ISMARA results: NR4A1

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for NR4A1

Z-value: 0.73

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Transcription factors associated with NR4A1

Gene Symbol	Gene ID	Gene Info
NR4A1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000123358.15	nuclear receptor subfamily 4 group A member 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NR4A1	hg19_v2_chr12_+_52445191_52445243	0.34	3.2e-07	Click!

Activity profile of NR4A1 motif

Sorted Z-values of NR4A1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_138763734 Show fit	30.75	ENST00000413199.1 ENST00000502927.2	PRR23C Ensembl NCBI GeneCards UniProt NextProt Show fit	proline rich 23C
chr11_-_111794446 Show fit	15.87	ENST00000527950.1	CRYAB Ensembl NCBI GeneCards UniProt NextProt Show fit	crystallin, alpha B
chr22_+_24891210 Show fit	14.46	ENST00000382760.2	UPB1 Ensembl NCBI GeneCards UniProt NextProt Show fit	ureidopropionase, beta
chr12_-_16759711 Show fit	10.53	ENST00000447609.1	LMO3 Ensembl NCBI GeneCards UniProt NextProt Show fit	LIM domain only 3 (rhombotin-like 2)
chr3_+_14989186 Show fit	10.50	ENST00000435454.1 ENST00000323373.6	NR2C2 Ensembl NCBI GeneCards UniProt NextProt Show fit	nuclear receptor subfamily 2, group C, member 2
chr8_-_120685608 Show fit	10.00	ENST00000427067.2	ENPP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	ectonucleotide pyrophosphatase/phosphodiesterase 2
chr13_-_33112823 Show fit	8.17	ENST00000504114.1	N4BP2L2 Ensembl NCBI GeneCards UniProt NextProt Show fit	NEDD4 binding protein 2-like 2
chr1_+_236849754 Show fit	8.12	ENST00000542672.1 ENST00000366578.4	ACTN2 Ensembl NCBI GeneCards UniProt NextProt Show fit	actinin, alpha 2
chr17_+_4855053 Show fit	7.88	ENST00000518175.1	ENO3 Ensembl NCBI GeneCards UniProt NextProt Show fit	enolase 3 (beta, muscle)
chr4_+_159593271 Show fit	7.73	ENST00000512251.1 ENST00000511912.1	ETFDH Ensembl NCBI GeneCards UniProt NextProt Show fit	electron-transferring-flavoprotein dehydrogenase

Showing 1 to 10 of 125 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of NR4A1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.5	17.5	GO:1902035	positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.1	16.2	GO:0006367	transcription initiation from RNA polymerase II promoter(GO:0006367)
0.9	15.9	GO:0007021	tubulin complex assembly(GO:0007021)
0.3	15.2	GO:0061621	NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
4.8	14.5	GO:0019482	beta-alanine metabolic process(GO:0019482)
0.8	14.3	GO:1901897	regulation of relaxation of cardiac muscle(GO:1901897)
0.8	12.7	GO:0006853	carnitine shuttle(GO:0006853)
0.4	11.7	GO:0034755	iron ion transmembrane transport(GO:0034755)
1.8	10.5	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.7	10.0	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)

Showing 1 to 10 of 63 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	24.0	GO:0005741	mitochondrial outer membrane(GO:0005741)
0.2	17.5	GO:0017053	transcriptional repressor complex(GO:0017053)
1.0	15.9	GO:0097512	cardiac myofibril(GO:0097512)
2.5	15.2	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.3	13.3	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
1.3	11.7	GO:0030868	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.3	8.1	GO:0031143	pseudopodium(GO:0031143)
0.3	7.7	GO:0031304	intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.6	7.5	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.5	6.7	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)

Showing 1 to 10 of 36 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	21.6	GO:0003707	steroid hormone receptor activity(GO:0003707)
0.4	17.5	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)
0.5	15.9	GO:0005212	structural constituent of eye lens(GO:0005212)
2.5	15.2	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.1	14.5	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1	13.6	GO:0017124	SH3 domain binding(GO:0017124)
0.9	12.3	GO:0004723	calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
1.9	11.7	GO:0072320	volume-sensitive chloride channel activity(GO:0072320)
2.5	10.0	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
1.8	9.2	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095)

Showing 1 to 10 of 64 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	15.8	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.4	14.9	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.1	8.5	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	7.9	PID ARF6 PATHWAY	Arf6 signaling events
0.1	7.5	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.1	6.2	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.1	6.1	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.2	6.0	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1	6.0	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.1	5.5	NABA PROTEOGLYCANS	Genes encoding proteoglycans

Showing 1 to 10 of 18 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	20.5	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.6	19.1	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
1.0	14.5	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.1	9.6	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.4	9.2	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.4	8.1	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.2	8.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.4	7.9	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.2	7.5	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.1	7.5	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases

Showing 1 to 10 of 32 entries

Results for NR4A1

Z-value: 0.73

Motif logo

Transcription factors associated with NR4A1

Activity-expression correlation:

Activity profile of NR4A1 motif

Sorted Z-values of NR4A1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of NR4A1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: