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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for NR2E3

Z-value: 0.25

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Transcription factors associated with NR2E3

Gene Symbol Gene ID Gene Info
NR2E3
ENSG00000031544.10 nuclear receptor subfamily 2 group E member 3

Activity profile of NR2E3 motif

Sorted Z-values of NR2E3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_60337684 45.14 ENST00000267484.5
RTN1
reticulon 1
chr3_-_195310802 32.50 ENST00000421243.1
ENST00000453131.1
APOD
apolipoprotein D
chr5_-_138210977 27.78 ENST00000274711.6
ENST00000521094.2
LRRTM2
leucine rich repeat transmembrane neuronal 2
chrX_-_13835147 25.83 ENST00000493677.1
ENST00000355135.2
GPM6B
glycoprotein M6B
chr12_+_79258444 25.44 ENST00000261205.4
SYT1
synaptotagmin I
chr22_+_41865109 25.10 ENST00000216254.4
ENST00000396512.3
ACO2
aconitase 2, mitochondrial
chr2_-_175712270 24.70 ENST00000295497.7
ENST00000444394.1
CHN1
chimerin 1
chr9_-_93405352 24.54 ENST00000375765.3
DIRAS2
DIRAS family, GTP-binding RAS-like 2
chr3_-_58563094 23.95 ENST00000464064.1
FAM107A
family with sequence similarity 107, member A
chr12_+_79258547 22.53 ENST00000457153.2
SYT1
synaptotagmin I
chr4_+_88896819 21.88 ENST00000237623.7
ENST00000395080.3
ENST00000508233.1
ENST00000360804.4
SPP1
secreted phosphoprotein 1
chr16_+_222846 20.00 ENST00000251595.6
ENST00000397806.1
HBA2
hemoglobin, alpha 2
chr12_-_45269430 15.71 ENST00000395487.2
NELL2
NEL-like 2 (chicken)
chr1_+_65775204 15.69 ENST00000371069.4
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr11_-_5271122 13.29 ENST00000330597.3
HBG1
hemoglobin, gamma A
chr16_+_2039946 12.62 ENST00000248121.2
ENST00000568896.1
SYNGR3
synaptogyrin 3
chr15_+_42696954 12.02 ENST00000337571.4
ENST00000569136.1
CAPN3
calpain 3, (p94)
chr7_-_137028534 11.92 ENST00000348225.2
PTN
pleiotrophin
chr7_-_137028498 11.90 ENST00000393083.2
PTN
pleiotrophin
chr15_+_42697018 11.70 ENST00000397204.4
CAPN3
calpain 3, (p94)
chr15_+_42696992 11.70 ENST00000561817.1
CAPN3
calpain 3, (p94)
chr13_-_45010939 11.57 ENST00000261489.2
TSC22D1
TSC22 domain family, member 1
chr1_+_10271674 11.31 ENST00000377086.1
KIF1B
kinesin family member 1B
chr4_-_87374283 11.30 ENST00000361569.2
MAPK10
mitogen-activated protein kinase 10
chr4_+_71587669 10.90 ENST00000381006.3
ENST00000226328.4
RUFY3
RUN and FYVE domain containing 3
chr3_-_33700933 10.88 ENST00000480013.1
CLASP2
cytoplasmic linker associated protein 2
chr5_+_140868717 10.82 ENST00000252087.1
PCDHGC5
protocadherin gamma subfamily C, 5
chr2_-_216257849 10.68 ENST00000456923.1
FN1
fibronectin 1
chr5_-_11589131 10.55 ENST00000511377.1
CTNND2
catenin (cadherin-associated protein), delta 2
chr3_-_33686743 10.20 ENST00000333778.6
ENST00000539981.1
CLASP2
cytoplasmic linker associated protein 2
chr3_+_69915385 10.00 ENST00000314589.5
MITF
microphthalmia-associated transcription factor
chr14_+_101297740 9.91 ENST00000555928.1
MEG3
maternally expressed 3 (non-protein coding)
chr8_-_22089533 9.84 ENST00000321613.3
PHYHIP
phytanoyl-CoA 2-hydroxylase interacting protein
chr8_-_22089845 9.75 ENST00000454243.2
PHYHIP
phytanoyl-CoA 2-hydroxylase interacting protein
chr2_-_224467093 9.64 ENST00000305409.2
SCG2
secretogranin II
chr9_-_116102530 9.56 ENST00000374195.3
ENST00000341761.4
WDR31
WD repeat domain 31
chr15_+_42697065 9.44 ENST00000565559.1
CAPN3
calpain 3, (p94)
chr1_-_153599426 9.40 ENST00000392622.1
S100A13
S100 calcium binding protein A13
chr6_+_69942298 9.35 ENST00000238918.8
BAI3
brain-specific angiogenesis inhibitor 3
chr1_-_144995074 9.34 ENST00000534536.1
PDE4DIP
phosphodiesterase 4D interacting protein
chr11_-_5276008 9.33 ENST00000336906.4
HBG2
hemoglobin, gamma G
chr5_+_140734570 9.13 ENST00000571252.1
PCDHGA4
protocadherin gamma subfamily A, 4
chr9_-_116102562 9.11 ENST00000374193.4
ENST00000465979.1
WDR31
WD repeat domain 31
chr19_+_33182823 8.72 ENST00000397061.3
NUDT19
nudix (nucleoside diphosphate linked moiety X)-type motif 19
chr1_-_153599732 8.71 ENST00000392623.1
S100A13
S100 calcium binding protein A13
chr18_-_5544241 8.43 ENST00000341928.2
ENST00000540638.2
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr16_-_66785497 8.27 ENST00000440564.2
ENST00000379482.2
ENST00000443351.2
ENST00000566150.1
DYNC1LI2
dynein, cytoplasmic 1, light intermediate chain 2
chr2_+_187454749 8.18 ENST00000261023.3
ENST00000374907.3
ITGAV
integrin, alpha V
chr2_+_166095898 7.83 ENST00000424833.1
ENST00000375437.2
ENST00000357398.3
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr21_-_27542972 7.81 ENST00000346798.3
ENST00000439274.2
ENST00000354192.3
ENST00000348990.5
ENST00000357903.3
ENST00000358918.3
ENST00000359726.3
APP
amyloid beta (A4) precursor protein
chr10_-_93392811 7.64 ENST00000238994.5
PPP1R3C
protein phosphatase 1, regulatory subunit 3C
chr1_-_95391315 7.59 ENST00000545882.1
ENST00000415017.1
CNN3
calponin 3, acidic
chr14_+_78870030 7.44 ENST00000553631.1
ENST00000554719.1
NRXN3
neurexin 3
chr7_-_130080818 7.23 ENST00000343969.5
ENST00000541543.1
ENST00000489512.1
CEP41
centrosomal protein 41kDa
chr7_-_79082867 7.12 ENST00000419488.1
ENST00000354212.4
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr19_-_13617037 7.11 ENST00000360228.5
CACNA1A
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
chr16_+_7382745 7.00 ENST00000436368.2
ENST00000311745.5
ENST00000355637.4
ENST00000340209.4
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr17_+_12692774 6.96 ENST00000379672.5
ENST00000340825.3
ARHGAP44
Rho GTPase activating protein 44
chr1_+_87797351 6.86 ENST00000370542.1
LMO4
LIM domain only 4
chr15_-_83240507 6.71 ENST00000564522.1
ENST00000398592.2
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr21_+_40752170 6.64 ENST00000333781.5
ENST00000541890.1
WRB
tryptophan rich basic protein
chr1_+_89829610 6.64 ENST00000370456.4
ENST00000535065.1
GBP6
guanylate binding protein family, member 6
chr5_+_161274940 6.60 ENST00000393943.4
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr4_+_128554081 6.57 ENST00000335251.6
ENST00000296461.5
INTU
inturned planar cell polarity protein
chr1_+_22979676 6.51 ENST00000432749.2
ENST00000314933.6
C1QB
complement component 1, q subcomponent, B chain
chr15_-_83240553 6.34 ENST00000423133.2
ENST00000398591.2
CPEB1
cytoplasmic polyadenylation element binding protein 1
chrX_+_102883887 6.29 ENST00000372625.3
ENST00000372624.3
TCEAL1
transcription elongation factor A (SII)-like 1
chr21_-_27543425 6.29 ENST00000448388.2
APP
amyloid beta (A4) precursor protein
chr15_+_43803143 6.26 ENST00000382031.1
MAP1A
microtubule-associated protein 1A
chr12_+_48516357 6.16 ENST00000549022.1
ENST00000547587.1
ENST00000312352.7
PFKM
phosphofructokinase, muscle
chrX_-_48858667 6.16 ENST00000376423.4
ENST00000376441.1
GRIPAP1
GRIP1 associated protein 1
chr8_-_67341208 6.12 ENST00000499642.1
RP11-346I3.4
RP11-346I3.4
chr5_+_161274685 6.10 ENST00000428797.2
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr1_-_144995002 5.90 ENST00000369356.4
PDE4DIP
phosphodiesterase 4D interacting protein
chr7_+_29519486 5.87 ENST00000409041.4
CHN2
chimerin 2
chrM_+_12331 5.66 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH dehydrogenase 5
chr12_+_20848486 5.66 ENST00000545102.1
SLCO1C1
solute carrier organic anion transporter family, member 1C1
chr4_-_153332886 5.66 ENST00000603841.1
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr1_+_28099683 5.66 ENST00000373943.4
STX12
syntaxin 12
chr3_-_33700589 5.55 ENST00000461133.3
ENST00000496954.2
CLASP2
cytoplasmic linker associated protein 2
chr5_+_161275320 5.52 ENST00000437025.2
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr12_-_91539918 5.50 ENST00000548218.1
DCN
decorin
chr11_-_71639670 5.40 ENST00000533047.1
ENST00000529844.1
RP11-849H4.2
Putative short transient receptor potential channel 2-like protein
chr12_+_53443963 5.34 ENST00000546602.1
ENST00000552570.1
ENST00000549700.1
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr12_+_53773944 5.32 ENST00000551969.1
ENST00000327443.4
SP1
Sp1 transcription factor
chr9_+_72002837 5.26 ENST00000377216.3
FAM189A2
family with sequence similarity 189, member A2
chr4_+_114214125 5.23 ENST00000509550.1
ANK2
ankyrin 2, neuronal
chr12_+_56477093 5.20 ENST00000549672.1
ENST00000415288.2
ERBB3
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
chr3_-_185826855 5.12 ENST00000306376.5
ETV5
ets variant 5
chr11_-_71639480 5.04 ENST00000529513.1
RP11-849H4.2
Putative short transient receptor potential channel 2-like protein
chr1_+_84630053 5.01 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr8_+_125954281 4.98 ENST00000510897.2
ENST00000533286.1
LINC00964
long intergenic non-protein coding RNA 964
chr2_-_50201327 4.96 ENST00000412315.1
NRXN1
neurexin 1
chr12_+_20848282 4.93 ENST00000545604.1
SLCO1C1
solute carrier organic anion transporter family, member 1C1
chr2_+_173600565 4.88 ENST00000397081.3
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr2_+_173600514 4.81 ENST00000264111.6
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr12_-_71182695 4.80 ENST00000342084.4
PTPRR
protein tyrosine phosphatase, receptor type, R
chr19_+_47759716 4.73 ENST00000221922.6
CCDC9
coiled-coil domain containing 9
chr5_+_140718396 4.72 ENST00000394576.2
PCDHGA2
protocadherin gamma subfamily A, 2
chr13_-_48575443 4.71 ENST00000378654.3
SUCLA2
succinate-CoA ligase, ADP-forming, beta subunit
chr7_-_100860851 4.68 ENST00000223127.3
PLOD3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr17_+_57232690 4.68 ENST00000262293.4
PRR11
proline rich 11
chr2_+_173686303 4.63 ENST00000397087.3
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr1_+_164528866 4.63 ENST00000420696.2
PBX1
pre-B-cell leukemia homeobox 1
chr1_+_233765353 4.61 ENST00000366620.1
KCNK1
potassium channel, subfamily K, member 1
chr5_+_137774706 4.58 ENST00000378339.2
ENST00000254901.5
ENST00000506158.1
REEP2
receptor accessory protein 2
chr19_-_11669960 4.53 ENST00000589171.1
ENST00000590700.1
ENST00000586683.1
ENST00000593077.1
ENST00000252445.3
ELOF1
elongation factor 1 homolog (S. cerevisiae)
chr2_+_172543919 4.50 ENST00000452242.1
ENST00000340296.4
DYNC1I2
dynein, cytoplasmic 1, intermediate chain 2
chr2_-_145277640 4.39 ENST00000539609.3
ZEB2
zinc finger E-box binding homeobox 2
chr17_+_39845134 4.36 ENST00000591776.1
ENST00000469257.1
EIF1
eukaryotic translation initiation factor 1
chr1_+_84630645 4.33 ENST00000394839.2
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr19_-_40596767 4.31 ENST00000599972.1
ENST00000450241.2
ENST00000595687.2
ZNF780A
zinc finger protein 780A
chr11_-_6426635 4.27 ENST00000608645.1
ENST00000608394.1
ENST00000529519.1
APBB1
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
chr3_-_73673991 4.27 ENST00000308537.4
ENST00000263666.4
PDZRN3
PDZ domain containing ring finger 3
chr12_+_20848377 4.25 ENST00000540354.1
ENST00000266509.2
ENST00000381552.1
SLCO1C1
solute carrier organic anion transporter family, member 1C1
chr11_+_88910620 4.13 ENST00000263321.5
TYR
tyrosinase
chr18_+_7754957 4.12 ENST00000400053.4
PTPRM
protein tyrosine phosphatase, receptor type, M
chr8_-_141810634 4.12 ENST00000521986.1
ENST00000523539.1
ENST00000538769.1
PTK2
protein tyrosine kinase 2
chr19_+_2977444 4.01 ENST00000246112.4
ENST00000453329.1
ENST00000482627.1
ENST00000452088.1
TLE6
transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)
chr19_-_36822595 3.99 ENST00000585356.1
ENST00000438368.2
ENST00000590622.1
LINC00665
long intergenic non-protein coding RNA 665
chr17_+_68165657 3.96 ENST00000243457.3
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chrX_-_148586804 3.92 ENST00000428056.2
ENST00000340855.6
ENST00000370441.4
ENST00000370443.4
IDS
iduronate 2-sulfatase
chr14_+_74004051 3.90 ENST00000557556.1
ACOT1
acyl-CoA thioesterase 1
chr3_+_186501336 3.90 ENST00000323963.5
ENST00000440191.2
ENST00000356531.5
EIF4A2
eukaryotic translation initiation factor 4A2
chr3_-_165555200 3.76 ENST00000479451.1
ENST00000540653.1
ENST00000488954.1
ENST00000264381.3
BCHE
butyrylcholinesterase
chr1_-_154150651 3.74 ENST00000302206.5
TPM3
tropomyosin 3
chr10_+_82168240 3.74 ENST00000372187.5
ENST00000372185.1
FAM213A
family with sequence similarity 213, member A
chr5_+_102201722 3.60 ENST00000274392.9
ENST00000455264.2
PAM
peptidylglycine alpha-amidating monooxygenase
chr4_-_186877806 3.56 ENST00000355634.5
SORBS2
sorbin and SH3 domain containing 2
chr3_-_129407535 3.56 ENST00000432054.2
TMCC1
transmembrane and coiled-coil domain family 1
chr11_+_65479702 3.55 ENST00000530446.1
ENST00000534104.1
ENST00000530605.1
ENST00000528198.1
ENST00000531880.1
ENST00000534650.1
KAT5
K(lysine) acetyltransferase 5
chr15_-_77197620 3.50 ENST00000565970.1
ENST00000563290.1
ENST00000565372.1
ENST00000564177.1
ENST00000568382.1
ENST00000563919.1
SCAPER
S-phase cyclin A-associated protein in the ER
chr3_-_149470229 3.41 ENST00000473414.1
COMMD2
COMM domain containing 2
chr1_+_22963158 3.39 ENST00000438241.1
C1QA
complement component 1, q subcomponent, A chain
chr18_-_53069419 3.36 ENST00000570177.2
TCF4
transcription factor 4
chr9_+_71939488 3.33 ENST00000455972.1
FAM189A2
family with sequence similarity 189, member A2
chr5_+_140710061 3.32 ENST00000517417.1
ENST00000378105.3
PCDHGA1
protocadherin gamma subfamily A, 1
chr15_+_73976715 3.32 ENST00000558689.1
ENST00000560786.2
ENST00000561213.1
ENST00000563584.1
ENST00000561416.1
CD276
CD276 molecule
chr6_-_91296737 3.31 ENST00000369332.3
ENST00000369329.3
MAP3K7
mitogen-activated protein kinase kinase kinase 7
chr4_+_100737954 3.31 ENST00000296414.7
ENST00000512369.1
DAPP1
dual adaptor of phosphotyrosine and 3-phosphoinositides
chr2_+_130737223 3.31 ENST00000410061.2
RAB6C
RAB6C, member RAS oncogene family
chr13_-_53422640 3.25 ENST00000338862.4
ENST00000377942.3
PCDH8
protocadherin 8
chr2_-_145277569 3.25 ENST00000303660.4
ZEB2
zinc finger E-box binding homeobox 2
chr1_+_24742264 3.24 ENST00000374399.4
ENST00000003912.3
ENST00000358028.4
ENST00000339255.2
NIPAL3
NIPA-like domain containing 3
chr6_+_22146851 3.21 ENST00000606197.1
CASC15
cancer susceptibility candidate 15 (non-protein coding)
chr9_+_71944241 3.16 ENST00000257515.8
FAM189A2
family with sequence similarity 189, member A2
chr5_+_102201509 3.14 ENST00000348126.2
ENST00000379787.4
PAM
peptidylglycine alpha-amidating monooxygenase
chr16_-_75569068 3.11 ENST00000336257.3
ENST00000565039.1
CHST5
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
chr12_+_122064398 3.09 ENST00000330079.7
ORAI1
ORAI calcium release-activated calcium modulator 1
chrX_+_65384052 3.05 ENST00000336279.5
ENST00000458621.1
HEPH
hephaestin
chr5_+_102201687 3.04 ENST00000304400.7
PAM
peptidylglycine alpha-amidating monooxygenase
chr17_-_41977964 3.04 ENST00000377184.3
MPP2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
chr20_-_9819674 2.96 ENST00000378429.3
PAK7
p21 protein (Cdc42/Rac)-activated kinase 7
chr13_+_98086445 2.89 ENST00000245304.4
RAP2A
RAP2A, member of RAS oncogene family
chr7_+_110731062 2.88 ENST00000308478.5
ENST00000451085.1
ENST00000422987.3
ENST00000421101.1
LRRN3
leucine rich repeat neuronal 3
chr19_-_54693521 2.84 ENST00000391754.1
ENST00000245615.1
ENST00000431666.2
MBOAT7
membrane bound O-acyltransferase domain containing 7
chr18_-_52989217 2.82 ENST00000570287.2
TCF4
transcription factor 4
chr11_-_108408895 2.81 ENST00000443411.1
ENST00000533052.1
EXPH5
exophilin 5
chr4_+_71588372 2.80 ENST00000536664.1
RUFY3
RUN and FYVE domain containing 3
chrX_-_10588595 2.74 ENST00000423614.1
ENST00000317552.4
MID1
midline 1 (Opitz/BBB syndrome)
chr12_-_25150373 2.73 ENST00000549828.1
C12orf77
chromosome 12 open reading frame 77
chrX_+_54835493 2.73 ENST00000396224.1
MAGED2
melanoma antigen family D, 2
chr13_-_103053946 2.73 ENST00000376131.4
FGF14
fibroblast growth factor 14
chr12_+_58138800 2.70 ENST00000547992.1
ENST00000552816.1
ENST00000547472.1
TSPAN31
tetraspanin 31
chr2_+_171036635 2.69 ENST00000484338.2
ENST00000334231.6
MYO3B
myosin IIIB
chr21_-_30257669 2.65 ENST00000303775.5
ENST00000351429.3
N6AMT1
N-6 adenine-specific DNA methyltransferase 1 (putative)
chrX_-_10588459 2.62 ENST00000380782.2
MID1
midline 1 (Opitz/BBB syndrome)
chr8_+_54764346 2.57 ENST00000297313.3
ENST00000344277.6
RGS20
regulator of G-protein signaling 20
chr15_+_75639296 2.56 ENST00000564500.1
ENST00000355059.4
ENST00000566752.1
NEIL1
nei endonuclease VIII-like 1 (E. coli)
chr14_+_74035763 2.48 ENST00000238651.5
ACOT2
acyl-CoA thioesterase 2
chr13_-_48575401 2.48 ENST00000433022.1
ENST00000544100.1
SUCLA2
succinate-CoA ligase, ADP-forming, beta subunit
chr19_+_41509851 2.48 ENST00000593831.1
ENST00000330446.5
CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chrX_+_65384182 2.48 ENST00000441993.2
ENST00000419594.1
HEPH
hephaestin
chr6_-_28220002 2.47 ENST00000377294.2
ZKSCAN4
zinc finger with KRAB and SCAN domains 4
chr19_-_12886327 2.44 ENST00000397668.3
ENST00000587178.1
ENST00000264827.5
HOOK2
hook microtubule-tethering protein 2
chr7_+_90338712 2.43 ENST00000265741.3
ENST00000406263.1
CDK14
cyclin-dependent kinase 14
chr8_+_132952112 2.42 ENST00000520362.1
ENST00000519656.1
EFR3A
EFR3 homolog A (S. cerevisiae)
chr6_+_45296391 2.41 ENST00000371436.6
ENST00000576263.1
RUNX2
runt-related transcription factor 2
chr3_+_181429704 2.41 ENST00000431565.2
ENST00000325404.1
SOX2
SRY (sex determining region Y)-box 2
chr9_-_90589402 2.36 ENST00000375871.4
ENST00000605159.1
ENST00000336654.5
CDK20
cyclin-dependent kinase 20
chr10_-_45474237 2.35 ENST00000448778.1
ENST00000298295.3
C10orf10
chromosome 10 open reading frame 10
chr7_+_92158083 2.32 ENST00000265732.5
ENST00000481551.1
ENST00000496410.1
RBM48
RNA binding motif protein 48
chr1_-_193155729 2.32 ENST00000367434.4
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr15_+_79165222 2.28 ENST00000559930.1
MORF4L1
mortality factor 4 like 1
chrX_+_107683096 2.28 ENST00000328300.6
ENST00000361603.2
COL4A5
collagen, type IV, alpha 5
chr9_-_14180778 2.27 ENST00000380924.1
ENST00000543693.1
NFIB
nuclear factor I/B
chr16_+_66878282 2.25 ENST00000338437.2
CA7
carbonic anhydrase VII
chr5_+_102455853 2.24 ENST00000515845.1
ENST00000321521.9
ENST00000507921.1
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr8_+_67579807 2.20 ENST00000519289.1
ENST00000519561.1
ENST00000521889.1
C8orf44-SGK3
C8orf44
C8orf44-SGK3 readthrough
chromosome 8 open reading frame 44
chr4_-_130692631 2.20 ENST00000500092.2
ENST00000509105.1
RP11-519M16.1
RP11-519M16.1
chr8_+_38677850 2.18 ENST00000518809.1
ENST00000520611.1
TACC1
transforming, acidic coiled-coil containing protein 1
chr1_+_203595689 2.12 ENST00000357681.5
ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr5_+_102201430 2.12 ENST00000438793.3
ENST00000346918.2
PAM
peptidylglycine alpha-amidating monooxygenase
chr2_+_237994519 2.07 ENST00000392008.2
ENST00000409334.1
ENST00000409629.1
COPS8
COP9 signalosome subunit 8
chr17_-_76870126 2.05 ENST00000586057.1
TIMP2
TIMP metallopeptidase inhibitor 2
chr12_+_81110684 2.04 ENST00000228644.3
MYF5
myogenic factor 5
chr12_+_32655048 2.04 ENST00000427716.2
ENST00000266482.3
FGD4
FYVE, RhoGEF and PH domain containing 4
chr14_+_74003818 2.02 ENST00000311148.4
ACOT1
acyl-CoA thioesterase 1
chr8_+_9953061 1.99 ENST00000522907.1
ENST00000528246.1
MSRA
methionine sulfoxide reductase A
chrX_+_103810874 1.97 ENST00000372582.1
IL1RAPL2
interleukin 1 receptor accessory protein-like 2

Network of associatons between targets according to the STRING database.

First level regulatory network of NR2E3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
16.0 48.0 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
10.8 32.5 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
7.9 23.8 GO:1904395 retinal rod cell differentiation(GO:0060221) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
7.5 44.9 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
7.3 21.9 GO:2000864 estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
5.0 25.1 GO:0035900 response to isolation stress(GO:0035900)
3.8 11.3 GO:1904647 response to rotenone(GO:1904647)
3.6 10.7 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
3.3 26.6 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
3.0 11.9 GO:0001519 peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179)
2.8 14.1 GO:0071874 cellular response to norepinephrine stimulus(GO:0071874)
2.6 25.8 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
2.3 9.3 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
2.3 27.8 GO:0002091 negative regulation of receptor internalization(GO:0002091)
2.1 6.2 GO:0093001 glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001)
2.0 8.2 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
1.9 9.3 GO:0097338 response to clozapine(GO:0097338)
1.8 7.2 GO:0006780 uroporphyrinogen III biosynthetic process(GO:0006780) uroporphyrinogen III metabolic process(GO:0046502)
1.7 15.7 GO:0016191 synaptic vesicle uncoating(GO:0016191)
1.7 5.2 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
1.6 13.0 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
1.6 24.4 GO:0015671 oxygen transport(GO:0015671)
1.6 4.7 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
1.5 4.6 GO:0050916 sensory perception of sweet taste(GO:0050916)
1.4 4.3 GO:0050760 negative regulation of thymidylate synthase biosynthetic process(GO:0050760)
1.4 7.1 GO:1901631 planar cell polarity pathway involved in axis elongation(GO:0003402) positive regulation of presynaptic membrane organization(GO:1901631) positive regulation of synaptic vesicle clustering(GO:2000809)
1.4 11.3 GO:0007258 JUN phosphorylation(GO:0007258)
1.4 15.2 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
1.3 3.8 GO:0014016 neuroblast differentiation(GO:0014016)
1.2 6.2 GO:1905244 regulation of modification of synaptic structure(GO:1905244)
1.2 7.2 GO:0018095 protein polyglutamylation(GO:0018095)
1.2 8.4 GO:0002175 protein localization to paranode region of axon(GO:0002175)
1.2 3.6 GO:1903249 regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204) negative regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901205) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283)
1.1 5.7 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
1.1 15.7 GO:0070050 neuron cellular homeostasis(GO:0070050)
1.1 6.6 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
1.1 14.1 GO:0070327 thyroid hormone transport(GO:0070327)
1.1 8.6 GO:0060075 regulation of resting membrane potential(GO:0060075)
1.0 4.1 GO:0043474 eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
1.0 5.1 GO:0098728 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
1.0 7.0 GO:0099563 negative regulation of Rac protein signal transduction(GO:0035021) modification of synaptic structure(GO:0099563)
0.9 18.2 GO:0071420 cellular response to histamine(GO:0071420)
0.9 5.3 GO:1900239 phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239)
0.9 6.9 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.8 4.8 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.8 2.3 GO:0060151 peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152)
0.7 0.7 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.7 9.6 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.7 12.4 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.7 24.7 GO:0008045 motor neuron axon guidance(GO:0008045)
0.7 4.0 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.6 1.9 GO:0019474 L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
0.6 5.5 GO:0051964 netrin-activated signaling pathway(GO:0038007) negative regulation of synapse assembly(GO:0051964)
0.6 7.8 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.6 3.4 GO:0016554 cytidine to uridine editing(GO:0016554)
0.5 1.6 GO:0008050 female courtship behavior(GO:0008050) positive regulation of female receptivity(GO:0045925)
0.5 1.6 GO:1902997 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
0.5 2.0 GO:0072166 posterior mesonephric tubule development(GO:0072166) negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302)
0.5 5.4 GO:0035372 protein localization to microtubule(GO:0035372)
0.5 1.9 GO:0060084 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) synaptic transmission involved in micturition(GO:0060084)
0.5 3.2 GO:0015693 magnesium ion transport(GO:0015693)
0.5 5.5 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.5 1.8 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.4 2.2 GO:0032849 positive regulation of cellular pH reduction(GO:0032849)
0.4 3.6 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.4 3.5 GO:0002051 osteoblast fate commitment(GO:0002051)
0.4 6.6 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.4 4.4 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.4 1.7 GO:0045872 positive regulation of rhodopsin gene expression(GO:0045872)
0.4 0.4 GO:0050917 sensory perception of umami taste(GO:0050917)
0.4 1.7 GO:0003095 pressure natriuresis(GO:0003095)
0.4 2.1 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.4 4.5 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.4 2.4 GO:0001714 endodermal cell fate specification(GO:0001714)
0.4 3.5 GO:0030091 protein repair(GO:0030091)
0.4 2.7 GO:0070294 renal sodium ion absorption(GO:0070294)
0.4 2.7 GO:1903421 regulation of synaptic vesicle recycling(GO:1903421)
0.4 1.9 GO:0030070 insulin processing(GO:0030070)
0.4 3.8 GO:0032074 negative regulation of nuclease activity(GO:0032074)
0.4 4.5 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.4 2.9 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.4 11.6 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.3 3.1 GO:0006477 protein sulfation(GO:0006477)
0.3 4.4 GO:0021819 layer formation in cerebral cortex(GO:0021819)
0.3 1.3 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.3 7.6 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.3 2.3 GO:0021730 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.3 1.6 GO:0018125 peptidyl-cysteine methylation(GO:0018125) minus-end-directed organelle transport along microtubule(GO:0072385)
0.3 1.8 GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865)
0.3 2.4 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.3 2.3 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.3 0.9 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.3 3.1 GO:0002115 store-operated calcium entry(GO:0002115)
0.3 1.9 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.3 0.5 GO:0070054 mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054) mRNA endonucleolytic cleavage involved in unfolded protein response(GO:0070055)
0.3 8.3 GO:0051642 centrosome localization(GO:0051642)
0.2 8.4 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.2 0.9 GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.2 0.5 GO:0010767 regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage(GO:0010767)
0.2 0.7 GO:0051673 pore formation in membrane of other organism(GO:0035915) membrane disruption in other organism(GO:0051673)
0.2 0.6 GO:0098758 response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759)
0.2 5.5 GO:0006825 copper ion transport(GO:0006825)
0.2 10.5 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.2 3.3 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.2 0.8 GO:0007525 somatic muscle development(GO:0007525)
0.2 5.2 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.2 10.0 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.2 1.0 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.2 1.3 GO:0035799 ureter maturation(GO:0035799)
0.2 4.1 GO:0031290 retinal ganglion cell axon guidance(GO:0031290)
0.2 3.9 GO:0030207 chondroitin sulfate catabolic process(GO:0030207)
0.2 2.0 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.2 2.3 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.2 0.7 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.2 0.5 GO:1902723 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723)
0.2 3.9 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.2 0.5 GO:1903413 cellular response to bile acid(GO:1903413)
0.2 0.6 GO:0072180 mesonephric duct morphogenesis(GO:0072180)
0.2 12.9 GO:0032411 positive regulation of transporter activity(GO:0032411)
0.1 1.2 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.1 3.6 GO:0000729 DNA double-strand break processing(GO:0000729)
0.1 0.7 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.1 3.6 GO:0046710 GDP metabolic process(GO:0046710)
0.1 2.1 GO:0000338 protein deneddylation(GO:0000338)
0.1 0.9 GO:1903232 melanosome assembly(GO:1903232)
0.1 2.0 GO:0006020 inositol metabolic process(GO:0006020)
0.1 1.4 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.1 2.5 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 19.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 0.9 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.1 0.7 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.1 0.5 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 2.3 GO:0003334 keratinocyte development(GO:0003334)
0.1 0.7 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.1 0.9 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.1 0.9 GO:0046146 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.1 5.1 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.1 8.0 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.1 3.3 GO:0010824 regulation of centrosome duplication(GO:0010824)
0.1 2.8 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 1.8 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.1 3.9 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.1 1.4 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.1 3.4 GO:0010039 response to iron ion(GO:0010039)
0.1 1.1 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.1 1.1 GO:0034197 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1 0.3 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.1 3.9 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 6.1 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.1 3.2 GO:0007528 neuromuscular junction development(GO:0007528)
0.1 5.7 GO:0048278 vesicle docking(GO:0048278)
0.1 2.4 GO:0045022 early endosome to late endosome transport(GO:0045022)
0.1 0.4 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
0.1 0.4 GO:0010897 negative regulation of triglyceride catabolic process(GO:0010897) secretory granule localization(GO:0032252)
0.1 0.3 GO:1904845 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.1 0.4 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.1 0.6 GO:0008298 intracellular mRNA localization(GO:0008298)
0.1 0.1 GO:0050955 thermoception(GO:0050955) detection of chemical stimulus involved in sensory perception of pain(GO:0050968)
0.1 1.6 GO:0035428 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.1 0.7 GO:0017121 phospholipid scrambling(GO:0017121)
0.1 0.3 GO:1901096 regulation of autophagosome maturation(GO:1901096) positive regulation of autophagosome maturation(GO:1901098)
0.1 1.0 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 1.3 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 1.5 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.1 GO:0042713 sperm ejaculation(GO:0042713)
0.0 0.2 GO:0032053 ciliary basal body organization(GO:0032053) positive regulation of protein localization to cilium(GO:1903566)
0.0 0.3 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.0 0.6 GO:0070307 lens fiber cell development(GO:0070307)
0.0 9.3 GO:0043406 positive regulation of MAP kinase activity(GO:0043406)
0.0 1.4 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 4.0 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 1.5 GO:0060338 regulation of type I interferon-mediated signaling pathway(GO:0060338)
0.0 1.9 GO:0045214 sarcomere organization(GO:0045214)
0.0 1.4 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 0.3 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.0 4.8 GO:0071346 cellular response to interferon-gamma(GO:0071346)
0.0 0.2 GO:0045007 depurination(GO:0045007)
0.0 0.6 GO:0016048 detection of temperature stimulus(GO:0016048)
0.0 0.8 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.4 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.0 0.2 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.0 8.0 GO:0001558 regulation of cell growth(GO:0001558)
0.0 0.9 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.0 0.9 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.8 GO:0048813 dendrite morphogenesis(GO:0048813)
0.0 0.9 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.7 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 1.5 GO:0006633 fatty acid biosynthetic process(GO:0006633)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
9.6 48.0 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
2.7 8.2 GO:0034686 integrin alphav-beta6 complex(GO:0034685) integrin alphav-beta8 complex(GO:0034686)
2.7 26.6 GO:0045180 basal cortex(GO:0045180)
2.0 18.4 GO:1990812 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
2.0 9.9 GO:0005602 complement component C1 complex(GO:0005602)
1.6 22.6 GO:0005833 hemoglobin complex(GO:0005833)
1.2 6.2 GO:0005945 6-phosphofructokinase complex(GO:0005945)
1.2 6.2 GO:0098837 postsynaptic recycling endosome(GO:0098837)
1.1 3.4 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
1.0 16.3 GO:0033270 paranode region of axon(GO:0033270)
0.9 4.6 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.9 7.1 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.9 3.6 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.8 10.7 GO:0005577 fibrinogen complex(GO:0005577)
0.8 5.7 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.8 9.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.8 13.0 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.7 56.7 GO:0030315 T-tubule(GO:0030315)
0.7 2.0 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.6 2.4 GO:0070695 FHF complex(GO:0070695)
0.6 9.6 GO:0031045 dense core granule(GO:0031045)
0.5 13.7 GO:0071437 invadopodium(GO:0071437)
0.5 43.0 GO:0031594 neuromuscular junction(GO:0031594)
0.5 5.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.5 16.0 GO:1902711 GABA-A receptor complex(GO:1902711)
0.4 16.2 GO:0042629 mast cell granule(GO:0042629)
0.4 12.6 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.4 5.5 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.3 5.7 GO:0031083 BLOC-1 complex(GO:0031083)
0.3 45.7 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.3 11.3 GO:1904115 axon cytoplasm(GO:1904115)
0.3 1.6 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.3 3.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.2 4.7 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.2 3.7 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.2 0.9 GO:0031905 early endosome lumen(GO:0031905)
0.2 2.3 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.2 22.2 GO:0043204 perikaryon(GO:0043204)
0.2 0.9 GO:0071012 catalytic step 1 spliceosome(GO:0071012)
0.2 1.2 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
0.2 51.4 GO:0060076 excitatory synapse(GO:0060076)
0.1 1.8 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 1.9 GO:0097060 synaptic membrane(GO:0097060)
0.1 3.0 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 0.9 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 23.0 GO:0022626 cytosolic ribosome(GO:0022626)
0.1 27.7 GO:0043209 myelin sheath(GO:0043209)
0.1 7.1 GO:0042734 presynaptic membrane(GO:0042734)
0.1 2.8 GO:0016580 Sin3 complex(GO:0016580)
0.1 4.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 0.8 GO:0016013 syntrophin complex(GO:0016013)
0.1 0.5 GO:0005594 collagen type IX trimer(GO:0005594)
0.1 1.9 GO:0031143 pseudopodium(GO:0031143)
0.1 5.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 1.6 GO:0097228 sperm principal piece(GO:0097228)
0.1 3.1 GO:0031228 intrinsic component of Golgi membrane(GO:0031228)
0.1 4.5 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 0.3 GO:0030430 host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655)
0.1 7.4 GO:0005814 centriole(GO:0005814)
0.1 27.8 GO:0031252 cell leading edge(GO:0031252)
0.1 3.3 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 4.1 GO:0005798 Golgi-associated vesicle(GO:0005798)
0.1 2.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 2.9 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 1.6 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 5.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 0.4 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 5.8 GO:0005875 microtubule associated complex(GO:0005875)
0.0 1.6 GO:0008180 COP9 signalosome(GO:0008180)
0.0 10.6 GO:0045121 membrane raft(GO:0045121)
0.0 7.1 GO:0030016 myofibril(GO:0030016)
0.0 22.2 GO:0043005 neuron projection(GO:0043005)
0.0 0.4 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 4.0 GO:0043202 lysosomal lumen(GO:0043202)
0.0 2.7 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.5 GO:0005771 multivesicular body(GO:0005771)
0.0 2.3 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.1 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 1.3 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)
0.0 0.3 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.9 GO:0031904 endosome lumen(GO:0031904)
0.0 0.9 GO:0031526 brush border membrane(GO:0031526)
0.0 1.3 GO:0098793 presynapse(GO:0098793)
0.0 0.7 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 2.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
9.6 48.0 GO:0030348 syntaxin-3 binding(GO:0030348)
8.4 25.1 GO:0051538 3 iron, 4 sulfur cluster binding(GO:0051538)
6.0 23.8 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
3.2 44.9 GO:0031432 titin binding(GO:0031432)
3.0 11.9 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
2.4 7.2 GO:0004775 succinate-CoA ligase (ADP-forming) activity(GO:0004775)
2.4 7.1 GO:0070699 type II activin receptor binding(GO:0070699)
2.3 18.2 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
2.0 27.8 GO:0042043 neurexin family protein binding(GO:0042043)
1.9 11.3 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
1.9 24.4 GO:0005344 oxygen transporter activity(GO:0005344)
1.8 14.1 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
1.6 8.2 GO:1990430 extracellular matrix protein binding(GO:1990430)
1.6 4.7 GO:0033823 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823) procollagen galactosyltransferase activity(GO:0050211)
1.4 14.1 GO:0051425 PTB domain binding(GO:0051425)
1.4 4.1 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
1.2 3.6 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
1.1 27.5 GO:0002162 dystroglycan binding(GO:0002162)
1.1 17.1 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
1.0 6.2 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.9 3.8 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.8 13.0 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.8 12.4 GO:0097109 neuroligin family protein binding(GO:0097109)
0.8 2.3 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.8 6.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.7 15.0 GO:0050786 RAGE receptor binding(GO:0050786)
0.7 3.5 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.6 12.8 GO:0045504 dynein heavy chain binding(GO:0045504)
0.6 5.5 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.6 1.8 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.6 9.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.6 31.3 GO:0015485 cholesterol binding(GO:0015485)
0.6 4.4 GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)
0.5 1.5 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.5 6.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.5 23.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.4 1.3 GO:0008267 poly-glutamine tract binding(GO:0008267)
0.4 2.2 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.4 3.1 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.4 5.2 GO:0038132 neuregulin binding(GO:0038132)
0.4 1.7 GO:0018685 alkane 1-monooxygenase activity(GO:0018685)
0.4 18.1 GO:0042169 SH2 domain binding(GO:0042169)
0.4 2.0 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.4 24.8 GO:0050840 extracellular matrix binding(GO:0050840)
0.4 2.0 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.4 8.9 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.4 7.1 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.3 7.8 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.3 3.3 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.3 11.1 GO:1990939 ATP-dependent microtubule motor activity(GO:1990939)
0.3 9.6 GO:0042056 chemoattractant activity(GO:0042056)
0.3 7.6 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.3 4.3 GO:0048156 tau protein binding(GO:0048156)
0.2 11.1 GO:0030552 cAMP binding(GO:0030552)
0.2 3.8 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.2 1.0 GO:0008422 beta-glucosidase activity(GO:0008422)
0.2 0.9 GO:0035651 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.2 3.2 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.2 1.4 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.2 5.3 GO:0071837 HMG box domain binding(GO:0071837)
0.2 9.1 GO:0070888 E-box binding(GO:0070888)
0.2 3.9 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 0.6 GO:0019959 interleukin-8 binding(GO:0019959)
0.2 2.4 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.2 3.9 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.2 0.7 GO:0016841 ammonia-lyase activity(GO:0016841)
0.2 7.6 GO:0050699 WW domain binding(GO:0050699)
0.2 2.5 GO:0008391 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.2 7.1 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.2 1.6 GO:0070324 thyroid hormone binding(GO:0070324)
0.2 4.5 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.2 0.6 GO:0060422 peptidyl-dipeptidase inhibitor activity(GO:0060422)
0.2 3.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 0.7 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.1 3.3 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 2.4 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 0.4 GO:0000035 acyl binding(GO:0000035)
0.1 0.4 GO:0047223 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity(GO:0047223)
0.1 13.7 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 1.8 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 2.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 1.6 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.1 1.9 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 0.9 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.1 1.3 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.1 4.8 GO:0030507 spectrin binding(GO:0030507)
0.1 0.5 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 3.6 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 1.6 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.1 3.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 7.0 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 1.3 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.1 2.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.6 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 1.5 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 9.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 1.9 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.1 3.8 GO:0016504 peptidase activator activity(GO:0016504)
0.1 3.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 1.0 GO:0005132 type I interferon receptor binding(GO:0005132)
0.1 0.9 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1 7.5 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 0.5 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.1 5.4 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 1.8 GO:0005521 lamin binding(GO:0005521)
0.1 6.9 GO:0008013 beta-catenin binding(GO:0008013)
0.1 22.7 GO:0003924 GTPase activity(GO:0003924)
0.1 0.1 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.1 3.4 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 0.4 GO:0015057 thrombin receptor activity(GO:0015057)
0.1 0.7 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 1.1 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 3.1 GO:0005507 copper ion binding(GO:0005507)
0.1 0.7 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 3.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 0.2 GO:0032408 MutLbeta complex binding(GO:0032406) MutSbeta complex binding(GO:0032408)
0.1 3.7 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.5 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.2 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.0 3.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.8 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 2.7 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 0.9 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 2.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 2.8 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 1.6 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.0 2.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 3.4 GO:0051015 actin filament binding(GO:0051015)
0.0 0.4 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172)
0.0 0.3 GO:0005537 mannose binding(GO:0005537)
0.0 0.8 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.9 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.2 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.9 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 1.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.7 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.9 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 8.5 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.8 GO:0005496 steroid binding(GO:0005496)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 59.3 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.8 33.8 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.8 23.8 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.5 17.8 PID NECTIN PATHWAY Nectin adhesion pathway
0.4 30.6 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.3 14.1 PID GLYPICAN 1PATHWAY Glypican 1 network
0.3 6.8 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.3 14.6 PID AURORA A PATHWAY Aurora A signaling
0.2 11.0 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.2 4.9 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.2 10.5 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.2 10.5 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 5.1 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 2.3 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 3.3 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.1 4.8 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 4.5 PID FGF PATHWAY FGF signaling pathway
0.1 2.6 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.1 0.7 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.1 0.9 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 1.3 ST GA12 PATHWAY G alpha 12 Pathway
0.1 1.7 ST G ALPHA I PATHWAY G alpha i Pathway
0.1 8.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.2 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.1 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 2.0 NABA COLLAGENS Genes encoding collagen proteins
0.0 4.3 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.9 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 3.0 PID NOTCH PATHWAY Notch signaling pathway
0.0 8.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.6 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.4 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.9 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.3 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.5 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 0.5 PID RHOA PATHWAY RhoA signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 48.0 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
1.2 28.6 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.9 9.9 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.7 14.6 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.6 16.2 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.6 14.1 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.6 11.2 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.6 18.2 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.5 8.2 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.5 21.7 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.5 3.3 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.4 14.6 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.3 9.4 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.3 3.1 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.3 4.8 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.3 7.1 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.3 7.8 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 41.0 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.2 5.7 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.2 4.4 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.2 6.8 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.2 5.5 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.2 3.8 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.2 5.7 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 2.2 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 13.1 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 0.4 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.1 2.5 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 6.1 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 3.9 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 1.9 REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.1 3.1 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.1 11.2 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.5 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.1 4.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 10.7 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 7.1 REACTOME REGULATION OF INSULIN SECRETION Genes involved in Regulation of Insulin Secretion
0.1 1.6 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 4.4 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 4.8 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 2.3 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 0.9 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 2.4 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 1.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 3.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.1 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 1.5 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 1.4 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 1.4 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.4 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 0.7 REACTOME DEFENSINS Genes involved in Defensins
0.0 0.6 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 0.9 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.0 REACTOME FGFR LIGAND BINDING AND ACTIVATION Genes involved in FGFR ligand binding and activation
0.0 0.4 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 0.9 REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane
0.0 0.4 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.2 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.9 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.8 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.3 REACTOME PEPTIDE HORMONE BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis
0.0 0.2 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.5 REACTOME SIGNALING BY ERBB4 Genes involved in Signaling by ERBB4