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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for NRF1
Z-value: 1.58
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Transcription factors associated with NRF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NRF1 | hg19_v2_chr7_+_129251531_129251601 | -0.37 | 1.7e-08 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NRF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.7 | 668.5 | GO:0050434 | positive regulation of viral transcription(GO:0050434) |
| 8.1 | 518.4 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 4.6 | 509.1 | GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) |
| 4.9 | 363.0 | GO:0070126 | mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126) |
| 10.9 | 349.7 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 3.9 | 346.8 | GO:0090114 | COPII-coated vesicle budding(GO:0090114) |
| 10.1 | 302.7 | GO:0000291 | nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
| 13.3 | 266.3 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 20.4 | 265.3 | GO:1904871 | regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) |
| 5.8 | 241.8 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 752.1 | GO:0070062 | extracellular exosome(GO:0070062) |
| 20.6 | 618.2 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 8.1 | 533.9 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 33.6 | 403.5 | GO:0005642 | annulate lamellae(GO:0005642) |
| 2.1 | 332.2 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 5.9 | 310.6 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 4.1 | 302.4 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 15.7 | 283.0 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 23.3 | 279.8 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 39.6 | 277.2 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 27.3 | 573.3 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 2.5 | 528.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 9.5 | 503.2 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 22.6 | 428.5 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 30.3 | 424.8 | GO:0030957 | Tat protein binding(GO:0030957) |
| 52.7 | 369.0 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 8.2 | 342.5 | GO:0004532 | exoribonuclease activity(GO:0004532) |
| 4.5 | 320.6 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 6.2 | 283.8 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 9.1 | 273.7 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.6 | 652.8 | PID PLK1 PATHWAY | PLK1 signaling events |
| 9.9 | 516.2 | PID BARD1 PATHWAY | BARD1 signaling events |
| 6.0 | 385.3 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 2.9 | 318.8 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 3.4 | 288.7 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 2.1 | 275.2 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 9.9 | 227.0 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 3.8 | 199.6 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 3.2 | 194.2 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 3.8 | 191.9 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.5 | 723.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 7.4 | 657.5 | REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 | Genes involved in SCF(Skp2)-mediated degradation of p27/p21 |
| 13.5 | 526.4 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 3.2 | 508.6 | REACTOME TRANSLATION | Genes involved in Translation |
| 19.5 | 467.5 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 7.4 | 398.7 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 3.6 | 332.1 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 2.1 | 322.1 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 6.0 | 299.9 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 4.1 | 299.7 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |