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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for NKX3-2
Z-value: 0.77
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Transcription factors associated with NKX3-2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NKX3-2 | hg19_v2_chr4_-_13546632_13546674 | 0.29 | 1.8e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX3-2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 25.4 | GO:0052565 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
| 0.2 | 23.5 | GO:0005977 | glycogen metabolic process(GO:0005977) |
| 0.4 | 19.6 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 0.5 | 15.9 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 1.8 | 14.2 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 0.5 | 14.1 | GO:0034080 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.3 | 13.5 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
| 0.1 | 13.5 | GO:0030183 | B cell differentiation(GO:0030183) |
| 1.9 | 13.2 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
| 0.3 | 12.4 | GO:0010107 | potassium ion import(GO:0010107) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 43.4 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 39.5 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 1.3 | 31.9 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.1 | 23.3 | GO:0030426 | growth cone(GO:0030426) |
| 0.1 | 22.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.4 | 20.6 | GO:0016235 | aggresome(GO:0016235) |
| 0.6 | 12.2 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.6 | 11.1 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.2 | 11.0 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 1.5 | 10.2 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 31.9 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.2 | 22.5 | GO:0051117 | ATPase binding(GO:0051117) |
| 0.1 | 20.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 17.1 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 2.0 | 16.3 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.3 | 13.8 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 1.6 | 13.2 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.7 | 13.2 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.1 | 12.2 | GO:0008083 | growth factor activity(GO:0008083) |
| 2.0 | 12.1 | GO:0015057 | thrombin receptor activity(GO:0015057) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 15.4 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.2 | 14.2 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.3 | 14.1 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.3 | 14.0 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 13.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 13.4 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 12.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.6 | 11.0 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.4 | 8.6 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 7.7 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 32.7 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.3 | 19.0 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.1 | 17.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.3 | 15.6 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.4 | 13.9 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.5 | 13.2 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.4 | 13.2 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.3 | 13.2 | REACTOME INWARDLY RECTIFYING K CHANNELS | Genes involved in Inwardly rectifying K+ channels |
| 0.1 | 12.2 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.4 | 11.0 | REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |