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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for OLIG2_NEUROD1_ATOH1
Z-value: 0.31
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Transcription factors associated with OLIG2_NEUROD1_ATOH1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000205927.4 | oligodendrocyte transcription factor 2 | |
| ENSG00000162992.3 | neuronal differentiation 1 | |
| ENSG00000172238.3 | atonal bHLH transcription factor 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| OLIG2 | hg19_v2_chr21_+_34398153_34398250 | 0.49 | 1.2e-14 | Click! |
| NEUROD1 | hg19_v2_chr2_-_182545603_182545603 | 0.22 | 1.3e-03 | Click! |
| ATOH1 | hg19_v2_chr4_+_94750014_94750042 | 0.16 | 2.1e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of OLIG2_NEUROD1_ATOH1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.6 | 50.5 | GO:0018032 | peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179) |
| 3.8 | 41.7 | GO:0030913 | paranodal junction assembly(GO:0030913) |
| 8.7 | 26.0 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 1.1 | 24.1 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 3.6 | 21.4 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 6.6 | 19.8 | GO:0035408 | histone H3-T6 phosphorylation(GO:0035408) |
| 6.5 | 19.6 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 1.6 | 16.4 | GO:0051612 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.3 | 16.4 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
| 0.6 | 15.8 | GO:0045725 | positive regulation of glycogen biosynthetic process(GO:0045725) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 57.5 | GO:0043204 | perikaryon(GO:0043204) |
| 1.3 | 41.1 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.5 | 25.2 | GO:0043034 | costamere(GO:0043034) |
| 0.1 | 21.5 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 18.2 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.9 | 16.0 | GO:0043194 | axon initial segment(GO:0043194) |
| 2.9 | 14.3 | GO:0005899 | insulin receptor complex(GO:0005899) |
| 0.0 | 12.9 | GO:0005874 | microtubule(GO:0005874) |
| 1.6 | 12.6 | GO:0060199 | clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203) |
| 0.6 | 12.2 | GO:0044295 | axonal growth cone(GO:0044295) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.6 | 50.5 | GO:0004598 | peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598) |
| 1.6 | 40.4 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.8 | 37.2 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.2 | 36.5 | GO:0005178 | integrin binding(GO:0005178) |
| 0.2 | 25.3 | GO:0044325 | ion channel binding(GO:0044325) |
| 1.1 | 22.2 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 4.3 | 21.4 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 6.6 | 19.8 | GO:0035403 | histone kinase activity (H3-T6 specific)(GO:0035403) |
| 0.4 | 19.6 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.7 | 18.3 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 51.8 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.4 | 24.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.8 | 18.1 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.3 | 15.4 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.2 | 13.6 | PID ATR PATHWAY | ATR signaling pathway |
| 0.3 | 12.5 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.4 | 9.7 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.1 | 8.4 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 7.0 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.1 | 6.2 | PID FGF PATHWAY | FGF signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 30.9 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.5 | 29.1 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.9 | 25.2 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.5 | 17.7 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.5 | 14.9 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.2 | 14.6 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.3 | 12.9 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.5 | 12.6 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.2 | 12.2 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.4 | 11.8 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |