ISMARA results: PAX6

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for PAX6

Z-value: 0.43

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Transcription factors associated with PAX6

Gene Symbol	Gene ID	Gene Info
PAX6 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000007372.16	paired box 6

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PAX6	hg19_v2_chr11_-_31832581_31832601, hg19_v2_chr11_-_31832862_31832884, hg19_v2_chr11_-_31832785_31832823, hg19_v2_chr11_-_31832207_31832226	0.14	4.6e-02	Click!

Activity profile of PAX6 motif

Sorted Z-values of PAX6 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_-_97501706 Show fit	10.52	ENST00000455086.1 ENST00000453600.1	ASNS Ensembl NCBI GeneCards UniProt NextProt Show fit	asparagine synthetase (glutamine-hydrolyzing)
chr2_-_175870085 Show fit	9.35	ENST00000409156.3	CHN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	chimerin 1
chr7_-_97501733 Show fit	8.64	ENST00000444334.1 ENST00000422745.1 ENST00000394308.3 ENST00000451771.1 ENST00000175506.4	ASNS Ensembl NCBI GeneCards UniProt NextProt Show fit	asparagine synthetase (glutamine-hydrolyzing)
chr12_-_45269430 Show fit	8.13	ENST00000395487.2	NELL2 Ensembl NCBI GeneCards UniProt NextProt Show fit	NEL-like 2 (chicken)
chr10_-_118765081 Show fit	8.00	ENST00000392903.2 ENST00000355371.4	KIAA1598 Ensembl NCBI GeneCards UniProt NextProt Show fit	KIAA1598
chr12_-_45270151 Show fit	7.74	ENST00000429094.2	NELL2 Ensembl NCBI GeneCards UniProt NextProt Show fit	NEL-like 2 (chicken)
chr12_-_45270077 Show fit	7.61	ENST00000551601.1 ENST00000549027.1 ENST00000452445.2	NELL2 Ensembl NCBI GeneCards UniProt NextProt Show fit	NEL-like 2 (chicken)
chr10_-_118764862 Show fit	7.28	ENST00000260777.10	KIAA1598 Ensembl NCBI GeneCards UniProt NextProt Show fit	KIAA1598
chr11_-_58343319 Show fit	7.21	ENST00000395074.2	LPXN Ensembl NCBI GeneCards UniProt NextProt Show fit	leupaxin
chr8_-_121457332 Show fit	6.72	ENST00000518918.1	MRPL13 Ensembl NCBI GeneCards UniProt NextProt Show fit	mitochondrial ribosomal protein L13

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX6

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	23.5	GO:0070050	neuron cellular homeostasis(GO:0070050)
4.8	19.2	GO:0070982	L-asparagine biosynthetic process(GO:0070981) L-asparagine metabolic process(GO:0070982)
0.4	14.7	GO:0008045	motor neuron axon guidance(GO:0008045)
0.1	14.1	GO:0046330	positive regulation of JNK cascade(GO:0046330)
0.2	13.5	GO:0070125	mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.2	12.3	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
3.3	10.0	GO:0070901	mitochondrial tRNA methylation(GO:0070901)
0.0	8.4	GO:0030307	positive regulation of cell growth(GO:0030307)
0.9	7.2	GO:0050859	negative regulation of B cell receptor signaling pathway(GO:0050859)
0.5	6.3	GO:0001915	negative regulation of T cell mediated cytotoxicity(GO:0001915)

Showing 1 to 10 of 112 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	18.5	GO:0048471	perinuclear region of cytoplasm(GO:0048471)
0.3	13.5	GO:0000315	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0	9.5	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.1	9.3	GO:0005758	mitochondrial intermembrane space(GO:0005758)
0.5	7.5	GO:0031080	nuclear pore outer ring(GO:0031080)
0.1	7.2	GO:0002102	podosome(GO:0002102)
0.0	6.6	GO:0000784	nuclear chromosome, telomeric region(GO:0000784)
0.7	6.3	GO:0005955	calcineurin complex(GO:0005955)
0.4	6.2	GO:0045277	respiratory chain complex IV(GO:0045277)
1.5	6.0	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)

Showing 1 to 10 of 60 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.8	19.2	GO:0004066	asparagine synthase (glutamine-hydrolyzing) activity(GO:0004066)
0.0	19.2	GO:0005509	calcium ion binding(GO:0005509)
0.4	17.3	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	15.1	GO:0046982	protein heterodimerization activity(GO:0046982)
0.1	13.5	GO:0003735	structural constituent of ribosome(GO:0003735)
0.0	6.5	GO:0019901	protein kinase binding(GO:0019901)
0.6	6.3	GO:0033192	calmodulin-dependent protein phosphatase activity(GO:0033192)
0.2	6.2	GO:0016676	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
1.0	6.0	GO:0030548	acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.2	6.0	GO:0004806	triglyceride lipase activity(GO:0004806)

Showing 1 to 10 of 90 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	25.1	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	14.7	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.1	8.0	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.1	7.1	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.1	6.0	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.1	5.2	PID ILK PATHWAY	Integrin-linked kinase signaling
0.1	4.5	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.1	4.5	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.0	4.0	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.1	2.4	PID CIRCADIAN PATHWAY	Circadian rhythm pathway

Showing 1 to 10 of 18 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	19.2	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.3	18.0	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.3	15.3	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.2	15.2	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.1	13.9	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.3	12.0	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.8	11.1	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.1	10.4	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.0	5.6	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.2	5.3	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism

Showing 1 to 10 of 43 entries

Results for PAX6

Z-value: 0.43

Motif logo

Transcription factors associated with PAX6

Activity-expression correlation:

Activity profile of PAX6 motif

Sorted Z-values of PAX6 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX6

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: