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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for OLIG1
Z-value: 0.64
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Transcription factors associated with OLIG1
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrX_-_13835147 Show fit | 13.60 |
ENST00000493677.1
ENST00000355135.2 |
glycoprotein M6B |
|
| chr19_+_18208603 Show fit | 13.06 |
ENST00000262811.6
|
microtubule associated serine/threonine kinase 3 |
|
| chr5_-_11588907 Show fit | 10.02 |
ENST00000513598.1
ENST00000503622.1 |
catenin (cadherin-associated protein), delta 2 |
|
| chr3_-_18480260 Show fit | 9.47 |
ENST00000454909.2
|
SATB homeobox 1 |
|
| chr5_-_11589131 Show fit | 8.24 |
ENST00000511377.1
|
catenin (cadherin-associated protein), delta 2 |
|
| chr4_-_153456153 Show fit | 7.96 |
ENST00000603548.1
|
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase |
|
| chr15_-_45670924 Show fit | 7.84 |
ENST00000396659.3
|
glycine amidinotransferase (L-arginine:glycine amidinotransferase) |
|
| chr3_-_98241358 Show fit | 7.75 |
ENST00000503004.1
ENST00000506575.1 ENST00000513452.1 ENST00000515620.1 |
claudin domain containing 1 |
|
| chrX_-_13835461 Show fit | 7.61 |
ENST00000316715.4
ENST00000356942.5 |
glycoprotein M6B |
|
| chr1_+_220863187 Show fit | 7.56 |
ENST00000294889.5
|
chromosome 1 open reading frame 115 |
Network of associatons between targets according to the STRING database.
First level regulatory network of OLIG1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 21.2 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.3 | 19.9 | GO:0060997 | dendritic spine morphogenesis(GO:0060997) |
| 0.0 | 10.5 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
| 1.2 | 9.4 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.6 | 9.4 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 1.6 | 8.0 | GO:2000638 | regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639) |
| 0.7 | 7.8 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 2.5 | 7.5 | GO:0002881 | negative regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002881) |
| 0.2 | 6.8 | GO:0016601 | Rac protein signal transduction(GO:0016601) |
| 0.6 | 6.6 | GO:2000580 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 25.9 | GO:0043204 | perikaryon(GO:0043204) |
| 0.4 | 11.0 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.0 | 10.5 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.0 | 9.9 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.2 | 9.5 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.9 | 9.4 | GO:0045180 | basal cortex(GO:0045180) |
| 0.0 | 9.0 | GO:0098857 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 1.1 | 8.0 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.1 | 7.8 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.3 | 7.5 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.2 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.0 | 13.0 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.5 | 11.2 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.2 | 10.1 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 10.0 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.1 | 9.5 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.3 | 8.5 | GO:0016769 | transferase activity, transferring nitrogenous groups(GO:0016769) |
| 1.0 | 8.0 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 2.5 | 7.5 | GO:0016495 | C-X3-C chemokine receptor activity(GO:0016495) |
| 0.3 | 6.6 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.5 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 7.2 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 6.8 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.1 | 6.5 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.1 | 4.9 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 4.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 4.3 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 3.6 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 3.4 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 3.2 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.5 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 8.2 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 8.0 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 6.6 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 5.9 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
| 0.1 | 5.6 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 5.0 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.2 | 4.7 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.1 | 4.4 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 4.1 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |