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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for PAX1_PAX9
Z-value: 0.10
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Transcription factors associated with PAX1_PAX9
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PAX9 | hg19_v2_chr14_+_37131058_37131139, hg19_v2_chr14_+_37126765_37126799 | 0.15 | 3.1e-02 | Click! |
| PAX1 | hg19_v2_chr20_+_21686290_21686311 | -0.03 | 6.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PAX1_PAX9
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 19.7 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
| 1.5 | 10.7 | GO:1904849 | positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546) |
| 0.4 | 6.1 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 2.0 | 6.0 | GO:0042700 | luteinizing hormone signaling pathway(GO:0042700) |
| 0.2 | 5.2 | GO:0032332 | positive regulation of chondrocyte differentiation(GO:0032332) |
| 0.9 | 3.6 | GO:0002880 | chronic inflammatory response to non-antigenic stimulus(GO:0002545) regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002880) |
| 0.1 | 2.5 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.0 | 2.1 | GO:0045124 | regulation of bone resorption(GO:0045124) |
| 0.7 | 2.0 | GO:2000276 | negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276) |
| 0.1 | 1.9 | GO:0033141 | positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 20.9 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 17.1 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 8.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 5.2 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 2.0 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.1 | 1.8 | GO:0090665 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.1 | 1.4 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 1.3 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.0 | 1.3 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 0.6 | GO:0097381 | photoreceptor disc membrane(GO:0097381) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 20.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.4 | 10.7 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.0 | 6.1 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.1 | 6.0 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.5 | 5.2 | GO:0070492 | oligosaccharide binding(GO:0070492) |
| 0.5 | 3.6 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) |
| 0.0 | 2.5 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.7 | 2.1 | GO:0042015 | interleukin-20 binding(GO:0042015) |
| 0.0 | 2.0 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.1 | 1.9 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 22.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 10.7 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.2 | 7.3 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.2 | 6.0 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 3.6 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 2.5 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 2.0 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 1.4 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 1.3 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.0 | 1.2 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 10.7 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.2 | 6.1 | REACTOME DESTABILIZATION OF MRNA BY KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 0.2 | 6.0 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.1 | 3.6 | REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
| 0.1 | 2.6 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.2 | 1.3 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.0 | 1.3 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.0 | 1.2 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 0.6 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 0.5 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |