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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for NR4A2
Z-value: 1.21
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Transcription factors associated with NR4A2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR4A2 | hg19_v2_chr2_-_157198860_157198978 | -0.39 | 3.2e-09 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_72936531 Show fit | 31.21 |
ENST00000339594.4
|
bromodomain adjacent to zinc finger domain, 1B |
|
| chr2_-_176046391 Show fit | 25.24 |
ENST00000392541.3
ENST00000409194.1 |
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9) |
|
| chr10_+_81107271 Show fit | 24.98 |
ENST00000448165.1
|
peptidylprolyl isomerase F |
|
| chr11_-_64014379 Show fit | 22.55 |
ENST00000309318.3
|
protein phosphatase 1, regulatory (inhibitor) subunit 14B |
|
| chr11_-_64013663 Show fit | 20.87 |
ENST00000392210.2
|
protein phosphatase 1, regulatory (inhibitor) subunit 14B |
|
| chr7_+_128399002 Show fit | 19.09 |
ENST00000493278.1
|
calumenin |
|
| chr10_+_51371390 Show fit | 17.94 |
ENST00000478381.1
ENST00000451577.2 ENST00000374098.2 ENST00000374097.2 |
translocase of inner mitochondrial membrane 23 homolog B (yeast) |
|
| chr20_+_3776936 Show fit | 17.92 |
ENST00000439880.2
|
cell division cycle 25B |
|
| chr20_+_3776371 Show fit | 17.80 |
ENST00000245960.5
|
cell division cycle 25B |
|
| chr4_-_71705060 Show fit | 16.86 |
ENST00000514161.1
|
G-rich RNA sequence binding factor 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR4A2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 49.7 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
| 0.8 | 49.2 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 13.8 | 41.4 | GO:2000276 | regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445) negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276) |
| 0.6 | 40.9 | GO:0006378 | mRNA polyadenylation(GO:0006378) |
| 0.9 | 36.3 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 3.6 | 35.7 | GO:0007144 | female meiosis I(GO:0007144) |
| 2.1 | 25.8 | GO:0048096 | chromatin-mediated maintenance of transcription(GO:0048096) |
| 5.1 | 25.6 | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588) |
| 1.6 | 22.5 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 3.6 | 21.7 | GO:2000567 | memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 77.6 | GO:0005753 | mitochondrial proton-transporting ATP synthase complex(GO:0005753) |
| 1.3 | 66.4 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 3.0 | 36.3 | GO:0005744 | mitochondrial inner membrane presequence translocase complex(GO:0005744) |
| 0.2 | 35.7 | GO:0000922 | spindle pole(GO:0000922) |
| 6.0 | 30.0 | GO:0045272 | plasma membrane respiratory chain complex I(GO:0045272) |
| 1.0 | 25.8 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 2.0 | 22.5 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.1 | 19.3 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.3 | 19.2 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 2.0 | 18.1 | GO:0072546 | ER membrane protein complex(GO:0072546) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.9 | 42.6 | GO:0015266 | protein channel activity(GO:0015266) |
| 3.0 | 41.4 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.9 | 40.7 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 1.3 | 36.3 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.3 | 35.7 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.2 | 30.7 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 1.5 | 30.0 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.9 | 25.8 | GO:0035173 | histone kinase activity(GO:0035173) |
| 0.0 | 23.2 | GO:0003723 | RNA binding(GO:0003723) |
| 3.6 | 21.7 | GO:0023025 | MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 48.8 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.3 | 36.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 2.6 | 35.7 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.2 | 14.3 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.3 | 13.9 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.8 | 11.7 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.2 | 11.5 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.3 | 10.4 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 7.0 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.2 | 6.7 | PID IL23 PATHWAY | IL23-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 79.2 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.8 | 64.3 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 43.2 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 1.3 | 35.7 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 1.4 | 32.5 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.1 | 15.6 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 13.9 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.5 | 13.1 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.5 | 11.7 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.7 | 11.3 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |