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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for NR1I3
Z-value: 0.14
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Transcription factors associated with NR1I3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR1I3 | hg19_v2_chr1_-_161207986_161208000 | -0.38 | 4.9e-09 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_145516560 Show fit | 6.20 |
ENST00000537888.1
|
peroxisomal biogenesis factor 11 beta |
|
| chr1_+_145516252 Show fit | 5.93 |
ENST00000369306.3
|
peroxisomal biogenesis factor 11 beta |
|
| chr14_+_53173910 Show fit | 5.77 |
ENST00000606149.1
ENST00000555339.1 ENST00000556813.1 |
proteasome (prosome, macropain) 26S subunit, ATPase, 6 |
|
| chr6_+_32407619 Show fit | 5.74 |
ENST00000395388.2
ENST00000374982.5 |
major histocompatibility complex, class II, DR alpha |
|
| chr14_+_53173890 Show fit | 5.73 |
ENST00000445930.2
|
proteasome (prosome, macropain) 26S subunit, ATPase, 6 |
|
| chr5_+_52856456 Show fit | 5.45 |
ENST00000296684.5
ENST00000506765.1 |
NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) |
|
| chr4_-_57524061 Show fit | 4.83 |
ENST00000508121.1
|
HOP homeobox |
|
| chr5_+_156712372 Show fit | 4.49 |
ENST00000541131.1
|
cytoplasmic FMR1 interacting protein 2 |
|
| chrX_+_118602363 Show fit | 4.45 |
ENST00000317881.8
|
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 |
|
| chr17_-_62502399 Show fit | 4.23 |
ENST00000450599.2
ENST00000585060.1 |
DEAD (Asp-Glu-Ala-Asp) box helicase 5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR1I3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 12.1 | GO:0044375 | regulation of peroxisome size(GO:0044375) |
| 0.5 | 11.5 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
| 0.5 | 7.9 | GO:1903800 | positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800) |
| 0.3 | 7.0 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
| 1.4 | 5.7 | GO:0002503 | peptide antigen assembly with MHC class II protein complex(GO:0002503) |
| 0.1 | 5.4 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.2 | 4.8 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
| 0.7 | 4.5 | GO:1901029 | adenine transport(GO:0015853) negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029) |
| 0.6 | 4.5 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 0.0 | 4.1 | GO:0006695 | cholesterol biosynthetic process(GO:0006695) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 12.1 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 1.0 | 11.5 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 1.9 | 11.4 | GO:0071817 | MMXD complex(GO:0071817) |
| 0.3 | 7.9 | GO:0071141 | SMAD protein complex(GO:0071141) |
| 0.3 | 5.7 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 5.4 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.2 | 4.1 | GO:0005639 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453) |
| 0.1 | 4.0 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.1 | 3.9 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.3 | 3.6 | GO:0030663 | COPI-coated vesicle membrane(GO:0030663) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 11.5 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 1.3 | 7.9 | GO:0035500 | MH2 domain binding(GO:0035500) |
| 0.4 | 5.7 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.1 | 5.4 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 1.1 | 4.5 | GO:0015207 | ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207) |
| 1.4 | 4.1 | GO:0050613 | delta14-sterol reductase activity(GO:0050613) |
| 0.3 | 4.0 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 1.3 | 3.9 | GO:0004450 | isocitrate dehydrogenase (NADP+) activity(GO:0004450) |
| 1.3 | 3.8 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 0.8 | 3.8 | GO:0052740 | 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 6.7 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 5.7 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 3.8 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 3.6 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.1 | 3.4 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 2.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 2.7 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 1.8 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 1.4 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.5 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.1 | 5.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 4.5 | REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS | Genes involved in Interactions of Vpr with host cellular proteins |
| 0.1 | 4.1 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.2 | 4.0 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.1 | 3.9 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 3.3 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.1 | 2.7 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.1 | 2.3 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.3 | 2.0 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |