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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ONECUT1
Z-value: 0.08
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Transcription factors associated with ONECUT1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ONECUT1 | hg19_v2_chr15_-_53082178_53082209 | -0.06 | 3.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_-_116840728 Show fit | 12.00 |
ENST00000265132.3
|
alpha-1-microglobulin/bikunin precursor |
|
| chr17_-_26697304 Show fit | 11.97 |
ENST00000536498.1
|
vitronectin |
|
| chr3_+_52811596 Show fit | 9.55 |
ENST00000542827.1
ENST00000273283.2 |
inter-alpha-trypsin inhibitor heavy chain 1 |
|
| chr13_-_46679144 Show fit | 8.21 |
ENST00000181383.4
|
carboxypeptidase B2 (plasma) |
|
| chr13_-_46679185 Show fit | 8.19 |
ENST00000439329.3
|
carboxypeptidase B2 (plasma) |
|
| chr5_-_176836577 Show fit | 7.54 |
ENST00000253496.3
|
coagulation factor XII (Hageman factor) |
|
| chr19_+_45449301 Show fit | 7.48 |
ENST00000591597.1
|
apolipoprotein C-II |
|
| chr17_-_64225508 Show fit | 6.80 |
ENST00000205948.6
|
apolipoprotein H (beta-2-glycoprotein I) |
|
| chr1_+_207262881 Show fit | 6.38 |
ENST00000451804.2
|
complement component 4 binding protein, beta |
|
| chr19_+_45449228 Show fit | 6.38 |
ENST00000252490.4
|
apolipoprotein C-II |
Network of associatons between targets according to the STRING database.
First level regulatory network of ONECUT1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.6 | 19.8 | GO:0010902 | positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902) |
| 1.9 | 16.9 | GO:0030450 | regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) regulation of opsonization(GO:1903027) |
| 4.1 | 16.4 | GO:0003330 | regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331) |
| 1.3 | 12.0 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.8 | 12.0 | GO:0033015 | porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149) |
| 1.5 | 11.8 | GO:0051918 | negative regulation of fibrinolysis(GO:0051918) |
| 0.4 | 10.5 | GO:0015695 | organic cation transport(GO:0015695) |
| 0.1 | 10.3 | GO:0046849 | bone remodeling(GO:0046849) |
| 0.1 | 9.5 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 2.5 | 7.5 | GO:0002541 | activation of plasma proteins involved in acute inflammatory response(GO:0002541) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 34.3 | GO:0072562 | blood microparticle(GO:0072562) |
| 2.5 | 19.8 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.0 | 17.7 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 16.9 | GO:0044217 | other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) |
| 0.9 | 16.6 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 3.0 | 12.0 | GO:0071062 | rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 0.1 | 8.8 | GO:0005903 | brush border(GO:0005903) |
| 0.1 | 8.1 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.4 | 5.3 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.2 | 5.0 | GO:0036019 | endolysosome(GO:0036019) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.3 | 26.6 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.5 | 16.4 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 3.0 | 12.0 | GO:0019862 | IgA binding(GO:0019862) |
| 0.8 | 12.0 | GO:0001871 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.3 | 10.3 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
| 0.1 | 9.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.4 | 8.4 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.1 | 8.3 | GO:0004866 | endopeptidase inhibitor activity(GO:0004866) |
| 0.8 | 6.4 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.2 | 5.5 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 40.4 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 35.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 7.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 2.7 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 2.5 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 2.5 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 2.4 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 2.1 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 1.8 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 1.8 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 20.1 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.6 | 16.9 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.7 | 13.6 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.1 | 10.2 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 9.9 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 5.7 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 5.3 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.2 | 4.8 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.2 | 4.7 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.2 | 4.2 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |