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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for NR1H2

Z-value: 0.56

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Transcription factors associated with NR1H2

Gene Symbol Gene ID Gene Info
NR1H2
ENSG00000131408.9 nuclear receptor subfamily 1 group H member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR1H2hg19_v2_chr19_+_50879705_50879775-0.161.7e-02Click!

Activity profile of NR1H2 motif

Sorted Z-values of NR1H2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_+_21693306 15.57 ENST00000540918.2
TTC39C
tetratricopeptide repeat domain 39C
chr3_-_195310802 13.98 ENST00000421243.1
ENST00000453131.1
APOD
apolipoprotein D
chr12_-_91573132 13.35 ENST00000550563.1
ENST00000546370.1
DCN
decorin
chr12_-_91573249 12.84 ENST00000550099.1
ENST00000546391.1
ENST00000551354.1
DCN
decorin
chr11_-_68518910 10.73 ENST00000544963.1
ENST00000443940.2
MTL5
metallothionein-like 5, testis-specific (tesmin)
chr8_-_27941380 8.29 ENST00000413272.2
ENST00000341513.6
NUGGC
nuclear GTPase, germinal center associated
chr4_-_681114 8.20 ENST00000503156.1
MFSD7
major facilitator superfamily domain containing 7
chr19_-_46296011 7.83 ENST00000377735.3
ENST00000270223.6
DMWD
dystrophia myotonica, WD repeat containing
chr1_-_237167718 7.20 ENST00000464121.2
MT1HL1
metallothionein 1H-like 1
chr19_-_7968427 6.83 ENST00000539278.1
AC010336.1
Uncharacterized protein
chr12_+_57914742 6.64 ENST00000551351.1
MBD6
methyl-CpG binding domain protein 6
chr8_-_48651648 6.51 ENST00000408965.3
CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr16_+_30710462 6.37 ENST00000262518.4
ENST00000395059.2
ENST00000344771.4
SRCAP
Snf2-related CREBBP activator protein
chr1_+_22962948 6.20 ENST00000374642.3
C1QA
complement component 1, q subcomponent, A chain
chr19_+_7968728 6.20 ENST00000397981.3
ENST00000545011.1
ENST00000397983.3
ENST00000397979.3
MAP2K7
mitogen-activated protein kinase kinase 7
chr10_-_70287231 5.79 ENST00000609923.1
SLC25A16
solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16
chr17_+_7184986 5.66 ENST00000317370.8
ENST00000571308.1
SLC2A4
solute carrier family 2 (facilitated glucose transporter), member 4
chr19_+_2977444 5.61 ENST00000246112.4
ENST00000453329.1
ENST00000482627.1
ENST00000452088.1
TLE6
transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)
chr16_-_1661988 5.42 ENST00000426508.2
IFT140
intraflagellar transport 140 homolog (Chlamydomonas)
chr1_-_67142710 4.95 ENST00000502413.2
AL139147.1
Uncharacterized protein
chrX_+_21874105 4.82 ENST00000429584.2
YY2
YY2 transcription factor
chr15_+_96876340 4.80 ENST00000453270.2
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr19_+_15752088 4.73 ENST00000585846.1
CYP4F3
cytochrome P450, family 4, subfamily F, polypeptide 3
chr7_+_100136811 4.60 ENST00000300176.4
ENST00000262935.4
AGFG2
ArfGAP with FG repeats 2
chr1_+_169337172 4.53 ENST00000367807.3
ENST00000367808.3
ENST00000329281.2
ENST00000420531.1
BLZF1
basic leucine zipper nuclear factor 1
chr1_+_13736907 4.52 ENST00000316412.5
PRAMEF20
PRAME family member 20
chr7_+_123485102 4.50 ENST00000488323.1
ENST00000223026.4
HYAL4
hyaluronoglucosaminidase 4
chr19_-_38806560 4.47 ENST00000591755.1
ENST00000337679.8
ENST00000339413.6
YIF1B
Yip1 interacting factor homolog B (S. cerevisiae)
chr1_+_13516066 4.19 ENST00000332192.6
PRAMEF21
PRAME family member 21
chr4_-_83483395 4.14 ENST00000515780.2
TMEM150C
transmembrane protein 150C
chr12_-_7125770 4.10 ENST00000261407.4
LPCAT3
lysophosphatidylcholine acyltransferase 3
chr11_+_10326612 4.06 ENST00000534464.1
ENST00000530439.1
ENST00000524948.1
ENST00000528655.1
ENST00000526492.1
ENST00000525063.1
ADM
adrenomedullin
chr14_-_77787198 4.02 ENST00000261534.4
POMT2
protein-O-mannosyltransferase 2
chr17_-_26694979 3.86 ENST00000438614.1
VTN
vitronectin
chr3_+_46921732 3.85 ENST00000418619.1
PTH1R
parathyroid hormone 1 receptor
chr11_+_1074870 3.83 ENST00000441003.2
ENST00000359061.5
MUC2
mucin 2, oligomeric mucus/gel-forming
chr10_-_70287172 3.69 ENST00000539557.1
SLC25A16
solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16
chrX_+_49020121 3.68 ENST00000415364.1
ENST00000376338.3
ENST00000425285.1
MAGIX
MAGI family member, X-linked
chr10_+_81838411 3.67 ENST00000372281.3
ENST00000372277.3
ENST00000372275.1
ENST00000372274.1
TMEM254
transmembrane protein 254
chr2_+_71357744 3.66 ENST00000498451.2
MPHOSPH10
M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
chr17_-_26695013 3.65 ENST00000555059.2
CTB-96E2.2
Homeobox protein SEBOX
chr2_-_32390801 3.65 ENST00000608489.1
RP11-563N4.1
RP11-563N4.1
chr15_-_90892669 3.60 ENST00000412799.2
GABARAPL3
GABA(A) receptors associated protein like 3, pseudogene
chr8_+_142402089 3.57 ENST00000521578.1
ENST00000520105.1
ENST00000523147.1
PTP4A3
protein tyrosine phosphatase type IVA, member 3
chr14_+_77787227 3.50 ENST00000216465.5
ENST00000361389.4
ENST00000554279.1
ENST00000557639.1
ENST00000349555.3
ENST00000556627.1
ENST00000557053.1
GSTZ1
glutathione S-transferase zeta 1
chr20_-_44600810 3.32 ENST00000322927.2
ENST00000426788.1
ZNF335
zinc finger protein 335
chr11_+_66276550 3.29 ENST00000419755.3
CTD-3074O7.11
Bardet-Biedl syndrome 1 protein
chr22_+_30792846 3.21 ENST00000312932.9
ENST00000428195.1
SEC14L2
SEC14-like 2 (S. cerevisiae)
chr2_+_44502597 3.21 ENST00000260649.6
ENST00000409387.1
SLC3A1
solute carrier family 3 (amino acid transporter heavy chain), member 1
chr14_-_22005343 3.17 ENST00000327430.3
SALL2
spalt-like transcription factor 2
chr1_+_169075554 3.17 ENST00000367815.4
ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr9_-_130829588 3.16 ENST00000373078.4
NAIF1
nuclear apoptosis inducing factor 1
chr4_+_108910870 3.15 ENST00000403312.1
ENST00000603302.1
ENST00000309522.3
HADH
hydroxyacyl-CoA dehydrogenase
chr17_-_42580738 3.05 ENST00000585614.1
ENST00000591680.1
ENST00000434000.1
ENST00000588554.1
ENST00000592154.1
GPATCH8
G patch domain containing 8
chr19_+_41768561 3.02 ENST00000599719.1
ENST00000601309.1
HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr11_-_62521614 2.96 ENST00000527994.1
ENST00000394807.3
ZBTB3
zinc finger and BTB domain containing 3
chr19_-_58427944 2.96 ENST00000312026.5
ENST00000536263.1
ENST00000598629.1
ENST00000595559.1
ENST00000597515.1
ENST00000599251.1
ENST00000598526.1
ZNF417
zinc finger protein 417
chr15_+_96875657 2.90 ENST00000559679.1
ENST00000394171.2
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr4_-_80247162 2.86 ENST00000286794.4
NAA11
N(alpha)-acetyltransferase 11, NatA catalytic subunit
chr14_-_22005062 2.84 ENST00000317492.5
SALL2
spalt-like transcription factor 2
chr1_-_40098672 2.82 ENST00000535435.1
HEYL
hes-related family bHLH transcription factor with YRPW motif-like
chr1_+_156338993 2.81 ENST00000368249.1
ENST00000368246.2
ENST00000537040.1
ENST00000400992.2
ENST00000255013.3
ENST00000451864.2
RHBG
Rh family, B glycoprotein (gene/pseudogene)
chr22_-_38577782 2.81 ENST00000430886.1
ENST00000332509.3
ENST00000447598.2
ENST00000435484.1
ENST00000402064.1
ENST00000436218.1
PLA2G6
phospholipase A2, group VI (cytosolic, calcium-independent)
chr3_-_49893958 2.78 ENST00000482243.1
ENST00000331456.2
ENST00000469027.1
TRAIP
TRAF interacting protein
chrX_+_1455478 2.76 ENST00000331035.4
IL3RA
interleukin 3 receptor, alpha (low affinity)
chr16_-_14788526 2.75 ENST00000438167.3
PLA2G10
phospholipase A2, group X
chr3_+_46283863 2.74 ENST00000545097.1
ENST00000541018.1
CCR3
chemokine (C-C motif) receptor 3
chr19_+_57631411 2.67 ENST00000254181.4
ENST00000600940.1
USP29
ubiquitin specific peptidase 29
chr17_+_32683456 2.67 ENST00000225844.2
CCL13
chemokine (C-C motif) ligand 13
chr22_-_38577731 2.66 ENST00000335539.3
PLA2G6
phospholipase A2, group VI (cytosolic, calcium-independent)
chr16_+_21312170 2.65 ENST00000338573.5
ENST00000561968.1
CRYM-AS1
CRYM antisense RNA 1
chr11_+_119039414 2.65 ENST00000409991.1
ENST00000292199.2
ENST00000409265.4
ENST00000409109.1
NLRX1
NLR family member X1
chr21_-_37432832 2.65 ENST00000332131.4
SETD4
SET domain containing 4
chr1_+_210001309 2.64 ENST00000491415.2
DIEXF
digestive organ expansion factor homolog (zebrafish)
chr3_+_9404526 2.61 ENST00000452837.2
ENST00000417036.1
ENST00000419437.1
ENST00000345094.3
ENST00000515662.2
THUMPD3
THUMP domain containing 3
chr21_-_37432764 2.61 ENST00000399212.1
ENST00000446166.1
SETD4
SET domain containing 4
chr4_-_7941596 2.54 ENST00000420658.1
ENST00000358461.2
AFAP1
actin filament associated protein 1
chr3_-_49466686 2.52 ENST00000273598.3
ENST00000436744.2
NICN1
nicolin 1
chr7_-_73153161 2.49 ENST00000395147.4
ABHD11
abhydrolase domain containing 11
chr1_+_26503894 2.47 ENST00000361530.6
ENST00000374253.5
CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr16_-_31147020 2.42 ENST00000568261.1
ENST00000567797.1
ENST00000317508.6
PRSS8
protease, serine, 8
chr8_-_93115445 2.40 ENST00000523629.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr1_+_100818156 2.39 ENST00000336454.3
CDC14A
cell division cycle 14A
chr13_-_33112823 2.37 ENST00000504114.1
N4BP2L2
NEDD4 binding protein 2-like 2
chr19_+_15751689 2.37 ENST00000586182.2
ENST00000591058.1
ENST00000221307.8
CYP4F3
cytochrome P450, family 4, subfamily F, polypeptide 3
chr14_-_70826438 2.35 ENST00000389912.6
COX16
COX16 cytochrome c oxidase assembly homolog (S. cerevisiae)
chr4_-_39033963 2.32 ENST00000381938.3
TMEM156
transmembrane protein 156
chr20_+_43343886 2.32 ENST00000190983.4
WISP2
WNT1 inducible signaling pathway protein 2
chr11_+_64692143 2.31 ENST00000164133.2
ENST00000532850.1
PPP2R5B
protein phosphatase 2, regulatory subunit B', beta
chr7_-_73153122 2.28 ENST00000458339.1
ABHD11
abhydrolase domain containing 11
chr12_+_122064398 2.21 ENST00000330079.7
ORAI1
ORAI calcium release-activated calcium modulator 1
chr21_+_43619796 2.20 ENST00000398457.2
ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr2_-_3521518 2.19 ENST00000382093.5
ADI1
acireductone dioxygenase 1
chr17_-_19648916 2.17 ENST00000444455.1
ENST00000439102.2
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr17_-_76975925 2.14 ENST00000591274.1
ENST00000589906.1
ENST00000591778.1
ENST00000589775.2
ENST00000585407.1
ENST00000262776.3
LGALS3BP
lectin, galactoside-binding, soluble, 3 binding protein
chr19_-_22193731 2.11 ENST00000601773.1
ENST00000397126.4
ENST00000601993.1
ENST00000599916.1
ZNF208
zinc finger protein 208
chr9_+_135937365 2.11 ENST00000372080.4
ENST00000351304.7
CEL
carboxyl ester lipase
chr11_-_506316 2.10 ENST00000532055.1
ENST00000531540.1
RNH1
ribonuclease/angiogenin inhibitor 1
chr1_-_161208013 2.05 ENST00000515452.1
ENST00000367983.4
NR1I3
nuclear receptor subfamily 1, group I, member 3
chr21_-_37432540 1.98 ENST00000443703.1
ENST00000399207.1
ENST00000399215.1
ENST00000442559.1
ENST00000399205.1
ENST00000429161.1
ENST00000424303.1
ENST00000399208.2
SETD4
SET domain containing 4
chr19_-_49658387 1.98 ENST00000595625.1
HRC
histidine rich calcium binding protein
chr6_-_31763408 1.96 ENST00000444930.2
VARS
valyl-tRNA synthetase
chr15_-_63674218 1.96 ENST00000178638.3
CA12
carbonic anhydrase XII
chr1_-_13115578 1.95 ENST00000414205.2
PRAMEF6
PRAME family member 6
chr4_+_5527117 1.84 ENST00000505296.1
C4orf6
chromosome 4 open reading frame 6
chr1_+_100818009 1.84 ENST00000370125.2
ENST00000361544.6
ENST00000370124.3
CDC14A
cell division cycle 14A
chr5_-_58652788 1.81 ENST00000405755.2
PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_-_161207953 1.81 ENST00000367982.4
NR1I3
nuclear receptor subfamily 1, group I, member 3
chr16_+_57769635 1.79 ENST00000379661.3
ENST00000562592.1
ENST00000566726.1
KATNB1
katanin p80 (WD repeat containing) subunit B 1
chr2_+_73441350 1.79 ENST00000389501.4
SMYD5
SMYD family member 5
chr6_+_36097992 1.79 ENST00000211287.4
MAPK13
mitogen-activated protein kinase 13
chr12_-_113841678 1.79 ENST00000552280.1
ENST00000257549.4
SDS
serine dehydratase
chr19_+_39881951 1.75 ENST00000315588.5
ENST00000594368.1
ENST00000599213.2
ENST00000596297.1
MED29
mediator complex subunit 29
chr1_+_87595433 1.73 ENST00000469312.2
ENST00000490006.2
RP5-1052I5.1
long intergenic non-protein coding RNA 1140
chr4_+_5526883 1.69 ENST00000195455.2
C4orf6
chromosome 4 open reading frame 6
chr22_-_36031181 1.69 ENST00000594060.1
AL049747.1
AL049747.1
chr9_-_86955657 1.65 ENST00000537648.1
SLC28A3
solute carrier family 28 (concentrative nucleoside transporter), member 3
chr17_+_4675175 1.64 ENST00000270560.3
TM4SF5
transmembrane 4 L six family member 5
chrX_+_23801280 1.63 ENST00000379251.3
ENST00000379253.3
ENST00000379254.1
ENST00000379270.4
SAT1
spermidine/spermine N1-acetyltransferase 1
chrX_-_2847366 1.63 ENST00000381154.1
ARSD
arylsulfatase D
chr6_-_144385698 1.59 ENST00000444202.1
ENST00000437412.1
PLAGL1
pleiomorphic adenoma gene-like 1
chr5_+_43120985 1.59 ENST00000515326.1
ZNF131
zinc finger protein 131
chr1_+_87458692 1.53 ENST00000370548.2
ENST00000356813.4
RP5-1052I5.2
HS2ST1
Heparan sulfate 2-O-sulfotransferase 1
heparan sulfate 2-O-sulfotransferase 1
chr7_-_56160625 1.51 ENST00000446428.1
ENST00000432123.1
ENST00000452681.2
ENST00000537360.1
PHKG1
phosphorylase kinase, gamma 1 (muscle)
chr3_+_39371255 1.51 ENST00000414803.1
ENST00000545843.1
CCR8
chemokine (C-C motif) receptor 8
chr1_-_161207986 1.46 ENST00000506209.1
ENST00000367980.2
NR1I3
nuclear receptor subfamily 1, group I, member 3
chr12_-_120765565 1.45 ENST00000423423.3
ENST00000308366.4
PLA2G1B
phospholipase A2, group IB (pancreas)
chr20_-_32262165 1.44 ENST00000606690.1
ENST00000246190.6
ENST00000439478.1
ENST00000375238.4
NECAB3
N-terminal EF-hand calcium binding protein 3
chr9_-_86955598 1.44 ENST00000376238.4
SLC28A3
solute carrier family 28 (concentrative nucleoside transporter), member 3
chrX_+_30248553 1.42 ENST00000361644.2
MAGEB3
melanoma antigen family B, 3
chr7_+_153584166 1.40 ENST00000404039.1
DPP6
dipeptidyl-peptidase 6
chr20_+_3052264 1.38 ENST00000217386.2
OXT
oxytocin/neurophysin I prepropeptide
chr22_+_36113919 1.33 ENST00000249044.2
APOL5
apolipoprotein L, 5
chr11_+_32851487 1.31 ENST00000257836.3
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr20_+_43343517 1.27 ENST00000372865.4
WISP2
WNT1 inducible signaling pathway protein 2
chr4_-_39640700 1.23 ENST00000295958.5
SMIM14
small integral membrane protein 14
chr16_+_29467780 1.18 ENST00000395400.3
SULT1A4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
chr17_+_78152274 1.18 ENST00000344227.2
ENST00000570421.1
CARD14
caspase recruitment domain family, member 14
chr2_-_165697920 1.18 ENST00000342193.4
ENST00000375458.2
COBLL1
cordon-bleu WH2 repeat protein-like 1
chr15_+_83776137 1.18 ENST00000322019.9
TM6SF1
transmembrane 6 superfamily member 1
chr11_-_35441597 1.17 ENST00000395753.1
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr10_+_126490354 1.17 ENST00000298492.5
FAM175B
family with sequence similarity 175, member B
chr16_-_30023615 1.17 ENST00000564979.1
ENST00000563378.1
DOC2A
double C2-like domains, alpha
chr9_+_34179003 1.14 ENST00000545103.1
ENST00000543944.1
ENST00000536252.1
ENST00000540348.1
ENST00000297661.4
ENST00000379186.4
UBAP1
ubiquitin associated protein 1
chr16_+_72042487 1.14 ENST00000572887.1
ENST00000219240.4
ENST00000574309.1
ENST00000576145.1
DHODH
dihydroorotate dehydrogenase (quinone)
chr12_-_322821 1.14 ENST00000359674.4
SLC6A12
solute carrier family 6 (neurotransmitter transporter), member 12
chr9_-_107690420 1.13 ENST00000423487.2
ENST00000374733.1
ENST00000374736.3
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr3_+_39371191 1.10 ENST00000326306.4
CCR8
chemokine (C-C motif) receptor 8
chr22_-_23974506 1.08 ENST00000317749.5
C22orf43
chromosome 22 open reading frame 43
chr13_-_33112899 1.06 ENST00000267068.3
ENST00000357505.6
ENST00000399396.3
N4BP2L2
NEDD4 binding protein 2-like 2
chr3_-_169587621 1.04 ENST00000523069.1
ENST00000316428.5
ENST00000264676.5
LRRC31
leucine rich repeat containing 31
chr7_-_56160666 1.01 ENST00000297373.2
PHKG1
phosphorylase kinase, gamma 1 (muscle)
chr17_-_49198216 0.97 ENST00000262013.7
ENST00000357122.4
SPAG9
sperm associated antigen 9
chr22_-_24096562 0.94 ENST00000398465.3
VPREB3
pre-B lymphocyte 3
chr11_-_35440796 0.93 ENST00000278379.3
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr17_-_35716019 0.91 ENST00000591148.1
ENST00000394406.2
ENST00000394403.1
ACACA
acetyl-CoA carboxylase alpha
chr16_+_3550924 0.91 ENST00000576634.1
ENST00000574369.1
ENST00000341633.5
ENST00000417763.2
ENST00000571025.1
CLUAP1
clusterin associated protein 1
chr16_+_56995854 0.90 ENST00000566128.1
CETP
cholesteryl ester transfer protein, plasma
chr2_+_228029281 0.78 ENST00000396578.3
COL4A3
collagen, type IV, alpha 3 (Goodpasture antigen)
chr20_+_34680620 0.73 ENST00000430276.1
ENST00000373950.2
ENST00000452261.1
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr12_-_125398850 0.72 ENST00000535859.1
ENST00000546271.1
ENST00000540700.1
ENST00000546120.1
UBC
ubiquitin C
chr19_+_16254488 0.71 ENST00000588246.1
ENST00000593031.1
HSH2D
hematopoietic SH2 domain containing
chr15_+_67835517 0.68 ENST00000395476.2
MAP2K5
mitogen-activated protein kinase kinase 5
chr1_+_150337100 0.67 ENST00000401000.4
RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr12_+_57998400 0.65 ENST00000548804.1
ENST00000550596.1
ENST00000551835.1
ENST00000549583.1
DTX3
deltex homolog 3 (Drosophila)
chr19_-_46285646 0.64 ENST00000458663.2
DMPK
dystrophia myotonica-protein kinase
chr1_+_24117693 0.63 ENST00000374503.3
ENST00000374502.3
LYPLA2
lysophospholipase II
chrX_+_102631248 0.63 ENST00000361298.4
ENST00000372645.3
ENST00000372635.1
NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr15_+_64386261 0.62 ENST00000560829.1
SNX1
sorting nexin 1
chr2_-_114036488 0.61 ENST00000263335.7
ENST00000397647.3
ENST00000348715.5
ENST00000429538.3
PAX8
paired box 8
chr17_-_41977964 0.61 ENST00000377184.3
MPP2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
chr1_+_23037323 0.57 ENST00000544305.1
ENST00000374630.3
ENST00000400191.3
ENST00000374632.3
EPHB2
EPH receptor B2
chrX_+_107334895 0.57 ENST00000372232.3
ENST00000345734.3
ENST00000372254.3
ATG4A
autophagy related 4A, cysteine peptidase
chr22_-_24096630 0.55 ENST00000248948.3
VPREB3
pre-B lymphocyte 3
chr2_-_216946500 0.50 ENST00000265322.7
PECR
peroxisomal trans-2-enoyl-CoA reductase
chr8_-_124749609 0.49 ENST00000262219.6
ENST00000419625.1
ANXA13
annexin A13
chr1_-_169337176 0.49 ENST00000472647.1
ENST00000367811.3
NME7
NME/NM23 family member 7
chr14_-_73925225 0.48 ENST00000356296.4
ENST00000355058.3
ENST00000359560.3
ENST00000557597.1
ENST00000554394.1
ENST00000555238.1
ENST00000535282.1
ENST00000555987.1
ENST00000555394.1
ENST00000554546.1
NUMB
numb homolog (Drosophila)
chr11_-_68519026 0.47 ENST00000255087.5
MTL5
metallothionein-like 5, testis-specific (tesmin)
chr19_-_54850417 0.43 ENST00000291759.4
LILRA4
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
chr13_+_49684445 0.41 ENST00000398316.3
FNDC3A
fibronectin type III domain containing 3A
chr17_-_8151353 0.40 ENST00000315684.8
CTC1
CTS telomere maintenance complex component 1
chr15_+_91473403 0.37 ENST00000394275.2
UNC45A
unc-45 homolog A (C. elegans)
chr7_-_74489609 0.37 ENST00000329959.4
ENST00000503250.2
ENST00000543840.1
WBSCR16
Williams-Beuren syndrome chromosome region 16
chr16_-_4465886 0.32 ENST00000539968.1
CORO7
coronin 7
chr16_+_577697 0.31 ENST00000562370.1
ENST00000568988.1
ENST00000219611.2
CAPN15
calpain 15
chr3_-_126327398 0.30 ENST00000383572.2
TXNRD3NB
thioredoxin reductase 3 neighbor
chr17_-_2169425 0.26 ENST00000570606.1
ENST00000354901.4
SMG6
SMG6 nonsense mediated mRNA decay factor
chr16_+_56995762 0.26 ENST00000200676.3
ENST00000379780.2
CETP
cholesteryl ester transfer protein, plasma
chrX_-_9001351 0.25 ENST00000362066.3
FAM9B
family with sequence similarity 9, member B
chr13_-_33112956 0.25 ENST00000505213.1
N4BP2L2
NEDD4 binding protein 2-like 2
chr20_-_39928705 0.22 ENST00000436099.2
ENST00000309060.3
ENST00000373261.1
ENST00000436440.2
ENST00000540170.1
ENST00000557816.1
ENST00000560361.1
ZHX3
zinc fingers and homeoboxes 3
chr19_+_44220247 0.22 ENST00000596627.1
IRGC
immunity-related GTPase family, cinema
chr6_-_167571817 0.18 ENST00000366834.1
GPR31
G protein-coupled receptor 31
chr11_-_35441524 0.11 ENST00000395750.1
ENST00000449068.1
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr8_-_61193947 0.09 ENST00000317995.4
CA8
carbonic anhydrase VIII
chr15_+_43663257 0.07 ENST00000260383.7
ENST00000564079.1
TUBGCP4
tubulin, gamma complex associated protein 4
chr17_+_71229346 0.05 ENST00000535032.2
ENST00000582793.1
C17orf80
chromosome 17 open reading frame 80
chr1_+_28879588 0.02 ENST00000373830.3
TRNAU1AP
tRNA selenocysteine 1 associated protein 1
chr20_-_39928756 0.01 ENST00000432768.2
ZHX3
zinc fingers and homeoboxes 3

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1H2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 14.0 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
2.2 26.2 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
1.9 7.7 GO:0009956 radial pattern formation(GO:0009956)
1.4 8.2 GO:0090238 positive regulation of arachidonic acid secretion(GO:0090238)
1.2 4.9 GO:0055099 response to high density lipoprotein particle(GO:0055099)
1.2 7.1 GO:0036101 leukotriene catabolic process(GO:0036100) leukotriene B4 catabolic process(GO:0036101) leukotriene B4 metabolic process(GO:0036102) icosanoid catabolic process(GO:1901523) fatty acid derivative catabolic process(GO:1901569)
0.9 2.8 GO:2000824 negative regulation of androgen receptor activity(GO:2000824)
0.9 2.8 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.9 5.6 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.9 3.6 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.8 4.1 GO:0045906 negative regulation of vasoconstriction(GO:0045906)
0.8 4.0 GO:1904098 regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
0.8 3.2 GO:0044861 protein transport into plasma membrane raft(GO:0044861) positive regulation of potassium ion import(GO:1903288)
0.8 6.2 GO:0035897 proteolysis in other organism(GO:0035897)
0.7 7.2 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.7 2.9 GO:0018002 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.7 2.0 GO:1901899 positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of calcium ion import into sarcoplasmic reticulum(GO:1902080) negative regulation of calcium ion import into sarcoplasmic reticulum(GO:1902081)
0.6 3.9 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.6 3.1 GO:0015860 pyrimidine nucleobase transport(GO:0015855) purine nucleoside transmembrane transport(GO:0015860) purine nucleobase transmembrane transport(GO:1904823)
0.6 2.3 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.5 1.6 GO:0009447 putrescine catabolic process(GO:0009447)
0.5 5.4 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.5 3.2 GO:1990822 L-cystine transport(GO:0015811) basic amino acid transmembrane transport(GO:1990822)
0.5 3.7 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.5 3.5 GO:0006572 tyrosine catabolic process(GO:0006572)
0.5 2.8 GO:0036015 response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016)
0.5 1.4 GO:0002125 maternal aggressive behavior(GO:0002125) positive regulation of female receptivity(GO:0045925)
0.4 1.8 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.4 1.1 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
0.4 3.6 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.3 2.0 GO:0055064 chloride ion homeostasis(GO:0055064)
0.3 5.4 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.3 2.2 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.3 1.8 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.3 1.1 GO:0090107 aminophospholipid transport(GO:0015917) regulation of high-density lipoprotein particle assembly(GO:0090107)
0.3 4.2 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.3 2.6 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.3 3.3 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.2 2.2 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.2 0.5 GO:0030860 regulation of polarized epithelial cell differentiation(GO:0030860)
0.2 0.9 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
0.2 4.5 GO:0030207 chondroitin sulfate catabolic process(GO:0030207)
0.2 3.6 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.2 4.1 GO:0036150 phosphatidylserine acyl-chain remodeling(GO:0036150)
0.2 0.6 GO:0070460 thyroid-stimulating hormone secretion(GO:0070460) regulation of thyroid-stimulating hormone secretion(GO:2000612)
0.2 1.8 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.2 2.2 GO:0002115 store-operated calcium entry(GO:0002115)
0.2 3.8 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.2 0.6 GO:0051697 protein delipidation(GO:0051697)
0.2 5.7 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)
0.2 0.7 GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.1 1.2 GO:0055091 phospholipid homeostasis(GO:0055091)
0.1 3.9 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.1 1.0 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.1 0.4 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
0.1 1.4 GO:0042983 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.1 0.7 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
0.1 4.8 GO:0034694 response to prostaglandin(GO:0034694)
0.1 6.2 GO:0010039 response to iron ion(GO:0010039)
0.1 2.6 GO:0030488 tRNA methylation(GO:0030488)
0.1 0.6 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.1 3.1 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.1 0.8 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.1 1.1 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.1 0.6 GO:1904783 positive regulation of NMDA glutamate receptor activity(GO:1904783)
0.1 0.4 GO:0048539 bone marrow development(GO:0048539)
0.1 1.2 GO:0051639 actin filament network formation(GO:0051639)
0.1 6.7 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.1 2.5 GO:0005980 glycogen catabolic process(GO:0005980)
0.1 0.5 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.1 3.2 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.1 1.2 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1 5.3 GO:0030521 androgen receptor signaling pathway(GO:0030521)
0.1 2.4 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.1 2.4 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.0 3.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.5 GO:0006228 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.0 0.6 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 3.2 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902108)
0.0 6.4 GO:0016573 histone acetylation(GO:0016573)
0.0 1.2 GO:0050427 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0 1.2 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.3 GO:1904354 negative regulation of telomere capping(GO:1904354)
0.0 1.8 GO:0032755 positive regulation of interleukin-6 production(GO:0032755)
0.0 3.7 GO:0007030 Golgi organization(GO:0007030)
0.0 4.6 GO:0021915 neural tube development(GO:0021915)
0.0 0.9 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 0.3 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 1.8 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.0 0.6 GO:0046710 GDP metabolic process(GO:0046710)
0.0 0.4 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.7 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 2.0 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 1.6 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.0 1.4 GO:1901379 regulation of potassium ion transmembrane transport(GO:1901379)
0.0 4.4 GO:0016579 protein deubiquitination(GO:0016579)
0.0 2.2 GO:0051591 response to cAMP(GO:0051591)
0.0 0.3 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 1.5 GO:0006023 aminoglycan biosynthetic process(GO:0006023) glycosaminoglycan biosynthetic process(GO:0006024)
0.0 2.1 GO:0007266 Rho protein signal transduction(GO:0007266)
0.0 0.4 GO:0002250 adaptive immune response(GO:0002250)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 26.2 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
1.2 6.2 GO:0005602 complement component C1 complex(GO:0005602)
1.0 3.9 GO:0071062 rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.9 5.4 GO:0030991 intraciliary transport particle A(GO:0030991)
0.7 3.7 GO:0034457 Mpp10 complex(GO:0034457)
0.7 5.7 GO:0032593 insulin-responsive compartment(GO:0032593)
0.6 4.2 GO:0060091 kinocilium(GO:0060091)
0.4 2.9 GO:0031415 NatA complex(GO:0031415)
0.4 2.1 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.3 6.6 GO:0010369 chromocenter(GO:0010369)
0.3 2.5 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.2 1.4 GO:0000137 Golgi cis cisterna(GO:0000137)
0.2 2.0 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.2 5.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 3.2 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.2 4.6 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 2.1 GO:0031089 platelet dense granule lumen(GO:0031089)
0.1 4.5 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 0.6 GO:0030905 retromer, tubulation complex(GO:0030905)
0.1 0.8 GO:0005587 collagen type IV trimer(GO:0005587)
0.1 3.6 GO:0000421 autophagosome membrane(GO:0000421)
0.1 5.9 GO:0031526 brush border membrane(GO:0031526)
0.1 8.4 GO:0005796 Golgi lumen(GO:0005796)
0.1 2.2 GO:0030673 axolemma(GO:0030673)
0.1 2.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.3 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.1 2.3 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 1.5 GO:0032040 small-subunit processome(GO:0032040)
0.0 7.2 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.7 GO:0016592 mediator complex(GO:0016592)
0.0 3.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.9 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 2.7 GO:0019867 mitochondrial outer membrane(GO:0005741) outer membrane(GO:0019867) organelle outer membrane(GO:0031968)
0.0 1.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 2.7 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.4 GO:0000782 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0 0.6 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.6 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.3 GO:0000800 lateral element(GO:0000800)
0.0 1.4 GO:0043195 terminal bouton(GO:0043195)
0.0 13.5 GO:0043025 neuronal cell body(GO:0043025)
0.0 0.5 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.2 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 2.3 GO:0055037 recycling endosome(GO:0055037)
0.0 1.1 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 1.4 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 4.6 GO:0005938 cell cortex(GO:0005938)
0.0 1.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 5.1 GO:0016607 nuclear speck(GO:0016607)
0.0 16.5 GO:0005615 extracellular space(GO:0005615)
0.0 3.9 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 1.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.1 GO:0052871 tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
1.0 3.1 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)
0.9 3.6 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
0.9 2.7 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.9 5.3 GO:0004882 androgen receptor activity(GO:0004882)
0.8 4.1 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.8 3.2 GO:0008431 vitamin E binding(GO:0008431)
0.8 3.9 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.7 2.2 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.7 2.9 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.7 2.8 GO:0035939 microsatellite binding(GO:0035939)
0.7 4.0 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.6 5.5 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.5 3.2 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.4 1.8 GO:0016841 ammonia-lyase activity(GO:0016841)
0.4 2.6 GO:0034511 U3 snoRNA binding(GO:0034511)
0.4 2.2 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.4 2.1 GO:0004771 sterol esterase activity(GO:0004771)
0.4 4.5 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.4 30.0 GO:0050840 extracellular matrix binding(GO:0050840)
0.4 5.7 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.4 1.2 GO:0017129 triglyceride binding(GO:0017129)
0.4 1.1 GO:0090556 apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.3 2.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.3 5.4 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.3 1.8 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.3 1.1 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.3 2.5 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.3 14.0 GO:0015485 cholesterol binding(GO:0015485)
0.2 6.9 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.2 0.9 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.2 2.6 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.2 2.1 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.2 3.2 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.2 1.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.2 7.7 GO:0001972 retinoic acid binding(GO:0001972)
0.2 1.8 GO:0004707 MAP kinase activity(GO:0004707)
0.2 2.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.2 0.5 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.2 3.1 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.1 1.4 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 2.7 GO:0004623 phospholipase A2 activity(GO:0004623)
0.1 0.4 GO:0004832 valine-tRNA ligase activity(GO:0004832)
0.1 0.6 GO:1990460 leptin receptor binding(GO:1990460)
0.1 2.1 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 3.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 3.6 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 1.6 GO:0004065 arylsulfatase activity(GO:0004065)
0.1 7.2 GO:0016279 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.1 1.3 GO:0008035 high-density lipoprotein particle binding(GO:0008035)
0.1 2.8 GO:0030506 ankyrin binding(GO:0030506)
0.1 1.5 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.1 9.5 GO:0015297 antiporter activity(GO:0015297)
0.1 1.0 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.1 1.8 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.1 4.2 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 3.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.6 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.1 8.0 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.1 1.2 GO:0050700 CARD domain binding(GO:0050700)
0.1 2.2 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 0.6 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 1.2 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 2.4 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 2.1 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 5.4 GO:0005179 hormone activity(GO:0005179)
0.0 0.5 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 4.8 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 3.3 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.4 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 0.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 1.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 2.7 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 3.0 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 14.2 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 2.0 GO:0051117 ATPase binding(GO:0051117)
0.0 1.2 GO:0003785 actin monomer binding(GO:0003785)
0.0 6.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.5 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 1.4 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.6 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 1.6 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 0.3 GO:0070182 DNA polymerase binding(GO:0070182)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 25.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.2 6.2 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 9.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 5.7 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 11.6 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 1.8 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 3.6 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 10.5 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.7 ST ADRENERGIC Adrenergic Pathway
0.0 5.3 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 1.6 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.6 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 1.4 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 1.1 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.7 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.7 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 2.2 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 1.6 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.8 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.6 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 2.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 26.2 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.7 9.5 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.6 13.8 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.6 6.2 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.3 6.2 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.2 21.6 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2 3.8 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.2 2.2 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.2 4.5 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 3.1 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.2 3.8 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.2 4.2 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 2.0 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 3.2 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.1 7.1 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 4.3 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.8 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.1 2.3 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.1 2.2 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 2.5 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 5.4 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 3.1 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 7.9 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 5.3 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.8 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 2.8 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 2.7 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 1.5 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.2 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.8 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 5.0 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.0 0.5 REACTOME SIGNALING BY NOTCH1 Genes involved in Signaling by NOTCH1
0.0 2.8 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.7 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.8 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.4 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.6 REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE