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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for NR0B1
Z-value: 0.25
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Transcription factors associated with NR0B1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR0B1 | hg19_v2_chrX_-_30327495_30327509, hg19_v2_chrX_-_30326445_30326605 | 0.06 | 3.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR0B1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 17.9 | GO:2000622 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.7 | 14.6 | GO:0071243 | cellular response to arsenic-containing substance(GO:0071243) |
| 0.3 | 13.9 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 1.5 | 13.5 | GO:0060633 | negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) |
| 2.0 | 11.7 | GO:0007386 | compartment pattern specification(GO:0007386) |
| 0.1 | 10.8 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.5 | 9.1 | GO:0016180 | snRNA processing(GO:0016180) |
| 2.9 | 8.8 | GO:1904800 | negative regulation of dendrite extension(GO:1903860) regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) negative regulation of branching morphogenesis of a nerve(GO:2000173) |
| 0.5 | 7.8 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 1.5 | 7.6 | GO:2000035 | positive regulation of somatic stem cell population maintenance(GO:1904674) regulation of stem cell division(GO:2000035) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 34.2 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.2 | 28.5 | GO:0016605 | PML body(GO:0016605) |
| 0.9 | 17.9 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 1.3 | 15.1 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.1 | 13.7 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.1 | 11.0 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 10.7 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 9.8 | GO:0001650 | fibrillar center(GO:0001650) |
| 1.0 | 9.1 | GO:0032039 | integrator complex(GO:0032039) |
| 0.1 | 8.9 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 17.9 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.9 | 16.6 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 1.5 | 15.1 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.1 | 14.4 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.3 | 11.7 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.6 | 11.5 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.1 | 10.7 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 2.1 | 10.3 | GO:0061665 | SUMO ligase activity(GO:0061665) |
| 0.3 | 8.2 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.9 | 8.1 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 20.7 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.3 | 15.1 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 10.5 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 7.8 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.2 | 6.5 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.1 | 6.3 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 6.2 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.1 | 5.6 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.1 | 5.5 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 4.0 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.3 | REACTOME ASPARAGINE N LINKED GLYCOSYLATION | Genes involved in Asparagine N-linked glycosylation |
| 0.5 | 17.4 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 12.3 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.3 | 10.8 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.4 | 8.1 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.1 | 7.0 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.2 | 6.0 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.1 | 5.9 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 5.8 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.3 | 5.7 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |