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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for NR1D1
Z-value: 0.29
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Transcription factors associated with NR1D1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR1D1 | hg19_v2_chr17_-_38256973_38256990 | 0.26 | 7.8e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR1D1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.8 | 18.8 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 3.1 | 15.3 | GO:0033274 | response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829) |
| 0.1 | 11.9 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.4 | 11.1 | GO:1903861 | positive regulation of dendrite extension(GO:1903861) |
| 0.9 | 10.4 | GO:0006108 | malate metabolic process(GO:0006108) |
| 0.4 | 7.9 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.6 | 6.7 | GO:0015074 | DNA integration(GO:0015074) |
| 0.2 | 6.7 | GO:0035590 | purinergic nucleotide receptor signaling pathway(GO:0035590) |
| 0.5 | 5.8 | GO:0021978 | telencephalon regionalization(GO:0021978) |
| 0.1 | 5.6 | GO:0005977 | glycogen metabolic process(GO:0005977) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.3 | GO:0005874 | microtubule(GO:0005874) |
| 0.3 | 12.9 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.3 | 12.4 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.1 | 10.9 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.0 | 7.7 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 7.4 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.0 | 7.1 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.3 | 6.7 | GO:0044453 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453) |
| 0.2 | 4.4 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 3.9 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 25.4 | GO:0003677 | DNA binding(GO:0003677) |
| 0.0 | 16.3 | GO:0015631 | tubulin binding(GO:0015631) |
| 3.1 | 15.3 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
| 0.1 | 12.4 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.1 | 11.9 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.2 | 11.1 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 2.1 | 10.4 | GO:0030060 | L-malate dehydrogenase activity(GO:0030060) |
| 0.2 | 7.0 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.6 | 6.7 | GO:0004931 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.0 | 5.7 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 18.8 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.2 | 12.9 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 5.3 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 3.7 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.1 | 3.0 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
| 0.0 | 2.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 1.8 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 1.8 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.0 | 0.8 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 0.7 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.3 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 11.3 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.2 | 10.4 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.2 | 4.5 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 3.0 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 2.3 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.1 | 1.8 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.1 | 1.8 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 1.8 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 1.0 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |