ISMARA results: NR1I2

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for NR1I2

Z-value: 0.40

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Transcription factors associated with NR1I2

Gene Symbol	Gene ID	Gene Info
NR1I2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000144852.12	nuclear receptor subfamily 1 group I member 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NR1I2	hg19_v2_chr3_+_119499331_119499331, hg19_v2_chr3_+_119501557_119501557	0.30	6.1e-06	Click!

Activity profile of NR1I2 motif

Sorted Z-values of NR1I2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_91576429 Show fit	46.20	ENST00000552145.1 ENST00000546745.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr11_+_117073850 Show fit	24.79	ENST00000529622.1	TAGLN Ensembl NCBI GeneCards UniProt NextProt Show fit	transgelin
chr12_-_91576561 Show fit	19.83	ENST00000547568.2 ENST00000552962.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr12_-_91576750 Show fit	15.24	ENST00000228329.5 ENST00000303320.3 ENST00000052754.5	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr3_+_153839149 Show fit	13.28	ENST00000465093.1 ENST00000465817.1	ARHGEF26 Ensembl NCBI GeneCards UniProt NextProt Show fit	Rho guanine nucleotide exchange factor (GEF) 26
chr11_+_62439126 Show fit	13.15	ENST00000377953.3	C11orf83 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 11 open reading frame 83
chr19_+_42817527 Show fit	12.41	ENST00000598766.1	TMEM145 Ensembl NCBI GeneCards UniProt NextProt Show fit	transmembrane protein 145
chr3_-_196065248 Show fit	11.63	ENST00000446879.1 ENST00000273695.3	TM4SF19 Ensembl NCBI GeneCards UniProt NextProt Show fit	transmembrane 4 L six family member 19
chr11_-_111783595 Show fit	11.46	ENST00000528628.1	CRYAB Ensembl NCBI GeneCards UniProt NextProt Show fit	crystallin, alpha B
chr16_-_4292071 Show fit	11.24	ENST00000399609.3	SRL Ensembl NCBI GeneCards UniProt NextProt Show fit	sarcalumenin

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1I2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.8	81.3	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.5	25.1	GO:0043268	positive regulation of potassium ion transport(GO:0043268)
0.0	23.4	GO:0030855	epithelial cell differentiation(GO:0030855)
1.2	22.5	GO:0007021	tubulin complex assembly(GO:0007021)
4.4	17.6	GO:0009956	radial pattern formation(GO:0009956)
0.5	16.3	GO:0061641	CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.6	14.6	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
1.1	13.4	GO:0001886	endothelial cell morphogenesis(GO:0001886)
0.3	12.4	GO:0032728	positive regulation of interferon-beta production(GO:0032728)
1.7	11.7	GO:0021730	trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)

Showing 1 to 10 of 202 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.8	81.3	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
1.5	24.1	GO:0097512	cardiac myofibril(GO:0097512)
0.0	21.9	GO:0031012	extracellular matrix(GO:0031012)
0.1	17.7	GO:0001650	fibrillar center(GO:0001650)
1.1	12.4	GO:0033018	sarcoplasmic reticulum lumen(GO:0033018)
1.0	11.7	GO:0044300	cerebellar mossy fiber(GO:0044300)
0.2	10.6	GO:0031907	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.7	9.6	GO:0005577	fibrinogen complex(GO:0005577)
0.0	9.5	GO:0000775	chromosome, centromeric region(GO:0000775)
1.2	9.4	GO:0005587	collagen type IV trimer(GO:0005587)

Showing 1 to 10 of 93 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	82.8	GO:0050840	extracellular matrix binding(GO:0050840)
0.2	34.7	GO:0051015	actin filament binding(GO:0051015)
0.1	28.9	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.7	20.7	GO:0005212	structural constituent of eye lens(GO:0005212)
0.1	19.2	GO:0044325	ion channel binding(GO:0044325)
0.4	18.4	GO:0001972	retinoic acid binding(GO:0001972)
0.1	17.6	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2	16.4	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1	16.3	GO:0003714	transcription corepressor activity(GO:0003714)
0.1	10.9	GO:0003707	steroid hormone receptor activity(GO:0003707)

Showing 1 to 10 of 145 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	81.9	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.3	25.3	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.1	22.4	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
0.3	22.0	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.1	15.9	PID AP1 PATHWAY	AP-1 transcription factor network
0.0	15.0	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	11.3	SIG CHEMOTAXIS	Genes related to chemotaxis
0.2	9.3	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.3	8.5	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.2	8.5	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.

Showing 1 to 10 of 42 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.0	81.3	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.3	32.0	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2	25.2	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.2	16.3	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.3	16.1	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.4	11.7	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
0.4	9.6	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.4	8.2	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.2	7.2	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type
0.1	7.2	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends

Showing 1 to 10 of 67 entries

Results for NR1I2

Z-value: 0.40

Motif logo

Transcription factors associated with NR1I2

Activity-expression correlation:

Activity profile of NR1I2 motif

Sorted Z-values of NR1I2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1I2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: