GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)


Results for NR4A2

Z-value: 1.21

Motif logo

Transcription factors associated with NR4A2

Gene Symbol Gene ID Gene Info
ENSG00000153234.9 nuclear receptor subfamily 4 group A member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of NR4A2 motif

Sorted Z-values of NR4A2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_72936531 31.21 ENST00000339594.4
bromodomain adjacent to zinc finger domain, 1B
chr2_-_176046391 25.24 ENST00000392541.3
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
chr10_+_81107271 24.98 ENST00000448165.1
peptidylprolyl isomerase F
chr11_-_64014379 22.55 ENST00000309318.3
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr11_-_64013663 20.87 ENST00000392210.2
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr7_+_128399002 19.09 ENST00000493278.1
chr10_+_51371390 17.94 ENST00000478381.1
translocase of inner mitochondrial membrane 23 homolog B (yeast)
chr20_+_3776936 17.92 ENST00000439880.2
cell division cycle 25B
chr20_+_3776371 17.80 ENST00000245960.5
cell division cycle 25B
chr4_-_71705060 16.86 ENST00000514161.1
G-rich RNA sequence binding factor 1
chr4_-_71705027 16.79 ENST00000545193.1
G-rich RNA sequence binding factor 1
chr10_+_81107216 16.39 ENST00000394579.3
peptidylprolyl isomerase F
chr8_+_145149930 16.12 ENST00000318911.4
cytochrome c-1
chr14_-_104387888 15.69 ENST00000286953.3
chromosome 14 open reading frame 2
chr3_-_167452262 14.17 ENST00000487947.2
programmed cell death 10
chr20_-_60718430 13.89 ENST00000370873.4
proteasome (prosome, macropain) subunit, alpha type, 7
chrX_-_109683446 13.80 ENST00000372057.1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr8_-_131028869 13.39 ENST00000518283.1
family with sequence similarity 49, member B
chr1_-_17380630 13.36 ENST00000375499.3
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
chr14_-_104387831 13.28 ENST00000557040.1
chromosome 14 open reading frame 2
chr2_-_207023918 12.91 ENST00000455934.2
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr2_-_207024134 12.66 ENST00000457011.1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr1_-_241683001 12.26 ENST00000366560.3
fumarate hydratase
chr1_+_32757668 11.75 ENST00000373548.3
histone deacetylase 1
chr5_-_133340326 11.52 ENST00000425992.1
voltage-dependent anion channel 1
chr3_-_167452298 11.44 ENST00000475915.2
programmed cell death 10
chr11_+_34938119 11.34 ENST00000227868.4
pyruvate dehydrogenase complex, component X
chr10_-_51623203 10.92 ENST00000444743.1
translocase of inner mitochondrial membrane 23 homolog (yeast)
chr16_-_69368774 10.86 ENST00000562949.1
Conserved oligomeric Golgi complex subunit 8
chr4_-_74088800 10.84 ENST00000509867.2
ankyrin repeat domain 17
chr10_-_120938303 10.78 ENST00000356951.3
peroxiredoxin 3
chr19_-_2328572 10.71 ENST00000252622.10
LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr10_+_14880157 10.47 ENST00000378372.3
heat shock 70kDa protein 14
chr1_+_155583012 10.45 ENST00000462250.2
misato 1, mitochondrial distribution and morphology regulator
chr3_+_138340067 10.43 ENST00000479848.1
Fas apoptotic inhibitory molecule
chr17_+_79670386 10.39 ENST00000333676.3
mitochondrial ribosomal protein L12
Mitochondrial dicarboxylate carrier; Uncharacterized protein; cDNA FLJ60124, highly similar to Mitochondrial dicarboxylate carrier
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr1_+_68150744 10.37 ENST00000370986.4
growth arrest and DNA-damage-inducible, alpha
chr16_-_85833109 10.33 ENST00000253457.3
ER membrane protein complex subunit 8
chr3_-_113465065 9.84 ENST00000497255.1
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr11_+_86748863 9.57 ENST00000340353.7
transmembrane protein 135
chr8_+_145582633 9.40 ENST00000540505.1
solute carrier family 52 (riboflavin transporter), member 2
chr22_-_43036607 9.19 ENST00000505920.1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G2
chr15_+_75335604 9.11 ENST00000563393.1
phosphopantothenoylcysteine decarboxylase
chr1_+_155179012 8.95 ENST00000609421.1
metaxin 1
chr11_+_66624527 8.86 ENST00000393952.3
leucine rich repeat and fibronectin type III domain containing 4
chr15_-_55562479 8.72 ENST00000564609.1
RAB27A, member RAS oncogene family
chr8_-_131028641 8.27 ENST00000523509.1
family with sequence similarity 49, member B
chr19_+_8509842 8.27 ENST00000325495.4
heterogeneous nuclear ribonucleoprotein M
chr2_+_198365122 7.98 ENST00000604458.1
HSPE1-MOB4 readthrough
chr2_+_85804614 7.81 ENST00000263864.5
vesicle-associated membrane protein 8
chr3_-_10028366 7.75 ENST00000429759.1
ER membrane protein complex subunit 3
chr4_+_41614720 7.61 ENST00000509277.1
LIM and calponin homology domains 1
chr1_+_201924619 7.49 ENST00000367287.4
translocase of inner mitochondrial membrane 17 homolog A (yeast)
chr4_-_71705082 7.23 ENST00000439371.1
G-rich RNA sequence binding factor 1
chr6_-_24667180 7.16 ENST00000545995.1
tyrosyl-DNA phosphodiesterase 2
chr5_-_137878887 7.16 ENST00000507939.1
eukaryotic translation termination factor 1
chr4_-_139163491 7.13 ENST00000280612.5
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr19_-_8008533 7.12 ENST00000597926.1
translocase of inner mitochondrial membrane 44 homolog (yeast)
chr19_-_10446449 7.02 ENST00000592439.1
intercellular adhesion molecule 3
chr6_-_24666819 6.78 ENST00000341060.3
tyrosyl-DNA phosphodiesterase 2
chr8_-_100905925 6.75 ENST00000518171.1
cytochrome c oxidase subunit VIc
chr2_+_234621551 6.61 ENST00000608381.1
UDP glucuronosyltransferase 1 family, polypeptide A8
UDP glucuronosyltransferase 1 family, polypeptide A5
chr14_+_23791159 6.57 ENST00000557702.1
poly(A) binding protein, nuclear 1
chr3_+_138340049 6.53 ENST00000464668.1
Fas apoptotic inhibitory molecule
chr3_+_179322573 6.43 ENST00000493866.1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
chr7_-_107642348 6.42 ENST00000393561.1
laminin, beta 1
chr16_-_30457048 6.41 ENST00000500504.2
selenophosphate synthetase 2
chr12_+_120875910 6.41 ENST00000551806.1
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial
chr10_+_22605374 6.40 ENST00000448361.1
COMM domain containing 3
chr22_+_30163340 6.35 ENST00000330029.6
ubiquinol-cytochrome c reductase, complex III subunit X
chr19_+_45394477 6.23 ENST00000252487.5
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr1_-_1711508 6.22 ENST00000378625.1
NAD kinase
chr8_-_53626974 5.95 ENST00000435644.2
RB1-inducible coiled-coil 1
chr1_-_205719295 5.91 ENST00000367142.4
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr19_+_1407517 5.90 ENST00000336761.6
DAZ associated protein 1
chr14_-_55369525 5.88 ENST00000543643.2
GTP cyclohydrolase 1
chr3_+_113465866 5.72 ENST00000273398.3
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr1_-_27816641 5.66 ENST00000430629.2
WAS protein family, member 2
chr2_-_26467557 5.63 ENST00000380649.3
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
chr2_+_198365095 5.63 ENST00000409468.1
heat shock 10kDa protein 1
chr9_+_115983808 5.41 ENST00000374210.6
solute carrier family 31 (copper transporter), member 1
chr2_+_109237717 5.41 ENST00000409441.1
LIM and senescent cell antigen-like domains 1
chr4_-_140216948 5.33 ENST00000265500.4
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
chr9_-_34048873 4.96 ENST00000449054.1
ubiquitin associated protein 2
chr5_-_137911049 4.84 ENST00000297185.3
heat shock 70kDa protein 9 (mortalin)
chr16_+_4674787 4.82 ENST00000262370.7
mahogunin ring finger 1, E3 ubiquitin protein ligase
chr18_-_12377283 4.70 ENST00000269143.3
AFG3-like AAA ATPase 2
chr19_+_46850251 4.63 ENST00000012443.4
protein phosphatase 5, catalytic subunit
chr3_+_159570722 4.59 ENST00000482804.1
schwannomin interacting protein 1
chr3_-_197025447 4.57 ENST00000346964.2
discs, large homolog 1 (Drosophila)
chr10_+_22605304 4.49 ENST00000475460.2
COMMD3-BMI1 readthrough
COMM domain containing 3
chr16_-_70729496 4.48 ENST00000567648.1
Vac14 homolog (S. cerevisiae)
chr8_-_145018905 4.45 ENST00000398774.2
chr2_-_207024233 4.44 ENST00000423725.1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr3_+_179322481 4.42 ENST00000259037.3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
chr15_-_55562582 4.40 ENST00000396307.2
RAB27A, member RAS oncogene family
chr8_-_100905850 4.30 ENST00000520271.1
cytochrome c oxidase subunit VIc
chr18_-_19284724 4.29 ENST00000580981.1
abhydrolase domain containing 3
chr20_-_62130474 4.09 ENST00000217182.3
eukaryotic translation elongation factor 1 alpha 2
chr7_+_39663485 4.05 ENST00000436179.1
v-ral simian leukemia viral oncogene homolog A (ras related)
chr4_+_81118647 3.97 ENST00000415738.2
PR domain containing 8
chr15_+_78441663 3.89 ENST00000299518.2
isocitrate dehydrogenase 3 (NAD+) alpha
chr22_+_31518938 3.83 ENST00000412985.1
inositol polyphosphate-5-phosphatase J
chr2_+_228678550 3.70 ENST00000409189.3
chemokine (C-C motif) ligand 20
chr1_-_20987851 3.59 ENST00000464364.1
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
chr20_-_13765526 3.54 ENST00000202816.1
ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
chr19_+_6739662 3.52 ENST00000313285.8
thyroid hormone receptor interactor 10
chr2_-_26467465 3.52 ENST00000457468.2
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
chr7_-_140179276 3.51 ENST00000443720.2
makorin ring finger protein 1
chr11_-_9336234 3.47 ENST00000528080.1
transmembrane protein 41B
chr17_-_56358287 3.37 ENST00000225275.3
chr17_-_56350797 3.35 ENST00000577220.1
chr11_+_67798363 3.27 ENST00000525628.1
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
chr1_-_20987889 3.27 ENST00000415136.2
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
chr16_-_30537839 3.22 ENST00000380412.5
zinc finger protein 768
chr8_-_100905363 3.02 ENST00000524245.1
cytochrome c oxidase subunit VIc
chr3_-_151034734 2.97 ENST00000260843.4
G protein-coupled receptor 87
chr5_+_218356 2.96 ENST00000264932.6
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr20_-_33999766 2.95 ENST00000349714.5
ubiquinol-cytochrome c reductase complex assembly factor 1
chr17_-_79167828 2.94 ENST00000570817.1
5-azacytidine induced 1
chr3_+_159557637 2.93 ENST00000445224.2
schwannomin interacting protein 1
chr4_-_40517984 2.92 ENST00000381795.6
RNA binding motif protein 47
chr20_-_1373606 2.91 ENST00000381715.1
FK506 binding protein 1A, 12kDa
chr2_+_234627424 2.80 ENST00000373409.3
UDP glucuronosyltransferase 1 family, polypeptide A4
chr2_+_119981384 2.67 ENST00000393108.2
STEAP family member 3, metalloreductase
chr12_-_57039739 2.67 ENST00000552959.1
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr4_-_151936416 2.55 ENST00000510413.1
LPS-responsive vesicle trafficking, beach and anchor containing
chrX_+_106045891 2.50 ENST00000357242.5
TBC1 domain family, member 8B (with GRAM domain)
chr15_+_43885252 2.49 ENST00000453782.1
creatine kinase, mitochondrial 1B
chr4_-_151936865 2.47 ENST00000535741.1
LPS-responsive vesicle trafficking, beach and anchor containing
chr4_+_41614909 2.44 ENST00000509454.1
LIM and calponin homology domains 1
chr15_+_43985725 2.36 ENST00000413453.2
creatine kinase, mitochondrial 1A
chr7_-_150777874 2.35 ENST00000540185.1
Fas-activated serine/threonine kinase
chr19_-_46476791 2.33 ENST00000263257.5
neuro-oncological ventral antigen 2
chr11_+_67798114 2.25 ENST00000453471.2
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
chr1_+_206858328 2.17 ENST00000367103.3
mitogen-activated protein kinase-activated protein kinase 2
chr7_-_150777949 2.12 ENST00000482571.1
Fas-activated serine/threonine kinase
chr15_+_43985084 2.06 ENST00000434505.1
creatine kinase, mitochondrial 1A
chr14_+_22320634 2.01 ENST00000390435.1
T cell receptor alpha variable 8-3
chr20_+_47538357 1.99 ENST00000371917.4
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
chr9_+_113431029 1.97 ENST00000189978.5
muscle, skeletal, receptor tyrosine kinase
chr21_-_35014027 1.93 ENST00000399442.1
crystallin, zeta (quinone reductase)-like 1
chr11_+_22696314 1.91 ENST00000532398.1
growth arrest-specific 2
chr7_-_150777920 1.90 ENST00000353841.2
Fas-activated serine/threonine kinase
chr11_-_66139199 1.81 ENST00000357440.2
solute carrier family 29 (equilibrative nucleoside transporter), member 2
chr9_+_113431059 1.78 ENST00000416899.2
muscle, skeletal, receptor tyrosine kinase
chr17_-_9940058 1.72 ENST00000585266.1
growth arrest-specific 7
chr22_+_40573921 1.71 ENST00000454349.2
trinucleotide repeat containing 6B
chr11_+_122709200 1.63 ENST00000227348.4
cytotoxic and regulatory T cell molecule
chr19_-_49552006 1.58 ENST00000391869.3
chorionic gonadotropin, beta polypeptide 1
chr10_-_33625154 1.55 ENST00000265371.4
neuropilin 1
chr7_-_91875109 1.51 ENST00000412043.2
KRIT1, ankyrin repeat containing
chr1_-_154164534 1.50 ENST00000271850.7
tropomyosin 3
chr7_-_151433342 1.45 ENST00000433631.2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr12_+_58166431 1.41 ENST00000333012.5
methyltransferase like 21B
chr7_+_73245193 1.40 ENST00000340958.2
claudin 4
chr22_-_37880543 1.37 ENST00000442496.1
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr20_+_30865429 1.36 ENST00000375712.3
kinesin family member 3B
chr5_-_149829314 1.35 ENST00000407193.1
ribosomal protein S14
chr7_+_112090483 1.34 ENST00000403825.3
interferon-related developmental regulator 1
chr7_-_151433393 1.33 ENST00000492843.1
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr22_-_30960876 1.30 ENST00000401975.1
galactose-3-O-sulfotransferase 1
chr3_-_197024965 1.29 ENST00000392382.2
discs, large homolog 1 (Drosophila)
chr12_+_6309963 1.26 ENST00000382515.2
CD9 molecule
chr12_-_108954933 1.25 ENST00000431469.2
squamous cell carcinoma antigen recognized by T cells 3
chr17_-_10276319 1.24 ENST00000252172.4
myosin, heavy chain 13, skeletal muscle
chr3_-_15540055 1.21 ENST00000605797.1
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr7_-_91875358 1.21 ENST00000458177.1
KRIT1, ankyrin repeat containing
chr2_+_191334212 1.18 ENST00000444317.1
major facilitator superfamily domain containing 6
chrX_-_63005405 1.16 ENST00000374878.1
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr13_+_102142296 1.14 ENST00000376162.3
integrin, beta-like 1 (with EGF-like repeat domains)
chr12_+_120875887 1.03 ENST00000229379.2
cytochrome c oxidase subunit VIa polypeptide 1
chr5_-_149829294 1.01 ENST00000401695.3
ribosomal protein S14
chr1_-_29508499 0.91 ENST00000373795.4
serine/arginine-rich splicing factor 4
chr3_-_46000064 0.85 ENST00000433878.1
FYVE and coiled-coil domain containing 1
chr19_+_45251804 0.73 ENST00000164227.5
B-cell CLL/lymphoma 3
chr7_-_81399355 0.62 ENST00000457544.2
hepatocyte growth factor (hepapoietin A; scatter factor)
chr19_-_49552363 0.59 ENST00000448456.3
chorionic gonadotropin, beta polypeptide 8
chr17_+_79679299 0.48 ENST00000331531.5
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr16_+_3704822 0.44 ENST00000414110.2
deoxyribonuclease I
chr12_-_108955070 0.43 ENST00000228284.3
squamous cell carcinoma antigen recognized by T cells 3
chr9_+_33629119 0.38 ENST00000331828.4
T cell receptor beta variable 21/OR9-2 (pseudogene)
chr17_-_27503770 0.36 ENST00000533112.1
myosin XVIIIA
chrX_-_153640420 0.34 ENST00000451865.1
deoxyribonuclease I-like 1
chr5_-_148758839 0.29 ENST00000261796.3
interleukin 17B
chr6_-_31628512 0.26 ENST00000375911.1
chromosome 6 open reading frame 47
chr11_-_19223523 0.21 ENST00000265968.3
cysteine and glycine-rich protein 3 (cardiac LIM protein)
chr6_+_107077435 0.17 ENST00000369046.4
glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
chr1_+_212738676 0.01 ENST00000366981.4
activating transcription factor 3

Network of associatons between targets according to the STRING database.

First level regulatory network of NR4A2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
13.8 41.4 GO:2000276 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445) negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276)
5.1 25.6 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
4.1 12.3 GO:0006106 fumarate metabolic process(GO:0006106)
3.6 10.8 GO:0071423 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) malate transmembrane transport(GO:0071423) oxaloacetate(2-) transmembrane transport(GO:1902356)
3.6 21.7 GO:2000567 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
3.6 10.8 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
3.6 35.7 GO:0007144 female meiosis I(GO:0007144)
3.5 10.5 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
3.3 49.7 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
2.7 10.8 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
2.6 7.8 GO:1903595 positive regulation of histamine secretion by mast cell(GO:1903595)
2.3 11.7 GO:0061198 fungiform papilla formation(GO:0061198)
2.3 9.4 GO:0032218 riboflavin transport(GO:0032218)
2.2 6.6 GO:1904247 positive regulation of polynucleotide adenylyltransferase activity(GO:1904247)
2.2 13.1 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
2.1 25.8 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
2.1 6.4 GO:0016260 selenocysteine biosynthetic process(GO:0016260)
2.0 5.9 GO:0051066 dihydrobiopterin metabolic process(GO:0051066)
1.6 9.8 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
1.6 22.5 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
1.6 6.4 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
1.6 9.4 GO:0006789 bilirubin conjugation(GO:0006789)
1.5 5.9 GO:0030242 pexophagy(GO:0030242)
1.5 5.9 GO:0019046 release from viral latency(GO:0019046)
1.3 11.3 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
1.2 3.7 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
1.2 16.3 GO:0006105 succinate metabolic process(GO:0006105)
1.2 8.1 GO:0015677 copper ion import(GO:0015677)
1.1 6.4 GO:0035965 cardiolipin acyl-chain remodeling(GO:0035965)
1.0 6.2 GO:0006741 NADP biosynthetic process(GO:0006741)
0.9 36.3 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.8 15.1 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.8 5.9 GO:1903760 regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760)
0.8 16.2 GO:0006851 mitochondrial calcium ion transport(GO:0006851)
0.8 49.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.7 6.7 GO:0001878 response to yeast(GO:0001878)
0.7 5.0 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.6 40.9 GO:0006378 mRNA polyadenylation(GO:0006378)
0.6 4.8 GO:1902037 negative regulation of hematopoietic stem cell differentiation(GO:1902037)
0.6 2.9 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.6 10.4 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.6 4.4 GO:0006600 creatine metabolic process(GO:0006600)
0.5 2.9 GO:0016554 cytidine to uridine editing(GO:0016554)
0.5 7.8 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.5 7.2 GO:0006449 regulation of translational termination(GO:0006449)
0.4 1.3 GO:0007518 myoblast fate determination(GO:0007518)
0.4 9.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.4 4.8 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.4 7.1 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.3 4.1 GO:0051665 membrane raft localization(GO:0051665)
0.3 1.5 GO:0021649 vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) endothelial tip cell fate specification(GO:0097102) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.3 4.6 GO:0016576 histone dephosphorylation(GO:0016576)
0.3 4.1 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.3 2.9 GO:0022417 protein maturation by protein folding(GO:0022417)
0.3 10.7 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.3 5.7 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.3 5.7 GO:0035855 megakaryocyte development(GO:0035855)
0.2 0.7 GO:0045082 positive regulation of interleukin-10 biosynthetic process(GO:0045082)
0.2 3.8 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.2 2.2 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.2 1.6 GO:0002860 positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.2 1.7 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.2 7.2 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.2 2.8 GO:0006853 carnitine shuttle(GO:0006853)
0.2 5.9 GO:0001893 maternal placenta development(GO:0001893)
0.2 1.1 GO:0044351 macropinocytosis(GO:0044351)
0.2 4.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 3.0 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1 1.3 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 1.4 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.1 2.7 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.1 5.4 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.1 13.9 GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
0.1 0.4 GO:1903028 positive regulation of opsonization(GO:1903028)
0.1 1.8 GO:1901642 nucleoside transmembrane transport(GO:1901642)
0.1 6.9 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.1 8.0 GO:0006457 protein folding(GO:0006457)
0.1 2.0 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 1.3 GO:0030913 paranodal junction assembly(GO:0030913)
0.1 2.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 4.0 GO:0014003 oligodendrocyte development(GO:0014003)
0.1 3.6 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.1 1.4 GO:0061436 establishment of skin barrier(GO:0061436)
0.1 4.5 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.1 7.0 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.1 1.7 GO:0016578 histone deubiquitination(GO:0016578)
0.1 8.9 GO:0006626 protein targeting to mitochondrion(GO:0006626)
0.1 1.6 GO:0030728 ovulation(GO:0030728)
0.1 0.2 GO:0035995 detection of muscle stretch(GO:0035995)
0.1 10.7 GO:0006302 double-strand break repair(GO:0006302)
0.0 1.9 GO:1901661 quinone metabolic process(GO:1901661)
0.0 15.7 GO:0043687 post-translational protein modification(GO:0043687)
0.0 2.5 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.9 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.0 3.8 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.0 5.4 GO:0006986 response to unfolded protein(GO:0006986)
0.0 0.3 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0 2.0 GO:0043066 negative regulation of apoptotic process(GO:0043066) negative regulation of programmed cell death(GO:0043069)
0.0 0.8 GO:0006308 DNA catabolic process(GO:0006308)
0.0 14.3 GO:0045087 innate immune response(GO:0045087)
0.0 3.3 GO:0007050 cell cycle arrest(GO:0007050)
0.0 5.5 GO:0002283 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
6.0 30.0 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
4.1 16.3 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
3.0 36.3 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
2.4 77.6 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
2.1 6.4 GO:0005607 laminin-2 complex(GO:0005607)
2.0 22.5 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
2.0 18.1 GO:0072546 ER membrane protein complex(GO:0072546)
1.5 10.7 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
1.4 9.8 GO:0031415 NatA complex(GO:0031415)
1.3 66.4 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
1.2 13.4 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
1.2 13.9 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
1.1 11.3 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
1.1 13.1 GO:0033093 Weibel-Palade body(GO:0033093)
1.0 8.3 GO:0042382 paraspeckles(GO:0042382)
1.0 5.9 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
1.0 25.8 GO:0005721 pericentric heterochromatin(GO:0005721)
0.9 6.2 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.8 10.8 GO:0008385 IkappaB kinase complex(GO:0008385)
0.7 2.0 GO:0005879 axonemal microtubule(GO:0005879)
0.7 4.6 GO:1990635 proximal dendrite(GO:1990635)
0.6 4.5 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.6 2.9 GO:1990425 ryanodine receptor complex(GO:1990425)
0.6 6.9 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.5 11.7 GO:0016580 Sin3 complex(GO:0016580)
0.5 5.9 GO:0097025 lateral loop(GO:0043219) MPP7-DLG1-LIN7 complex(GO:0097025)
0.5 1.4 GO:0005873 plus-end kinesin complex(GO:0005873)
0.4 5.7 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.4 5.2 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.4 1.7 GO:0071001 U4/U6 snRNP(GO:0071001)
0.4 4.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.4 5.7 GO:0031209 SCAR complex(GO:0031209)
0.3 6.6 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.3 19.2 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.3 4.0 GO:0042405 nuclear inclusion body(GO:0042405)
0.3 10.4 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 13.9 GO:0016235 aggresome(GO:0016235)
0.2 5.7 GO:0098800 inner mitochondrial membrane protein complex(GO:0098800)
0.2 35.7 GO:0000922 spindle pole(GO:0000922)
0.2 4.4 GO:0030056 hemidesmosome(GO:0030056)
0.2 0.7 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.2 3.5 GO:0001891 phagocytic cup(GO:0001891)
0.1 1.5 GO:0002116 semaphorin receptor complex(GO:0002116) sorting endosome(GO:0097443)
0.1 16.9 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 2.8 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 7.8 GO:0031201 SNARE complex(GO:0031201)
0.1 3.2 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 2.5 GO:0012505 endomembrane system(GO:0012505)
0.1 1.2 GO:0043083 synaptic cleft(GO:0043083)
0.1 7.1 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 1.5 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 3.6 GO:0043198 dendritic shaft(GO:0043198)
0.1 10.9 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.1 6.7 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 19.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 12.8 GO:0005840 ribosome(GO:0005840)
0.1 0.9 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 4.1 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 1.2 GO:0032982 myosin filament(GO:0032982)
0.1 17.9 GO:0031965 nuclear membrane(GO:0031965)
0.0 3.3 GO:0005811 lipid particle(GO:0005811)
0.0 1.3 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 1.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 6.0 GO:0005741 mitochondrial outer membrane(GO:0005741) organelle outer membrane(GO:0031968)
0.0 3.7 GO:0043235 receptor complex(GO:0043235)
0.0 3.9 GO:0005770 late endosome(GO:0005770)
0.0 1.7 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 5.9 GO:0016607 nuclear speck(GO:0016607)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
5.4 16.3 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
5.4 16.1 GO:0045155 electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity(GO:0045155)
4.6 13.9 GO:0036317 tyrosyl-RNA phosphodiesterase activity(GO:0036317) 5'-tyrosyl-DNA phosphodiesterase activity(GO:0070260)
3.9 42.6 GO:0015266 protein channel activity(GO:0015266)
3.6 10.8 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131)
3.6 21.7 GO:0023025 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
3.0 41.4 GO:0016018 cyclosporin A binding(GO:0016018)
2.3 9.4 GO:0032217 riboflavin transporter activity(GO:0032217)
2.3 9.2 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
2.1 6.4 GO:0004756 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
2.1 6.4 GO:0033867 Fas-activated serine/threonine kinase activity(GO:0033867)
1.5 30.0 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
1.4 11.5 GO:0015288 porin activity(GO:0015288)
1.4 7.1 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
1.4 11.3 GO:0004738 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
1.3 10.8 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
1.3 36.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
1.2 3.7 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
1.2 7.2 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
1.1 6.3 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
1.0 5.9 GO:0019238 cyclohydrolase activity(GO:0019238)
1.0 3.9 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.9 40.7 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.9 25.8 GO:0035173 histone kinase activity(GO:0035173)
0.9 4.3 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.8 11.7 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.8 9.8 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.7 7.8 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.7 6.9 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.7 2.7 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.7 12.4 GO:0017070 U6 snRNA binding(GO:0017070)
0.6 4.4 GO:0004111 creatine kinase activity(GO:0004111)
0.5 5.4 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.5 5.9 GO:0097016 L27 domain binding(GO:0097016)
0.5 15.1 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.5 13.1 GO:0031489 myosin V binding(GO:0031489)
0.5 13.9 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.4 19.2 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.4 3.8 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445) phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.3 1.4 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.3 5.9 GO:0035613 RNA stem-loop binding(GO:0035613)
0.3 1.9 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.3 2.3 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.3 2.8 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.3 35.7 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.3 5.7 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769)
0.2 9.4 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.2 1.5 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.2 6.2 GO:0003951 NAD+ kinase activity(GO:0003951)
0.2 2.9 GO:0019855 calcium channel inhibitor activity(GO:0019855) type I transforming growth factor beta receptor binding(GO:0034713)
0.2 4.1 GO:0003746 translation elongation factor activity(GO:0003746)
0.2 12.3 GO:0016836 hydro-lyase activity(GO:0016836)
0.2 30.7 GO:0047485 protein N-terminus binding(GO:0047485)
0.2 1.3 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.2 9.1 GO:0016831 carboxy-lyase activity(GO:0016831)
0.2 4.4 GO:0030506 ankyrin binding(GO:0030506)
0.1 4.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 3.0 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 6.7 GO:0004601 peroxidase activity(GO:0004601)
0.1 12.7 GO:0051087 chaperone binding(GO:0051087)
0.1 0.4 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.1 6.6 GO:0070063 RNA polymerase binding(GO:0070063)
0.1 0.9 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 1.8 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.1 2.0 GO:0050811 GABA receptor binding(GO:0050811)
0.1 0.9 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 19.2 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 1.1 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 6.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 4.4 GO:0032947 protein complex scaffold(GO:0032947)
0.0 2.7 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 3.7 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 5.7 GO:0017124 SH3 domain binding(GO:0017124)
0.0 1.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 4.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 2.1 GO:0017022 myosin binding(GO:0017022)
0.0 1.2 GO:0000146 microfilament motor activity(GO:0000146)
0.0 1.7 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 4.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 2.5 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 23.2 GO:0003723 RNA binding(GO:0003723)
0.0 1.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.2 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0 1.5 GO:0005178 integrin binding(GO:0005178)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 35.7 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.8 11.7 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.6 48.8 PID ILK PATHWAY Integrin-linked kinase signaling
0.3 10.4 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.3 13.9 PID CD40 PATHWAY CD40/CD40L signaling
0.3 36.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.3 6.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 11.5 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.2 2.9 PID ALK2 PATHWAY ALK2 signaling events
0.2 6.7 PID IL23 PATHWAY IL23-mediated signaling events
0.2 14.3 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 7.0 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 3.5 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 4.1 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.1 1.5 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.1 0.7 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.1 4.6 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 1.1 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.3 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 1.2 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 1.9 PID MTOR 4PATHWAY mTOR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 79.2 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
1.4 32.5 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
1.3 35.7 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.8 64.3 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.7 11.3 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.7 9.1 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.5 11.7 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.5 9.2 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.5 13.1 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.4 4.5 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.4 6.6 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.4 9.4 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.3 5.9 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.3 10.8 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.3 8.4 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.3 5.9 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.2 5.4 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.2 43.2 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.2 13.9 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.2 5.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.2 6.9 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.2 6.4 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 5.1 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.2 7.1 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.2 1.7 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
0.2 6.2 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 2.9 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 6.1 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.1 1.5 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 2.8 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 15.6 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 8.7 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 3.8 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 9.2 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 2.0 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 1.4 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 3.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 2.5 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 1.4 REACTOME KINESINS Genes involved in Kinesins
0.0 1.8 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 4.7 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 1.4 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 1.2 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 2.9 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.3 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.5 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.4 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 3.5 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 3.1 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives