Project
GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for PAX4
Z-value: 0.55
Motif logo
Transcription factors associated with PAX4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PAX4 | hg19_v2_chr7_-_127255724_127255780 | -0.10 | 1.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PAX4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 48.0 | GO:0050672 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 5.7 | 40.2 | GO:0039663 | fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800) |
| 0.3 | 33.1 | GO:0031295 | T cell costimulation(GO:0031295) |
| 7.6 | 30.3 | GO:0002503 | peptide antigen assembly with MHC class II protein complex(GO:0002503) |
| 1.5 | 27.9 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 1.0 | 25.8 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 0.6 | 22.5 | GO:0045730 | respiratory burst(GO:0045730) |
| 2.7 | 19.2 | GO:2000334 | lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
| 4.5 | 18.0 | GO:2001191 | gamma-delta T cell activation involved in immune response(GO:0002290) negative regulation of interferon-beta secretion(GO:0035548) regulation of gamma-delta T cell activation involved in immune response(GO:2001191) positive regulation of gamma-delta T cell activation involved in immune response(GO:2001193) |
| 0.2 | 15.4 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 65.4 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 38.7 | GO:0005770 | late endosome(GO:0005770) |
| 0.0 | 34.7 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 26.5 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.2 | 23.6 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.1 | 23.1 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 20.9 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.6 | 18.8 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.3 | 15.4 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 2.0 | 13.8 | GO:0002178 | palmitoyltransferase complex(GO:0002178) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.7 | 65.4 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 3.7 | 40.2 | GO:0016494 | C-X-C chemokine receptor activity(GO:0016494) |
| 0.0 | 29.1 | GO:0003682 | chromatin binding(GO:0003682) |
| 3.7 | 25.8 | GO:0047894 | flavonol 3-sulfotransferase activity(GO:0047894) |
| 3.2 | 19.2 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 1.4 | 18.8 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 4.5 | 18.0 | GO:0030107 | HLA-A specific inhibitory MHC class I receptor activity(GO:0030107) |
| 0.3 | 15.4 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.9 | 13.8 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.7 | 13.1 | GO:0050786 | RAGE receptor binding(GO:0050786) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 46.5 | PID S1P S1P3 PATHWAY | S1P3 pathway |
| 0.6 | 30.5 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 17.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 15.0 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.3 | 13.9 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.2 | 11.6 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.4 | 10.5 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 8.6 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 5.5 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.2 | 4.0 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.0 | 40.2 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |
| 1.6 | 35.1 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.4 | 30.9 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.9 | 25.8 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.3 | 18.8 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.2 | 18.5 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.4 | 13.1 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.3 | 10.5 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.1 | 8.4 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 7.5 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |