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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for NR2E1

Z-value: 0.68

Motif logo

Transcription factors associated with NR2E1

Gene Symbol Gene ID Gene Info
ENSG00000112333.7 nuclear receptor subfamily 2 group E member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR2E1hg19_v2_chr6_+_108487245_1084872620.391.7e-09Click!

Activity profile of NR2E1 motif

Sorted Z-values of NR2E1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_21786179 60.50 ENST00000377113.5
cancer susceptibility candidate 10
chr12_-_91539918 49.80 ENST00000548218.1
decorin
chr11_-_111794446 26.79 ENST00000527950.1
crystallin, alpha B
chr5_-_42811986 25.70 ENST00000511224.1
ENST00000507920.1
ENST00000510965.1
selenoprotein P, plasma, 1
chr12_-_91572278 20.95 ENST00000425043.1
ENST00000420120.2
ENST00000441303.2
ENST00000456569.2
decorin
chr11_-_5276008 19.93 ENST00000336906.4
hemoglobin, gamma G
chr11_-_5271122 19.65 ENST00000330597.3
hemoglobin, gamma A
chr14_+_69865401 16.78 ENST00000556605.1
ENST00000336643.5
ENST00000031146.4
solute carrier family 39, member 9
chr11_-_111781454 15.87 ENST00000533280.1
crystallin, alpha B
chr17_-_66951474 14.95 ENST00000269080.2
ATP-binding cassette, sub-family A (ABC1), member 8
chr12_-_91546926 14.46 ENST00000550758.1
decorin
chr11_-_111781554 12.51 ENST00000526167.1
ENST00000528961.1
crystallin, alpha B
chr17_-_26695013 11.47 ENST00000555059.2
Homeobox protein SEBOX
chr1_+_25944341 11.27 ENST00000263979.3
mannosidase, alpha, class 1C, member 1
chr6_+_31916733 10.56 ENST00000483004.1
complement factor B
chr17_-_26694979 10.37 ENST00000438614.1
vitronectin
chr17_-_42327236 10.34 ENST00000399246.2
AC003102.1
chr17_-_46667594 10.02 ENST00000476342.1
ENST00000460160.1
ENST00000472863.1
homeobox B3
chr8_+_80523962 10.01 ENST00000518491.1
stathmin-like 2
chr5_-_160279207 9.72 ENST00000327245.5
ATPase, class V, type 10B
chr17_-_46667628 9.60 ENST00000498678.1
homeobox B3
chr1_+_150229554 9.60 ENST00000369111.4
carbonic anhydrase XIV
chr7_+_142829162 9.48 ENST00000291009.3
prolactin-induced protein
chr3_+_52812523 9.38 ENST00000540715.1
inter-alpha-trypsin inhibitor heavy chain 1
chr1_+_152850787 9.35 ENST00000368765.3
sperm mitochondria-associated cysteine-rich protein
chr12_+_10366016 8.83 ENST00000546017.1
ENST00000535576.1
ENST00000539170.1
GABA(A) receptor-associated protein like 1
chr8_-_86253888 8.81 ENST00000522389.1
ENST00000432364.2
ENST00000517618.1
carbonic anhydrase I
chr17_-_29624343 8.79 ENST00000247271.4
oligodendrocyte myelin glycoprotein
chr17_-_43138463 8.38 ENST00000310604.4
dephospho-CoA kinase domain containing
chr7_-_100026280 8.36 ENST00000360951.4
ENST00000398027.2
ENST00000324725.6
ENST00000472716.1
zinc finger, CW type with PWWP domain 1
chr6_+_161123270 8.25 ENST00000366924.2
ENST00000308192.9
ENST00000418964.1
plasminogen
chr6_-_46922659 8.25 ENST00000265417.7
G protein-coupled receptor 116
chr10_+_124320156 8.16 ENST00000338354.3
ENST00000344338.3
ENST00000330163.4
ENST00000368909.3
ENST00000368955.3
ENST00000368956.2
deleted in malignant brain tumors 1
chr10_+_11784360 8.11 ENST00000379215.4
ENST00000420401.1
enoyl CoA hydratase domain containing 3
chr14_-_93799360 7.96 ENST00000334746.5
ENST00000554565.1
ENST00000298896.3
BTB (POZ) domain containing 7
chr3_+_14989186 7.95 ENST00000435454.1
ENST00000323373.6
nuclear receptor subfamily 2, group C, member 2
chr1_+_76262552 7.71 ENST00000263187.3
mutS homolog 4
chr11_-_62783276 7.49 ENST00000535878.1
ENST00000545207.1
solute carrier family 22 (organic anion transporter), member 8
chr11_-_62783303 7.44 ENST00000336232.2
ENST00000430500.2
solute carrier family 22 (organic anion transporter), member 8
chr17_+_29664830 7.40 ENST00000444181.2
ENST00000417592.2
neurofibromin 1
chrX_-_65253506 7.38 ENST00000427538.1
V-set and immunoglobulin domain containing 4
chr2_+_67624430 7.31 ENST00000272342.5
Ewing tumor-associated antigen 1
chr5_-_135290705 7.22 ENST00000274507.1
leukocyte cell-derived chemotaxin 2
chr3_+_52813932 7.13 ENST00000537050.1
inter-alpha-trypsin inhibitor heavy chain 1
chr10_+_124320195 7.10 ENST00000359586.6
deleted in malignant brain tumors 1
chr12_-_52887034 7.05 ENST00000330722.6
keratin 6A
chr3_+_69788576 6.85 ENST00000352241.4
ENST00000448226.2
microphthalmia-associated transcription factor
chr5_-_140013275 6.67 ENST00000512545.1
ENST00000302014.6
ENST00000401743.2
CD14 molecule
chr17_+_73975292 6.61 ENST00000397640.1
ENST00000416485.1
ENST00000588202.1
ENST00000590676.1
ENST00000586891.1
TEN1 CST complex subunit
chr9_-_99064429 6.58 ENST00000375263.3
hydroxysteroid (17-beta) dehydrogenase 3
chr9_+_87285539 6.53 ENST00000359847.3
neurotrophic tyrosine kinase, receptor, type 2
chr15_-_88799384 6.48 ENST00000540489.2
ENST00000557856.1
ENST00000558676.1
neurotrophic tyrosine kinase, receptor, type 3
chr4_+_96012614 6.38 ENST00000264568.4
bone morphogenetic protein receptor, type IB
chrX_-_65259900 6.35 ENST00000412866.2
V-set and immunoglobulin domain containing 4
chr1_-_244006528 6.35 ENST00000336199.5
ENST00000263826.5
v-akt murine thymoma viral oncogene homolog 3
chrX_-_53711064 6.24 ENST00000342160.3
ENST00000446750.1
HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
chr5_-_160973649 6.22 ENST00000393959.1
ENST00000517547.1
gamma-aminobutyric acid (GABA) A receptor, beta 2
chr11_-_62476965 6.22 ENST00000405837.1
ENST00000531524.1
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr14_+_22977587 6.21 ENST00000390504.1
T cell receptor alpha joining 33
chr3_+_69915385 6.20 ENST00000314589.5
microphthalmia-associated transcription factor
chr16_+_3451184 6.20 ENST00000575752.1
ENST00000571936.1
ENST00000344823.5
zinc finger protein 174
chrX_-_153236620 6.17 ENST00000369984.4
host cell factor C1 (VP16-accessory protein)
chr17_-_41623691 6.14 ENST00000545954.1
ets variant 4
chr15_+_58702742 6.12 ENST00000356113.6
ENST00000414170.3
lipase, hepatic
chr17_+_56315787 6.11 ENST00000262290.4
ENST00000421678.2
lactoperoxidase
chr3_-_101232019 6.10 ENST00000394095.2
ENST00000394091.1
ENST00000394094.2
ENST00000358203.3
ENST00000348610.3
ENST00000314261.7
SUMO1/sentrin specific peptidase 7
chrX_+_136648297 6.00 ENST00000287538.5
Zic family member 3
chr3_+_69985792 5.98 ENST00000531774.1
microphthalmia-associated transcription factor
chrX_-_65259914 5.89 ENST00000374737.4
ENST00000455586.2
V-set and immunoglobulin domain containing 4
chr8_+_11561660 5.88 ENST00000526716.1
ENST00000335135.4
ENST00000528027.1
GATA binding protein 4
chr17_-_73975444 5.80 ENST00000293217.5
ENST00000537812.1
acyl-CoA oxidase 1, palmitoyl
chr13_+_25338290 5.78 ENST00000255324.5
ENST00000381921.1
ENST00000255325.6
ring finger protein 17
chr14_+_61654271 5.67 ENST00000555185.1
ENST00000557294.1
ENST00000556778.1
protein kinase C, eta
chr9_-_16727978 5.52 ENST00000418777.1
ENST00000468187.2
basonuclin 2
chr4_+_88571429 5.51 ENST00000339673.6
ENST00000282479.7
dentin matrix acidic phosphoprotein 1
chr11_-_57004658 5.27 ENST00000606794.1
apelin receptor
chr10_-_115423792 5.26 ENST00000369360.3
ENST00000360478.3
ENST00000359988.3
ENST00000369358.4
nebulin-related anchoring protein
chr20_-_4229721 5.25 ENST00000379453.4
adrenoceptor alpha 1D
chr12_+_111471828 5.20 ENST00000261726.6
cut-like homeobox 2
chr10_-_21463116 5.17 ENST00000417816.2
nebulette
chr4_-_47983519 5.16 ENST00000358519.4
ENST00000544810.1
ENST00000402813.3
cyclic nucleotide gated channel alpha 1
chr9_-_91793675 5.11 ENST00000375835.4
ENST00000375830.1
SHC (Src homology 2 domain containing) transforming protein 3
chr1_+_32042105 5.10 ENST00000457433.2
ENST00000441210.2
tubulointerstitial nephritis antigen-like 1
chrX_-_106362013 5.10 ENST00000372487.1
ENST00000372479.3
ENST00000203616.8
RNA binding motif protein 41
chr17_-_41623716 5.06 ENST00000319349.5
ets variant 4
chr20_-_30310656 5.05 ENST00000376055.4
BCL2-like 1
chr7_-_8301768 4.98 ENST00000265577.7
islet cell autoantigen 1, 69kDa
chr6_+_148663729 4.92 ENST00000367467.3
SAM and SH3 domain containing 1
chr1_-_116311402 4.83 ENST00000261448.5
calsequestrin 2 (cardiac muscle)
chr10_-_29084886 4.80 ENST00000608061.1
ENST00000443246.2
ENST00000446012.1
long intergenic non-protein coding RNA 837
chr9_-_21368075 4.78 ENST00000449498.1
interferon, alpha 13
chr4_+_71063641 4.73 ENST00000514097.1
odontogenic, ameloblast asssociated
chr9_-_75567962 4.72 ENST00000297785.3
ENST00000376939.1
aldehyde dehydrogenase 1 family, member A1
chr20_-_30310693 4.68 ENST00000307677.4
ENST00000420653.1
BCL2-like 1
chr1_-_48866517 4.67 ENST00000371841.1
spermatogenesis associated 6
chr17_-_43138357 4.61 ENST00000342350.5
dephospho-CoA kinase domain containing
chr2_-_87248975 4.59 ENST00000409310.2
ENST00000355705.3
plasminogen-like B1
chr5_+_140743859 4.58 ENST00000518069.1
protocadherin gamma subfamily A, 5
chr16_+_56385290 4.58 ENST00000564727.1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
chr6_+_26156551 4.55 ENST00000304218.3
histone cluster 1, H1e
chr3_-_116164306 4.50 ENST00000490035.2
limbic system-associated membrane protein
chr20_+_43160458 4.47 ENST00000372889.1
ENST00000372887.1
ENST00000372882.3
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr2_+_113885138 4.44 ENST00000409930.3
interleukin 1 receptor antagonist
chr18_+_29027696 4.42 ENST00000257189.4
desmoglein 3
chr21_-_36260980 4.37 ENST00000344691.4
ENST00000358356.5
runt-related transcription factor 1
chr5_-_9546180 4.37 ENST00000382496.5
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr6_+_31515337 4.35 ENST00000376148.4
ENST00000376145.4
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr5_-_33892046 4.34 ENST00000352040.3
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr5_-_11588907 4.31 ENST00000513598.1
ENST00000503622.1
catenin (cadherin-associated protein), delta 2
chr2_+_88047606 4.28 ENST00000359481.4
plasminogen-like B2
chr5_-_33892204 4.27 ENST00000504830.1
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr7_-_8301682 4.27 ENST00000396675.3
ENST00000430867.1
islet cell autoantigen 1, 69kDa
chrX_-_33146477 4.23 ENST00000378677.2
dystrophin
chr2_-_196933536 4.23 ENST00000312428.6
ENST00000410072.1
dynein, axonemal, heavy chain 7
chr20_+_57875457 4.14 ENST00000337938.2
ENST00000311585.7
ENST00000371028.2
endothelin 3
chrX_+_47078069 4.10 ENST00000357227.4
ENST00000519758.1
ENST00000520893.1
ENST00000517426.1
cyclin-dependent kinase 16
chr1_-_20834586 4.05 ENST00000264198.3
mitochondrial E3 ubiquitin protein ligase 1
chr7_-_113559104 3.94 ENST00000284601.3
protein phosphatase 1, regulatory subunit 3A
chr12_-_71031220 3.88 ENST00000334414.6
protein tyrosine phosphatase, receptor type, B
chrX_+_150866779 3.68 ENST00000370353.3
proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)
chr16_-_66952742 3.68 ENST00000565235.2
ENST00000568632.1
ENST00000565796.1
cadherin 16, KSP-cadherin
chr12_-_71031185 3.63 ENST00000548122.1
ENST00000551525.1
ENST00000550358.1
protein tyrosine phosphatase, receptor type, B
chr16_+_47496023 3.57 ENST00000567200.1
phosphorylase kinase, beta
chr1_-_154155595 3.54 ENST00000328159.4
ENST00000368531.2
ENST00000323144.7
ENST00000368533.3
ENST00000341372.3
tropomyosin 3
chr3_-_148939835 3.52 ENST00000264613.6
ceruloplasmin (ferroxidase)
chr5_+_137203465 3.47 ENST00000239926.4
myotilin
chr4_+_3388057 3.43 ENST00000538395.1
regulator of G-protein signaling 12
chr6_-_161085291 3.42 ENST00000316300.5
lipoprotein, Lp(a)
chr2_+_3705785 3.42 ENST00000252505.3
allantoicase
chr9_-_5304432 3.39 ENST00000416837.1
ENST00000308420.3
relaxin 2
chr10_+_17794251 3.38 ENST00000377495.1
ENST00000338221.5
transmembrane protein 236
chr3_+_113616317 3.35 ENST00000440446.2
ENST00000488680.1
GRAM domain containing 1C
chr18_+_22040593 3.34 ENST00000256906.4
histamine receptor H4
chr3_+_42897512 3.32 ENST00000493193.1
atypical chemokine receptor 2
chr6_-_41715128 3.31 ENST00000356667.4
ENST00000373025.3
ENST00000425343.2
progastricsin (pepsinogen C)
chr14_+_31494841 3.30 ENST00000556232.1
ENST00000216366.4
ENST00000334725.4
ENST00000554609.1
ENST00000554345.1
adaptor-related protein complex 4, sigma 1 subunit
chr11_-_30038490 3.22 ENST00000328224.6
potassium voltage-gated channel, shaker-related subfamily, member 4
chr3_+_189349162 3.13 ENST00000264731.3
ENST00000382063.4
ENST00000418709.2
ENST00000320472.5
ENST00000392460.3
ENST00000440651.2
tumor protein p63
chr12_-_122018859 3.11 ENST00000536437.1
ENST00000377071.4
ENST00000538046.2
lysine (K)-specific demethylase 2B
chr7_-_107443652 2.98 ENST00000340010.5
ENST00000422236.2
ENST00000453332.1
solute carrier family 26 (anion exchanger), member 3
chr4_+_4861385 2.96 ENST00000382723.4
msh homeobox 1
chr4_-_123542224 2.94 ENST00000264497.3
interleukin 21
chr2_-_169887827 2.90 ENST00000263817.6
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr9_-_95166841 2.89 ENST00000262551.4
osteoglycin
chr6_+_106546808 2.89 ENST00000369089.3
PR domain containing 1, with ZNF domain
chr20_-_30310797 2.88 ENST00000422920.1
BCL2-like 1
chr5_-_127873496 2.87 ENST00000508989.1
fibrillin 2
chr7_+_39125365 2.85 ENST00000559001.1
ENST00000464276.2
POU class 6 homeobox 2
chr12_-_58135903 2.82 ENST00000257897.3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr13_+_109248500 2.81 ENST00000356711.2
myosin XVI
chr2_+_11679963 2.77 ENST00000263834.5
growth regulation by estrogen in breast cancer 1
chr5_+_32711829 2.70 ENST00000415167.2
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chrX_+_47444613 2.68 ENST00000445623.1
TIMP metallopeptidase inhibitor 1
chr2_-_74555293 2.68 ENST00000358683.4
solute carrier family 4 (sodium bicarbonate cotransporter), member 5
chr5_-_55412774 2.67 ENST00000434982.2
ankyrin repeat domain 55
chr3_-_58196939 2.67 ENST00000394549.2
ENST00000461914.3
deoxyribonuclease I-like 3
chr22_-_40929812 2.65 ENST00000422851.1
megakaryoblastic leukemia (translocation) 1
chr17_+_1959369 2.62 ENST00000576444.1
ENST00000322941.3
hypermethylated in cancer 1
chr1_+_159141397 2.61 ENST00000368124.4
ENST00000368125.4
ENST00000416746.1
cell adhesion molecule 3
chr18_+_22040620 2.60 ENST00000426880.2
histamine receptor H4
chr9_-_5339873 2.59 ENST00000223862.1
ENST00000223858.4
relaxin 1
chr6_+_131521120 2.53 ENST00000537868.1
A kinase (PRKA) anchor protein 7
chr12_-_56236690 2.52 ENST00000322569.4
matrix metallopeptidase 19
chr16_-_10652993 2.51 ENST00000536829.1
epithelial membrane protein 2
chr7_-_151217001 2.51 ENST00000262187.5
Ras homolog enriched in brain
chr4_-_141348999 2.50 ENST00000325617.5
calmegin
chr15_-_42783303 2.50 ENST00000565380.1
ENST00000564754.1
zinc finger protein 106
chr11_-_13517565 2.46 ENST00000282091.1
ENST00000529816.1
parathyroid hormone
chr2_-_183291741 2.44 ENST00000351439.5
ENST00000409365.1
phosphodiesterase 1A, calmodulin-dependent
chr6_+_33048222 2.43 ENST00000428835.1
major histocompatibility complex, class II, DP beta 1
chr1_-_154155675 2.43 ENST00000330188.9
ENST00000341485.5
tropomyosin 3
chr8_+_77593448 2.43 ENST00000521891.2
zinc finger homeobox 4
chr3_+_69985734 2.42 ENST00000314557.6
ENST00000394351.3
microphthalmia-associated transcription factor
chr4_-_70505358 2.38 ENST00000457664.2
ENST00000604629.1
ENST00000604021.1
UDP glucuronosyltransferase 2 family, polypeptide A2
chr3_-_58196688 2.37 ENST00000486455.1
deoxyribonuclease I-like 3
chr1_-_68698222 2.34 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
wntless Wnt ligand secretion mediator
chr7_+_134832808 2.27 ENST00000275767.3
transmembrane protein 140
chr19_-_633576 2.27 ENST00000588649.2
polymerase (RNA) mitochondrial (DNA directed)
chr16_-_73082274 2.25 ENST00000268489.5
zinc finger homeobox 3
chr12_-_82152444 2.22 ENST00000549325.1
ENST00000550584.2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr11_-_83984231 2.21 ENST00000330014.6
ENST00000537455.1
ENST00000376106.3
ENST00000418306.2
ENST00000531015.1
discs, large homolog 2 (Drosophila)
chr11_-_8832182 2.20 ENST00000527510.1
ENST00000528527.1
ENST00000528523.1
ENST00000313726.6
suppression of tumorigenicity 5
chr3_+_46616017 2.20 ENST00000542931.1
teratocarcinoma-derived growth factor 1
chr4_-_122085469 2.19 ENST00000057513.3
TNFAIP3 interacting protein 3
chr5_-_127873659 2.19 ENST00000262464.4
fibrillin 2
chr9_+_21440440 2.16 ENST00000276927.1
interferon, alpha 1
chr3_+_148508845 2.12 ENST00000491148.1
carboxypeptidase B1 (tissue)
chr16_-_20709066 2.12 ENST00000520010.1
acyl-CoA synthetase medium-chain family member 1
chr7_-_14942283 2.08 ENST00000402815.1
diacylglycerol kinase, beta 90kDa
chr16_-_66952779 2.08 ENST00000570262.1
ENST00000394055.3
ENST00000299752.4
cadherin 16, KSP-cadherin
chr11_+_63742050 2.03 ENST00000314133.3
ENST00000535431.1
cytochrome c oxidase subunit VIIIA (ubiquitous)
Uncharacterized protein
chr9_-_95166884 2.01 ENST00000375561.5
osteoglycin
chr1_-_154150651 2.01 ENST00000302206.5
tropomyosin 3
chr5_+_137203557 2.00 ENST00000515645.1
myotilin
chr7_+_80267973 1.97 ENST00000394788.3
ENST00000447544.2
CD36 molecule (thrombospondin receptor)
chr17_+_19186292 1.97 ENST00000395626.1
ENST00000571254.1
epsin 2
chr2_+_90077680 1.96 ENST00000390270.2
immunoglobulin kappa variable 3D-20
chr15_-_43559055 1.96 ENST00000220420.5
ENST00000349114.4
transglutaminase 5
chr17_-_41738931 1.91 ENST00000329168.3
ENST00000549132.1
mesenchyme homeobox 1
chr7_-_72936608 1.91 ENST00000404251.1
bromodomain adjacent to zinc finger domain, 1B

Network of associatons between targets according to the STRING database.

First level regulatory network of NR2E1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 85.8 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
4.3 8.6 GO:1902548 negative regulation of cellular response to vascular endothelial growth factor stimulus(GO:1902548)
3.9 19.6 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
3.1 55.2 GO:0007021 tubulin complex assembly(GO:0007021)
2.7 8.2 GO:2000048 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
2.6 39.6 GO:0015671 oxygen transport(GO:0015671)
2.5 10.0 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
2.5 7.4 GO:0061534 gamma-aminobutyric acid secretion, neurotransmission(GO:0061534)
2.4 7.1 GO:0051710 regulation of cytolysis in other organism(GO:0051710)
2.2 6.5 GO:0048691 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
2.0 5.9 GO:0003285 septum secundum development(GO:0003285)
1.9 11.3 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
1.8 1.8 GO:0050880 regulation of tube size(GO:0035150) regulation of blood vessel size(GO:0050880)
1.7 6.7 GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
1.6 4.7 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
1.6 4.7 GO:0061624 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
1.5 6.2 GO:0019046 release from viral latency(GO:0019046)
1.5 15.3 GO:0043152 induction of bacterial agglutination(GO:0043152)
1.5 11.9 GO:0046898 response to cycloheximide(GO:0046898)
1.4 8.3 GO:0061370 testosterone biosynthetic process(GO:0061370)
1.4 15.0 GO:0042908 xenobiotic transport(GO:0042908)
1.3 9.4 GO:0007341 penetration of zona pellucida(GO:0007341)
1.3 5.2 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
1.3 6.5 GO:0099540 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551)
1.3 6.4 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
1.2 4.9 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
1.2 1.2 GO:0071350 interleukin-15-mediated signaling pathway(GO:0035723) cellular response to interleukin-15(GO:0071350)
1.2 30.2 GO:0006957 complement activation, alternative pathway(GO:0006957)
1.2 10.4 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
1.1 3.4 GO:0043605 cellular amide catabolic process(GO:0043605)
1.0 3.1 GO:0021678 midbrain-hindbrain boundary morphogenesis(GO:0021555) fourth ventricle development(GO:0021592) third ventricle development(GO:0021678)
1.0 4.1 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
1.0 6.0 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
1.0 3.0 GO:0090427 activation of meiosis(GO:0090427)
1.0 2.9 GO:0048867 stem cell fate determination(GO:0048867)
0.9 7.7 GO:0051026 chiasma assembly(GO:0051026)
0.8 2.5 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.8 4.1 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.8 3.1 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.7 2.9 GO:0015722 canalicular bile acid transport(GO:0015722)
0.7 5.7 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.7 2.1 GO:0019605 benzoate metabolic process(GO:0018874) butyrate metabolic process(GO:0019605)
0.7 2.1 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.7 16.8 GO:0006829 zinc II ion transport(GO:0006829)
0.6 7.1 GO:0070170 regulation of tooth mineralization(GO:0070170)
0.6 13.0 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.6 4.2 GO:0036159 inner dynein arm assembly(GO:0036159)
0.6 15.6 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.6 2.9 GO:0033078 extrathymic T cell differentiation(GO:0033078)
0.6 1.7 GO:0006533 aspartate catabolic process(GO:0006533)
0.6 1.7 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.6 4.5 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.6 2.3 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.6 1.7 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.6 2.2 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.6 5.1 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.6 1.7 GO:0070295 renal water absorption(GO:0070295)
0.6 4.4 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.6 3.3 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.5 2.7 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.5 4.8 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.5 5.3 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.5 8.8 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.5 1.9 GO:0001757 somite specification(GO:0001757) sclerotome development(GO:0061056)
0.5 9.5 GO:0034374 low-density lipoprotein particle remodeling(GO:0034374)
0.5 1.9 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.5 1.8 GO:0055014 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
0.4 1.3 GO:0045014 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.4 2.6 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.4 3.0 GO:0001554 luteolysis(GO:0001554)
0.4 21.4 GO:0015701 bicarbonate transport(GO:0015701)
0.4 21.7 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.4 4.8 GO:0086068 Purkinje myocyte to ventricular cardiac muscle cell signaling(GO:0086029) Purkinje myocyte to ventricular cardiac muscle cell communication(GO:0086068)
0.4 5.8 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.4 4.2 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.4 9.7 GO:0045332 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.3 7.3 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.3 14.9 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.3 5.2 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.3 4.4 GO:0048843 positive regulation of axon extension involved in axon guidance(GO:0048842) negative regulation of axon extension involved in axon guidance(GO:0048843)
0.3 2.7 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.3 2.0 GO:0071724 toll-like receptor TLR6:TLR2 signaling pathway(GO:0038124) response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726)
0.3 6.2 GO:0071420 cellular response to histamine(GO:0071420)
0.3 4.9 GO:0035641 locomotory exploration behavior(GO:0035641)
0.3 1.2 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.3 2.7 GO:0002158 osteoclast proliferation(GO:0002158)
0.3 4.8 GO:0045793 positive regulation of cell size(GO:0045793)
0.3 4.3 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.3 4.9 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.3 5.0 GO:0010623 programmed cell death involved in cell development(GO:0010623)
0.3 4.5 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.3 5.5 GO:0043586 tongue development(GO:0043586)
0.3 6.6 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.3 4.4 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.3 6.2 GO:0034389 lipid particle organization(GO:0034389)
0.2 5.2 GO:0007614 short-term memory(GO:0007614)
0.2 4.7 GO:0044458 motile cilium assembly(GO:0044458)
0.2 0.9 GO:0048840 otolith development(GO:0048840)
0.2 2.2 GO:0007350 blastoderm segmentation(GO:0007350) tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.2 2.6 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.2 5.8 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 2.8 GO:0046069 cGMP catabolic process(GO:0046069)
0.2 4.5 GO:0030252 growth hormone secretion(GO:0030252)
0.2 1.4 GO:0048664 neuron fate determination(GO:0048664)
0.1 2.5 GO:2001212 regulation of vasculogenesis(GO:2001212)
0.1 0.7 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.1 5.5 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.1 1.7 GO:0051775 response to redox state(GO:0051775)
0.1 2.5 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.1 4.6 GO:0014072 response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278)
0.1 4.1 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.1 2.1 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.1 1.1 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.1 8.0 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.1 2.8 GO:0042177 negative regulation of protein catabolic process(GO:0042177)
0.1 5.4 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.1 3.7 GO:0010863 positive regulation of phospholipase C activity(GO:0010863)
0.1 2.0 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 1.8 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.1 0.4 GO:0070327 thyroid hormone transport(GO:0070327)
0.1 2.4 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.1 1.0 GO:0000733 DNA strand renaturation(GO:0000733)
0.1 2.2 GO:0097120 receptor localization to synapse(GO:0097120)
0.1 0.8 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1 6.2 GO:0006513 protein monoubiquitination(GO:0006513)
0.1 2.5 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.1 0.5 GO:0042481 regulation of odontogenesis(GO:0042481)
0.1 7.3 GO:0070268 cornification(GO:0070268)
0.1 6.1 GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway(GO:0007188)
0.1 1.8 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 7.5 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 2.0 GO:0006897 endocytosis(GO:0006897)
0.1 2.1 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 3.2 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.1 2.4 GO:0032729 positive regulation of interferon-gamma production(GO:0032729)
0.0 2.8 GO:0050771 negative regulation of axonogenesis(GO:0050771)
0.0 2.2 GO:0002756 MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.0 1.0 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 4.4 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 3.5 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.0 9.3 GO:0006836 neurotransmitter transport(GO:0006836)
0.0 2.4 GO:0014047 glutamate secretion(GO:0014047)
0.0 0.3 GO:2001023 regulation of response to drug(GO:2001023)
0.0 3.4 GO:0030819 positive regulation of cAMP biosynthetic process(GO:0030819)
0.0 1.5 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.4 GO:0008343 adult feeding behavior(GO:0008343) regulation of melanin biosynthetic process(GO:0048021) positive regulation of melanin biosynthetic process(GO:0048023) regulation of secondary metabolite biosynthetic process(GO:1900376) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0 3.4 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0 0.1 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.0 2.7 GO:0021549 cerebellum development(GO:0021549)
0.0 1.1 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.0 0.6 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.7 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.0 0.1 GO:0002525 acute inflammatory response to non-antigenic stimulus(GO:0002525) regulation of acute inflammatory response to non-antigenic stimulus(GO:0002877) positive regulation of acute inflammatory response to non-antigenic stimulus(GO:0002879)
0.0 0.3 GO:0023019 signal transduction involved in regulation of gene expression(GO:0023019)
0.0 0.9 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 1.3 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 4.8 GO:0016197 endosomal transport(GO:0016197)
0.0 0.0 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.0 1.2 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.0 GO:0042109 negative regulation of tolerance induction(GO:0002644) lymphotoxin A production(GO:0032641) interleukin-4 biosynthetic process(GO:0042097) lymphotoxin A biosynthetic process(GO:0042109) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.0 1.9 GO:0002377 immunoglobulin production(GO:0002377)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
6.1 85.2 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
3.4 55.2 GO:0097512 cardiac myofibril(GO:0097512)
2.8 39.6 GO:0005833 hemoglobin complex(GO:0005833)
2.6 10.4 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
1.9 7.7 GO:0005713 recombination nodule(GO:0005713)
1.4 8.2 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
1.3 6.7 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
1.2 4.8 GO:0030314 junctional membrane complex(GO:0030314)
1.2 4.7 GO:0097224 sperm connecting piece(GO:0097224)
0.9 15.3 GO:0042589 zymogen granule membrane(GO:0042589)
0.9 5.3 GO:0005927 muscle tendon junction(GO:0005927)
0.8 10.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.5 6.4 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.5 6.2 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.5 4.2 GO:0016013 syntrophin complex(GO:0016013)
0.4 8.0 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.4 2.9 GO:0046581 intercellular canaliculus(GO:0046581)
0.4 7.4 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.4 6.6 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.3 1.7 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.3 4.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.3 5.2 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.3 4.2 GO:0005858 axonemal dynein complex(GO:0005858)
0.3 11.3 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 8.8 GO:0000421 autophagosome membrane(GO:0000421)
0.2 5.1 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.2 5.1 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.2 1.0 GO:0016589 NURF complex(GO:0016589)
0.2 6.5 GO:1902711 GABA-A receptor complex(GO:1902711)
0.2 3.0 GO:0097225 sperm midpiece(GO:0097225)
0.2 7.1 GO:0045095 keratin filament(GO:0045095)
0.2 4.1 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.2 1.9 GO:0031906 late endosome lumen(GO:0031906)
0.1 11.5 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 2.0 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 9.5 GO:0034358 plasma lipoprotein particle(GO:0034358) lipoprotein particle(GO:1990777)
0.1 4.4 GO:0030057 desmosome(GO:0030057)
0.1 0.9 GO:0042383 sarcolemma(GO:0042383)
0.1 2.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 5.1 GO:0031904 endosome lumen(GO:0031904)
0.1 17.5 GO:0031225 anchored component of membrane(GO:0031225)
0.1 5.8 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 4.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 2.0 GO:0030128 clathrin coat of endocytic vesicle(GO:0030128)
0.1 16.7 GO:0072562 blood microparticle(GO:0072562)
0.1 1.3 GO:0005922 connexon complex(GO:0005922)
0.1 2.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 2.0 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 1.8 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 2.4 GO:0048786 presynaptic active zone(GO:0048786)
0.1 10.0 GO:0030018 Z disc(GO:0030018)
0.1 0.9 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 2.8 GO:0016459 myosin complex(GO:0016459)
0.1 10.0 GO:0030426 growth cone(GO:0030426)
0.1 7.4 GO:0031901 early endosome membrane(GO:0031901)
0.1 4.5 GO:0008021 synaptic vesicle(GO:0008021)
0.1 4.9 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.8 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 4.9 GO:0043234 protein complex(GO:0043234)
0.0 4.2 GO:0005901 caveola(GO:0005901)
0.0 6.2 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 3.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 4.3 GO:0043204 perikaryon(GO:0043204)
0.0 1.2 GO:0042101 T cell receptor complex(GO:0042101)
0.0 48.8 GO:0005615 extracellular space(GO:0005615)
0.0 3.3 GO:0055037 recycling endosome(GO:0055037)
0.0 5.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.7 GO:0009925 basal plasma membrane(GO:0009925)
0.0 2.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.9 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 1.7 GO:0015030 Cajal body(GO:0015030)
0.0 4.5 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 1.8 GO:0030133 transport vesicle(GO:0030133)
0.0 1.3 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 2.3 GO:0000428 DNA-directed RNA polymerase complex(GO:0000428) RNA polymerase complex(GO:0030880)
0.0 1.5 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 3.3 GO:0043235 receptor complex(GO:0043235)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 13.0 GO:0004140 dephospho-CoA kinase activity(GO:0004140)
3.0 39.6 GO:0005344 oxygen transporter activity(GO:0005344)
2.2 6.7 GO:0016019 peptidoglycan receptor activity(GO:0016019)
1.9 15.0 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
1.8 57.1 GO:0005212 structural constituent of eye lens(GO:0005212)
1.7 5.2 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
1.5 4.4 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
1.4 8.3 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
1.3 6.5 GO:0060175 brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
1.3 95.3 GO:0050840 extracellular matrix binding(GO:0050840)
1.1 5.7 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
1.1 8.8 GO:0004064 arylesterase activity(GO:0004064)
1.1 4.4 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
1.0 8.2 GO:1990405 protein antigen binding(GO:1990405)
1.0 11.3 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.9 4.7 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.9 10.2 GO:0051434 BH3 domain binding(GO:0051434)
0.9 6.2 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.8 6.5 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.8 4.5 GO:0032564 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.7 2.9 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.7 3.6 GO:0031708 endothelin B receptor binding(GO:0031708)
0.7 17.2 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.7 6.4 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.7 9.6 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.7 5.9 GO:0004969 histamine receptor activity(GO:0004969)
0.6 5.8 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.6 20.6 GO:0015301 anion:anion antiporter activity(GO:0015301)
0.6 5.1 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.6 8.8 GO:0030957 Tat protein binding(GO:0030957)
0.6 12.8 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.6 7.4 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.6 5.1 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.5 5.9 GO:0051525 NFAT protein binding(GO:0051525)
0.5 6.2 GO:0043996 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.5 6.6 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.5 2.7 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.4 9.7 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.4 1.6 GO:0033906 protein tyrosine kinase inhibitor activity(GO:0030292) hyaluronoglucuronidase activity(GO:0033906)
0.4 5.2 GO:0005221 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.4 2.8 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.4 3.5 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.4 4.7 GO:0032027 myosin light chain binding(GO:0032027)
0.4 3.1 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.4 7.7 GO:0030983 mismatched DNA binding(GO:0030983)
0.4 6.1 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.4 21.7 GO:0070888 E-box binding(GO:0070888)
0.4 1.8 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.3 1.7 GO:0030348 syntaxin-3 binding(GO:0030348)
0.3 1.0 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.3 3.4 GO:0001968 fibronectin binding(GO:0001968)
0.3 10.6 GO:0001848 complement binding(GO:0001848)
0.3 3.3 GO:0019957 C-C chemokine binding(GO:0019957)
0.3 7.5 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.3 12.2 GO:0051393 alpha-actinin binding(GO:0051393)
0.3 3.1 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.3 4.9 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.2 4.2 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.2 1.7 GO:0004046 aminoacylase activity(GO:0004046)
0.2 5.2 GO:0031005 filamin binding(GO:0031005)
0.2 2.0 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.2 3.4 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.2 1.2 GO:0042289 MHC class II protein binding(GO:0042289)
0.2 2.1 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.2 1.9 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.2 4.5 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.2 0.8 GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509)
0.2 4.2 GO:0002162 dystroglycan binding(GO:0002162)
0.2 4.1 GO:0019789 SUMO transferase activity(GO:0019789)
0.2 19.6 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.2 7.3 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.2 1.3 GO:0005497 androgen binding(GO:0005497)
0.2 1.9 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.2 0.7 GO:0008420 CTD phosphatase activity(GO:0008420)
0.2 1.7 GO:0070492 oligosaccharide binding(GO:0070492)
0.2 16.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 3.2 GO:0030955 potassium ion binding(GO:0030955)
0.2 2.1 GO:0005132 type I interferon receptor binding(GO:0005132)
0.1 2.6 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 2.9 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 1.1 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.1 2.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 14.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 10.0 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 2.5 GO:0048018 receptor agonist activity(GO:0048018)
0.1 2.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 2.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 1.0 GO:0036310 annealing helicase activity(GO:0036310)
0.1 8.0 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 2.5 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 6.1 GO:0004601 peroxidase activity(GO:0004601)
0.1 1.3 GO:0005243 gap junction channel activity(GO:0005243)
0.1 4.5 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 1.0 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.1 0.6 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.1 2.5 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 0.4 GO:0031781 melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.1 2.1 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 2.0 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 9.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 3.3 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 2.4 GO:0042605 peptide antigen binding(GO:0042605)
0.1 7.4 GO:0005179 hormone activity(GO:0005179)
0.1 2.4 GO:0003785 actin monomer binding(GO:0003785)
0.1 2.2 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 2.2 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 0.4 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.1 3.0 GO:0002039 p53 binding(GO:0002039)
0.0 1.7 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.9 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 2.3 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 5.1 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.2 GO:0017040 ceramidase activity(GO:0017040)
0.0 2.9 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 1.8 GO:0050681 androgen receptor binding(GO:0050681)
0.0 0.3 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.0 1.6 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 1.3 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 1.8 GO:0001618 virus receptor activity(GO:0001618)
0.0 8.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 1.5 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 10.5 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 2.5 GO:0005178 integrin binding(GO:0005178)
0.0 0.9 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 2.8 GO:0061659 ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 4.0 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.0 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.0 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.0 0.7 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 82.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.4 10.2 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.4 18.6 ST GAQ PATHWAY G alpha q Pathway
0.3 10.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.3 6.5 PID SHP2 PATHWAY SHP2 signaling
0.3 4.3 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.3 28.5 PID ATF2 PATHWAY ATF-2 transcription factor network
0.3 4.6 PID S1P S1P4 PATHWAY S1P4 pathway
0.2 7.9 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.2 12.8 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.2 1.3 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.2 6.3 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.2 9.3 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 9.3 PID ENDOTHELIN PATHWAY Endothelins
0.1 5.2 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.1 6.7 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 35.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 11.2 PID LKB1 PATHWAY LKB1 signaling events
0.1 29.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 7.1 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 2.8 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 6.5 PID BMP PATHWAY BMP receptor signaling
0.1 1.7 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.1 1.7 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 6.2 PID P53 REGULATION PATHWAY p53 pathway
0.1 1.9 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 6.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 1.8 PID AP1 PATHWAY AP-1 transcription factor network
0.1 2.2 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.1 1.9 PID IL27 PATHWAY IL27-mediated signaling events
0.1 2.6 PID RHOA PATHWAY RhoA signaling pathway
0.0 1.0 PID ARF 3PATHWAY Arf1 pathway
0.0 2.8 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.8 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.2 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 2.9 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.3 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.6 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 12.3 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 3.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 85.2 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
1.2 18.4 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.9 5.1 REACTOME SHC MEDIATED SIGNALLING Genes involved in SHC-mediated signalling
0.7 14.9 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.6 8.3 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.6 5.3 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.6 4.7 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.6 6.7 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.5 10.6 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.4 15.0 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.4 4.9 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.3 10.2 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.3 5.9 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.3 5.8 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.3 8.2 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 4.5 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.3 6.1 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.3 1.6 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.2 1.2 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.2 2.9 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.2 10.4 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.2 4.4 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.2 12.8 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.2 6.5 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.2 3.4 REACTOME LIPOPROTEIN METABOLISM Genes involved in Lipoprotein metabolism
0.2 1.8 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.2 4.7 REACTOME AMYLOIDS Genes involved in Amyloids
0.2 4.4 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.2 9.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.2 7.7 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.2 12.2 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.2 6.4 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 3.5 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 4.6 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1 3.8 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 2.4 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 1.7 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 2.2 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 4.4 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.1 15.1 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.3 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 2.8 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 3.2 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.1 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.1 1.7 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 0.7 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 0.6 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.9 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 2.4 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 1.8 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 3.4 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 1.2 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 3.2 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 2.9 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.8 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.8 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 2.2 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 2.3 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.7 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 1.6 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.0 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism