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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for NR2E3
Z-value: 0.25
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Transcription factors associated with NR2E3
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_60337684 Show fit | 45.14 |
ENST00000267484.5
|
reticulon 1 |
|
| chr3_-_195310802 Show fit | 32.50 |
ENST00000421243.1
ENST00000453131.1 |
apolipoprotein D |
|
| chr5_-_138210977 Show fit | 27.78 |
ENST00000274711.6
ENST00000521094.2 |
leucine rich repeat transmembrane neuronal 2 |
|
| chrX_-_13835147 Show fit | 25.83 |
ENST00000493677.1
ENST00000355135.2 |
glycoprotein M6B |
|
| chr12_+_79258444 Show fit | 25.44 |
ENST00000261205.4
|
synaptotagmin I |
|
| chr22_+_41865109 Show fit | 25.10 |
ENST00000216254.4
ENST00000396512.3 |
aconitase 2, mitochondrial |
|
| chr2_-_175712270 Show fit | 24.70 |
ENST00000295497.7
ENST00000444394.1 |
chimerin 1 |
|
| chr9_-_93405352 Show fit | 24.54 |
ENST00000375765.3
|
DIRAS family, GTP-binding RAS-like 2 |
|
| chr3_-_58563094 Show fit | 23.95 |
ENST00000464064.1
|
family with sequence similarity 107, member A |
|
| chr12_+_79258547 Show fit | 22.53 |
ENST00000457153.2
|
synaptotagmin I |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR2E3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 16.0 | 48.0 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 7.5 | 44.9 | GO:0070315 | G1 to G0 transition involved in cell differentiation(GO:0070315) |
| 10.8 | 32.5 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 2.3 | 27.8 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) |
| 3.3 | 26.6 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 2.6 | 25.8 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 5.0 | 25.1 | GO:0035900 | response to isolation stress(GO:0035900) |
| 0.7 | 24.7 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 1.6 | 24.4 | GO:0015671 | oxygen transport(GO:0015671) |
| 7.9 | 23.8 | GO:1904395 | retinal rod cell differentiation(GO:0060221) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 56.7 | GO:0030315 | T-tubule(GO:0030315) |
| 0.2 | 51.4 | GO:0060076 | excitatory synapse(GO:0060076) |
| 9.6 | 48.0 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.3 | 45.7 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.5 | 43.0 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.1 | 27.8 | GO:0031252 | cell leading edge(GO:0031252) |
| 0.1 | 27.7 | GO:0043209 | myelin sheath(GO:0043209) |
| 2.7 | 26.6 | GO:0045180 | basal cortex(GO:0045180) |
| 0.1 | 23.0 | GO:0022626 | cytosolic ribosome(GO:0022626) |
| 1.6 | 22.6 | GO:0005833 | hemoglobin complex(GO:0005833) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.6 | 48.0 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 3.2 | 44.9 | GO:0031432 | titin binding(GO:0031432) |
| 0.6 | 31.3 | GO:0015485 | cholesterol binding(GO:0015485) |
| 2.0 | 27.8 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 1.1 | 27.5 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 8.4 | 25.1 | GO:0051538 | 3 iron, 4 sulfur cluster binding(GO:0051538) |
| 0.4 | 24.8 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 1.9 | 24.4 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 6.0 | 23.8 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
| 0.5 | 23.7 | GO:0046875 | ephrin receptor binding(GO:0046875) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 59.3 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.8 | 33.8 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.4 | 30.6 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.8 | 23.8 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.5 | 17.8 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.3 | 14.6 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.3 | 14.1 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.2 | 11.0 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.2 | 10.5 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.2 | 10.5 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 48.0 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.2 | 41.0 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 1.2 | 28.6 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.5 | 21.7 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.6 | 18.2 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.6 | 16.2 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.7 | 14.6 | REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.4 | 14.6 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.6 | 14.1 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.1 | 13.1 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |