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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for PAX6

Z-value: 0.43

Motif logo

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Transcription factors associated with PAX6

Gene Symbol Gene ID Gene Info
PAX6
ENSG00000007372.16 paired box 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PAX6hg19_v2_chr11_-_31832581_31832601,
hg19_v2_chr11_-_31832862_31832884,
hg19_v2_chr11_-_31832785_31832823,
hg19_v2_chr11_-_31832207_31832226		0.144.6e-02Click!

Activity profile of PAX6 motif

Sorted Z-values of PAX6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_97501706 10.52 ENST00000455086.1
ENST00000453600.1
ASNS
asparagine synthetase (glutamine-hydrolyzing)
chr2_-_175870085 9.35 ENST00000409156.3
CHN1
chimerin 1
chr7_-_97501733 8.64 ENST00000444334.1
ENST00000422745.1
ENST00000394308.3
ENST00000451771.1
ENST00000175506.4
ASNS
asparagine synthetase (glutamine-hydrolyzing)
chr12_-_45269430 8.13 ENST00000395487.2
NELL2
NEL-like 2 (chicken)
chr10_-_118765081 8.00 ENST00000392903.2
ENST00000355371.4
KIAA1598
KIAA1598
chr12_-_45270151 7.74 ENST00000429094.2
NELL2
NEL-like 2 (chicken)
chr12_-_45270077 7.61 ENST00000551601.1
ENST00000549027.1
ENST00000452445.2
NELL2
NEL-like 2 (chicken)
chr10_-_118764862 7.28 ENST00000260777.10
KIAA1598
KIAA1598
chr11_-_58343319 7.21 ENST00000395074.2
LPXN
leupaxin
chr8_-_121457332 6.72 ENST00000518918.1
MRPL13
mitochondrial ribosomal protein L13
chr10_-_75226166 6.28 ENST00000544628.1
PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr1_-_89458287 6.21 ENST00000370485.2
CCBL2
cysteine conjugate-beta lyase 2
chr11_-_11374904 6.03 ENST00000528848.2
CSNK2A3
casein kinase 2, alpha 3 polypeptide
chr7_-_150754935 5.97 ENST00000297518.4
CDK5
cyclin-dependent kinase 5
chr9_+_42704004 5.92 ENST00000457288.1
CBWD7
COBW domain containing 7
chrX_-_13835147 5.76 ENST00000493677.1
ENST00000355135.2
GPM6B
glycoprotein M6B
chr1_+_84609944 5.75 ENST00000370685.3
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr1_-_86174065 5.61 ENST00000370574.3
ENST00000431532.2
ZNHIT6
zinc finger, HIT-type containing 6
chr2_-_175869936 5.39 ENST00000409900.3
CHN1
chimerin 1
chr6_+_125474795 5.12 ENST00000304877.13
ENST00000534000.1
ENST00000368402.5
ENST00000368388.2
TPD52L1
tumor protein D52-like 1
chr13_-_24007815 5.05 ENST00000382298.3
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr1_-_89458415 4.87 ENST00000321792.5
ENST00000370491.3
RBMXL1
CCBL2
RNA binding motif protein, X-linked-like 1
cysteine conjugate-beta lyase 2
chr8_-_121457608 4.87 ENST00000306185.3
MRPL13
mitochondrial ribosomal protein L13
chr13_+_25875785 4.76 ENST00000381747.3
NUPL1
nucleoporin like 1
chr1_+_73771844 4.73 ENST00000440762.1
ENST00000444827.1
ENST00000415686.1
ENST00000411903.1
RP4-598G3.1
RP4-598G3.1
chr2_-_29093132 4.70 ENST00000306108.5
TRMT61B
tRNA methyltransferase 61 homolog B (S. cerevisiae)
chr12_-_47473425 4.58 ENST00000550413.1
AMIGO2
adhesion molecule with Ig-like domain 2
chr5_-_98262240 4.54 ENST00000284049.3
CHD1
chromodomain helicase DNA binding protein 1
chr12_-_2986107 4.45 ENST00000359843.3
ENST00000342628.2
ENST00000361953.3
FOXM1
forkhead box M1
chr12_+_69080734 4.42 ENST00000378905.2
NUP107
nucleoporin 107kDa
chr2_+_114195268 4.37 ENST00000259199.4
ENST00000416503.2
ENST00000433343.2
CBWD2
COBW domain containing 2
chr2_+_172778952 4.36 ENST00000392584.1
ENST00000264108.4
HAT1
histone acetyltransferase 1
chr20_+_62887081 4.34 ENST00000369758.4
ENST00000299468.7
ENST00000609372.1
ENST00000610196.1
ENST00000308824.6
PCMTD2
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
chrX_-_124097620 4.28 ENST00000371130.3
ENST00000422452.2
TENM1
teneurin transmembrane protein 1
chr4_-_69215467 4.22 ENST00000579690.1
YTHDC1
YTH domain containing 1
chr1_+_39491984 4.22 ENST00000372969.3
ENST00000372967.3
NDUFS5
NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)
chr16_+_84801852 4.12 ENST00000569925.1
ENST00000567526.1
USP10
ubiquitin specific peptidase 10
chr9_-_128412696 4.04 ENST00000420643.1
MAPKAP1
mitogen-activated protein kinase associated protein 1
chr6_-_79944336 4.02 ENST00000344726.5
ENST00000275036.7
HMGN3
high mobility group nucleosomal binding domain 3
chrX_+_77154935 3.90 ENST00000481445.1
COX7B
cytochrome c oxidase subunit VIIb
chr1_-_87380002 3.87 ENST00000331835.5
SEP15
Homo sapiens 15 kDa selenoprotein (SEP15), transcript variant 2, mRNA.
chrX_-_92928557 3.77 ENST00000373079.3
ENST00000475430.2
NAP1L3
nucleosome assembly protein 1-like 3
chr4_+_113970772 3.73 ENST00000504454.1
ENST00000394537.3
ENST00000357077.4
ENST00000264366.6
ANK2
ankyrin 2, neuronal
chr8_+_41347915 3.55 ENST00000518270.1
ENST00000520817.1
GOLGA7
golgin A7
chr2_+_109204909 3.52 ENST00000393310.1
LIMS1
LIM and senescent cell antigen-like domains 1
chr10_+_118350468 3.46 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
PNLIPRP1
pancreatic lipase-related protein 1
chr19_-_14945933 3.46 ENST00000322301.3
OR7A5
olfactory receptor, family 7, subfamily A, member 5
chr12_-_47473707 3.41 ENST00000429635.1
AMIGO2
adhesion molecule with Ig-like domain 2
chr6_+_125474939 3.38 ENST00000527711.1
TPD52L1
tumor protein D52-like 1
chr6_+_125474992 3.38 ENST00000528193.1
TPD52L1
tumor protein D52-like 1
chr6_+_125475335 3.31 ENST00000532429.1
ENST00000534199.1
TPD52L1
tumor protein D52-like 1
chrX_-_53461288 3.24 ENST00000375298.4
ENST00000375304.5
HSD17B10
hydroxysteroid (17-beta) dehydrogenase 10
chr10_+_118350522 3.21 ENST00000530319.1
ENST00000527980.1
ENST00000471549.1
ENST00000534537.1
PNLIPRP1
pancreatic lipase-related protein 1
chr6_-_41039567 3.12 ENST00000468811.1
OARD1
O-acyl-ADP-ribose deacylase 1
chr1_-_229644034 3.12 ENST00000366678.3
ENST00000261396.3
ENST00000537506.1
NUP133
nucleoporin 133kDa
chr2_+_228189941 3.07 ENST00000353339.3
ENST00000354503.6
ENST00000530359.1
ENST00000531278.1
ENST00000409565.1
ENST00000452930.1
ENST00000409616.1
ENST00000337110.7
ENST00000525195.1
ENST00000534203.1
ENST00000524634.1
ENST00000349901.7
MFF
mitochondrial fission factor
chr21_-_35014027 2.88 ENST00000399442.1
ENST00000413017.2
ENST00000445393.1
ENST00000417979.1
ENST00000426935.1
ENST00000381540.3
ENST00000361534.2
ENST00000381554.3
CRYZL1
crystallin, zeta (quinone reductase)-like 1
chr1_-_165738072 2.84 ENST00000481278.1
TMCO1
transmembrane and coiled-coil domains 1
chr10_+_13628921 2.83 ENST00000378572.3
PRPF18
pre-mRNA processing factor 18
chr15_+_51973680 2.82 ENST00000542355.2
SCG3
secretogranin III
chr11_-_57298187 2.76 ENST00000525158.1
ENST00000257245.4
ENST00000525587.1
TIMM10
translocase of inner mitochondrial membrane 10 homolog (yeast)
chr1_+_87380299 2.75 ENST00000370551.4
ENST00000370550.5
HS2ST1
heparan sulfate 2-O-sulfotransferase 1
chr15_+_51973550 2.74 ENST00000220478.3
SCG3
secretogranin III
chr2_+_228189867 2.74 ENST00000423098.1
ENST00000304593.9
MFF
mitochondrial fission factor
chr16_-_3767551 2.73 ENST00000246957.5
TRAP1
TNF receptor-associated protein 1
chr1_+_79115503 2.70 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr4_+_115519577 2.64 ENST00000310836.6
UGT8
UDP glycosyltransferase 8
chr17_-_73389737 2.52 ENST00000392563.1
GRB2
growth factor receptor-bound protein 2
chr8_-_95487331 2.50 ENST00000336148.5
RAD54B
RAD54 homolog B (S. cerevisiae)
chr1_-_87379785 2.49 ENST00000401030.3
ENST00000370554.1
SEP15
Homo sapiens 15 kDa selenoprotein (SEP15), transcript variant 2, mRNA.
chr11_-_102401469 2.48 ENST00000260227.4
MMP7
matrix metallopeptidase 7 (matrilysin, uterine)
chr2_-_85645545 2.47 ENST00000409275.1
CAPG
capping protein (actin filament), gelsolin-like
chr3_-_142297668 2.45 ENST00000350721.4
ENST00000383101.3
ATR
ataxia telangiectasia and Rad3 related
chrX_-_6146876 2.41 ENST00000381095.3
NLGN4X
neuroligin 4, X-linked
chr16_-_3767506 2.39 ENST00000538171.1
TRAP1
TNF receptor-associated protein 1
chr5_+_96212185 2.32 ENST00000379904.4
ERAP2
endoplasmic reticulum aminopeptidase 2
chr11_-_10828892 2.30 ENST00000525681.1
EIF4G2
eukaryotic translation initiation factor 4 gamma, 2
chr6_+_88299833 2.29 ENST00000392844.3
ENST00000257789.4
ENST00000546266.1
ENST00000417380.2
ORC3
origin recognition complex, subunit 3
chr1_-_184006829 2.27 ENST00000361927.4
COLGALT2
collagen beta(1-O)galactosyltransferase 2
chr5_+_85913721 2.26 ENST00000247655.3
ENST00000509578.1
ENST00000515763.1
COX7C
cytochrome c oxidase subunit VIIc
chr2_-_153573965 2.26 ENST00000448428.1
PRPF40A
PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
chr11_+_60223225 2.14 ENST00000524807.1
ENST00000345732.4
MS4A1
membrane-spanning 4-domains, subfamily A, member 1
chr1_-_156722015 2.10 ENST00000368209.5
HDGF
hepatoma-derived growth factor
chr14_+_88471468 2.09 ENST00000267549.3
GPR65
G protein-coupled receptor 65
chr12_+_27175476 2.07 ENST00000546323.1
ENST00000282892.3
MED21
mediator complex subunit 21
chrX_-_53461305 2.03 ENST00000168216.6
HSD17B10
hydroxysteroid (17-beta) dehydrogenase 10
chr2_-_136743169 2.02 ENST00000264161.4
DARS
aspartyl-tRNA synthetase
chr16_-_1401799 2.01 ENST00000007390.2
TSR3
TSR3, 20S rRNA accumulation, homolog (S. cerevisiae)
chr7_+_65552756 1.99 ENST00000450043.1
AC068533.7
AC068533.7
chr11_-_3078838 1.99 ENST00000397111.5
CARS
cysteinyl-tRNA synthetase
chr15_+_68924327 1.97 ENST00000543950.1
CORO2B
coronin, actin binding protein, 2B
chr6_-_43027105 1.91 ENST00000230413.5
ENST00000487429.1
ENST00000489623.1
ENST00000468957.1
MRPL2
mitochondrial ribosomal protein L2
chr11_+_60223312 1.88 ENST00000532491.1
ENST00000532073.1
ENST00000534668.1
ENST00000528313.1
ENST00000533306.1
MS4A1
membrane-spanning 4-domains, subfamily A, member 1
chr2_-_163008903 1.87 ENST00000418842.2
ENST00000375497.3
GCG
glucagon
chr2_-_154335300 1.81 ENST00000325926.3
RPRM
reprimo, TP53 dependent G2 arrest mediator candidate
chr11_-_117748138 1.80 ENST00000527717.1
FXYD6
FXYD domain containing ion transport regulator 6
chr6_-_131321863 1.77 ENST00000528282.1
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr1_+_167298281 1.73 ENST00000367862.5
POU2F1
POU class 2 homeobox 1
chr2_+_109204743 1.70 ENST00000332345.6
LIMS1
LIM and senescent cell antigen-like domains 1
chr2_+_192109911 1.69 ENST00000418908.1
ENST00000339514.4
ENST00000392318.3
MYO1B
myosin IB
chr22_-_30968813 1.63 ENST00000443111.2
ENST00000443136.1
ENST00000426220.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr2_+_220363579 1.58 ENST00000313597.5
ENST00000373917.3
ENST00000358215.3
ENST00000373908.1
ENST00000455657.1
ENST00000435316.1
ENST00000341142.3
GMPPA
GDP-mannose pyrophosphorylase A
chr7_-_87342564 1.56 ENST00000265724.3
ENST00000416177.1
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr3_-_119379719 1.52 ENST00000493094.1
POPDC2
popeye domain containing 2
chr2_+_192110199 1.50 ENST00000304164.4
MYO1B
myosin IB
chr3_+_51663407 1.48 ENST00000432863.1
ENST00000296477.3
RAD54L2
RAD54-like 2 (S. cerevisiae)
chr15_-_65282274 1.46 ENST00000204566.2
SPG21
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
chr8_+_59323823 1.46 ENST00000399598.2
UBXN2B
UBX domain protein 2B
chr12_+_113354341 1.45 ENST00000553152.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr2_+_202098166 1.45 ENST00000392263.2
ENST00000264274.9
ENST00000392259.2
ENST00000392266.3
ENST00000432109.2
ENST00000264275.5
CASP8
caspase 8, apoptosis-related cysteine peptidase
chr11_+_33563821 1.44 ENST00000321505.4
ENST00000265654.5
ENST00000389726.3
KIAA1549L
KIAA1549-like
chr7_-_76255444 1.40 ENST00000454397.1
POMZP3
POM121 and ZP3 fusion
chr19_-_50370509 1.40 ENST00000596014.1
PNKP
polynucleotide kinase 3'-phosphatase
chr10_+_18629628 1.38 ENST00000377329.4
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr2_+_191334212 1.37 ENST00000444317.1
ENST00000535751.1
MFSD6
major facilitator superfamily domain containing 6
chr19_+_35820064 1.34 ENST00000341773.6
ENST00000600131.1
ENST00000270311.6
ENST00000595780.1
ENST00000597916.1
ENST00000593867.1
ENST00000600424.1
ENST00000599811.1
ENST00000536635.2
ENST00000085219.5
ENST00000544992.2
ENST00000419549.2
CD22
CD22 molecule
chr11_-_117747327 1.33 ENST00000584230.1
ENST00000527429.1
ENST00000584394.1
ENST00000532984.1
FXYD6
FXYD6-FXYD2
FXYD domain containing ion transport regulator 6
FXYD6-FXYD2 readthrough
chr19_+_35939154 1.31 ENST00000599180.2
FFAR2
free fatty acid receptor 2
chr7_+_90338712 1.30 ENST00000265741.3
ENST00000406263.1
CDK14
cyclin-dependent kinase 14
chr10_+_91092241 1.30 ENST00000371811.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr22_-_36220420 1.22 ENST00000473487.2
RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr12_-_121476959 1.21 ENST00000339275.5
OASL
2'-5'-oligoadenylate synthetase-like
chr8_+_21916680 1.18 ENST00000358242.3
ENST00000415253.1
DMTN
dematin actin binding protein
chr12_-_85306594 1.15 ENST00000266682.5
SLC6A15
solute carrier family 6 (neutral amino acid transporter), member 15
chr4_-_87281224 1.11 ENST00000395169.3
ENST00000395161.2
MAPK10
mitogen-activated protein kinase 10
chr12_+_10460549 1.11 ENST00000543420.1
ENST00000543777.1
KLRD1
killer cell lectin-like receptor subfamily D, member 1
chr8_+_21916710 1.11 ENST00000523266.1
ENST00000519907.1
DMTN
dematin actin binding protein
chr13_+_25875662 1.09 ENST00000381736.3
ENST00000463407.1
ENST00000381718.3
NUPL1
nucleoporin like 1
chr11_-_117747607 1.07 ENST00000540359.1
ENST00000539526.1
FXYD6
FXYD domain containing ion transport regulator 6
chr19_-_41903161 1.06 ENST00000602129.1
ENST00000593771.1
ENST00000596905.1
ENST00000221233.4
EXOSC5
exosome component 5
chr10_-_13523073 1.02 ENST00000440282.1
BEND7
BEN domain containing 7
chr6_+_167704798 1.00 ENST00000230256.3
UNC93A
unc-93 homolog A (C. elegans)
chr3_-_196910721 0.97 ENST00000443183.1
DLG1
discs, large homolog 1 (Drosophila)
chr16_-_18911366 0.97 ENST00000565224.1
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr17_-_79633590 0.91 ENST00000374741.3
ENST00000571503.1
OXLD1
oxidoreductase-like domain containing 1
chr14_+_22320634 0.91 ENST00000390435.1
TRAV8-3
T cell receptor alpha variable 8-3
chr2_-_86116093 0.89 ENST00000377332.3
ST3GAL5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr1_+_77333117 0.88 ENST00000477717.1
ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr11_-_102576537 0.84 ENST00000260229.4
MMP27
matrix metallopeptidase 27
chr7_-_150864635 0.84 ENST00000297537.4
GBX1
gastrulation brain homeobox 1
chr11_-_117747434 0.84 ENST00000529335.2
ENST00000530956.1
ENST00000260282.4
FXYD6
FXYD domain containing ion transport regulator 6
chr17_-_39041479 0.80 ENST00000167588.3
KRT20
keratin 20
chr5_+_140254884 0.77 ENST00000398631.2
PCDHA12
protocadherin alpha 12
chr11_-_28129656 0.76 ENST00000263181.6
KIF18A
kinesin family member 18A
chr5_+_140602904 0.74 ENST00000515856.2
ENST00000239449.4
PCDHB14
protocadherin beta 14
chr6_+_25652501 0.72 ENST00000334979.6
SCGN
secretagogin, EF-hand calcium binding protein
chr4_-_174320687 0.72 ENST00000296506.3
SCRG1
stimulator of chondrogenesis 1
chr15_+_52155001 0.71 ENST00000544199.1
TMOD3
tropomodulin 3 (ubiquitous)
chr8_+_18067602 0.69 ENST00000307719.4
ENST00000545197.1
ENST00000539092.1
ENST00000541942.1
ENST00000518029.1
NAT1
N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr19_-_51920835 0.69 ENST00000442846.3
ENST00000530476.1
SIGLEC10
sialic acid binding Ig-like lectin 10
chr17_+_7239821 0.68 ENST00000158762.3
ENST00000570457.2
ACAP1
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr6_+_25652432 0.66 ENST00000377961.2
SCGN
secretagogin, EF-hand calcium binding protein
chr5_+_152870734 0.65 ENST00000521843.2
GRIA1
glutamate receptor, ionotropic, AMPA 1
chr15_-_23034322 0.64 ENST00000539711.2
ENST00000560039.1
ENST00000398013.3
ENST00000337451.3
ENST00000359727.4
ENST00000398014.2
NIPA2
non imprinted in Prader-Willi/Angelman syndrome 2
chr2_-_70520539 0.59 ENST00000482975.2
ENST00000438261.1
SNRPG
small nuclear ribonucleoprotein polypeptide G
chr17_-_39023462 0.57 ENST00000251643.4
KRT12
keratin 12
chr1_+_26758790 0.56 ENST00000427245.2
ENST00000525682.2
ENST00000236342.7
ENST00000526219.1
ENST00000374185.3
ENST00000360009.2
DHDDS
dehydrodolichyl diphosphate synthase
chr7_+_66461798 0.56 ENST00000359626.5
ENST00000442959.1
TYW1
tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
chr5_+_143191726 0.56 ENST00000289448.2
HMHB1
histocompatibility (minor) HB-1
chr17_+_36283971 0.55 ENST00000327454.6
ENST00000378174.5
TBC1D3F
TBC1 domain family, member 3F
chr2_+_145780739 0.54 ENST00000597173.1
ENST00000602108.1
ENST00000420472.1
TEX41
testis expressed 41 (non-protein coding)
chr7_+_76109827 0.51 ENST00000446820.2
DTX2
deltex homolog 2 (Drosophila)
chr9_-_128246769 0.49 ENST00000444226.1
MAPKAP1
mitogen-activated protein kinase associated protein 1
chr4_+_70894130 0.46 ENST00000526767.1
ENST00000530128.1
ENST00000381057.3
HTN3
histatin 3
chr5_-_135231516 0.45 ENST00000274520.1
IL9
interleukin 9
chrX_-_130423386 0.43 ENST00000370903.3
IGSF1
immunoglobulin superfamily, member 1
chr8_-_33370607 0.42 ENST00000360742.5
ENST00000523305.1
TTI2
TELO2 interacting protein 2
chr1_+_2005425 0.40 ENST00000461106.2
PRKCZ
protein kinase C, zeta
chr3_-_15540055 0.37 ENST00000605797.1
ENST00000435459.2
COLQ
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr12_-_10007448 0.37 ENST00000538152.1
CLEC2B
C-type lectin domain family 2, member B
chrX_-_80457385 0.36 ENST00000451455.1
ENST00000436386.1
ENST00000358130.2
HMGN5
high mobility group nucleosome binding domain 5
chr10_+_13628933 0.36 ENST00000417658.1
ENST00000320054.4
PRPF18
pre-mRNA processing factor 18
chr16_-_71264558 0.35 ENST00000448089.2
ENST00000393550.2
ENST00000448691.1
ENST00000393567.2
ENST00000321489.5
ENST00000539973.1
ENST00000288168.10
ENST00000545267.1
ENST00000541601.1
ENST00000538248.1
HYDIN
HYDIN, axonemal central pair apparatus protein
chr17_+_43224684 0.33 ENST00000332499.2
HEXIM1
hexamethylene bis-acetamide inducible 1
chr4_-_16077741 0.33 ENST00000447510.2
ENST00000540805.1
ENST00000539194.1
PROM1
prominin 1
chr11_-_87908600 0.32 ENST00000531138.1
ENST00000526372.1
ENST00000243662.6
RAB38
RAB38, member RAS oncogene family
chr11_+_57105991 0.29 ENST00000263314.2
P2RX3
purinergic receptor P2X, ligand-gated ion channel, 3
chr14_+_24099318 0.27 ENST00000432832.2
DHRS2
dehydrogenase/reductase (SDR family) member 2
chr5_+_119799927 0.27 ENST00000407149.2
ENST00000379551.2
PRR16
proline rich 16
chr1_-_201368707 0.25 ENST00000391967.2
LAD1
ladinin 1
chr2_-_70475730 0.25 ENST00000445587.1
ENST00000433529.2
ENST00000415783.2
TIA1
TIA1 cytotoxic granule-associated RNA binding protein
chr2_+_232135245 0.25 ENST00000446447.1
ARMC9
armadillo repeat containing 9
chr1_-_165738085 0.25 ENST00000464650.1
ENST00000392129.6
TMCO1
transmembrane and coiled-coil domains 1
chr5_-_169725231 0.24 ENST00000046794.5
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr11_+_118175132 0.23 ENST00000361763.4
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr19_-_51920873 0.21 ENST00000441969.3
ENST00000525998.1
ENST00000436984.2
SIGLEC10
sialic acid binding Ig-like lectin 10
chr16_-_51185172 0.20 ENST00000251020.4
SALL1
spalt-like transcription factor 1
chr18_+_32173276 0.20 ENST00000591816.1
ENST00000588125.1
ENST00000598334.1
ENST00000588684.1
ENST00000554864.3
ENST00000399121.5
ENST00000595022.1
ENST00000269190.7
ENST00000399097.3
DTNA
dystrobrevin, alpha
chr6_-_26033796 0.18 ENST00000259791.2
HIST1H2AB
histone cluster 1, H2ab
chr2_-_162931052 0.18 ENST00000360534.3
DPP4
dipeptidyl-peptidase 4
chr12_-_56352368 0.16 ENST00000549404.1
PMEL
premelanosome protein
chr13_+_53602894 0.14 ENST00000219022.2
OLFM4
olfactomedin 4
chr11_+_4788500 0.13 ENST00000380390.1
MMP26
matrix metallopeptidase 26
chr19_+_50936142 0.09 ENST00000357701.5
MYBPC2
myosin binding protein C, fast type
chr1_-_8585945 0.09 ENST00000377464.1
RERE
arginine-glutamic acid dipeptide (RE) repeats
chr4_+_71063641 0.09 ENST00000514097.1
ODAM
odontogenic, ameloblast asssociated
chrX_-_64196376 0.07 ENST00000447788.2
ZC4H2
zinc finger, C4H2 domain containing
chr8_-_62602327 0.07 ENST00000445642.3
ENST00000517847.2
ENST00000389204.4
ENST00000517661.1
ENST00000517903.1
ENST00000522603.1
ENST00000522349.1
ENST00000522835.1
ENST00000541428.1
ENST00000518306.1
ASPH
aspartate beta-hydroxylase
chr1_-_201368653 0.06 ENST00000367313.3
LAD1
ladinin 1
chrX_-_130423240 0.06 ENST00000370910.1
ENST00000370901.4
IGSF1
immunoglobulin superfamily, member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 19.2 GO:0070982 L-asparagine biosynthetic process(GO:0070981) L-asparagine metabolic process(GO:0070982)
3.3 10.0 GO:0070901 mitochondrial tRNA methylation(GO:0070901)
1.7 23.5 GO:0070050 neuron cellular homeostasis(GO:0070050)
1.3 5.1 GO:0009386 translational attenuation(GO:0009386)
1.2 3.7 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
1.2 5.8 GO:1900063 regulation of peroxisome organization(GO:1900063)
1.2 5.8 GO:0097338 response to clozapine(GO:0097338)
1.1 3.2 GO:0071030 nuclear mRNA surveillance of spliceosomal pre-mRNA splicing(GO:0071030) nuclear retention of unspliced pre-mRNA at the site of transcription(GO:0071048)
1.0 6.0 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.9 5.6 GO:0048254 snoRNA localization(GO:0048254)
0.9 7.2 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.9 4.4 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.8 0.8 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.8 2.4 GO:1904868 telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.8 3.1 GO:0051664 nuclear pore distribution(GO:0031081) nuclear pore localization(GO:0051664)
0.8 2.3 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.8 4.5 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.7 4.4 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.7 3.6 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.7 2.0 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.7 2.0 GO:0006423 cysteinyl-tRNA aminoacylation(GO:0006423)
0.6 1.9 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.6 5.8 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.5 6.3 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.5 1.4 GO:0052056 modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148)
0.5 4.3 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.4 4.5 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
0.4 1.3 GO:0002232 leukocyte chemotaxis involved in inflammatory response(GO:0002232) cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.4 14.7 GO:0008045 motor neuron axon guidance(GO:0008045)
0.4 2.3 GO:0070560 protein secretion by platelet(GO:0070560)
0.4 1.1 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.3 5.1 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.3 2.8 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.3 2.4 GO:0090394 negative regulation of excitatory postsynaptic potential(GO:0090394)
0.3 6.2 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.3 3.1 GO:0006983 ER overload response(GO:0006983)
0.3 1.4 GO:0098502 DNA dephosphorylation(GO:0098502)
0.2 1.4 GO:0035803 egg coat formation(GO:0035803)
0.2 1.2 GO:0035524 proline transmembrane transport(GO:0035524)
0.2 1.4 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.2 1.6 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.2 12.3 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.2 4.5 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.2 1.2 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.2 13.5 GO:0070125 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.2 2.3 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1 0.3 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.1 2.5 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.1 1.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 1.0 GO:1903760 regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760)
0.1 5.2 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.1 1.6 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.1 0.9 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 4.2 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 0.3 GO:2000768 positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
0.1 2.2 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 1.3 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.1 2.5 GO:0044849 estrous cycle(GO:0044849)
0.1 0.2 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 14.1 GO:0046330 positive regulation of JNK cascade(GO:0046330)
0.1 4.1 GO:0019985 translesion synthesis(GO:0019985)
0.1 0.7 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 0.6 GO:0006489 dolichyl diphosphate biosynthetic process(GO:0006489) dolichyl diphosphate metabolic process(GO:0046465)
0.1 0.9 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.1 0.6 GO:0015693 magnesium ion transport(GO:0015693)
0.1 2.9 GO:1901661 quinone metabolic process(GO:1901661)
0.1 5.0 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.1 2.1 GO:0010447 response to acidic pH(GO:0010447)
0.1 4.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 0.8 GO:0072520 seminiferous tubule development(GO:0072520)
0.1 0.4 GO:2000664 positive regulation of interleukin-5 secretion(GO:2000664)
0.1 0.4 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)
0.1 4.0 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.1 0.7 GO:0009410 xenobiotic metabolic process(GO:0006805) response to xenobiotic stimulus(GO:0009410) cellular response to xenobiotic stimulus(GO:0071466)
0.1 0.3 GO:0006581 acetylcholine catabolic process in synaptic cleft(GO:0001507) acetylcholine catabolic process(GO:0006581)
0.0 1.4 GO:0051480 regulation of cytosolic calcium ion concentration(GO:0051480)
0.0 1.5 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 0.2 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0 0.2 GO:0036343 psychomotor behavior(GO:0036343)
0.0 0.3 GO:1903232 melanosome assembly(GO:1903232)
0.0 0.1 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0 4.0 GO:0042100 B cell proliferation(GO:0042100)
0.0 8.4 GO:0030307 positive regulation of cell growth(GO:0030307)
0.0 0.8 GO:0045109 intermediate filament organization(GO:0045109)
0.0 2.0 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 2.1 GO:0001824 blastocyst development(GO:0001824)
0.0 2.7 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 2.3 GO:0032465 regulation of cytokinesis(GO:0032465)
0.0 0.7 GO:0048821 erythrocyte development(GO:0048821)
0.0 3.2 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.0 5.1 GO:0002576 platelet degranulation(GO:0002576)
0.0 0.2 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.0 2.1 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.0 1.7 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.1 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.0 0.1 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.6 GO:0008334 histone mRNA metabolic process(GO:0008334)
0.0 1.4 GO:0032508 DNA duplex unwinding(GO:0032508)
0.0 0.1 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
0.0 1.1 GO:0002228 natural killer cell mediated immunity(GO:0002228)
0.0 0.3 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 2.4 GO:0006024 aminoglycan biosynthetic process(GO:0006023) glycosaminoglycan biosynthetic process(GO:0006024)
0.0 0.9 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.3 GO:1901798 positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0 0.4 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.0 0.4 GO:0021591 ventricular system development(GO:0021591) trachea development(GO:0060438)
0.0 0.4 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.3 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 2.4 GO:0008213 protein methylation(GO:0006479) protein alkylation(GO:0008213)
0.0 1.0 GO:0030574 collagen catabolic process(GO:0030574)
0.0 1.1 GO:0002027 regulation of heart rate(GO:0002027)
0.0 0.2 GO:0032438 melanosome organization(GO:0032438) pigment granule organization(GO:0048753)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 GO:0031515 tRNA (m1A) methyltransferase complex(GO:0031515)
1.5 6.0 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
1.1 3.2 GO:0071020 post-spliceosomal complex(GO:0071020)
1.1 5.3 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
0.8 2.3 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.7 5.1 GO:0070852 cell body fiber(GO:0070852)
0.7 5.6 GO:0070761 pre-snoRNP complex(GO:0070761)
0.7 6.3 GO:0005955 calcineurin complex(GO:0005955)
0.5 3.6 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.5 7.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.4 1.3 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.4 2.5 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.4 6.2 GO:0045277 respiratory chain complex IV(GO:0045277)
0.3 2.8 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.3 13.5 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.3 5.8 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.3 4.5 GO:0031932 TORC2 complex(GO:0031932)
0.2 2.3 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 2.2 GO:0008290 F-actin capping protein complex(GO:0008290) Flemming body(GO:0090543)
0.1 0.8 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 0.7 GO:0044308 axonal spine(GO:0044308)
0.1 7.2 GO:0002102 podosome(GO:0002102)
0.1 2.9 GO:0071004 U2-type prespliceosome(GO:0071004)
0.1 1.6 GO:0008091 spectrin(GO:0008091)
0.1 9.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 1.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 2.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 1.1 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 2.0 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 5.8 GO:0032592 integral component of mitochondrial membrane(GO:0032592)
0.1 1.0 GO:0097025 lateral loop(GO:0043219) MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 3.7 GO:0043034 costamere(GO:0043034)
0.1 1.4 GO:0097342 ripoptosome(GO:0097342)
0.1 0.8 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 0.3 GO:0031905 early endosome lumen(GO:0031905)
0.1 2.1 GO:0016592 mediator complex(GO:0016592)
0.1 0.4 GO:0045179 apical cortex(GO:0045179)
0.0 0.2 GO:0036398 TCR signalosome(GO:0036398)
0.0 6.6 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.0 1.5 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.2 GO:0097165 nuclear stress granule(GO:0097165)
0.0 3.3 GO:0016459 myosin complex(GO:0016459)
0.0 0.3 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 9.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.7 GO:0042383 sarcolemma(GO:0042383)
0.0 0.2 GO:0010369 chromocenter(GO:0010369)
0.0 3.8 GO:0016607 nuclear speck(GO:0016607)
0.0 18.5 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.2 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.4 GO:0044447 axoneme part(GO:0044447)
0.0 2.4 GO:0001650 fibrillar center(GO:0001650)
0.0 0.3 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.2 GO:0032585 multivesicular body membrane(GO:0032585)
0.0 0.7 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.7 GO:0044306 neuron projection terminus(GO:0044306)
0.0 1.9 GO:0031965 nuclear membrane(GO:0031965)
0.0 1.5 GO:0045121 membrane raft(GO:0045121)
0.0 0.1 GO:0032541 cortical endoplasmic reticulum(GO:0032541)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 19.2 GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity(GO:0004066)
1.6 4.7 GO:0016426 tRNA (adenine) methyltransferase activity(GO:0016426) tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
1.4 4.3 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
1.1 3.2 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
1.0 6.0 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.8 2.3 GO:0050211 procollagen galactosyltransferase activity(GO:0050211)
0.7 2.1 GO:0015616 DNA translocase activity(GO:0015616)
0.7 2.0 GO:0004817 cysteine-tRNA ligase activity(GO:0004817)
0.6 6.3 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.5 2.9 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.4 2.0 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.4 5.6 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.4 5.8 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.4 17.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.3 1.4 GO:0051733 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734) polynucleotide phosphatase activity(GO:0098518)
0.3 4.2 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.3 1.6 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.3 0.9 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.3 1.4 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.3 5.3 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.3 2.7 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.2 5.1 GO:0070628 proteasome binding(GO:0070628)
0.2 3.6 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.2 1.6 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.2 6.0 GO:0004806 triglyceride lipase activity(GO:0004806)
0.2 1.2 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.2 1.1 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.2 6.2 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 4.5 GO:0070300 phosphatidic acid binding(GO:0070300)
0.2 2.4 GO:0032407 MutSalpha complex binding(GO:0032407)
0.2 5.6 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.2 1.1 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.2 2.7 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.2 1.6 GO:0042731 PH domain binding(GO:0042731)
0.2 0.7 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.2 1.4 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.2 2.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.2 1.4 GO:0032190 acrosin binding(GO:0032190)
0.1 5.6 GO:0030507 spectrin binding(GO:0030507)
0.1 3.2 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 2.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 2.1 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 4.0 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.1 5.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 2.3 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.1 2.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 4.0 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 3.9 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 2.6 GO:0035250 UDP-galactosyltransferase activity(GO:0035250)
0.1 1.0 GO:0097016 L27 domain binding(GO:0097016)
0.1 0.7 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 1.5 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 4.2 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.3 GO:0035651 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.1 2.3 GO:0070064 proline-rich region binding(GO:0070064)
0.1 0.9 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 13.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 4.1 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 0.3 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.1 0.6 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 3.3 GO:0019213 deacetylase activity(GO:0019213)
0.0 1.7 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 0.3 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 2.1 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 0.6 GO:0010181 FMN binding(GO:0010181)
0.0 0.2 GO:0042608 T cell receptor binding(GO:0042608)
0.0 1.3 GO:0030332 cyclin binding(GO:0030332)
0.0 2.3 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.4 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.0 3.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.1 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.6 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 0.1 GO:0008267 poly-glutamine tract binding(GO:0008267)
0.0 0.8 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 2.7 GO:0005262 calcium channel activity(GO:0005262)
0.0 0.7 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 2.8 GO:0051087 chaperone binding(GO:0051087)
0.0 15.1 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 1.2 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 19.2 GO:0005509 calcium ion binding(GO:0005509)
0.0 3.8 GO:0051015 actin filament binding(GO:0051015)
0.0 0.9 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 1.5 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.3 GO:0042805 actinin binding(GO:0042805)
0.0 1.2 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.0 0.0 GO:0034711 inhibin binding(GO:0034711)
0.0 3.8 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 6.5 GO:0019901 protein kinase binding(GO:0019901)
0.0 1.5 GO:0004386 helicase activity(GO:0004386)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 14.7 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 8.0 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 6.0 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 7.1 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.1 25.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.4 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 4.5 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.1 5.2 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 4.5 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.1 1.4 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 1.4 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 4.0 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 1.0 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.9 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.0 0.7 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 1.6 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.2 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.7 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 11.1 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.7 19.2 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.3 15.3 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.3 18.0 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.3 12.0 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.2 2.5 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.2 15.2 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.2 5.3 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.2 2.3 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.2 2.4 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.2 5.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 10.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 1.6 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 1.1 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 4.0 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 4.5 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.1 1.9 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 1.6 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 1.4 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.1 13.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.7 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 1.1 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 2.3 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 1.2 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.0 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 2.3 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 1.7 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 2.8 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 4.0 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.7 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 5.6 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.6 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 1.6 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.8 REACTOME KINESINS Genes involved in Kinesins
0.0 0.9 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 2.1 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.4 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.5 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.9 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.2 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 2.1 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 2.8 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 0.9 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell