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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for NR1I3

Z-value: 0.14

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Transcription factors associated with NR1I3

Gene Symbol Gene ID Gene Info
NR1I3
ENSG00000143257.7 nuclear receptor subfamily 1 group I member 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR1I3hg19_v2_chr1_-_161207986_161208000-0.384.9e-09Click!

Activity profile of NR1I3 motif

Sorted Z-values of NR1I3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_145516560 6.20 ENST00000537888.1
PEX11B
peroxisomal biogenesis factor 11 beta
chr1_+_145516252 5.93 ENST00000369306.3
PEX11B
peroxisomal biogenesis factor 11 beta
chr14_+_53173910 5.77 ENST00000606149.1
ENST00000555339.1
ENST00000556813.1
PSMC6
proteasome (prosome, macropain) 26S subunit, ATPase, 6
chr6_+_32407619 5.74 ENST00000395388.2
ENST00000374982.5
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr14_+_53173890 5.73 ENST00000445930.2
PSMC6
proteasome (prosome, macropain) 26S subunit, ATPase, 6
chr5_+_52856456 5.45 ENST00000296684.5
ENST00000506765.1
NDUFS4
NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
chr4_-_57524061 4.83 ENST00000508121.1
HOPX
HOP homeobox
chr5_+_156712372 4.49 ENST00000541131.1
CYFIP2
cytoplasmic FMR1 interacting protein 2
chrX_+_118602363 4.45 ENST00000317881.8
SLC25A5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr17_-_62502399 4.23 ENST00000450599.2
ENST00000585060.1
DDX5
DEAD (Asp-Glu-Ala-Asp) box helicase 5
chr1_-_225616515 4.10 ENST00000338179.2
ENST00000425080.1
LBR
lamin B receptor
chr11_-_82611448 4.04 ENST00000393399.2
ENST00000313010.3
PRCP
prolylcarboxypeptidase (angiotensinase C)
chr2_-_209118974 3.90 ENST00000415913.1
ENST00000415282.1
ENST00000446179.1
IDH1
isocitrate dehydrogenase 1 (NADP+), soluble
chr12_-_118810688 3.86 ENST00000542532.1
ENST00000392533.3
TAOK3
TAO kinase 3
chr1_+_153330322 3.76 ENST00000368738.3
S100A9
S100 calcium binding protein A9
chr16_-_66968055 3.73 ENST00000568572.1
FAM96B
family with sequence similarity 96, member B
chr17_-_62502639 3.68 ENST00000225792.5
ENST00000581697.1
ENST00000584279.1
ENST00000577922.1
DDX5
DEAD (Asp-Glu-Ala-Asp) box helicase 5
chr19_-_48894104 3.59 ENST00000597017.1
KDELR1
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
chr1_-_149900122 3.35 ENST00000271628.8
SF3B4
splicing factor 3b, subunit 4, 49kDa
chr16_-_66968265 3.25 ENST00000567511.1
ENST00000422424.2
FAM96B
family with sequence similarity 96, member B
chr10_-_73848764 2.73 ENST00000317376.4
ENST00000412663.1
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr2_-_86790593 2.72 ENST00000263856.4
ENST00000409225.2
CHMP3
charged multivesicular body protein 3
chr17_-_53499310 2.71 ENST00000262065.3
MMD
monocyte to macrophage differentiation-associated
chr18_-_19284724 2.67 ENST00000580981.1
ENST00000289119.2
ABHD3
abhydrolase domain containing 3
chr14_-_22005018 2.62 ENST00000546363.1
SALL2
spalt-like transcription factor 2
chr6_-_31509714 2.35 ENST00000456662.1
ENST00000431908.1
ENST00000456976.1
ENST00000428450.1
ENST00000453105.2
ENST00000418897.1
ENST00000415382.2
ENST00000449074.2
ENST00000419020.1
ENST00000428098.1
DDX39B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr3_-_58419537 2.28 ENST00000474765.1
ENST00000485460.1
ENST00000302746.6
ENST00000383714.4
PDHB
pyruvate dehydrogenase (lipoamide) beta
chr7_+_143079000 2.20 ENST00000392910.2
ZYX
zyxin
chr11_-_59950519 2.16 ENST00000528851.1
MS4A6A
membrane-spanning 4-domains, subfamily A, member 6A
chr9_-_75567962 2.02 ENST00000297785.3
ENST00000376939.1
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr15_+_85523671 1.94 ENST00000310298.4
ENST00000557957.1
PDE8A
phosphodiesterase 8A
chr12_+_53693812 1.92 ENST00000549488.1
C12orf10
chromosome 12 open reading frame 10
chr16_+_67906919 1.85 ENST00000358933.5
EDC4
enhancer of mRNA decapping 4
chr12_+_100594557 1.82 ENST00000546902.1
ENST00000552376.1
ENST00000551617.1
ACTR6
ARP6 actin-related protein 6 homolog (yeast)
chr8_+_11351876 1.81 ENST00000529894.1
BLK
B lymphoid tyrosine kinase
chr1_-_205290865 1.71 ENST00000367157.3
NUAK2
NUAK family, SNF1-like kinase, 2
chr7_+_101460882 1.60 ENST00000292535.7
ENST00000549414.2
ENST00000550008.2
ENST00000546411.2
ENST00000556210.1
CUX1
cut-like homeobox 1
chr15_+_43985084 1.57 ENST00000434505.1
ENST00000411750.1
CKMT1A
creatine kinase, mitochondrial 1A
chr1_-_23886285 1.53 ENST00000374561.5
ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr19_-_6604094 1.46 ENST00000597430.2
CD70
CD70 molecule
chr9_-_35361262 1.41 ENST00000599954.1
AL160274.1
HCG17281; PRO0038; Uncharacterized protein
chr15_+_43885252 1.41 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
CKMT1B
creatine kinase, mitochondrial 1B
chr17_-_26695013 1.39 ENST00000555059.2
CTB-96E2.2
Homeobox protein SEBOX
chr8_-_53626974 1.38 ENST00000435644.2
ENST00000518710.1
ENST00000025008.5
ENST00000517963.1
RB1CC1
RB1-inducible coiled-coil 1
chrX_-_110655391 1.37 ENST00000356915.2
ENST00000356220.3
DCX
doublecortin
chr17_-_26694979 1.35 ENST00000438614.1
VTN
vitronectin
chr1_-_1690014 1.30 ENST00000400922.2
ENST00000342348.5
NADK
NAD kinase
chr1_+_26036093 1.18 ENST00000374329.1
MAN1C1
mannosidase, alpha, class 1C, member 1
chr18_-_19283649 1.15 ENST00000584464.1
ENST00000578270.1
ABHD3
abhydrolase domain containing 3
chr1_-_32210275 1.06 ENST00000440175.2
BAI2
brain-specific angiogenesis inhibitor 2
chr4_+_70894130 0.77 ENST00000526767.1
ENST00000530128.1
ENST00000381057.3
HTN3
histatin 3
chr18_-_23671139 0.72 ENST00000579061.1
ENST00000542420.2
SS18
synovial sarcoma translocation, chromosome 18
chr16_-_4465886 0.64 ENST00000539968.1
CORO7
coronin 7
chr9_-_80646374 0.54 ENST00000286548.4
GNAQ
guanine nucleotide binding protein (G protein), q polypeptide
chr13_-_95131923 0.51 ENST00000377028.5
ENST00000446125.1
DCT
dopachrome tautomerase
chr14_-_22005062 0.37 ENST00000317492.5
SALL2
spalt-like transcription factor 2
chr1_+_32930647 0.21 ENST00000609129.1
ZBTB8B
zinc finger and BTB domain containing 8B
chr1_+_154377669 0.17 ENST00000368485.3
ENST00000344086.4
IL6R
interleukin 6 receptor
chr18_-_23670546 0.14 ENST00000542743.1
ENST00000545952.1
ENST00000539849.1
ENST00000415083.2
SS18
synovial sarcoma translocation, chromosome 18
chr9_+_35605274 0.12 ENST00000336395.5
TESK1
testis-specific kinase 1
chr6_+_96969672 0.09 ENST00000369278.4
UFL1
UFM1-specific ligase 1
chr5_-_39270725 0.05 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYB
FYN binding protein
chr1_+_44401479 0.04 ENST00000438616.3
ARTN
artemin
chr19_+_676385 0.03 ENST00000166139.4
FSTL3
follistatin-like 3 (secreted glycoprotein)

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1I3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 12.1 GO:0044375 regulation of peroxisome size(GO:0044375)
1.4 5.7 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
1.3 3.9 GO:0006097 glyoxylate cycle(GO:0006097)
1.3 3.8 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
1.0 4.0 GO:0002254 regulation of thyroid hormone mediated signaling pathway(GO:0002155) kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353)
0.7 4.5 GO:1901029 adenine transport(GO:0015853) negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.7 2.0 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.6 4.5 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.5 7.9 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.5 11.5 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.3 1.4 GO:0030242 pexophagy(GO:0030242)
0.3 2.7 GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510)
0.3 3.6 GO:0006621 protein retention in ER lumen(GO:0006621)
0.3 7.0 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.3 2.4 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.3 1.3 GO:0006741 NADP biosynthetic process(GO:0006741)
0.3 2.3 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.2 1.8 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.2 4.8 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.2 1.2 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.2 3.9 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.2 3.3 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 1.6 GO:0006600 creatine metabolic process(GO:0006600)
0.1 2.7 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 1.5 GO:0030903 notochord development(GO:0030903)
0.1 5.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 3.8 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.1 1.9 GO:1903206 negative regulation of hydrogen peroxide-induced cell death(GO:1903206)
0.1 0.5 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.1 1.3 GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949)
0.1 0.2 GO:0002384 hepatic immune response(GO:0002384)
0.1 1.8 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
0.0 0.5 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0 1.6 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 4.1 GO:0006695 cholesterol biosynthetic process(GO:0006695)
0.0 1.7 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.9 GO:0097150 neuronal stem cell population maintenance(GO:0097150)
0.0 0.6 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.8 GO:0050832 defense response to fungus(GO:0050832)
0.0 3.0 GO:0021915 neural tube development(GO:0021915)
0.0 0.3 GO:0035641 locomotory exploration behavior(GO:0035641)
0.0 2.2 GO:0030038 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 0.1 GO:1990564 protein ufmylation(GO:0071569) protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 11.4 GO:0071817 MMXD complex(GO:0071817)
1.0 11.5 GO:0031595 nuclear proteasome complex(GO:0031595)
0.5 12.1 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.3 7.9 GO:0071141 SMAD protein complex(GO:0071141)
0.3 1.3 GO:0071062 rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.3 5.7 GO:0042613 MHC class II protein complex(GO:0042613)
0.3 3.6 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.2 1.4 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.2 2.3 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.2 2.4 GO:0005688 U6 snRNP(GO:0005688)
0.2 2.7 GO:0000815 ESCRT III complex(GO:0000815)
0.2 4.1 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.1 3.3 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.1 3.0 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 5.4 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 3.9 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 4.0 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.2 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.9 GO:0071564 npBAF complex(GO:0071564)
0.0 1.2 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.5 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 2.7 GO:0031902 late endosome membrane(GO:0031902)
0.0 2.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 2.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.1 GO:0050613 delta14-sterol reductase activity(GO:0050613)
1.3 7.9 GO:0035500 MH2 domain binding(GO:0035500)
1.3 3.9 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
1.3 3.8 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
1.1 4.5 GO:0015207 ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
1.0 11.5 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.9 3.6 GO:0005046 KDEL sequence binding(GO:0005046)
0.8 3.8 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.6 2.3 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.4 5.7 GO:0032395 MHC class II receptor activity(GO:0032395)
0.4 2.0 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.3 2.4 GO:0030621 U4 snRNA binding(GO:0030621)
0.3 4.0 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.2 1.6 GO:0004111 creatine kinase activity(GO:0004111)
0.2 2.7 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.1 2.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 5.4 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 3.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.5 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.1 1.3 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 0.5 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.1 2.7 GO:0004672 protein kinase activity(GO:0004672)
0.1 0.2 GO:0004915 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.1 1.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.3 GO:0003951 NAD+ kinase activity(GO:0003951)
0.0 1.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.5 GO:0005504 fatty acid binding(GO:0005504)
0.0 1.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.9 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 1.4 GO:0032947 protein complex scaffold(GO:0032947)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.6 PID ARF 3PATHWAY Arf1 pathway
0.1 3.8 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 5.7 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 6.7 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 3.4 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 2.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.5 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 1.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.8 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 1.4 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 2.7 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 7.1 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.4 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.2 ST STAT3 PATHWAY STAT3 Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 4.0 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.2 11.5 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 2.3 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 4.1 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 2.7 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 1.8 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 3.9 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 4.5 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.1 5.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 3.3 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.5 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 1.8 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 1.6 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 1.2 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.2 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 1.9 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events