit 1A
chr3_+_160117418 2.42 ENST00000465903.1
ENST00000485645.1
ENST00000360111.2
ENST00000472991.1
ENST00000467468.1
ENST00000469762.1
ENST00000489573.1
ENST00000462787.1
ENST00000490207.1
ENST00000485867.1
structural maintenance of chromosomes 4
chr18_+_61445007 2.39 ENST00000447428.1
ENST00000546027.1
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr19_-_44174305 2.38 ENST00000601723.1
ENST00000339082.3
plasminogen activator, urokinase receptor
chr2_+_64068844 2.34 ENST00000337130.5
UDP-glucose pyrophosphorylase 2
chr7_+_79765071 2.33 ENST00000457358.2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
chr15_+_99645277 2.32 ENST00000336292.6
ENST00000328642.7
synemin, intermediate filament protein
chr11_+_67798090 2.27 ENST00000313468.5
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
chr11_+_67798363 2.24 ENST00000525628.1
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
chr5_+_150404904 2.19 ENST00000521632.1
glutathione peroxidase 3 (plasma)
chrX_-_114253536 2.14 ENST00000371936.1
interleukin 13 receptor, alpha 2
chr6_-_144385698 2.13 ENST00000444202.1
ENST00000437412.1
pleiomorphic adenoma gene-like 1
chr10_-_120938303 2.10 ENST00000356951.3
ENST00000298510.2
peroxiredoxin 3
chr2_+_64069459 2.06 ENST00000445915.2
ENST00000475462.1
UDP-glucose pyrophosphorylase 2
chr11_+_67798114 2.04 ENST00000453471.2
ENST00000528492.1
ENST00000526339.1
ENST00000525419.1
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
chr20_-_56286479 2.04 ENST00000265626.4
prostate transmembrane protein, androgen induced 1
chr1_+_186798073 2.03 ENST00000367466.3
ENST00000442353.2
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr21_-_27107198 2.02 ENST00000400094.1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr5_+_179125368 1.99 ENST00000502296.1
ENST00000504734.1
ENST00000415618.2
calnexin
chr7_+_5938351 1.98 ENST00000325974.6
CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
chr1_-_153066998 1.97 ENST00000368750.3
small proline-rich protein 2E
chr5_+_34915444 1.96 ENST00000336767.5
BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)
chr5_+_125758813 1.96 ENST00000285689.3
ENST00000515200.1
GRAM domain containing 3
chr6_-_26124138 1.96 ENST00000314332.5
ENST00000396984.1
histone cluster 1, H2bc
chr10_-_32345305 1.93 ENST00000302418.4
kinesin family member 5B
chr5_+_125758865 1.93 ENST00000542322.1
ENST00000544396.1
GRAM domain containing 3
chrX_-_153637612 1.87 ENST00000369807.1
ENST00000369808.3
deoxyribonuclease I-like 1
chr1_-_154164534 1.84 ENST00000271850.7
ENST00000368530.2
tropomyosin 3
chr5_+_96038476 1.79 ENST00000511049.1
ENST00000309190.5
ENST00000510156.1
ENST00000509903.1
ENST00000511782.1
ENST00000504465.1
calpastatin
chr1_-_193029192 1.75 ENST00000417752.1
ENST00000367452.4
ubiquitin carboxyl-terminal hydrolase L5
chr16_-_3074231 1.75 ENST00000572355.1
ENST00000248089.3
ENST00000574980.1
ENST00000354679.3
ENST00000396916.1
ENST00000573842.1
host cell factor C1 regulator 1 (XPO1 dependent)
chr7_+_135242652 1.73 ENST00000285968.6
ENST00000440390.2
nucleoporin 205kDa
chr8_-_97247759 1.71 ENST00000518406.1
ENST00000523920.1
ENST00000287022.5
ubiquinol-cytochrome c reductase binding protein
chr14_-_68066849 1.68 ENST00000558493.1
ENST00000561272.1
phosphatidylinositol glycan anchor biosynthesis, class H
chr11_-_62323702 1.68 ENST00000530285.1
AHNAK nucleoprotein
chr6_-_82462425 1.66 ENST00000369754.3
ENST00000320172.6
ENST00000369756.3
family with sequence similarity 46, member A
chr6_+_43603552 1.65 ENST00000372171.4
MAD2L1 binding protein
chr19_+_54609230 1.64 ENST00000420296.1
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
chr4_-_170924888 1.62 ENST00000502832.1
ENST00000393704.3
microfibrillar-associated protein 3-like
chr7_-_6865826 1.62 ENST00000538180.1
CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
chr2_-_79313973 1.60 ENST00000454188.1
regenerating islet-derived 1 beta
chr7_+_7222233 1.57 ENST00000436587.2
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
chr8_-_38034192 1.52 ENST00000520755.1
LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr1_+_173793641 1.50 ENST00000361951.4
aspartyl-tRNA synthetase 2, mitochondrial
chr4_+_37962018 1.49 ENST00000504686.1
pituitary tumor-transforming 2
chr16_-_66864806 1.47 ENST00000566336.1
ENST00000394074.2
ENST00000563185.2
ENST00000359087.4
ENST00000379463.2
ENST00000565535.1
ENST00000290810.3
NEDD8 activating enzyme E1 subunit 1
chr6_-_144416737 1.46 ENST00000367569.2
splicing factor 3b, subunit 5, 10kDa
chrX_+_151081351 1.41 ENST00000276344.2
melanoma antigen family A, 4
chr6_+_24775641 1.37 ENST00000378054.2
ENST00000476555.1
geminin, DNA replication inhibitor
chr6_+_26251835 1.37 ENST00000356350.2
histone cluster 1, H2bh
chr3_+_139062838 1.36 ENST00000310776.4
ENST00000465056.1
ENST00000465373.1
mitochondrial ribosomal protein S22
chr4_-_90757364 1.34 ENST00000508895.1
synuclein, alpha (non A4 component of amyloid precursor)
chrX_-_107681633 1.32 ENST00000394872.2
ENST00000334504.7
collagen, type IV, alpha 6
chr17_+_80674559 1.30 ENST00000269373.6
ENST00000535965.1
ENST00000577128.1
ENST00000573158.1
fructosamine 3 kinase related protein
chr15_-_55563072 1.30 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
RAB27A, member RAS oncogene family
chr7_+_5938386 1.29 ENST00000537980.1
CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
chr6_-_57087042 1.27 ENST00000317483.3
RAB23, member RAS oncogene family
chr14_-_102829051 1.25 ENST00000536961.2
ENST00000541568.2
ENST00000216756.6
cyclin-dependent kinase 2 interacting protein
chr5_+_140723601 1.24 ENST00000253812.6
protocadherin gamma subfamily A, 3
chr7_-_7680601 1.23 ENST00000396682.2
replication protein A3, 14kDa
chr11_+_65337901 1.23 ENST00000309328.3
ENST00000531405.1
ENST00000527920.1
ENST00000526877.1
ENST00000533115.1
ENST00000526433.1
Sjogren syndrome/scleroderma autoantigen 1
chr3_-_48632593 1.23 ENST00000454817.1
ENST00000328333.8
collagen, type VII, alpha 1
chr4_+_70916119 1.20 ENST00000246896.3
ENST00000511674.1
histatin 1
chr8_-_38034234 1.17 ENST00000311351.4
LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr12_+_22199108 1.14 ENST00000229329.2
cytidine monophosphate N-acetylneuraminic acid synthetase
chr17_+_66521936 1.13 ENST00000592800.1
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr19_+_52704346 1.12 ENST00000462990.1
protein phosphatase 2, regulatory subunit A, alpha
chr1_+_173793777 1.11 ENST00000239457.5
aspartyl-tRNA synthetase 2, mitochondrial
chr5_-_43412418 1.08 ENST00000537013.1
ENST00000361115.4
chemokine (C-C motif) ligand 28
chr14_+_95078714 1.07 ENST00000393078.3
ENST00000393080.4
ENST00000467132.1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr4_-_90756769 1.06 ENST00000345009.4
ENST00000505199.1
ENST00000502987.1
synuclein, alpha (non A4 component of amyloid precursor)
chr4_-_141677267 1.02 ENST00000442267.2
TBC1 domain family, member 9 (with GRAM domain)
chr4_+_88529681 1.00 ENST00000399271.1
dentin sialophosphoprotein
chr1_+_95616933 0.99 ENST00000604203.1
TMEM56-RWDD3 readthrough
chr17_+_33914460 0.98 ENST00000537622.2
adaptor-related protein complex 2, beta 1 subunit
chr3_+_132316081 0.98 ENST00000249887.2
atypical chemokine receptor 4
chr19_-_55791563 0.98 ENST00000588971.1
ENST00000255631.5
ENST00000587551.1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr11_-_118901559 0.97 ENST00000330775.7
ENST00000545985.1
ENST00000357590.5
ENST00000538950.1
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr1_-_153085984 0.96 ENST00000468739.1
small proline-rich protein 2F
chr14_-_71067360 0.96 ENST00000554963.1
ENST00000430055.2
ENST00000440435.2
ENST00000256379.5
mediator complex subunit 6
chr12_-_57039739 0.94 ENST00000552959.1
ENST00000551020.1
ENST00000553007.2
ENST00000552919.1
ENST00000552104.1
ENST00000262030.3
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr10_+_91461337 0.90 ENST00000260753.4
ENST00000416354.1
ENST00000394289.2
ENST00000371728.3
kinesin family member 20B
chr2_-_187367356 0.90 ENST00000595956.1
AC018867.2
chr5_-_150138551 0.90 ENST00000446090.2
ENST00000447998.2
dynactin 4 (p62)
chr6_-_135271219 0.89 ENST00000367847.2
ENST00000367845.2
aldehyde dehydrogenase 8 family, member A1
chr6_+_43266063 0.88 ENST00000372574.3
solute carrier family 22 (organic anion transporter), member 7
chr12_-_49333446 0.87 ENST00000537495.1
Uncharacterized protein
chr19_+_10362882 0.87 ENST00000393733.2
ENST00000588502.1
mitochondrial ribosomal protein L4
chr1_-_208417620 0.86 ENST00000367033.3
plexin A2
chr22_+_18632666 0.84 ENST00000215794.7
ubiquitin specific peptidase 18
chr19_+_17970677 0.84 ENST00000222247.5
ribosomal protein L18a
chr2_+_173686303 0.82 ENST00000397087.3
Rap guanine nucleotide exchange factor (GEF) 4
chr1_+_196621156 0.81 ENST00000359637.2
complement factor H
chr7_-_2883928 0.81 ENST00000275364.3
guanine nucleotide binding protein (G protein) alpha 12
chr22_+_42017987 0.80 ENST00000405506.1
X-ray repair complementing defective repair in Chinese hamster cells 6
chr19_-_55791540 0.80 ENST00000433386.2
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr14_-_68066975 0.78 ENST00000559581.1
ENST00000560722.1
ENST00000559415.1
ENST00000216452.4
phosphatidylinositol glycan anchor biosynthesis, class H
chr2_-_162931052 0.78 ENST00000360534.3
dipeptidyl-peptidase 4
chr6_-_160210715 0.77 ENST00000392168.2
ENST00000321394.7
t-complex 1
chr20_-_36661826 0.74 ENST00000373448.2
ENST00000373447.3
TELO2 interacting protein 1
chr19_-_5719860 0.74 ENST00000590729.1
lon peptidase 1, mitochondrial
chr5_-_77072085 0.73 ENST00000518338.2
ENST00000520039.1
ENST00000306388.6
ENST00000520361.1
tubulin folding cofactor A
chr1_-_154832316 0.72 ENST00000361147.4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr17_+_42422662 0.71 ENST00000593167.1
ENST00000585512.1
ENST00000591740.1
ENST00000592783.1
ENST00000587387.1
ENST00000588237.1
ENST00000589265.1
granulin
chr2_-_55496344 0.71 ENST00000403721.1
ENST00000263629.4
mitochondrial translational initiation factor 2
chrX_-_102757802 0.69 ENST00000372633.1
RAB40A, member RAS oncogene family
chr20_+_123010 0.68 ENST00000382398.3
defensin, beta 126
chr12_-_111926342 0.67 ENST00000389154.3
ataxin 2
chr12_+_12966250 0.66 ENST00000352940.4
ENST00000358007.3
ENST00000544400.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
chr2_-_55496174 0.66 ENST00000417363.1
ENST00000412530.1
ENST00000394600.3
ENST00000366137.2
ENST00000420637.1
mitochondrial translational initiation factor 2
chr16_-_69373396 0.65 ENST00000562595.1
ENST00000562081.1
ENST00000306875.4
component of oligomeric golgi complex 8
chr6_-_135271260 0.65 ENST00000265605.2
aldehyde dehydrogenase 8 family, member A1
chr12_-_4553385 0.64 ENST00000543077.1
fibroblast growth factor 6
chr16_+_56969284 0.63 ENST00000568358.1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr19_+_17970693 0.62 ENST00000600147.1
ENST00000599898.1
ribosomal protein L18a
chr19_-_55791431 0.62 ENST00000593263.1
ENST00000376343.3
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr6_-_22297730 0.59 ENST00000306482.1
prolactin
chr15_+_58702742 0.57 ENST00000356113.6
ENST00000414170.3
lipase, hepatic
chr6_+_26124373 0.56 ENST00000377791.2
ENST00000602637.1
histone cluster 1, H2ac
chr14_-_74551172 0.54 ENST00000553458.1
aldehyde dehydrogenase 6 family, member A1
chr7_+_141463897 0.53 ENST00000247879.2
taste receptor, type 2, member 3
chr17_+_33914276 0.53 ENST00000592545.1
ENST00000538556.1
ENST00000312678.8
ENST00000589344.1
adaptor-related protein complex 2, beta 1 subunit
chr17_+_42422637 0.51 ENST00000053867.3
ENST00000588143.1
granulin
chr1_+_84873913 0.51 ENST00000370662.3
deoxyribonuclease II beta
chr6_-_26216872 0.50 ENST00000244601.3
histone cluster 1, H2bg
chr17_-_37009882 0.50 ENST00000378096.3
ENST00000394332.1
ENST00000394333.1
ENST00000577407.1
ENST00000479035.2
ribosomal protein L23
chr11_+_64073022 0.49 ENST00000406310.1
ENST00000000442.6
ENST00000539594.1
estrogen-related receptor alpha
chr6_+_42928485 0.46 ENST00000372808.3
glycine N-methyltransferase
chr10_+_18629628 0.45 ENST00000377329.4
calcium channel, voltage-dependent, beta 2 subunit
chr2_+_48541776 0.44 ENST00000413569.1
ENST00000340553.3
forkhead box N2
chr1_-_153113927 0.41 ENST00000368752.4
small proline-rich protein 2B
chr11_-_89956461 0.39 ENST00000320585.6
cysteine and histidine-rich domain (CHORD) containing 1
chr1_-_60392452 0.39 ENST00000371204.3
cytochrome P450, family 2, subfamily J, polypeptide 2
chr15_-_31393910 0.37 ENST00000397795.2
ENST00000256552.6
ENST00000559179.1
transient receptor potential cation channel, subfamily M, member 1
chr13_+_115000521 0.37 ENST00000252457.5
ENST00000375308.1
cell division cycle 16
chr17_+_41150793 0.37 ENST00000586277.1
ribosomal protein L27
chrX_-_47341928 0.36 ENST00000313116.7
zinc finger protein 41
chr11_+_8704748 0.36 ENST00000526562.1
ENST00000525981.1
ribosomal protein L27a
chr8_-_93029865 0.36 ENST00000422361.2
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr11_-_19223523 0.35 ENST00000265968.3
cysteine and glycine-rich protein 3 (cardiac LIM protein)
chr6_+_37321823 0.35 ENST00000487950.1
ENST00000469731.1
ring finger protein 8, E3 ubiquitin protein ligase
chrX_-_31285042 0.34 ENST00000378680.2
ENST00000378723.3
dystrophin
chr6_+_143999072 0.34 ENST00000440869.2
ENST00000367582.3
ENST00000451827.2
phosphatase and actin regulator 2
chr21_-_46964306 0.34 ENST00000443742.1
ENST00000528477.1
ENST00000567670.1
solute carrier family 19 (folate transporter), member 1
chr17_+_41150479 0.34 ENST00000589913.1
ribosomal protein L27
chr12_-_10562356 0.33 ENST00000309384.1
killer cell lectin-like receptor subfamily C, member 4
chr15_+_44084503 0.33 ENST00000409960.2
ENST00000409646.1
ENST00000594896.1
ENST00000339624.5
ENST00000409291.1
ENST00000402131.1
ENST00000403425.1
ENST00000430901.1
small EDRK-rich factor 2
chr12_-_43833515 0.33 ENST00000549670.1
ENST00000395541.2
ADAM metallopeptidase with thrombospondin type 1 motif, 20
chr2_+_113672770 0.32 ENST00000311328.2
interleukin 37
chr1_+_57320437 0.31 ENST00000361249.3
complement component 8, alpha polypeptide
chr6_+_26217159 0.30 ENST00000303910.2
histone cluster 1, H2ae
chrX_-_24665353 0.30 ENST00000379144.2
phosphate cytidylyltransferase 1, choline, beta
chr17_-_2966901 0.30 ENST00000575751.1
olfactory receptor, family 1, subfamily D, member 5
chr6_-_160210604 0.28 ENST00000420894.2
ENST00000539756.1
ENST00000544255.1
t-complex 1
chr17_-_7145475 0.28 ENST00000571129.1
ENST00000571253.1
ENST00000573928.1
GABA(A) receptor-associated protein
chr17_+_68100989 0.26 ENST00000585558.1
ENST00000392670.1
potassium inwardly-rectifying channel, subfamily J, member 16
chr12_+_110011571 0.26 ENST00000539696.1
ENST00000228510.3
ENST00000392727.3
mevalonate kinase
chrX_-_153236819 0.25 ENST00000354233.3
host cell factor C1 (VP16-accessory protein)
chr15_-_33360085 0.25 ENST00000334528.9
formin 1
chr19_+_58193337 0.24 ENST00000601064.1
ENST00000282296.5
ENST00000356715.4
zinc finger protein 551
chr17_+_41150290 0.23 ENST00000589037.1
ENST00000253788.5
ribosomal protein L27
chr11_+_9482512 0.23 ENST00000396602.2
ENST00000530463.1
ENST00000533542.1
ENST00000532577.1
ENST00000396597.3
zinc finger protein 143
chr12_+_113229452 0.23 ENST00000389385.4
rabphilin 3A homolog (mouse)
chr4_-_70626314 0.23 ENST00000510821.1
sulfotransferase family, cytosolic, 1B, member 1
chr2_-_163008903 0.22 ENST00000418842.2
ENST00000375497.3
glucagon
chr8_-_16035454 0.21 ENST00000355282.2
macrophage scavenger receptor 1
chr16_+_57406368 0.21 ENST00000006053.6
ENST00000563383.1
chemokine (C-X3-C motif) ligand 1

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX3-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 11.6 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
2.1 10.5 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
2.1 8.3 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
2.0 6.0 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
1.4 9.6 GO:0021730 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
1.2 9.4 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
1.0 3.9 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.9 4.4 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.9 2.6 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.8 2.4 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.8 3.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.7 2.2 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.7 2.1 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
0.7 8.2 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.6 3.5 GO:0010643 cell communication by chemical coupling(GO:0010643)
0.6 2.3 GO:0031443 fast-twitch skeletal muscle fiber contraction(GO:0031443)
0.5 2.0 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.5 8.0 GO:0051639 actin filament network formation(GO:0051639)
0.5 2.4 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) regulation of peroxidase activity(GO:2000468) positive regulation of peroxidase activity(GO:2000470)
0.4 3.9 GO:1902459 positive regulation of stem cell population maintenance(GO:1902459)
0.4 5.1 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.4 1.9 GO:0035617 stress granule disassembly(GO:0035617)
0.3 5.1 GO:0032836 glomerular basement membrane development(GO:0032836)
0.3 1.5 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.3 6.8 GO:0071888 macrophage apoptotic process(GO:0071888)
0.3 1.5 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.3 1.1 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.3 5.4 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.3 2.1 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.3 3.5 GO:0051599 response to hydrostatic pressure(GO:0051599)
0.2 0.7 GO:0070407 oxidation-dependent protein catabolic process(GO:0070407)
0.2 2.1 GO:0043305 negative regulation of mast cell degranulation(GO:0043305)
0.2 1.4 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
0.2 0.9 GO:1903438 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.2 2.9 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.2 1.3 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.2 1.1 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.2 1.7 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.2 0.8 GO:0036343 negative regulation of extracellular matrix disassembly(GO:0010716) psychomotor behavior(GO:0036343)
0.2 2.3 GO:1904322 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.2 7.2 GO:0019430 removal of superoxide radicals(GO:0019430)
0.2 1.4 GO:0032790 ribosome disassembly(GO:0032790)
0.2 0.9 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
0.2 0.9 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.2 1.1 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.1 2.7 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.1 0.6 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.1 1.1 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.1 1.0 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.1 3.0 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 8.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 0.4 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.1 1.8 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.1 12.2 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.1 2.0 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 3.2 GO:0097503 sialylation(GO:0097503)
0.1 0.7 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.1 1.8 GO:0021670 lateral ventricle development(GO:0021670)
0.1 1.6 GO:0060576 intestinal epithelial cell development(GO:0060576)
0.1 2.0 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 0.5 GO:0072717 cellular response to actinomycin D(GO:0072717)
0.1 0.4 GO:0019046 release from viral latency(GO:0019046)
0.1 1.7 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.1 7.2 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.1 0.4 GO:0035995 detection of muscle stretch(GO:0035995)
0.1 4.6 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.1 0.3 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.1 0.3 GO:0098838 methotrexate transport(GO:0051958) reduced folate transmembrane transport(GO:0098838)
0.1 1.3 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.1 0.2 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 1.6 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.1 3.8 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 0.9 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.1 0.5 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.1 1.1 GO:2000480 negative regulation of activated T cell proliferation(GO:0046007) negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 1.5 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.1 0.2 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.1 1.2 GO:0070987 error-free translesion synthesis(GO:0070987)
0.1 0.2 GO:0050902 leukocyte adhesive activation(GO:0050902)
0.1 2.0 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.1 4.7 GO:0042255 ribosome assembly(GO:0042255)
0.1 0.9 GO:0007097 nuclear migration(GO:0007097)
0.1 0.6 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.1 0.7 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.1 1.1 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.1 0.3 GO:0045636 positive regulation of melanocyte differentiation(GO:0045636)
0.0 0.3 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.0 1.1 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 2.7 GO:0018149 peptide cross-linking(GO:0018149)
0.0 1.5 GO:0005977 glycogen metabolic process(GO:0005977)
0.0 0.6 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.0 1.2 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.1 GO:0016334 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
0.0 1.5 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.3 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 2.2 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 0.3 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 1.8 GO:0033275 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 0.6 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0 0.7 GO:0032006 regulation of TOR signaling(GO:0032006)
0.0 0.4 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.4 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.0 0.1 GO:0071896 protein localization to adherens junction(GO:0071896)
0.0 0.9 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.8 GO:0010762 regulation of fibroblast migration(GO:0010762)
0.0 2.5 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 1.0 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.2 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.0 0.5 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.0 1.3 GO:0030574 collagen catabolic process(GO:0030574)
0.0 0.3 GO:0006968 cellular defense response(GO:0006968)
0.0 1.2 GO:0070126 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.0 0.8 GO:0060338 regulation of type I interferon-mediated signaling pathway(GO:0060338)
0.0 0.3 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.3 GO:0010107 potassium ion import(GO:0010107)
0.0 0.5 GO:1900078 positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0 0.7 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 0.7 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.7 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.7 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.3 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.4 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.8 9.1 GO:0071438 invadopodium membrane(GO:0071438)
0.8 5.7 GO:0036021 endolysosome lumen(GO:0036021)
0.8 9.6 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.8 2.3 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.8 3.9 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.4 1.7 GO:0044611 nuclear pore inner ring(GO:0044611)
0.4 11.0 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.4 2.7 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.4 2.7 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.2 2.5 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.2 2.1 GO:0000796 condensin complex(GO:0000796)
0.2 0.9 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.2 5.9 GO:0005685 U1 snRNP(GO:0005685)
0.2 2.0 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.2 2.9 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.2 1.3 GO:0005587 collagen type IV trimer(GO:0005587)
0.2 2.1 GO:0008385 IkappaB kinase complex(GO:0008385)
0.2 10.6 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 0.8 GO:0070847 core mediator complex(GO:0070847)
0.2 1.7 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.1 1.9 GO:0035253 ciliary rootlet(GO:0035253)
0.1 1.5 GO:0005686 U2 snRNP(GO:0005686)
0.1 13.1 GO:0035580 specific granule lumen(GO:0035580)
0.1 0.9 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.1 0.9 GO:0070938 contractile ring(GO:0070938)
0.1 3.5 GO:0005921 gap junction(GO:0005921)
0.1 2.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.6 GO:1990037 Lewy body core(GO:1990037)
0.1 3.5 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 1.8 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 0.7 GO:0031931 TORC1 complex(GO:0031931)
0.1 0.4 GO:0035838 growing cell tip(GO:0035838)
0.1 1.8 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.1 4.9 GO:0016235 aggresome(GO:0016235)
0.1 2.8 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 1.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 1.1 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.1 1.5 GO:0036020 endolysosome membrane(GO:0036020)
0.1 0.9 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 8.0 GO:0032432 actin filament bundle(GO:0032432)
0.1 14.5 GO:0001726 ruffle(GO:0001726)
0.1 0.9 GO:0005869 dynactin complex(GO:0005869)
0.1 3.0 GO:0001533 cornified envelope(GO:0001533)
0.1 1.1 GO:0031588 cAMP-dependent protein kinase complex(GO:0005952) nucleotide-activated protein kinase complex(GO:0031588)
0.1 2.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 1.4 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 2.5 GO:0000786 nucleosome(GO:0000786)
0.0 1.2 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 0.6 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.5 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.3 GO:0005579 membrane attack complex(GO:0005579)
0.0 1.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 4.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.4 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 3.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.1 GO:0042643 actomyosin, actin portion(GO:0042643)
0.0 2.3 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 0.8 GO:0043034 costamere(GO:0043034)
0.0 0.6 GO:0031904 endosome lumen(GO:0031904)
0.0 0.9 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.1 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 1.3 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 3.1 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.3 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.3 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.7 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.3 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.6 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.2 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.7 GO:0005844 polysome(GO:0005844)
0.0 4.6 GO:0000790 nuclear chromatin(GO:0000790)
0.0 0.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.5 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.4 GO:0005876 spindle microtubule(GO:0005876)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 8.3 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
2.1 8.2 GO:0008112 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
1.5 4.4 GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
1.0 3.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.9 6.0 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.8 7.2 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.8 3.2 GO:0052798 beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798)
0.5 2.6 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.5 1.9 GO:0099609 microtubule lateral binding(GO:0099609)
0.5 2.4 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.4 10.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.4 3.9 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.4 3.0 GO:0004111 creatine kinase activity(GO:0004111)
0.3 1.0 GO:0015119 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.3 2.5 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.3 1.8 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.3 2.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.2 2.5 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.2 0.7 GO:0070362 mitochondrial light strand promoter anti-sense binding(GO:0070361) mitochondrial heavy strand promoter anti-sense binding(GO:0070362) mitochondrial heavy strand promoter sense binding(GO:0070364)
0.2 1.7 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.2 2.6 GO:0008430 selenium binding(GO:0008430)
0.2 5.7 GO:0001968 fibronectin binding(GO:0001968)
0.2 2.0 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.2 0.6 GO:0005148 prolactin receptor binding(GO:0005148)
0.2 2.3 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.2 3.5 GO:0005522 profilin binding(GO:0005522)
0.2 0.5 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.2 2.7 GO:0004526 ribonuclease P activity(GO:0004526)
0.2 0.9 GO:0043532 angiostatin binding(GO:0043532)
0.2 2.3 GO:0019215 intermediate filament binding(GO:0019215)
0.2 8.2 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 2.6 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 0.7 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 6.0 GO:0050699 WW domain binding(GO:0050699)
0.1 3.8 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 0.5 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 1.6 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 3.9 GO:0070064 proline-rich region binding(GO:0070064)
0.1 1.5 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.1 1.4 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.1 1.6 GO:0048531 beta-1,3-galactosyltransferase activity(GO:0048531)
0.1 2.2 GO:0000339 RNA cap binding(GO:0000339)
0.1 1.4 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.1 2.9 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.3 GO:0008518 reduced folate carrier activity(GO:0008518) methotrexate transporter activity(GO:0015350)
0.1 1.8 GO:0070628 proteasome binding(GO:0070628)
0.1 11.4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 1.7 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.1 0.9 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.1 7.5 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.1 1.5 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 0.5 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.1 1.1 GO:0008603 cAMP-dependent protein kinase inhibitor activity(GO:0004862) cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 6.0 GO:0008013 beta-catenin binding(GO:0008013)
0.1 0.9 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 1.3 GO:0031489 myosin V binding(GO:0031489)
0.0 0.5 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.8 GO:0050780 dopamine receptor binding(GO:0050780)
0.0 3.5 GO:0097110 scaffold protein binding(GO:0097110)
0.0 0.8 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.4 GO:0031433 telethonin binding(GO:0031433)
0.0 0.6 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.8 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.5 GO:0005542 folic acid binding(GO:0005542)
0.0 1.0 GO:0019956 chemokine binding(GO:0019956)
0.0 3.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.9 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 1.4 GO:0005198 structural molecule activity(GO:0005198)
0.0 0.8 GO:0030552 cAMP binding(GO:0030552)
0.0 1.1 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 2.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.0 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.9 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 5.5 GO:0051015 actin filament binding(GO:0051015)
0.0 9.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 1.9 GO:0004536 deoxyribonuclease activity(GO:0004536)
0.0 1.5 GO:0030414 peptidase inhibitor activity(GO:0030414)
0.0 0.3 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 1.2 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.4 GO:0070330 aromatase activity(GO:0070330)
0.0 1.1 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 2.1 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 3.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 1.7 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 1.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 1.5 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.3 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.1 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 0.2 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.5 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.4 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.3 GO:0001848 complement binding(GO:0001848)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 8.3 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.2 2.1 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.2 3.1 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 11.8 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 11.6 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 5.6 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 6.1 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 4.4 PID ERBB4 PATHWAY ErbB4 signaling events
0.1 19.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.0 PID EPHB FWD PATHWAY EPHB forward signaling
0.1 2.6 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.9 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 1.1 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 2.1 PID AURORA B PATHWAY Aurora B signaling
0.0 0.8 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 1.1 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 1.3 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.2 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 2.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.6 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.5 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.3 PID ATM PATHWAY ATM pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 12.9 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.3 9.6 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.3 10.5 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.2 4.4 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.2 6.8 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 3.2 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 2.3 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.1 2.0 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.1 3.9 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 10.1 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1 3.0 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 2.6 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 2.0 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 9.9 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 1.4 REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX Genes involved in CDT1 association with the CDC6:ORC:origin complex
0.1 1.2 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 2.6 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 8.5 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.1 4.7 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 0.7 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.1 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 1.1 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.1 1.5 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 0.7 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.1 1.1 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 6.7 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.1 0.9 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.1 0.5 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 2.5 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.8 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.6 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.9 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.9 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 2.6 REACTOME EXTRACELLULAR MATRIX ORGANIZATION Genes involved in Extracellular matrix organization
0.0 1.1 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 1.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.8 REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.0 0.6 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 1.3 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.8 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.2 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.8 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.3 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 1.0 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.6 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.6 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.8 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 3.0 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.4 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.0 0.1 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.3 REACTOME GABA B RECEPTOR ACTIVATION Genes involved in GABA B receptor activation
0.0 0.2 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.3 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis