ISMARA results: NR2F2

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for NR2F2

Z-value: 0.49

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Transcription factors associated with NR2F2

Gene Symbol	Gene ID	Gene Info
NR2F2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000185551.8	nuclear receptor subfamily 2 group F member 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NR2F2	hg19_v2_chr15_+_96875657_96875794	0.38	1.0e-08	Click!

Activity profile of NR2F2 motif

Sorted Z-values of NR2F2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr16_-_23607598 Show fit	13.02	ENST00000562133.1 ENST00000570319.1 ENST00000007516.3	NDUFAB1 Ensembl NCBI GeneCards UniProt NextProt Show fit	NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa
chr15_-_63448973 Show fit	10.81	ENST00000462430.1	RPS27L Ensembl NCBI GeneCards UniProt NextProt Show fit	ribosomal protein S27-like
chr7_+_116139744 Show fit	10.50	ENST00000343213.2	CAV2 Ensembl NCBI GeneCards UniProt NextProt Show fit	caveolin 2
chrX_+_118602363 Show fit	10.21	ENST00000317881.8	SLC25A5 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr3_-_185641681 Show fit	10.05	ENST00000259043.7	TRA2B Ensembl NCBI GeneCards UniProt NextProt Show fit	transformer 2 beta homolog (Drosophila)
chr14_-_24616426 Show fit	9.88	ENST00000216802.5	PSME2 Ensembl NCBI GeneCards UniProt NextProt Show fit	proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr2_+_201170770 Show fit	9.67	ENST00000409988.3 ENST00000409385.1	SPATS2L Ensembl NCBI GeneCards UniProt NextProt Show fit	spermatogenesis associated, serine-rich 2-like
chr12_+_52626898 Show fit	9.49	ENST00000331817.5	KRT7 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin 7
chr19_+_36631867 Show fit	9.36	ENST00000588780.1	CAPNS1 Ensembl NCBI GeneCards UniProt NextProt Show fit	calpain, small subunit 1
chr8_-_121457332 Show fit	9.07	ENST00000518918.1	MRPL13 Ensembl NCBI GeneCards UniProt NextProt Show fit	mitochondrial ribosomal protein L13

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of NR2F2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	30.4	GO:0097031	NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.6	27.2	GO:0006363	termination of RNA polymerase I transcription(GO:0006363)
0.3	22.8	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
1.8	21.5	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.5	19.1	GO:0042407	cristae formation(GO:0042407)
0.6	18.9	GO:0006622	protein targeting to lysosome(GO:0006622)
0.5	18.5	GO:0070911	global genome nucleotide-excision repair(GO:0070911)
2.0	18.3	GO:0046073	dTMP biosynthetic process(GO:0006231) dTMP metabolic process(GO:0046073)
0.2	17.8	GO:0070268	cornification(GO:0070268)
0.7	17.7	GO:0000028	ribosomal small subunit assembly(GO:0000028)

Showing 1 to 10 of 263 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	37.8	GO:0045271	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.4	27.5	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
1.7	25.7	GO:0044754	autolysosome(GO:0044754)
0.2	22.7	GO:0035578	azurophil granule lumen(GO:0035578)
0.6	22.5	GO:0000315	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1	22.2	GO:0019866	mitochondrial inner membrane(GO:0005743) organelle inner membrane(GO:0019866)
3.7	22.1	GO:0008537	proteasome activator complex(GO:0008537)
0.8	21.4	GO:0002080	acrosomal membrane(GO:0002080)
1.0	17.5	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)
1.2	17.4	GO:0042405	nuclear inclusion body(GO:0042405)

Showing 1 to 10 of 155 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	24.8	GO:0008137	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1	23.2	GO:0003735	structural constituent of ribosome(GO:0003735)
3.2	22.1	GO:0061133	endopeptidase activator activity(GO:0061133)
0.2	19.9	GO:0032947	protein complex scaffold(GO:0032947)
1.0	17.5	GO:0001054	RNA polymerase I activity(GO:0001054)
0.5	16.4	GO:0070717	poly-purine tract binding(GO:0070717)
0.3	15.9	GO:0000049	tRNA binding(GO:0000049)
0.7	15.2	GO:0032794	GTPase activating protein binding(GO:0032794)
1.7	13.6	GO:0004308	exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
0.2	13.4	GO:0015485	cholesterol binding(GO:0015485)

Showing 1 to 10 of 198 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	37.2	PID MTOR 4PATHWAY	mTOR signaling pathway
0.1	20.3	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	19.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	14.9	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.2	13.4	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.2	12.0	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.2	11.5	PID ARF6 PATHWAY	Arf6 signaling events
0.2	11.1	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.2	9.9	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.2	9.4	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms

Showing 1 to 10 of 54 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	34.6	REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.9	33.9	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.4	31.1	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.5	23.7	REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	Genes involved in Interactions of Vpr with host cellular proteins
0.3	22.9	REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.8	17.5	REACTOME RNA POL III CHAIN ELONGATION	Genes involved in RNA Polymerase III Chain Elongation
1.0	17.4	REACTOME PROCESSING OF INTRONLESS PRE MRNAS	Genes involved in Processing of Intronless Pre-mRNAs
0.5	17.1	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
0.3	16.7	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.1	14.3	REACTOME TRANSLATION	Genes involved in Translation

Showing 1 to 10 of 90 entries

Results for NR2F2

Z-value: 0.49

Motif logo

Transcription factors associated with NR2F2

Activity-expression correlation:

Activity profile of NR2F2 motif

Sorted Z-values of NR2F2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of NR2F2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: