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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for NR2F1
Z-value: 0.50
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Transcription factors associated with NR2F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR2F1 | hg19_v2_chr5_+_92919043_92919082 | 0.08 | 2.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR2F1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.0 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.4 | 10.1 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 0.7 | 9.8 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 1.6 | 9.7 | GO:1990822 | basic amino acid transmembrane transport(GO:1990822) |
| 0.6 | 9.7 | GO:0090361 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.4 | 7.5 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 0.9 | 7.3 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 2.3 | 7.0 | GO:0032581 | ER-dependent peroxisome organization(GO:0032581) |
| 0.4 | 6.6 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 1.1 | 6.4 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 30.1 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.0 | 26.1 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 13.5 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 12.3 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.3 | 9.8 | GO:0031305 | intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305) |
| 0.1 | 8.8 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 7.1 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.3 | 7.0 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.1 | 6.7 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.4 | 6.6 | GO:0097512 | cardiac myofibril(GO:0097512) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 12.0 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.6 | 10.2 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.9 | 9.7 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
| 0.0 | 9.7 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 1.5 | 9.2 | GO:0048039 | ubiquinone binding(GO:0048039) |
| 0.1 | 7.6 | GO:0005504 | fatty acid binding(GO:0005504) |
| 1.9 | 7.5 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
| 0.0 | 6.7 | GO:0004386 | helicase activity(GO:0004386) |
| 0.2 | 6.6 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 1.1 | 6.4 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.7 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 9.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 9.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 8.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 7.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 5.3 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 5.3 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 5.3 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 4.8 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.0 | 4.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.6 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.7 | 12.0 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.2 | 9.7 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 8.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.0 | 7.1 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.1 | 6.7 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.2 | 6.4 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.2 | 5.9 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.2 | 5.5 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.3 | 5.4 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |