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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ONECUT2_ONECUT3
Z-value: 0.88
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Transcription factors associated with ONECUT2_ONECUT3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ONECUT2 | hg19_v2_chr18_+_55102917_55102985 | -0.58 | 1.1e-20 | Click! |
| ONECUT3 | hg19_v2_chr19_+_1752372_1752372 | -0.47 | 3.7e-13 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_32384693 Show fit | 20.71 |
ENST00000602683.1
ENST00000470404.1 |
protein tyrosine phosphatase type IVA, member 2 |
|
| chr20_+_36405665 Show fit | 14.36 |
ENST00000373469.1
|
catenin, beta like 1 |
|
| chr2_+_102413726 Show fit | 12.99 |
ENST00000350878.4
|
mitogen-activated protein kinase kinase kinase kinase 4 |
|
| chr1_+_207943667 Show fit | 9.50 |
ENST00000462968.2
|
CD46 molecule, complement regulatory protein |
|
| chr1_+_99127225 Show fit | 9.42 |
ENST00000370189.5
ENST00000529992.1 |
sorting nexin 7 |
|
| chr3_-_141747439 Show fit | 8.71 |
ENST00000467667.1
|
transcription factor Dp-2 (E2F dimerization partner 2) |
|
| chr9_-_139372141 Show fit | 7.83 |
ENST00000313050.7
|
SEC16 homolog A (S. cerevisiae) |
|
| chr7_-_23510086 Show fit | 7.82 |
ENST00000258729.3
|
insulin-like growth factor 2 mRNA binding protein 3 |
|
| chr3_+_159557637 Show fit | 7.13 |
ENST00000445224.2
|
schwannomin interacting protein 1 |
|
| chr6_+_56954808 Show fit | 7.06 |
ENST00000510483.1
ENST00000370706.4 ENST00000357489.3 |
zinc finger protein 451 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ONECUT2_ONECUT3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 20.7 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.3 | 14.7 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.1 | 14.7 | GO:0051225 | spindle assembly(GO:0051225) |
| 0.6 | 13.0 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.3 | 12.0 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.2 | 12.0 | GO:0016445 | somatic diversification of immunoglobulins(GO:0016445) |
| 1.1 | 10.1 | GO:0045959 | regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) regulation of opsonization(GO:1903027) |
| 3.2 | 9.7 | GO:0090149 | synaptic vesicle recycling via endosome(GO:0036466) mitochondrial membrane fission(GO:0090149) |
| 1.1 | 9.5 | GO:0045916 | negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258) |
| 0.3 | 9.2 | GO:0046475 | glycerophospholipid catabolic process(GO:0046475) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.2 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.0 | 14.9 | GO:0005769 | early endosome(GO:0005769) |
| 1.6 | 14.7 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.0 | 14.7 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.7 | 14.4 | GO:0000974 | Prp19 complex(GO:0000974) |
| 0.0 | 11.6 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 10.1 | GO:0044216 | other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) |
| 0.1 | 9.7 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 9.6 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 3.2 | 9.5 | GO:0002079 | inner acrosomal membrane(GO:0002079) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.2 | 20.7 | GO:0004727 | prenylated protein tyrosine phosphatase activity(GO:0004727) |
| 0.3 | 15.1 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 1.6 | 13.0 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.0 | 12.1 | GO:0003712 | transcription cofactor activity(GO:0003712) |
| 0.0 | 10.7 | GO:0019901 | protein kinase binding(GO:0019901) |
| 0.3 | 10.6 | GO:0001848 | complement binding(GO:0001848) |
| 0.3 | 9.9 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.5 | 9.7 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.3 | 9.2 | GO:0004622 | lysophospholipase activity(GO:0004622) |
| 0.0 | 7.9 | GO:0003714 | transcription corepressor activity(GO:0003714) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 20.7 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.2 | 17.9 | PID E2F PATHWAY | E2F transcription factor network |
| 0.2 | 15.4 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.4 | 14.7 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 9.3 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 8.1 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 7.3 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.4 | 6.5 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 5.2 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.1 | 4.9 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 19.6 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.5 | 19.2 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.1 | 8.4 | REACTOME APOPTOTIC EXECUTION PHASE | Genes involved in Apoptotic execution phase |
| 0.0 | 7.8 | REACTOME DIABETES PATHWAYS | Genes involved in Diabetes pathways |
| 0.3 | 7.3 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 7.0 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 6.0 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 5.9 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 5.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 4.9 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |