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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for OTX2_CRX

Z-value: 0.41

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Transcription factors associated with OTX2_CRX

Gene Symbol Gene ID Gene Info
OTX2
ENSG00000165588.12 orthodenticle homeobox 2
CRX
ENSG00000105392.11 cone-rod homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
CRXhg19_v2_chr19_+_48325097_483252110.534.6e-17Click!

Activity profile of OTX2_CRX motif

Sorted Z-values of OTX2_CRX motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_55866104 12.70 ENST00000326529.4
COX6B2
cytochrome c oxidase subunit VIb polypeptide 2 (testis)
chr2_-_175711133 8.21 ENST00000409597.1
ENST00000413882.1
CHN1
chimerin 1
chr19_-_55866061 8.10 ENST00000588572.2
ENST00000593184.1
ENST00000589467.1
COX6B2
cytochrome c oxidase subunit VIb polypeptide 2 (testis)
chr5_-_88179302 7.33 ENST00000504921.2
MEF2C
myocyte enhancer factor 2C
chr20_-_18774614 6.88 ENST00000412553.1
LINC00652
long intergenic non-protein coding RNA 652
chr22_-_38380543 6.55 ENST00000396884.2
SOX10
SRY (sex determining region Y)-box 10
chr19_+_18208603 5.97 ENST00000262811.6
MAST3
microtubule associated serine/threonine kinase 3
chr14_-_22005343 5.76 ENST00000327430.3
SALL2
spalt-like transcription factor 2
chr6_+_150920999 5.45 ENST00000367328.1
ENST00000367326.1
PLEKHG1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr14_-_22005062 5.25 ENST00000317492.5
SALL2
spalt-like transcription factor 2
chr6_+_111580508 5.23 ENST00000368847.4
KIAA1919
KIAA1919
chr14_-_101034407 4.93 ENST00000443071.2
ENST00000557378.1
BEGAIN
brain-enriched guanylate kinase-associated
chr7_-_100171270 4.63 ENST00000538735.1
SAP25
Sin3A-associated protein, 25kDa
chr11_-_111794446 4.52 ENST00000527950.1
CRYAB
crystallin, alpha B
chr5_-_24645078 4.09 ENST00000264463.4
CDH10
cadherin 10, type 2 (T2-cadherin)
chr12_-_16758059 3.80 ENST00000261169.6
LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_-_16758304 3.80 ENST00000320122.6
LMO3
LIM domain only 3 (rhombotin-like 2)
chr18_+_32290218 3.73 ENST00000348997.5
ENST00000588949.1
ENST00000597599.1
DTNA
dystrobrevin, alpha
chr17_-_48207157 3.68 ENST00000330175.4
ENST00000503131.1
SAMD14
sterile alpha motif domain containing 14
chr15_+_43985084 3.62 ENST00000434505.1
ENST00000411750.1
CKMT1A
creatine kinase, mitochondrial 1A
chr3_-_49058479 3.61 ENST00000440857.1
DALRD3
DALR anticodon binding domain containing 3
chr7_-_97881429 3.60 ENST00000420697.1
ENST00000379795.3
ENST00000415086.1
ENST00000542604.1
ENST00000447648.2
TECPR1
tectonin beta-propeller repeat containing 1
chr18_-_64271363 3.59 ENST00000262150.2
CDH19
cadherin 19, type 2
chr5_-_88179017 3.57 ENST00000514028.1
ENST00000514015.1
ENST00000503075.1
ENST00000437473.2
MEF2C
myocyte enhancer factor 2C
chr15_+_43885252 3.49 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
CKMT1B
creatine kinase, mitochondrial 1B
chrX_+_15767971 3.45 ENST00000479740.1
ENST00000454127.2
CA5B
carbonic anhydrase VB, mitochondrial
chr8_-_110656995 3.45 ENST00000276646.9
ENST00000533065.1
SYBU
syntabulin (syntaxin-interacting)
chr5_-_88178964 3.43 ENST00000513252.1
ENST00000508569.1
ENST00000510942.1
ENST00000506554.1
MEF2C
myocyte enhancer factor 2C
chr16_-_58004992 3.33 ENST00000564448.1
ENST00000251102.8
ENST00000311183.4
CNGB1
cyclic nucleotide gated channel beta 1
chr3_+_129247479 3.33 ENST00000296271.3
RHO
rhodopsin
chr11_-_111783595 3.25 ENST00000528628.1
CRYAB
crystallin, alpha B
chr5_-_11588907 3.15 ENST00000513598.1
ENST00000503622.1
CTNND2
catenin (cadherin-associated protein), delta 2
chr3_+_4535025 3.15 ENST00000302640.8
ENST00000354582.6
ENST00000423119.2
ENST00000357086.4
ENST00000456211.2
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr15_-_27184664 3.11 ENST00000541819.2
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chrX_-_54384425 3.09 ENST00000375169.3
ENST00000354646.2
WNK3
WNK lysine deficient protein kinase 3
chr11_-_62752455 3.01 ENST00000360421.4
SLC22A6
solute carrier family 22 (organic anion transporter), member 6
chr5_-_11589131 3.00 ENST00000511377.1
CTNND2
catenin (cadherin-associated protein), delta 2
chr11_-_62752429 2.96 ENST00000377871.3
SLC22A6
solute carrier family 22 (organic anion transporter), member 6
chrX_+_69488174 2.96 ENST00000480877.2
ENST00000307959.8
ARR3
arrestin 3, retinal (X-arrestin)
chrX_+_41306575 2.90 ENST00000342595.2
ENST00000378220.1
NYX
nyctalopin
chr9_-_13279563 2.82 ENST00000541718.1
MPDZ
multiple PDZ domain protein
chr11_-_62752162 2.69 ENST00000458333.2
ENST00000421062.2
SLC22A6
solute carrier family 22 (organic anion transporter), member 6
chr4_+_154125565 2.58 ENST00000338700.5
TRIM2
tripartite motif containing 2
chrX_-_6146876 2.58 ENST00000381095.3
NLGN4X
neuroligin 4, X-linked
chr9_+_17135016 2.56 ENST00000425824.1
ENST00000262360.5
ENST00000380641.4
CNTLN
centlein, centrosomal protein
chr9_+_34179003 2.55 ENST00000545103.1
ENST00000543944.1
ENST00000536252.1
ENST00000540348.1
ENST00000297661.4
ENST00000379186.4
UBAP1
ubiquitin associated protein 1
chr17_-_40264692 2.52 ENST00000591220.1
ENST00000251642.3
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr2_+_183943464 2.52 ENST00000354221.4
DUSP19
dual specificity phosphatase 19
chr5_-_149324306 2.51 ENST00000255266.5
PDE6A
phosphodiesterase 6A, cGMP-specific, rod, alpha
chr9_-_13279589 2.50 ENST00000319217.7
MPDZ
multiple PDZ domain protein
chr9_+_17134980 2.49 ENST00000380647.3
CNTLN
centlein, centrosomal protein
chr19_+_56166360 2.49 ENST00000308924.4
U2AF2
U2 small nuclear RNA auxiliary factor 2
chr4_-_153601136 2.46 ENST00000504064.1
ENST00000304385.3
TMEM154
transmembrane protein 154
chr5_+_161494521 2.45 ENST00000356592.3
GABRG2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr1_+_20396649 2.43 ENST00000375108.3
PLA2G5
phospholipase A2, group V
chr11_-_128894053 2.42 ENST00000392657.3
ARHGAP32
Rho GTPase activating protein 32
chr3_-_50605150 2.34 ENST00000357203.3
C3orf18
chromosome 3 open reading frame 18
chr12_-_13248598 2.32 ENST00000337630.6
ENST00000545699.1
GSG1
germ cell associated 1
chr1_+_18957500 2.32 ENST00000375375.3
PAX7
paired box 7
chr13_+_31191920 2.26 ENST00000255304.4
USPL1
ubiquitin specific peptidase like 1
chr7_-_128171123 2.26 ENST00000608477.1
RP11-212P7.2
RP11-212P7.2
chr3_-_50605077 2.20 ENST00000426034.1
ENST00000441239.1
C3orf18
chromosome 3 open reading frame 18
chr21_+_33245548 2.15 ENST00000270112.2
HUNK
hormonally up-regulated Neu-associated kinase
chr5_+_140345820 2.11 ENST00000289269.5
PCDHAC2
protocadherin alpha subfamily C, 2
chr2_+_120770581 2.10 ENST00000263713.5
EPB41L5
erythrocyte membrane protein band 4.1 like 5
chr10_+_95848824 2.09 ENST00000371385.3
ENST00000371375.1
PLCE1
phospholipase C, epsilon 1
chr9_+_103204553 2.07 ENST00000502978.1
ENST00000334943.6
MSANTD3-TMEFF1
TMEFF1
MSANTD3-TMEFF1 readthrough
transmembrane protein with EGF-like and two follistatin-like domains 1
chr1_+_11751748 2.04 ENST00000294485.5
DRAXIN
dorsal inhibitory axon guidance protein
chr2_+_120770645 2.02 ENST00000443902.2
EPB41L5
erythrocyte membrane protein band 4.1 like 5
chrX_+_129473859 1.98 ENST00000424447.1
SLC25A14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr10_-_104178857 1.96 ENST00000020673.5
PSD
pleckstrin and Sec7 domain containing
chr11_+_61522844 1.92 ENST00000265460.5
MYRF
myelin regulatory factor
chr5_+_161494770 1.90 ENST00000414552.2
ENST00000361925.4
GABRG2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr12_+_7941989 1.89 ENST00000229307.4
NANOG
Nanog homeobox
chr17_-_9808887 1.87 ENST00000226193.5
RCVRN
recoverin
chr8_+_104892639 1.86 ENST00000436393.2
RIMS2
regulating synaptic membrane exocytosis 2
chr5_-_95768973 1.84 ENST00000311106.3
PCSK1
proprotein convertase subtilisin/kexin type 1
chr3_-_98241358 1.79 ENST00000503004.1
ENST00000506575.1
ENST00000513452.1
ENST00000515620.1
CLDND1
claudin domain containing 1
chr12_+_133757995 1.79 ENST00000536435.2
ENST00000228289.5
ENST00000541211.2
ENST00000500625.3
ENST00000539248.2
ENST00000542711.2
ENST00000536899.2
ENST00000542986.2
ENST00000537565.1
ENST00000541975.2
ZNF268
zinc finger protein 268
chr12_-_13248562 1.76 ENST00000457134.2
ENST00000537302.1
GSG1
germ cell associated 1
chr19_+_48325097 1.74 ENST00000221996.7
ENST00000539067.1
CRX
cone-rod homeobox
chr6_+_31554636 1.72 ENST00000433492.1
LST1
leukocyte specific transcript 1
chr18_-_21891460 1.71 ENST00000357041.4
OSBPL1A
oxysterol binding protein-like 1A
chr3_-_54962100 1.68 ENST00000273286.5
LRTM1
leucine-rich repeats and transmembrane domains 1
chr17_-_71640227 1.64 ENST00000388726.3
ENST00000392650.3
SDK2
sidekick cell adhesion molecule 2
chr10_-_76868931 1.56 ENST00000372700.3
ENST00000473072.2
ENST00000491677.2
ENST00000607131.1
ENST00000372702.3
DUSP13
dual specificity phosphatase 13
chr2_+_170366203 1.51 ENST00000284669.1
KLHL41
kelch-like family member 41
chr7_-_128415844 1.51 ENST00000249389.2
OPN1SW
opsin 1 (cone pigments), short-wave-sensitive
chr13_-_52027134 1.50 ENST00000311234.4
ENST00000425000.1
ENST00000463928.1
ENST00000442263.3
ENST00000398119.2
INTS6
integrator complex subunit 6
chr10_+_95372289 1.49 ENST00000371447.3
PDE6C
phosphodiesterase 6C, cGMP-specific, cone, alpha prime
chr11_-_128712362 1.49 ENST00000392664.2
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chr3_-_45838011 1.45 ENST00000358525.4
ENST00000413781.1
SLC6A20
solute carrier family 6 (proline IMINO transporter), member 20
chrX_-_49089771 1.45 ENST00000376251.1
ENST00000323022.5
ENST00000376265.2
CACNA1F
calcium channel, voltage-dependent, L type, alpha 1F subunit
chr3_+_137483579 1.38 ENST00000306087.1
SOX14
SRY (sex determining region Y)-box 14
chr4_+_170541835 1.38 ENST00000504131.2
CLCN3
chloride channel, voltage-sensitive 3
chr11_-_118436606 1.38 ENST00000530872.1
IFT46
intraflagellar transport 46 homolog (Chlamydomonas)
chr12_-_21487829 1.36 ENST00000445053.1
ENST00000452078.1
ENST00000458504.1
ENST00000422327.1
ENST00000421294.1
SLCO1A2
solute carrier organic anion transporter family, member 1A2
chrX_-_153363125 1.35 ENST00000407218.1
ENST00000453960.2
MECP2
methyl CpG binding protein 2 (Rett syndrome)
chr15_+_33603147 1.35 ENST00000415757.3
ENST00000389232.4
RYR3
ryanodine receptor 3
chr9_+_82188077 1.35 ENST00000425506.1
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr10_-_48390973 1.34 ENST00000224600.4
RBP3
retinol binding protein 3, interstitial
chr8_-_91095099 1.34 ENST00000265431.3
CALB1
calbindin 1, 28kDa
chr12_-_13248705 1.33 ENST00000396310.2
GSG1
germ cell associated 1
chr18_+_29769978 1.32 ENST00000269202.6
ENST00000581447.1
MEP1B
meprin A, beta
chrY_+_16634483 1.30 ENST00000382872.1
NLGN4Y
neuroligin 4, Y-linked
chr3_-_170626418 1.28 ENST00000474096.1
ENST00000295822.2
EIF5A2
eukaryotic translation initiation factor 5A2
chr20_+_4702548 1.27 ENST00000305817.2
PRND
prion protein 2 (dublet)
chr21_-_19775973 1.26 ENST00000284885.3
TMPRSS15
transmembrane protease, serine 15
chr8_-_145701718 1.23 ENST00000377317.4
FOXH1
forkhead box H1
chr1_+_17248418 1.18 ENST00000375541.5
CROCC
ciliary rootlet coiled-coil, rootletin
chr2_+_33661382 1.17 ENST00000402538.3
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr7_+_136553824 1.16 ENST00000320658.5
ENST00000453373.1
ENST00000397608.3
ENST00000402486.3
ENST00000401861.1
CHRM2
cholinergic receptor, muscarinic 2
chr16_-_325910 1.15 ENST00000359740.5
ENST00000316163.5
ENST00000431291.2
ENST00000397770.3
ENST00000397768.3
RGS11
regulator of G-protein signaling 11
chr19_-_44124019 1.14 ENST00000300811.3
ZNF428
zinc finger protein 428
chr6_-_42690312 1.13 ENST00000230381.5
PRPH2
peripherin 2 (retinal degeneration, slow)
chr2_-_30144432 1.11 ENST00000389048.3
ALK
anaplastic lymphoma receptor tyrosine kinase
chr6_+_31554826 1.11 ENST00000376089.2
ENST00000396112.2
LST1
leukocyte specific transcript 1
chr15_-_34610962 1.09 ENST00000290209.5
SLC12A6
solute carrier family 12 (potassium/chloride transporter), member 6
chr22_-_19137796 1.08 ENST00000086933.2
GSC2
goosecoid homeobox 2
chr1_-_241799232 1.07 ENST00000366553.1
CHML
choroideremia-like (Rab escort protein 2)
chr1_+_159141397 1.07 ENST00000368124.4
ENST00000368125.4
ENST00000416746.1
CADM3
cell adhesion molecule 3
chr13_-_79980315 1.05 ENST00000438737.2
RBM26
RNA binding motif protein 26
chr4_-_102267953 1.05 ENST00000523694.2
ENST00000507176.1
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr1_-_165414414 1.01 ENST00000359842.5
RXRG
retinoid X receptor, gamma
chr4_+_96012614 1.01 ENST00000264568.4
BMPR1B
bone morphogenetic protein receptor, type IB
chr12_+_81101277 1.00 ENST00000228641.3
MYF6
myogenic factor 6 (herculin)
chr5_-_524445 1.00 ENST00000514375.1
ENST00000264938.3
SLC9A3
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
chrX_-_101771645 0.99 ENST00000289373.4
TMSB15A
thymosin beta 15a
chr6_+_35310391 0.99 ENST00000337400.2
ENST00000311565.4
ENST00000540939.1
PPARD
peroxisome proliferator-activated receptor delta
chr6_+_42141029 0.98 ENST00000372958.1
GUCA1A
guanylate cyclase activator 1A (retina)
chr18_-_28681950 0.97 ENST00000251081.6
DSC2
desmocollin 2
chr8_-_87755878 0.96 ENST00000320005.5
CNGB3
cyclic nucleotide gated channel beta 3
chr10_-_74114714 0.96 ENST00000338820.3
ENST00000394903.2
ENST00000444643.2
DNAJB12
DnaJ (Hsp40) homolog, subfamily B, member 12
chr12_+_58138800 0.95 ENST00000547992.1
ENST00000552816.1
ENST00000547472.1
TSPAN31
tetraspanin 31
chr19_-_42931567 0.92 ENST00000244289.4
LIPE
lipase, hormone-sensitive
chr12_-_13248732 0.91 ENST00000396302.3
GSG1
germ cell associated 1
chr15_-_35047166 0.90 ENST00000290374.4
GJD2
gap junction protein, delta 2, 36kDa
chr3_-_45837959 0.90 ENST00000353278.4
ENST00000456124.2
SLC6A20
solute carrier family 6 (proline IMINO transporter), member 20
chrX_-_153363188 0.87 ENST00000303391.6
MECP2
methyl CpG binding protein 2 (Rett syndrome)
chr15_+_93443419 0.85 ENST00000557381.1
ENST00000420239.2
CHD2
chromodomain helicase DNA binding protein 2
chr1_-_21606013 0.84 ENST00000357071.4
ECE1
endothelin converting enzyme 1
chr1_-_117664317 0.82 ENST00000256649.4
ENST00000369464.3
ENST00000485032.1
TRIM45
tripartite motif containing 45
chr9_-_20622478 0.82 ENST00000355930.6
ENST00000380338.4
MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr6_-_35480640 0.81 ENST00000428978.1
ENST00000322263.4
TULP1
tubby like protein 1
chr12_+_58138664 0.81 ENST00000257910.3
TSPAN31
tetraspanin 31
chr1_-_53608289 0.78 ENST00000371491.4
SLC1A7
solute carrier family 1 (glutamate transporter), member 7
chr6_+_31554962 0.78 ENST00000376092.3
ENST00000376086.3
ENST00000303757.8
ENST00000376093.2
ENST00000376102.3
LST1
leukocyte specific transcript 1
chr1_-_13452656 0.77 ENST00000376132.3
PRAMEF13
PRAME family member 13
chr12_-_56848426 0.77 ENST00000257979.4
MIP
major intrinsic protein of lens fiber
chr6_+_31555045 0.74 ENST00000396101.3
ENST00000490742.1
LST1
leukocyte specific transcript 1
chr11_-_118436707 0.74 ENST00000264020.2
ENST00000264021.3
IFT46
intraflagellar transport 46 homolog (Chlamydomonas)
chr1_+_209757051 0.74 ENST00000009105.1
ENST00000423146.1
ENST00000361322.2
CAMK1G
calcium/calmodulin-dependent protein kinase IG
chr1_+_26644441 0.74 ENST00000374213.2
CD52
CD52 molecule
chr3_-_9291063 0.70 ENST00000383836.3
SRGAP3
SLIT-ROBO Rho GTPase activating protein 3
chr19_-_44123734 0.70 ENST00000598676.1
ZNF428
zinc finger protein 428
chr10_+_35464513 0.70 ENST00000494479.1
ENST00000463314.1
ENST00000342105.3
ENST00000495301.1
ENST00000463960.1
CREM
cAMP responsive element modulator
chr17_+_68100989 0.69 ENST00000585558.1
ENST00000392670.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr12_+_85673868 0.67 ENST00000316824.3
ALX1
ALX homeobox 1
chr8_-_133123406 0.66 ENST00000434736.2
HHLA1
HERV-H LTR-associating 1
chr19_+_2476116 0.65 ENST00000215631.4
ENST00000587345.1
GADD45B
growth arrest and DNA-damage-inducible, beta
chr14_-_36789783 0.64 ENST00000605579.1
ENST00000604336.1
ENST00000359527.7
ENST00000603139.1
ENST00000318473.7
MBIP
MAP3K12 binding inhibitory protein 1
chr12_+_70133152 0.64 ENST00000550536.1
ENST00000362025.5
RAB3IP
RAB3A interacting protein
chr3_-_32612263 0.64 ENST00000432458.2
ENST00000424991.1
ENST00000273130.4
DYNC1LI1
dynein, cytoplasmic 1, light intermediate chain 1
chr19_-_10121144 0.62 ENST00000264828.3
COL5A3
collagen, type V, alpha 3
chr1_-_53608249 0.62 ENST00000371494.4
SLC1A7
solute carrier family 1 (glutamate transporter), member 7
chr10_+_52750930 0.61 ENST00000401604.2
PRKG1
protein kinase, cGMP-dependent, type I
chr14_-_36789865 0.60 ENST00000416007.4
MBIP
MAP3K12 binding inhibitory protein 1
chr19_-_51538118 0.59 ENST00000529888.1
KLK12
kallikrein-related peptidase 12
chr3_-_48229846 0.59 ENST00000302506.3
ENST00000351231.3
ENST00000437972.1
CDC25A
cell division cycle 25A
chr16_-_68269971 0.59 ENST00000565858.1
ESRP2
epithelial splicing regulatory protein 2
chr4_+_68424434 0.59 ENST00000265404.2
ENST00000396225.1
STAP1
signal transducing adaptor family member 1
chr11_+_128563652 0.56 ENST00000527786.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr21_-_34915147 0.54 ENST00000381831.3
ENST00000381839.3
GART
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
chr18_-_28682374 0.54 ENST00000280904.6
DSC2
desmocollin 2
chr2_-_214016314 0.54 ENST00000434687.1
ENST00000374319.4
IKZF2
IKAROS family zinc finger 2 (Helios)
chrX_-_15619076 0.53 ENST00000252519.3
ACE2
angiotensin I converting enzyme 2
chr5_-_58882219 0.53 ENST00000505453.1
ENST00000360047.5
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_-_67197760 0.51 ENST00000539540.1
ENST00000540433.1
ENST00000541947.1
ENST00000538373.1
GRIP1
glutamate receptor interacting protein 1
chr10_-_86001210 0.49 ENST00000372105.3
LRIT1
leucine-rich repeat, immunoglobulin-like and transmembrane domains 1
chr2_+_128175997 0.47 ENST00000234071.3
ENST00000429925.1
ENST00000442644.1
ENST00000453608.2
PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr19_-_48547294 0.46 ENST00000293255.2
CABP5
calcium binding protein 5
chr3_+_173302222 0.43 ENST00000361589.4
NLGN1
neuroligin 1
chr16_-_31076273 0.42 ENST00000426488.2
ZNF668
zinc finger protein 668
chr8_+_61591337 0.42 ENST00000423902.2
CHD7
chromodomain helicase DNA binding protein 7
chr2_-_119605253 0.41 ENST00000295206.6
EN1
engrailed homeobox 1
chr22_-_30867973 0.39 ENST00000402286.1
ENST00000401751.1
ENST00000539629.1
ENST00000403066.1
ENST00000215812.4
SEC14L3
SEC14-like 3 (S. cerevisiae)
chr14_+_96722152 0.38 ENST00000216629.6
BDKRB1
bradykinin receptor B1
chr16_-_31076332 0.37 ENST00000539836.3
ENST00000535577.1
ENST00000442862.2
ZNF668
zinc finger protein 668
chr20_+_42984330 0.36 ENST00000316673.4
ENST00000609795.1
ENST00000457232.1
ENST00000609262.1
HNF4A
hepatocyte nuclear factor 4, alpha
chr10_+_118350468 0.35 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
PNLIPRP1
pancreatic lipase-related protein 1
chr14_-_22005018 0.35 ENST00000546363.1
SALL2
spalt-like transcription factor 2
chr1_+_180897269 0.33 ENST00000367587.1
KIAA1614
KIAA1614
chr10_-_94003003 0.32 ENST00000412050.4
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr4_-_102268484 0.31 ENST00000394853.4
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr15_-_31453359 0.30 ENST00000542188.1
TRPM1
transient receptor potential cation channel, subfamily M, member 1
chrX_+_153409678 0.30 ENST00000369951.4
OPN1LW
opsin 1 (cone pigments), long-wave-sensitive
chr1_-_173174681 0.30 ENST00000367718.1
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr12_-_53171128 0.29 ENST00000332411.2
KRT76
keratin 76
chr6_+_35310312 0.28 ENST00000448077.2
ENST00000360694.3
ENST00000418635.2
ENST00000444397.1
PPARD
peroxisome proliferator-activated receptor delta
chr5_-_33984741 0.27 ENST00000382102.3
ENST00000509381.1
ENST00000342059.3
ENST00000345083.5
SLC45A2
solute carrier family 45, member 2

Network of associatons between targets according to the STRING database.

First level regulatory network of OTX2_CRX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 14.3 GO:0003185 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
2.9 8.7 GO:0097254 renal tubular secretion(GO:0097254)
1.6 6.6 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
1.4 4.1 GO:0003383 apical constriction(GO:0003383) mesoderm migration involved in gastrulation(GO:0007509)
1.3 7.6 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
1.2 3.6 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.8 3.1 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.7 2.2 GO:1900114 positive regulation of histone H3-K9 trimethylation(GO:1900114)
0.6 2.5 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.6 3.2 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.6 2.4 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.6 1.8 GO:0045897 positive regulation of transcription during mitosis(GO:0045897)
0.6 2.3 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.4 2.1 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.4 1.2 GO:0007231 osmosensory signaling pathway(GO:0007231)
0.4 1.2 GO:2000824 negative regulation of androgen receptor activity(GO:2000824)
0.4 3.6 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.4 7.5 GO:0071420 cellular response to histamine(GO:0071420)
0.3 5.6 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.3 1.7 GO:0046532 regulation of photoreceptor cell differentiation(GO:0046532)
0.3 6.2 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.3 2.4 GO:0015824 proline transport(GO:0015824)
0.3 1.0 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.3 3.6 GO:0006600 creatine metabolic process(GO:0006600)
0.3 5.1 GO:0018298 protein-chromophore linkage(GO:0018298)
0.3 1.9 GO:0001714 endodermal cell fate specification(GO:0001714)
0.3 2.3 GO:0016926 protein desumoylation(GO:0016926)
0.3 5.1 GO:0007021 tubulin complex assembly(GO:0007021)
0.3 1.1 GO:0036269 swimming behavior(GO:0036269)
0.3 1.4 GO:0048388 endosomal lumen acidification(GO:0048388)
0.3 1.1 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.2 1.5 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.2 2.8 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.2 1.2 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.2 7.5 GO:0008045 motor neuron axon guidance(GO:0008045)
0.2 1.9 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.2 0.8 GO:0034959 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.2 1.9 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.2 1.0 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.2 2.8 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.2 0.2 GO:0016199 axon midline choice point recognition(GO:0016199)
0.2 0.6 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760) negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
0.2 0.9 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.2 1.7 GO:0086042 cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.2 1.3 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.2 1.6 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.2 1.3 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.2 0.5 GO:0044537 regulation of circulating fibrinogen levels(GO:0044537)
0.2 2.6 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.1 1.3 GO:0071286 cellular response to magnesium ion(GO:0071286)
0.1 0.4 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.1 0.4 GO:0061743 motor learning(GO:0061743)
0.1 2.5 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.1 1.1 GO:0018344 protein geranylgeranylation(GO:0018344)
0.1 0.3 GO:0045900 negative regulation of translational elongation(GO:0045900)
0.1 0.5 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051)
0.1 2.6 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.1 1.0 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.1 0.3 GO:2000523 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.1 2.0 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 6.2 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.1 0.9 GO:0021516 dorsal spinal cord development(GO:0021516)
0.1 3.7 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.1 2.5 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.1 1.5 GO:0016180 snRNA processing(GO:0016180)
0.1 0.8 GO:0007379 segment specification(GO:0007379) positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 0.6 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.1 1.4 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.1 0.2 GO:0021562 vestibulocochlear nerve development(GO:0021562)
0.1 1.0 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.1 0.5 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.1 0.3 GO:0045726 regulation of integrin biosynthetic process(GO:0045113) positive regulation of integrin biosynthetic process(GO:0045726)
0.1 3.4 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 10.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 0.3 GO:0048859 formation of anatomical boundary(GO:0048859)
0.1 1.3 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.1 1.0 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 11.3 GO:0021915 neural tube development(GO:0021915)
0.1 0.5 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 2.1 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.1 0.2 GO:0002326 B cell lineage commitment(GO:0002326)
0.1 0.3 GO:0048733 sebaceous gland development(GO:0048733)
0.1 10.6 GO:0007601 visual perception(GO:0007601)
0.1 0.4 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 1.8 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.4 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 4.2 GO:0032945 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.0 1.7 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.0 0.6 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.0 0.1 GO:1903625 negative regulation of DNA catabolic process(GO:1903625)
0.0 3.2 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.0 0.2 GO:1990034 calcium ion export from cell(GO:1990034)
0.0 1.3 GO:0010107 potassium ion import(GO:0010107)
0.0 1.4 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 1.7 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.2 GO:0001711 endodermal cell fate commitment(GO:0001711)
0.0 0.8 GO:0060348 bone development(GO:0060348)
0.0 1.3 GO:1901998 toxin transport(GO:1901998)
0.0 2.2 GO:0009060 aerobic respiration(GO:0009060)
0.0 1.0 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.7 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.0 1.3 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 0.4 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.6 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.0 0.9 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.6 GO:0006612 protein targeting to membrane(GO:0006612)
0.0 0.7 GO:0045730 respiratory burst(GO:0045730)
0.0 0.6 GO:0030199 collagen fibril organization(GO:0030199)
0.0 2.2 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.1 GO:0035063 nuclear speck organization(GO:0035063)
0.0 0.2 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.1 GO:0060737 prostate epithelial cord elongation(GO:0060523) prostate gland morphogenetic growth(GO:0060737)
0.0 1.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 1.8 GO:0007155 cell adhesion(GO:0007155) biological adhesion(GO:0022610)
0.0 0.1 GO:0044800 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.0 0.2 GO:0000086 G2/M transition of mitotic cell cycle(GO:0000086) cell cycle G2/M phase transition(GO:0044839)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 20.8 GO:0030061 mitochondrial crista(GO:0030061)
0.5 2.5 GO:0089701 U2AF(GO:0089701)
0.5 7.8 GO:0097512 cardiac myofibril(GO:0097512)
0.5 4.1 GO:0005955 calcineurin complex(GO:0005955)
0.4 11.4 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.4 2.6 GO:0000813 ESCRT I complex(GO:0000813)
0.3 8.5 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.3 1.2 GO:0032279 asymmetric synapse(GO:0032279)
0.3 1.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.3 5.3 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.3 3.4 GO:0097433 dense body(GO:0097433)
0.2 7.5 GO:1902711 GABA-A receptor complex(GO:1902711)
0.2 0.8 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
0.2 0.6 GO:0005588 collagen type V trimer(GO:0005588)
0.2 1.2 GO:0032444 activin responsive factor complex(GO:0032444)
0.2 6.6 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.2 1.5 GO:0032039 integrator complex(GO:0032039)
0.1 9.3 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 3.6 GO:0000421 autophagosome membrane(GO:0000421)
0.1 1.2 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 2.1 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 1.2 GO:0035253 ciliary rootlet(GO:0035253)
0.1 2.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 1.0 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 0.3 GO:0035838 growing cell tip(GO:0035838)
0.1 8.8 GO:0005901 caveola(GO:0005901)
0.1 1.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 2.9 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 0.2 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 1.7 GO:0005921 gap junction(GO:0005921)
0.1 0.2 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 1.5 GO:0030057 desmosome(GO:0030057)
0.0 5.1 GO:0005814 centriole(GO:0005814)
0.0 6.0 GO:0043204 perikaryon(GO:0043204)
0.0 6.1 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.3 GO:0071438 invadopodium membrane(GO:0071438)
0.0 1.9 GO:0048786 presynaptic active zone(GO:0048786)
0.0 4.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 18.7 GO:0098794 postsynapse(GO:0098794)
0.0 2.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 0.2 GO:0005916 fascia adherens(GO:0005916)
0.0 0.2 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.8 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 1.8 GO:0030133 transport vesicle(GO:0030133)
0.0 1.1 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 2.0 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.3 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 1.3 GO:0005643 nuclear pore(GO:0005643)
0.0 0.5 GO:0005796 Golgi lumen(GO:0005796)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.6 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.9 8.7 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.8 14.3 GO:0003680 AT DNA binding(GO:0003680)
0.8 3.3 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.8 3.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.6 2.8 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.5 2.5 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.5 5.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.5 3.6 GO:0004111 creatine kinase activity(GO:0004111)
0.4 2.2 GO:0002046 opsin binding(GO:0002046)
0.4 1.2 GO:0030366 molybdopterin synthase activity(GO:0030366)
0.3 1.3 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.3 4.4 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.3 3.1 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.3 4.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.3 0.9 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.3 2.3 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.3 8.1 GO:0005212 structural constituent of eye lens(GO:0005212)
0.3 1.0 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.2 1.5 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.2 2.4 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.2 1.2 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.2 1.4 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.2 1.3 GO:0005499 vitamin D binding(GO:0005499)
0.2 2.5 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.2 3.4 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.2 1.0 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.2 2.2 GO:0010385 double-stranded methylated DNA binding(GO:0010385)
0.2 1.7 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.2 8.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 1.1 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.2 5.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 3.6 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 1.4 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.1 0.4 GO:0004947 bradykinin receptor activity(GO:0004947)
0.1 1.7 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 0.6 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.1 2.4 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.1 1.0 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 0.5 GO:0016882 cyclo-ligase activity(GO:0016882)
0.1 1.1 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 3.0 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1 1.0 GO:0015386 sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.1 1.0 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 6.5 GO:0070063 RNA polymerase binding(GO:0070063)
0.1 1.1 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 0.6 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1 4.6 GO:0019894 kinesin binding(GO:0019894)
0.1 1.3 GO:0016918 retinal binding(GO:0016918)
0.1 0.5 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.1 2.0 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 2.1 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 1.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 0.4 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.1 1.2 GO:0019992 diacylglycerol binding(GO:0019992)
0.1 1.4 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 0.9 GO:0005243 gap junction channel activity(GO:0005243)
0.1 6.5 GO:0008013 beta-catenin binding(GO:0008013)
0.1 5.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 0.7 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 1.7 GO:0015248 sterol transporter activity(GO:0015248)
0.1 1.2 GO:0070410 co-SMAD binding(GO:0070410)
0.1 1.3 GO:0036041 long-chain fatty acid binding(GO:0036041)
0.0 0.4 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 1.3 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.3 GO:0015252 hydrogen ion channel activity(GO:0015252)
0.0 3.9 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.7 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 1.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 2.4 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 0.5 GO:0005402 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402)
0.0 1.6 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.5 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.6 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.6 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 3.0 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 1.0 GO:0003785 actin monomer binding(GO:0003785)
0.0 4.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.3 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 1.0 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 13.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 6.1 GO:0000287 magnesium ion binding(GO:0000287)
0.0 2.6 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.2 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 5.0 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.9 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.6 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 2.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.6 GO:0043394 proteoglycan binding(GO:0043394)
0.0 3.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.6 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 1.6 GO:0004386 helicase activity(GO:0004386)
0.0 1.9 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 1.3 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 1.1 GO:0008233 peptidase activity(GO:0008233)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 9.7 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.2 14.3 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 8.2 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 1.1 PID CONE PATHWAY Visual signal transduction: Cones
0.1 2.3 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 3.3 PID RAS PATHWAY Regulation of Ras family activation
0.1 2.3 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.6 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.4 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.0 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 1.3 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.0 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.2 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.6 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.0 PID BMP PATHWAY BMP receptor signaling
0.0 0.4 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.4 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 1.4 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.3 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 1.7 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.1 REACTOME OPSINS Genes involved in Opsins
0.4 8.7 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.4 14.3 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.2 7.5 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.2 3.4 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.2 2.4 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.1 4.1 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 2.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.8 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 1.4 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 3.1 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 2.5 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.1 1.4 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.9 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 1.7 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 1.2 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 7.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.6 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 1.5 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.5 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.9 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 2.7 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 1.0 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 1.2 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 7.1 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.4 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 2.1 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.3 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.2 REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.1 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation