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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for NR1H2
Z-value: 0.56
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Transcription factors associated with NR1H2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR1H2 | hg19_v2_chr19_+_50879705_50879775 | -0.16 | 1.7e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr18_+_21693306 Show fit | 15.57 |
ENST00000540918.2
|
tetratricopeptide repeat domain 39C |
|
| chr3_-_195310802 Show fit | 13.98 |
ENST00000421243.1
ENST00000453131.1 |
apolipoprotein D |
|
| chr12_-_91573132 Show fit | 13.35 |
ENST00000550563.1
ENST00000546370.1 |
decorin |
|
| chr12_-_91573249 Show fit | 12.84 |
ENST00000550099.1
ENST00000546391.1 ENST00000551354.1 |
decorin |
|
| chr11_-_68518910 Show fit | 10.73 |
ENST00000544963.1
ENST00000443940.2 |
metallothionein-like 5, testis-specific (tesmin) |
|
| chr8_-_27941380 Show fit | 8.29 |
ENST00000413272.2
ENST00000341513.6 |
nuclear GTPase, germinal center associated |
|
| chr4_-_681114 Show fit | 8.20 |
ENST00000503156.1
|
major facilitator superfamily domain containing 7 |
|
| chr19_-_46296011 Show fit | 7.83 |
ENST00000377735.3
ENST00000270223.6 |
dystrophia myotonica, WD repeat containing |
|
| chr1_-_237167718 Show fit | 7.20 |
ENST00000464121.2
|
metallothionein 1H-like 1 |
|
| chr19_-_7968427 Show fit | 6.83 |
ENST00000539278.1
|
Uncharacterized protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR1H2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 26.2 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 4.7 | 14.0 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 1.4 | 8.2 | GO:0090238 | positive regulation of arachidonic acid secretion(GO:0090238) |
| 1.9 | 7.7 | GO:0009956 | radial pattern formation(GO:0009956) |
| 0.7 | 7.2 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
| 1.2 | 7.1 | GO:0036101 | leukotriene catabolic process(GO:0036100) leukotriene B4 catabolic process(GO:0036101) leukotriene B4 metabolic process(GO:0036102) icosanoid catabolic process(GO:1901523) fatty acid derivative catabolic process(GO:1901569) |
| 0.1 | 6.7 | GO:0045669 | positive regulation of osteoblast differentiation(GO:0045669) |
| 0.0 | 6.4 | GO:0016573 | histone acetylation(GO:0016573) |
| 0.8 | 6.2 | GO:0035897 | proteolysis in other organism(GO:0035897) |
| 0.1 | 6.2 | GO:0010039 | response to iron ion(GO:0010039) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 26.2 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 16.5 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 13.5 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.1 | 8.4 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 7.2 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.3 | 6.6 | GO:0010369 | chromocenter(GO:0010369) |
| 1.2 | 6.2 | GO:0005602 | complement component C1 complex(GO:0005602) |
| 0.1 | 5.9 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.7 | 5.7 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.9 | 5.4 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 30.0 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 14.2 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.3 | 14.0 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.1 | 9.5 | GO:0015297 | antiporter activity(GO:0015297) |
| 0.1 | 8.0 | GO:0008080 | N-acetyltransferase activity(GO:0008080) |
| 0.2 | 7.7 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 7.2 | GO:0016279 | lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279) |
| 2.4 | 7.1 | GO:0052871 | tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259) |
| 0.2 | 6.9 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.0 | 6.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 25.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 11.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 10.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 9.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 6.2 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 5.7 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 5.3 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 3.6 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 2.7 | ST ADRENERGIC | Adrenergic Pathway |
| 0.0 | 2.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 26.2 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.2 | 21.6 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.6 | 13.8 | REACTOME ACYL CHAIN REMODELLING OF PE | Genes involved in Acyl chain remodelling of PE |
| 0.7 | 9.5 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.1 | 7.9 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 7.1 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.6 | 6.2 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.3 | 6.2 | REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.1 | 5.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 5.3 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |