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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for OTX1
Z-value: 1.35
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Transcription factors associated with OTX1
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_177631497 Show fit | 31.60 |
ENST00000358344.3
|
heterogeneous nuclear ribonucleoprotein A/B |
|
| chr11_-_65626753 Show fit | 28.78 |
ENST00000526975.1
ENST00000531413.1 |
cofilin 1 (non-muscle) |
|
| chr12_-_54071181 Show fit | 25.26 |
ENST00000338662.5
|
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9) |
|
| chr16_-_58163299 Show fit | 24.04 |
ENST00000262498.3
|
chromosome 16 open reading frame 80 |
|
| chr16_+_33605231 Show fit | 23.59 |
ENST00000570121.2
|
immunoglobulin heavy variable 3/OR16-12 (non-functional) |
|
| chr2_-_85637459 Show fit | 22.09 |
ENST00000409921.1
|
capping protein (actin filament), gelsolin-like |
|
| chr2_-_161350305 Show fit | 22.02 |
ENST00000348849.3
|
RNA binding motif, single stranded interacting protein 1 |
|
| chr4_-_122744998 Show fit | 19.92 |
ENST00000274026.5
|
cyclin A2 |
|
| chr3_+_138340067 Show fit | 19.35 |
ENST00000479848.1
|
Fas apoptotic inhibitory molecule |
|
| chr19_-_47616992 Show fit | 18.85 |
ENST00000253048.5
|
zinc finger CCCH-type containing 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of OTX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.7 | 33.6 | GO:2000812 | regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) regulation of barbed-end actin filament capping(GO:2000812) positive regulation of barbed-end actin filament capping(GO:2000814) |
| 0.0 | 29.7 | GO:0043066 | negative regulation of apoptotic process(GO:0043066) |
| 0.4 | 28.4 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.4 | 27.3 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.8 | 25.3 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 1.3 | 23.7 | GO:0046341 | CDP-diacylglycerol metabolic process(GO:0046341) |
| 1.1 | 22.1 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.1 | 22.0 | GO:0001837 | epithelial to mesenchymal transition(GO:0001837) |
| 0.1 | 20.6 | GO:0006260 | DNA replication(GO:0006260) |
| 5.0 | 19.9 | GO:0071373 | cellular response to cocaine(GO:0071314) cellular response to luteinizing hormone stimulus(GO:0071373) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 38.9 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.9 | 33.6 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.0 | 30.0 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.4 | 28.4 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.5 | 27.3 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 1.4 | 25.3 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 1.5 | 22.1 | GO:0008290 | F-actin capping protein complex(GO:0008290) Flemming body(GO:0090543) |
| 0.3 | 20.3 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 6.6 | 19.9 | GO:0097124 | cyclin A2-CDK2 complex(GO:0097124) |
| 1.2 | 18.6 | GO:0005869 | dynactin complex(GO:0005869) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 55.9 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.2 | 50.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.3 | 35.1 | GO:1902936 | phosphatidylinositol bisphosphate binding(GO:1902936) |
| 0.5 | 28.4 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.5 | 27.3 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.9 | 25.3 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.1 | 25.0 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 24.6 | GO:0003723 | RNA binding(GO:0003723) |
| 7.9 | 23.7 | GO:0003881 | CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity(GO:0003881) |
| 0.4 | 23.7 | GO:0097472 | cyclin-dependent protein kinase activity(GO:0097472) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 42.1 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 1.1 | 33.6 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.5 | 23.9 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.8 | 19.9 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.4 | 18.6 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.5 | 16.8 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.2 | 13.3 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.7 | 13.0 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.5 | 11.9 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 9.2 | PID E2F PATHWAY | E2F transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 48.7 | REACTOME SEMA3A PAK DEPENDENT AXON REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |
| 0.4 | 29.7 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.3 | 29.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.3 | 23.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.2 | 22.6 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.7 | 19.9 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 1.2 | 19.8 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.2 | 16.5 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.5 | 16.3 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 16.2 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |