Project
GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for OSR1_OSR2
Z-value: 1.43
Motif logo
Transcription factors associated with OSR1_OSR2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| OSR2 | hg19_v2_chr8_+_99956662_99956686 | -0.16 | 2.0e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of OSR1_OSR2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 25.8 | 77.5 | GO:0031660 | regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) response to DDT(GO:0046680) histone H3-S10 phosphorylation involved in chromosome condensation(GO:2000775) |
| 0.7 | 51.2 | GO:0070125 | mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126) |
| 14.7 | 44.2 | GO:0006428 | isoleucyl-tRNA aminoacylation(GO:0006428) |
| 5.1 | 30.9 | GO:0055129 | proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129) |
| 7.0 | 27.9 | GO:0044837 | assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837) |
| 0.1 | 26.2 | GO:0007018 | microtubule-based movement(GO:0007018) |
| 0.0 | 21.6 | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter(GO:0000122) |
| 0.2 | 19.4 | GO:0035722 | interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349) |
| 1.5 | 19.2 | GO:0033617 | mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034) |
| 4.3 | 17.0 | GO:0010796 | regulation of multivesicular body size(GO:0010796) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.5 | 77.5 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 1.9 | 51.2 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 2.1 | 44.2 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 5.6 | 27.9 | GO:0097149 | centralspindlin complex(GO:0097149) |
| 0.2 | 19.8 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.7 | 19.2 | GO:0031304 | intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305) |
| 0.0 | 18.4 | GO:0031966 | mitochondrial membrane(GO:0031966) |
| 0.0 | 18.0 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 17.5 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 3.4 | 17.0 | GO:0098837 | postsynaptic recycling endosome(GO:0098837) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.1 | 77.5 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 0.0 | 57.6 | GO:0003723 | RNA binding(GO:0003723) |
| 14.7 | 44.2 | GO:0004822 | isoleucine-tRNA ligase activity(GO:0004822) |
| 7.7 | 30.9 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
| 0.9 | 27.9 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.6 | 25.1 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.4 | 23.3 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.6 | 23.0 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.1 | 18.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.7 | 17.0 | GO:0031489 | myosin V binding(GO:0031489) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 101.1 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 1.0 | 44.2 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.5 | 27.9 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.6 | 17.0 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.1 | 10.7 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 10.4 | PID ATR PATHWAY | ATR signaling pathway |
| 0.2 | 7.8 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.2 | 7.6 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 6.6 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 4.9 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.8 | 86.7 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 1.2 | 44.2 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 1.1 | 30.9 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 1.1 | 27.9 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 21.0 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.2 | 17.4 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.3 | 17.0 | REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS | Genes involved in Regulation of Water Balance by Renal Aquaporins |
| 0.6 | 14.6 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.2 | 11.8 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.2 | 11.1 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |