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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for NR1H4

Z-value: 1.21

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Transcription factors associated with NR1H4

Gene Symbol Gene ID Gene Info
NR1H4
ENSG00000012504.9 nuclear receptor subfamily 1 group H member 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR1H4hg19_v2_chr12_+_100897130_1008972310.435.4e-11Click!

Activity profile of NR1H4 motif

Sorted Z-values of NR1H4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_21492113 33.33 ENST00000554094.1
NDRG2
NDRG family member 2
chr14_-_21492251 32.32 ENST00000554398.1
NDRG2
NDRG family member 2
chr9_+_74526384 29.48 ENST00000334731.2
ENST00000377031.3
C9orf85
chromosome 9 open reading frame 85
chr5_-_139944196 22.58 ENST00000357560.4
APBB3
amyloid beta (A4) precursor protein-binding, family B, member 3
chr5_-_139943830 21.97 ENST00000412920.3
ENST00000511201.2
ENST00000356738.2
ENST00000354402.5
ENST00000358580.5
ENST00000508496.2
APBB3
amyloid beta (A4) precursor protein-binding, family B, member 3
chr14_-_21945057 20.46 ENST00000397762.1
RAB2B
RAB2B, member RAS oncogene family
chr22_-_20104700 18.15 ENST00000439169.2
ENST00000445045.1
ENST00000404751.3
ENST00000252136.7
ENST00000403707.3
TRMT2A
tRNA methyltransferase 2 homolog A (S. cerevisiae)
chr20_+_30640004 17.86 ENST00000520553.1
ENST00000518730.1
ENST00000375852.2
HCK
hemopoietic cell kinase
chr20_+_30639991 15.89 ENST00000534862.1
ENST00000538448.1
ENST00000375862.2
HCK
hemopoietic cell kinase
chr12_-_57914275 15.57 ENST00000547303.1
ENST00000552740.1
ENST00000547526.1
ENST00000551116.1
ENST00000346473.3
DDIT3
DNA-damage-inducible transcript 3
chr12_+_57914742 15.51 ENST00000551351.1
MBD6
methyl-CpG binding domain protein 6
chrX_+_103031421 15.27 ENST00000433491.1
ENST00000418604.1
ENST00000443502.1
PLP1
proteolipid protein 1
chr8_+_9046503 14.79 ENST00000512942.2
RP11-10A14.5
RP11-10A14.5
chr11_-_64511575 14.69 ENST00000431822.1
ENST00000377486.3
ENST00000394432.3
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr3_-_57113314 13.97 ENST00000338458.4
ENST00000468727.1
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chrX_+_103031758 13.94 ENST00000303958.2
ENST00000361621.2
PLP1
proteolipid protein 1
chr3_-_38071122 13.86 ENST00000334661.4
PLCD1
phospholipase C, delta 1
chr16_+_23847339 13.72 ENST00000303531.7
PRKCB
protein kinase C, beta
chr3_+_14989186 13.72 ENST00000435454.1
ENST00000323373.6
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr9_-_137809718 13.72 ENST00000371806.3
FCN1
ficolin (collagen/fibrinogen domain containing) 1
chr12_+_58013693 13.15 ENST00000320442.4
ENST00000379218.2
SLC26A10
solute carrier family 26, member 10
chr19_+_1071203 12.88 ENST00000543365.1
HMHA1
histocompatibility (minor) HA-1
chr22_+_20104947 12.55 ENST00000402752.1
RANBP1
RAN binding protein 1
chr14_-_25103472 12.51 ENST00000216341.4
ENST00000382542.1
ENST00000382540.1
GZMB
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr3_+_122296465 12.10 ENST00000483793.1
PARP15
poly (ADP-ribose) polymerase family, member 15
chr16_+_23847267 11.99 ENST00000321728.7
PRKCB
protein kinase C, beta
chr19_+_50706866 11.96 ENST00000440075.2
ENST00000376970.2
ENST00000425460.1
ENST00000599920.1
ENST00000601313.1
MYH14
myosin, heavy chain 14, non-muscle
chr11_+_45868957 11.90 ENST00000443527.2
CRY2
cryptochrome 2 (photolyase-like)
chr19_+_35629702 11.73 ENST00000351325.4
FXYD1
FXYD domain containing ion transport regulator 1
chr14_-_25103388 11.49 ENST00000526004.1
ENST00000415355.3
GZMB
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr12_+_109273806 10.91 ENST00000228476.3
ENST00000547768.1
DAO
D-amino-acid oxidase
chr10_-_75634260 10.23 ENST00000372765.1
ENST00000351293.3
CAMK2G
calcium/calmodulin-dependent protein kinase II gamma
chr3_-_49158218 9.82 ENST00000417901.1
ENST00000306026.5
ENST00000434032.2
USP19
ubiquitin specific peptidase 19
chr11_-_71639670 9.73 ENST00000533047.1
ENST00000529844.1
RP11-849H4.2
Putative short transient receptor potential channel 2-like protein
chr15_+_83776137 9.73 ENST00000322019.9
TM6SF1
transmembrane 6 superfamily member 1
chr5_+_140588269 9.31 ENST00000541609.1
ENST00000239450.2
PCDHB12
protocadherin beta 12
chr10_-_75634326 8.97 ENST00000322635.3
ENST00000444854.2
ENST00000423381.1
ENST00000322680.3
ENST00000394762.2
CAMK2G
calcium/calmodulin-dependent protein kinase II gamma
chr3_-_49158312 8.67 ENST00000398892.3
ENST00000453664.1
ENST00000398888.2
USP19
ubiquitin specific peptidase 19
chr12_+_100661156 8.59 ENST00000360820.2
SCYL2
SCY1-like 2 (S. cerevisiae)
chr1_+_28206150 8.47 ENST00000456990.1
THEMIS2
thymocyte selection associated family member 2
chr17_+_43318434 8.31 ENST00000587489.1
FMNL1
formin-like 1
chr17_+_73975292 8.29 ENST00000397640.1
ENST00000416485.1
ENST00000588202.1
ENST00000590676.1
ENST00000586891.1
TEN1
TEN1 CST complex subunit
chr1_+_14026722 8.28 ENST00000376048.5
PRDM2
PR domain containing 2, with ZNF domain
chr6_+_127587755 8.19 ENST00000368314.1
ENST00000476956.1
ENST00000609447.1
ENST00000356799.2
ENST00000477776.1
ENST00000609944.1
RNF146
ring finger protein 146
chr1_+_36789335 8.18 ENST00000373137.2
RP11-268J15.5
RP11-268J15.5
chr22_+_32149927 8.14 ENST00000437411.1
ENST00000535622.1
ENST00000536766.1
ENST00000400242.3
ENST00000266091.3
ENST00000400249.2
ENST00000400246.1
ENST00000382105.2
DEPDC5
DEP domain containing 5
chr16_+_69166418 8.09 ENST00000314423.7
ENST00000562237.1
ENST00000567460.1
ENST00000566227.1
ENST00000352319.4
ENST00000563094.1
CIRH1A
cirrhosis, autosomal recessive 1A (cirhin)
chr3_+_52489503 8.03 ENST00000345716.4
NISCH
nischarin
chr3_-_50383096 7.93 ENST00000442887.1
ENST00000360165.3
ZMYND10
zinc finger, MYND-type containing 10
chr6_+_30594619 7.87 ENST00000318999.7
ENST00000376485.4
ENST00000376478.2
ENST00000319027.5
ENST00000376483.4
ENST00000329992.8
ENST00000330083.5
ATAT1
alpha tubulin acetyltransferase 1
chr8_-_101321584 7.80 ENST00000523167.1
RNF19A
ring finger protein 19A, RBR E3 ubiquitin protein ligase
chr1_+_25598989 7.76 ENST00000454452.2
RHD
Rh blood group, D antigen
chr12_-_8088871 7.65 ENST00000075120.7
SLC2A3
solute carrier family 2 (facilitated glucose transporter), member 3
chr1_+_36690011 7.57 ENST00000354618.5
ENST00000469141.2
ENST00000478853.1
THRAP3
thyroid hormone receptor associated protein 3
chr22_+_22786288 7.56 ENST00000390301.2
IGLV1-36
immunoglobulin lambda variable 1-36
chr1_-_109584716 7.35 ENST00000531337.1
ENST00000529074.1
ENST00000369965.4
WDR47
WD repeat domain 47
chr19_+_10197463 7.30 ENST00000590378.1
ENST00000397881.3
C19orf66
chromosome 19 open reading frame 66
chr1_-_109584768 7.26 ENST00000357672.3
WDR47
WD repeat domain 47
chr5_+_149569520 7.26 ENST00000230671.2
ENST00000524041.1
SLC6A7
solute carrier family 6 (neurotransmitter transporter), member 7
chr12_-_56727487 7.05 ENST00000548043.1
ENST00000425394.2
PAN2
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr6_+_127588020 7.05 ENST00000309649.3
ENST00000610162.1
ENST00000610153.1
ENST00000608991.1
ENST00000480444.1
RNF146
ring finger protein 146
chr3_-_120461378 7.04 ENST00000273375.3
RABL3
RAB, member of RAS oncogene family-like 3
chr3_-_28390581 6.89 ENST00000479665.1
AZI2
5-azacytidine induced 2
chr1_-_109584608 6.74 ENST00000400794.3
ENST00000528747.1
ENST00000369962.3
ENST00000361054.3
WDR47
WD repeat domain 47
chr11_-_58345569 6.72 ENST00000528954.1
ENST00000528489.1
LPXN
leupaxin
chr19_-_50311896 6.51 ENST00000529634.2
FUZ
fuzzy planar cell polarity protein
chr20_+_62369623 6.42 ENST00000467211.1
RP4-583P15.14
RP4-583P15.14
chr17_-_73975444 6.21 ENST00000293217.5
ENST00000537812.1
ACOX1
acyl-CoA oxidase 1, palmitoyl
chr12_-_56727676 6.13 ENST00000547572.1
ENST00000257931.5
ENST00000440411.3
PAN2
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr19_-_633576 6.08 ENST00000588649.2
POLRMT
polymerase (RNA) mitochondrial (DNA directed)
chr6_-_49681235 5.82 ENST00000339139.4
CRISP2
cysteine-rich secretory protein 2
chr3_+_111260954 5.79 ENST00000283285.5
CD96
CD96 molecule
chr14_+_101297740 5.75 ENST00000555928.1
MEG3
maternally expressed 3 (non-protein coding)
chr17_-_73257667 5.75 ENST00000538886.1
ENST00000580799.1
ENST00000351904.7
ENST00000537686.1
GGA3
golgi-associated, gamma adaptin ear containing, ARF binding protein 3
chr11_-_7041466 5.68 ENST00000536068.1
ENST00000278314.4
ZNF214
zinc finger protein 214
chr3_+_111260856 5.61 ENST00000352690.4
CD96
CD96 molecule
chr1_+_44412577 5.57 ENST00000372343.3
IPO13
importin 13
chr10_-_95360983 5.31 ENST00000371464.3
RBP4
retinol binding protein 4, plasma
chr5_+_79331164 5.28 ENST00000350881.2
THBS4
thrombospondin 4
chr11_-_71639480 5.27 ENST00000529513.1
RP11-849H4.2
Putative short transient receptor potential channel 2-like protein
chr17_-_1083078 5.05 ENST00000574266.1
ENST00000302538.5
ABR
active BCR-related
chr7_+_94139105 5.04 ENST00000297273.4
CASD1
CAS1 domain containing 1
chr16_+_70258261 5.03 ENST00000594734.1
FKSG63
FKSG63
chr12_+_6898638 4.97 ENST00000011653.4
CD4
CD4 molecule
chr1_-_25256368 4.94 ENST00000308873.6
RUNX3
runt-related transcription factor 3
chr1_+_202317815 4.89 ENST00000608999.1
ENST00000336894.4
ENST00000480184.1
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr22_+_23247030 4.86 ENST00000390324.2
IGLJ3
immunoglobulin lambda joining 3
chr7_+_49813255 4.80 ENST00000340652.4
VWC2
von Willebrand factor C domain containing 2
chr4_+_123073464 4.79 ENST00000264501.4
KIAA1109
KIAA1109
chr2_+_219433281 4.75 ENST00000273064.6
ENST00000509807.2
ENST00000542068.1
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr22_+_31090793 4.57 ENST00000332585.6
ENST00000382310.3
ENST00000446658.2
OSBP2
oxysterol binding protein 2
chr5_+_133450365 4.52 ENST00000342854.5
ENST00000321603.6
ENST00000321584.4
ENST00000378564.1
ENST00000395029.1
TCF7
transcription factor 7 (T-cell specific, HMG-box)
chr17_-_43568062 4.43 ENST00000421073.2
ENST00000584420.1
ENST00000589780.1
ENST00000430334.3
PLEKHM1
pleckstrin homology domain containing, family M (with RUN domain) member 1
chr19_+_10196981 4.38 ENST00000591813.1
C19orf66
chromosome 19 open reading frame 66
chr11_+_7534999 4.29 ENST00000528947.1
ENST00000299492.4
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr17_-_26879567 4.08 ENST00000581945.1
ENST00000444148.1
ENST00000301032.4
ENST00000335765.4
UNC119
unc-119 homolog (C. elegans)
chrX_+_152224766 4.03 ENST00000370265.4
ENST00000447306.1
PNMA3
paraneoplastic Ma antigen 3
chr17_-_74023291 4.03 ENST00000586740.1
EVPL
envoplakin
chr18_-_67624160 3.80 ENST00000581982.1
ENST00000280200.4
CD226
CD226 molecule
chr2_-_178937478 3.56 ENST00000286063.6
PDE11A
phosphodiesterase 11A
chrX_-_49965009 3.49 ENST00000437370.1
ENST00000376064.3
ENST00000448865.1
AKAP4
A kinase (PRKA) anchor protein 4
chr19_-_36304201 3.46 ENST00000301175.3
PRODH2
proline dehydrogenase (oxidase) 2
chr3_+_121903181 3.46 ENST00000498619.1
CASR
calcium-sensing receptor
chr6_-_33771757 3.44 ENST00000507738.1
ENST00000266003.5
ENST00000430124.2
MLN
motilin
chr5_-_16509101 3.44 ENST00000399793.2
FAM134B
family with sequence similarity 134, member B
chr7_+_94536898 3.43 ENST00000433360.1
ENST00000340694.4
ENST00000424654.1
PPP1R9A
protein phosphatase 1, regulatory subunit 9A
chr17_-_2614927 3.40 ENST00000435359.1
CLUH
clustered mitochondria (cluA/CLU1) homolog
chr3_+_54157480 3.27 ENST00000490478.1
CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr1_-_1334685 3.26 ENST00000400809.3
ENST00000408918.4
CCNL2
cyclin L2
chr11_-_118305921 3.26 ENST00000532619.1
RP11-770J1.4
RP11-770J1.4
chr1_-_27240455 3.24 ENST00000254227.3
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr7_-_752074 3.13 ENST00000360274.4
PRKAR1B
protein kinase, cAMP-dependent, regulatory, type I, beta
chr3_+_186560476 3.04 ENST00000320741.2
ENST00000444204.2
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr17_+_59529743 3.02 ENST00000589003.1
ENST00000393853.4
TBX4
T-box 4
chr3_+_186560462 3.00 ENST00000412955.2
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr17_+_7533439 2.99 ENST00000441599.2
ENST00000380450.4
ENST00000416273.3
ENST00000575903.1
ENST00000576830.1
ENST00000571153.1
ENST00000575618.1
ENST00000576152.1
SHBG
sex hormone-binding globulin
chr22_-_29457832 2.93 ENST00000216071.4
C22orf31
chromosome 22 open reading frame 31
chr3_+_50606901 2.90 ENST00000455834.1
HEMK1
HemK methyltransferase family member 1
chr17_+_64298944 2.79 ENST00000413366.3
PRKCA
protein kinase C, alpha
chr3_-_194119083 2.66 ENST00000401815.1
GP5
glycoprotein V (platelet)
chr2_-_182545603 2.65 ENST00000295108.3
NEUROD1
neuronal differentiation 1
chrX_-_106449656 2.47 ENST00000372466.4
ENST00000421752.1
ENST00000372461.3
NUP62CL
nucleoporin 62kDa C-terminal like
chr19_-_44860820 2.43 ENST00000354340.4
ENST00000337401.4
ENST00000587909.1
ZNF112
zinc finger protein 112
chr20_-_3644046 2.39 ENST00000290417.2
ENST00000319242.3
GFRA4
GDNF family receptor alpha 4
chr12_-_58135903 2.37 ENST00000257897.3
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr11_-_62380199 2.29 ENST00000419857.1
ENST00000394773.2
EML3
echinoderm microtubule associated protein like 3
chr14_+_24025194 2.21 ENST00000404535.3
ENST00000288014.6
THTPA
thiamine triphosphatase
chr14_+_24025462 2.20 ENST00000556015.1
ENST00000554970.1
ENST00000554789.1
THTPA
thiamine triphosphatase
chr2_+_73441350 2.18 ENST00000389501.4
SMYD5
SMYD family member 5
chr2_+_192542850 2.13 ENST00000410026.2
NABP1
nucleic acid binding protein 1
chr17_+_41177220 2.13 ENST00000587250.2
ENST00000544533.1
RND2
Rho family GTPase 2
chr12_+_52306113 2.13 ENST00000547400.1
ENST00000550683.1
ENST00000419526.2
ACVRL1
activin A receptor type II-like 1
chr11_+_67250490 2.01 ENST00000528641.2
ENST00000279146.3
AIP
aryl hydrocarbon receptor interacting protein
chr3_+_183873240 2.00 ENST00000431765.1
DVL3
dishevelled segment polarity protein 3
chr10_-_119806085 1.99 ENST00000355624.3
RAB11FIP2
RAB11 family interacting protein 2 (class I)
chr16_+_66995121 1.99 ENST00000303334.4
CES3
carboxylesterase 3
chr3_-_128294929 1.97 ENST00000356020.2
C3orf27
chromosome 3 open reading frame 27
chr11_-_6341724 1.85 ENST00000530979.1
PRKCDBP
protein kinase C, delta binding protein
chr1_-_25747283 1.82 ENST00000346452.4
ENST00000340849.4
ENST00000349438.4
ENST00000294413.7
ENST00000413854.1
ENST00000455194.1
ENST00000243186.6
ENST00000425135.1
RHCE
Rh blood group, CcEe antigens
chr1_+_12123414 1.81 ENST00000263932.2
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr16_+_89238149 1.67 ENST00000289746.2
CDH15
cadherin 15, type 1, M-cadherin (myotubule)
chr19_+_10563567 1.57 ENST00000344979.3
PDE4A
phosphodiesterase 4A, cAMP-specific
chr19_-_11689752 1.55 ENST00000592659.1
ENST00000592828.1
ENST00000218758.5
ENST00000412435.2
ACP5
acid phosphatase 5, tartrate resistant
chr5_+_32710736 1.51 ENST00000415685.2
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr5_-_33892204 1.45 ENST00000504830.1
ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr5_-_33892046 1.45 ENST00000352040.3
ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr5_-_177423243 1.41 ENST00000308304.2
PROP1
PROP paired-like homeobox 1
chr1_+_25598872 1.28 ENST00000328664.4
RHD
Rh blood group, D antigen
chr16_+_66995144 1.28 ENST00000394037.1
CES3
carboxylesterase 3
chr16_-_1429627 1.25 ENST00000248104.7
UNKL
unkempt family zinc finger-like
chr9_-_138391692 1.24 ENST00000429260.2
C9orf116
chromosome 9 open reading frame 116
chr1_-_160040038 1.14 ENST00000368089.3
KCNJ10
potassium inwardly-rectifying channel, subfamily J, member 10
chr11_-_65624415 1.13 ENST00000524553.1
ENST00000527344.1
CFL1
cofilin 1 (non-muscle)
chr19_-_42636617 1.12 ENST00000529067.1
ENST00000529952.1
ENST00000533720.1
ENST00000389341.5
ENST00000342301.4
POU2F2
POU class 2 homeobox 2
chr1_-_149908217 1.10 ENST00000369140.3
MTMR11
myotubularin related protein 11
chr2_+_207024306 1.08 ENST00000236957.5
ENST00000392221.1
ENST00000392222.2
ENST00000445505.1
EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr2_+_33172012 1.05 ENST00000404816.2
LTBP1
latent transforming growth factor beta binding protein 1
chr17_-_9940058 1.05 ENST00000585266.1
GAS7
growth arrest-specific 7
chr1_+_25599018 1.04 ENST00000417538.2
ENST00000357542.4
ENST00000568195.1
ENST00000342055.5
ENST00000423810.2
RHD
Rh blood group, D antigen
chr5_-_83680603 1.03 ENST00000296591.5
EDIL3
EGF-like repeats and discoidin I-like domains 3
chr11_-_4414880 1.02 ENST00000254436.7
ENST00000543625.1
TRIM21
tripartite motif containing 21
chr22_-_50700140 1.00 ENST00000215659.8
MAPK12
mitogen-activated protein kinase 12
chr18_-_3880051 0.98 ENST00000584874.1
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr2_-_64371546 0.77 ENST00000358912.4
PELI1
pellino E3 ubiquitin protein ligase 1
chrX_+_47420516 0.73 ENST00000377045.4
ENST00000290277.6
ENST00000377039.2
ARAF
v-raf murine sarcoma 3611 viral oncogene homolog
chr17_+_34136459 0.68 ENST00000588240.1
ENST00000590273.1
ENST00000588441.1
ENST00000587272.1
ENST00000592237.1
ENST00000311979.3
TAF15
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
chr1_+_26560676 0.65 ENST00000451429.2
ENST00000252992.4
CEP85
centrosomal protein 85kDa
chr11_-_72070206 0.59 ENST00000544382.1
CLPB
ClpB caseinolytic peptidase B homolog (E. coli)
chr12_-_71003568 0.58 ENST00000547715.1
ENST00000451516.2
ENST00000538708.1
ENST00000550857.1
ENST00000261266.5
PTPRB
protein tyrosine phosphatase, receptor type, B
chr19_+_1026566 0.57 ENST00000348419.3
ENST00000565096.2
ENST00000562958.2
ENST00000562075.2
ENST00000607102.1
CNN2
calponin 2
chr10_-_49701686 0.53 ENST00000417247.2
ARHGAP22
Rho GTPase activating protein 22
chr10_+_47083454 0.52 ENST00000374312.1
NPY4R
neuropeptide Y receptor Y4
chrX_+_148793714 0.45 ENST00000355220.5
MAGEA11
melanoma antigen family A, 11
chrX_+_7137475 0.33 ENST00000217961.4
STS
steroid sulfatase (microsomal), isozyme S
chr3_-_126327398 0.31 ENST00000383572.2
TXNRD3NB
thioredoxin reductase 3 neighbor
chr10_+_64564469 0.24 ENST00000373783.1
ADO
2-aminoethanethiol (cysteamine) dioxygenase
chr5_+_139927213 0.23 ENST00000310331.2
EIF4EBP3
eukaryotic translation initiation factor 4E binding protein 3
chr7_-_22233442 0.21 ENST00000401957.2
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chrX_+_66764375 0.17 ENST00000374690.3
AR
androgen receptor
chr3_+_190105909 0.13 ENST00000456423.1
CLDN16
claudin 16
chr2_+_108905095 0.11 ENST00000251481.6
ENST00000326853.5
SULT1C2
sulfotransferase family, cytosolic, 1C, member 2
chr19_+_11546153 0.09 ENST00000591946.1
ENST00000252455.2
ENST00000412601.1
PRKCSH
protein kinase C substrate 80K-H

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1H4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
11.2 33.7 GO:0002522 leukocyte migration involved in immune response(GO:0002522)
9.5 28.5 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
5.1 15.2 GO:0002727 natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727)
4.6 13.7 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
4.1 65.7 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
4.0 11.9 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
3.9 15.6 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
3.6 10.9 GO:0006524 alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080)
3.4 24.0 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
2.5 7.6 GO:0070837 dehydroascorbic acid transport(GO:0070837)
2.2 13.2 GO:0019532 oxalate transport(GO:0019532)
2.0 12.1 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
2.0 6.0 GO:2000532 renal albumin absorption(GO:0097018) regulation of renal albumin absorption(GO:2000532) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
2.0 11.7 GO:0010734 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
1.7 29.2 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
1.7 5.1 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
1.6 6.5 GO:0060825 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314)
1.5 6.1 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
1.5 7.3 GO:0035524 proline transmembrane transport(GO:0035524)
1.2 8.6 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
1.1 4.4 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
1.1 5.3 GO:0048807 female genitalia morphogenesis(GO:0048807)
1.1 5.3 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
1.0 4.1 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186)
1.0 8.1 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
1.0 19.2 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)
1.0 5.0 GO:0071350 interleukin-15-mediated signaling pathway(GO:0035723) cellular response to interleukin-15(GO:0071350)
1.0 2.9 GO:0044728 DNA alkylation(GO:0006305) DNA methylation(GO:0006306) DNA methylation or demethylation(GO:0044728)
0.9 18.5 GO:1900037 negative regulation of skeletal muscle tissue development(GO:0048642) regulation of cellular response to hypoxia(GO:1900037)
0.9 4.5 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.9 2.6 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.9 3.4 GO:1904048 regulation of spontaneous neurotransmitter secretion(GO:1904048)
0.8 6.7 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.8 7.9 GO:1900227 positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)
0.7 7.9 GO:0036159 inner dynein arm assembly(GO:0036159)
0.6 1.8 GO:0032639 TRAIL production(GO:0032639) regulation of TRAIL production(GO:0032679) positive regulation of TRAIL production(GO:0032759)
0.6 4.8 GO:0030856 regulation of epithelial cell differentiation(GO:0030856)
0.6 2.9 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.6 3.5 GO:0010133 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
0.4 8.0 GO:0048243 norepinephrine secretion(GO:0048243)
0.4 8.3 GO:0051014 actin filament severing(GO:0051014)
0.4 8.3 GO:0008340 determination of adult lifespan(GO:0008340)
0.4 6.2 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.4 12.0 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.4 11.9 GO:0015695 organic cation transport(GO:0015695)
0.4 3.4 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.4 18.1 GO:0001510 RNA methylation(GO:0001510)
0.3 7.6 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.3 13.2 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.3 2.0 GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.3 8.3 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.3 3.3 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.3 1.6 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.3 1.4 GO:0060126 hypophysis morphogenesis(GO:0048850) diencephalon morphogenesis(GO:0048852) somatotropin secreting cell differentiation(GO:0060126)
0.3 1.0 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.3 6.9 GO:0032607 interferon-alpha production(GO:0032607)
0.3 5.8 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.2 2.1 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.2 15.2 GO:0051865 protein autoubiquitination(GO:0051865)
0.2 1.1 GO:2000769 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) regulation of barbed-end actin filament capping(GO:2000812) positive regulation of barbed-end actin filament capping(GO:2000814)
0.2 2.4 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.2 2.1 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.2 3.6 GO:0046069 cGMP catabolic process(GO:0046069)
0.2 3.5 GO:0005513 detection of calcium ion(GO:0005513)
0.2 3.1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.2 0.8 GO:0008063 Toll signaling pathway(GO:0008063)
0.2 4.9 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.2 1.1 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.2 20.5 GO:0045921 positive regulation of exocytosis(GO:0045921)
0.2 3.5 GO:0044458 motile cilium assembly(GO:0044458)
0.2 14.7 GO:0071277 cellular response to calcium ion(GO:0071277)
0.2 0.2 GO:0060599 lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599)
0.2 13.9 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.1 2.7 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.1 4.8 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.1 1.5 GO:0002158 osteoclast proliferation(GO:0002158)
0.1 1.1 GO:0045471 response to ethanol(GO:0045471)
0.1 1.6 GO:0006198 cAMP catabolic process(GO:0006198)
0.1 1.0 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.1 14.0 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 1.0 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.1 3.3 GO:0034383 low-density lipoprotein particle clearance(GO:0034383)
0.1 8.7 GO:0002377 immunoglobulin production(GO:0002377)
0.1 2.1 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.1 2.0 GO:0003091 renal water homeostasis(GO:0003091)
0.0 3.2 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.0 9.0 GO:0000209 protein polyubiquitination(GO:0000209)
0.0 3.7 GO:0007286 spermatid development(GO:0007286)
0.0 7.8 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 3.3 GO:0061337 cardiac conduction(GO:0061337)
0.0 0.2 GO:0071692 sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694)
0.0 7.0 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 4.9 GO:0006937 regulation of muscle contraction(GO:0006937)
0.0 3.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.2 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.0 3.0 GO:0035113 embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113)
0.0 1.1 GO:0018149 peptide cross-linking(GO:0018149)
0.0 2.4 GO:0042177 negative regulation of protein catabolic process(GO:0042177)
0.0 7.8 GO:0007264 small GTPase mediated signal transduction(GO:0007264)
0.0 0.3 GO:0006706 steroid catabolic process(GO:0006706)
0.0 0.2 GO:0045947 negative regulation of translational initiation(GO:0045947)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 15.6 GO:1990622 CHOP-ATF3 complex(GO:1990622)
4.4 13.2 GO:0031251 PAN complex(GO:0031251)
2.4 12.0 GO:0097513 myosin II filament(GO:0097513)
2.3 13.7 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
1.4 8.1 GO:1990130 Iml1 complex(GO:1990130)
0.8 7.9 GO:0097427 microtubule bundle(GO:0097427)
0.7 15.5 GO:0010369 chromocenter(GO:0010369)
0.7 3.4 GO:0044326 dendritic spine neck(GO:0044326)
0.6 11.7 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.6 8.3 GO:0000782 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.5 2.1 GO:0070876 SOSS complex(GO:0070876)
0.5 2.0 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.5 8.3 GO:0032059 bleb(GO:0032059)
0.4 6.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.4 24.0 GO:0001772 immunological synapse(GO:0001772)
0.4 19.2 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.3 35.4 GO:0005901 caveola(GO:0005901)
0.3 7.9 GO:0034451 centriolar satellite(GO:0034451)
0.3 17.1 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.3 59.0 GO:0030426 growth cone(GO:0030426)
0.3 7.6 GO:0035145 exon-exon junction complex(GO:0035145)
0.3 8.6 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.2 4.6 GO:0097440 apical dendrite(GO:0097440)
0.2 5.0 GO:0042101 T cell receptor complex(GO:0042101)
0.2 4.1 GO:0051233 spindle midzone(GO:0051233)
0.2 4.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.2 1.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.2 5.3 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.1 6.7 GO:0002102 podosome(GO:0002102)
0.1 2.5 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.1 16.3 GO:0032587 ruffle membrane(GO:0032587)
0.1 5.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 14.2 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 4.5 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 5.8 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 6.1 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 3.6 GO:0043204 perikaryon(GO:0043204)
0.1 2.1 GO:0002080 acrosomal membrane(GO:0002080)
0.1 7.6 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.1 2.0 GO:0030057 desmosome(GO:0030057)
0.1 18.0 GO:0043209 myelin sheath(GO:0043209)
0.1 10.0 GO:0055037 recycling endosome(GO:0055037)
0.1 0.6 GO:0000242 pericentriolar material(GO:0000242)
0.1 22.8 GO:0005874 microtubule(GO:0005874)
0.1 3.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 5.2 GO:0005581 collagen trimer(GO:0005581)
0.0 3.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 15.6 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 6.4 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 92.5 GO:0005886 plasma membrane(GO:0005886)
0.0 2.6 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
9.5 28.5 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
2.5 7.6 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
2.4 29.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
2.2 13.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
1.8 18.5 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
1.6 7.9 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
1.5 7.3 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
1.4 19.8 GO:0033691 sialic acid binding(GO:0033691)
1.4 19.2 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
1.2 32.5 GO:0071949 FAD binding(GO:0071949)
1.1 22.2 GO:0032794 GTPase activating protein binding(GO:0032794)
1.0 15.6 GO:0008140 cAMP response element binding protein binding(GO:0008140)
1.0 5.0 GO:0042289 MHC class II protein binding(GO:0042289)
0.8 14.7 GO:0019992 diacylglycerol binding(GO:0019992)
0.7 13.2 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.6 3.6 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.5 33.7 GO:0001784 phosphotyrosine binding(GO:0001784)
0.5 2.1 GO:0016361 activin receptor activity, type I(GO:0016361)
0.5 44.6 GO:0001540 beta-amyloid binding(GO:0001540)
0.5 12.1 GO:0070403 NAD+ binding(GO:0070403)
0.5 7.6 GO:0042809 vitamin D receptor binding(GO:0042809)
0.5 5.0 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.4 5.8 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.4 3.2 GO:0005497 androgen binding(GO:0005497)
0.4 18.1 GO:0008173 RNA methyltransferase activity(GO:0008173)
0.4 8.6 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.4 11.9 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.4 5.3 GO:0016918 retinal binding(GO:0016918)
0.3 2.4 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.3 1.5 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.2 3.2 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.2 7.8 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.2 11.7 GO:0017080 sodium channel regulator activity(GO:0017080)
0.2 19.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 1.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.2 1.8 GO:0048406 nerve growth factor binding(GO:0048406)
0.2 0.5 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.2 8.3 GO:0042162 telomeric DNA binding(GO:0042162)
0.2 8.3 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.2 3.1 GO:0008603 cAMP-dependent protein kinase inhibitor activity(GO:0004862) cAMP-dependent protein kinase regulator activity(GO:0008603)
0.2 2.0 GO:0019215 intermediate filament binding(GO:0019215)
0.1 5.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 2.0 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 2.5 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 1.4 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1 3.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 3.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 1.6 GO:0008199 ferric iron binding(GO:0008199)
0.1 6.1 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.1 4.6 GO:0015485 cholesterol binding(GO:0015485)
0.1 9.8 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.1 3.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 3.5 GO:0051018 protein kinase A binding(GO:0051018)
0.1 16.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 2.9 GO:0008276 protein methyltransferase activity(GO:0008276)
0.1 1.1 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 25.0 GO:0003924 GTPase activity(GO:0003924)
0.1 18.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 1.0 GO:0004707 MAP kinase activity(GO:0004707)
0.1 1.6 GO:0030552 cAMP binding(GO:0030552)
0.1 2.6 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 4.0 GO:0008270 zinc ion binding(GO:0008270)
0.0 0.2 GO:0050436 microfibril binding(GO:0050436)
0.0 2.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.2 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 2.2 GO:0008168 methyltransferase activity(GO:0008168)
0.0 5.3 GO:0008083 growth factor activity(GO:0008083)
0.0 3.4 GO:0005179 hormone activity(GO:0005179)
0.0 0.6 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.7 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 3.3 GO:0005262 calcium channel activity(GO:0005262)
0.0 1.9 GO:0008013 beta-catenin binding(GO:0008013)
0.0 2.0 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 2.1 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 4.4 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.2 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 8.4 GO:0008047 enzyme activator activity(GO:0008047)
0.0 0.3 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 1.3 GO:0005525 GTP binding(GO:0005525)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 62.3 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.8 24.0 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.6 81.2 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.5 19.2 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.5 11.9 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.4 10.7 PID ARF 3PATHWAY Arf1 pathway
0.3 14.7 PID RAS PATHWAY Regulation of Ras family activation
0.3 9.7 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.2 19.0 PID RHOA REG PATHWAY Regulation of RhoA activity
0.2 1.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 3.2 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 3.5 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.1 3.2 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.1 1.8 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 2.1 PID ALK1 PATHWAY ALK1 signaling events
0.1 1.0 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 3.1 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 8.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.4 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 4.5 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 2.0 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.7 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.1 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 4.8 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 15.6 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
1.0 28.5 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
1.0 5.0 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.9 33.7 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.4 7.6 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.3 14.7 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.3 19.0 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.3 7.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.3 6.2 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.3 12.0 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.3 14.3 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.2 11.9 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.2 2.7 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.2 3.5 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 15.2 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 4.7 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 13.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 3.1 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 2.6 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 3.6 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 6.0 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 5.3 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 0.8 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 1.1 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 1.0 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.1 1.7 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 2.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.1 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.1 2.0 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 5.3 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.0 6.1 REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
0.0 0.3 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 3.4 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 5.0 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 2.2 REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES Genes involved in Transmission across Chemical Synapses