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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for NKX6-3
Z-value: 0.08
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Transcription factors associated with NKX6-3
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_+_125132803 Show fit | 3.58 |
ENST00000540753.1
|
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) |
|
| chr3_-_141747950 Show fit | 3.30 |
ENST00000497579.1
|
transcription factor Dp-2 (E2F dimerization partner 2) |
|
| chr9_+_125133315 Show fit | 1.92 |
ENST00000223423.4
ENST00000362012.2 |
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) |
|
| chr8_-_90769422 Show fit | 1.88 |
ENST00000524190.1
ENST00000523859.1 |
RP11-37B2.1 |
|
| chr4_+_80584903 Show fit | 1.83 |
ENST00000506460.1
|
RP11-452C8.1 |
|
| chr3_-_141719195 Show fit | 1.70 |
ENST00000397991.4
|
transcription factor Dp-2 (E2F dimerization partner 2) |
|
| chr13_+_53602894 Show fit | 1.52 |
ENST00000219022.2
|
olfactomedin 4 |
|
| chr7_-_25268104 Show fit | 1.40 |
ENST00000222674.2
|
neuropeptide VF precursor |
|
| chr11_-_13517565 Show fit | 1.35 |
ENST00000282091.1
ENST00000529816.1 |
parathyroid hormone |
|
| chr14_-_51027838 Show fit | 1.29 |
ENST00000555216.1
|
mitogen-activated protein kinase kinase kinase kinase 5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX6-3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.5 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 0.1 | 5.0 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.1 | 1.8 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.2 | 1.5 | GO:2000389 | regulation of neutrophil extravasation(GO:2000389) |
| 0.5 | 1.4 | GO:1900158 | positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158) |
| 0.1 | 1.4 | GO:0032277 | negative regulation of gonadotropin secretion(GO:0032277) |
| 0.1 | 1.3 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.1 | 0.9 | GO:0042420 | dopamine catabolic process(GO:0042420) |
| 0.1 | 0.8 | GO:0002414 | immunoglobulin transcytosis in epithelial cells(GO:0002414) |
| 0.1 | 0.6 | GO:0045078 | positive regulation of interferon-gamma biosynthetic process(GO:0045078) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.5 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.0 | 5.0 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 1.5 | GO:1904724 | specific granule lumen(GO:0035580) tertiary granule lumen(GO:1904724) |
| 0.0 | 0.7 | GO:0032982 | myosin filament(GO:0032982) |
| 0.0 | 0.6 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.1 | 0.5 | GO:0033186 | CAF-1 complex(GO:0033186) |
| 0.1 | 0.4 | GO:0005726 | perichromatin fibrils(GO:0005726) |
| 0.0 | 0.3 | GO:0043073 | germ cell nucleus(GO:0043073) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 5.5 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
| 0.1 | 1.4 | GO:0048018 | receptor agonist activity(GO:0048018) |
| 0.1 | 1.3 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.1 | 0.9 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 0.2 | 0.8 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 0.0 | 0.7 | GO:0000146 | microfilament motor activity(GO:0000146) |
| 0.0 | 0.7 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.1 | 0.6 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.1 | 0.6 | GO:0038051 | glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051) |
| 0.1 | 0.6 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.0 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 1.3 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.0 | 1.1 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 1.0 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.4 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.0 | 1.4 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.6 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 0.4 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 0.3 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.0 | 0.2 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |