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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for OVOL1

Z-value: 0.24

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Transcription factors associated with OVOL1

Gene Symbol Gene ID Gene Info
OVOL1
ENSG00000172818.5 ovo like transcriptional repressor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
OVOL1hg19_v2_chr11_+_65554493_655545460.203.0e-03Click!

Activity profile of OVOL1 motif

Sorted Z-values of OVOL1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_84419101 5.34 ENST00000520302.1
ENST00000520213.1
ENST00000439399.2
ENST00000428679.2
ENST00000437520.1
SNAP91
synaptosomal-associated protein, 91kDa
chr10_-_73848086 3.44 ENST00000536168.1
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr10_-_21786179 3.39 ENST00000377113.5
CASC10
cancer susceptibility candidate 10
chr10_-_73848764 3.24 ENST00000317376.4
ENST00000412663.1
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr5_+_140739537 3.16 ENST00000522605.1
PCDHGB2
protocadherin gamma subfamily B, 2
chr10_-_73848531 2.86 ENST00000373109.2
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr5_-_16509101 2.46 ENST00000399793.2
FAM134B
family with sequence similarity 134, member B
chr5_+_140261703 1.88 ENST00000409494.1
ENST00000289272.2
PCDHA13
protocadherin alpha 13
chr1_+_174846570 1.45 ENST00000392064.2
RABGAP1L
RAB GTPase activating protein 1-like
chr3_-_165555200 1.18 ENST00000479451.1
ENST00000540653.1
ENST00000488954.1
ENST00000264381.3
BCHE
butyrylcholinesterase
chr2_-_183387064 0.98 ENST00000536095.1
ENST00000331935.6
ENST00000358139.2
ENST00000456212.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr2_-_183387283 0.88 ENST00000435564.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr14_+_29241910 0.85 ENST00000399387.4
ENST00000552957.1
ENST00000548213.1
C14orf23
chromosome 14 open reading frame 23
chr4_+_39408470 0.84 ENST00000257408.4
KLB
klotho beta
chr17_-_7145475 0.80 ENST00000571129.1
ENST00000571253.1
ENST00000573928.1
GABARAP
GABA(A) receptor-associated protein
chr7_-_38389573 0.57 ENST00000390344.2
TRGV5
T cell receptor gamma variable 5
chr7_+_119913688 0.56 ENST00000331113.4
KCND2
potassium voltage-gated channel, Shal-related subfamily, member 2
chr2_-_183387430 0.51 ENST00000410103.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr19_-_46296011 0.46 ENST00000377735.3
ENST00000270223.6
DMWD
dystrophia myotonica, WD repeat containing
chr11_-_75017734 0.18 ENST00000532525.1
ARRB1
arrestin, beta 1
chr15_+_75335604 0.06 ENST00000563393.1
PPCDC
phosphopantothenoylcysteine decarboxylase
chr20_+_54823788 0.03 ENST00000243911.2
MC3R
melanocortin 3 receptor

Network of associatons between targets according to the STRING database.

First level regulatory network of OVOL1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 9.5 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.4 1.2 GO:0014016 neuroblast differentiation(GO:0014016)
0.2 5.3 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.1 2.4 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 0.8 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.0 0.8 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.6 GO:0045475 locomotor rhythm(GO:0045475)
0.0 5.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.4 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.2 GO:0090240 follicle-stimulating hormone signaling pathway(GO:0042699) positive regulation of histone H4 acetylation(GO:0090240)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 5.5 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.8 GO:0097225 sperm midpiece(GO:0097225)
0.0 9.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.6 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 9.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.3 2.4 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.3 1.2 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.2 5.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.2 0.8 GO:0008422 beta-glucosidase activity(GO:0008422)
0.1 0.6 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 0.2 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.0 0.8 GO:0050811 GABA receptor binding(GO:0050811)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 9.5 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 2.4 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.8 REACTOME FGFR LIGAND BINDING AND ACTIVATION Genes involved in FGFR ligand binding and activation
0.0 0.6 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels