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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for PAX8
Z-value: 0.18
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Transcription factors associated with PAX8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PAX8 | hg19_v2_chr2_-_113999260_113999274 | -0.06 | 4.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrX_-_151938171 Show fit | 11.08 |
ENST00000393902.3
ENST00000417212.1 ENST00000370278.3 |
melanoma antigen family A, 3 |
|
| chr1_-_27952741 Show fit | 10.05 |
ENST00000399173.1
|
feline Gardner-Rasheed sarcoma viral oncogene homolog |
|
| chr14_-_106054659 Show fit | 7.63 |
ENST00000390539.2
|
immunoglobulin heavy constant alpha 2 (A2m marker) |
|
| chrX_+_151867214 Show fit | 7.33 |
ENST00000329342.5
ENST00000412733.1 ENST00000457643.1 |
melanoma antigen family A, 6 |
|
| chr6_-_27858570 Show fit | 7.30 |
ENST00000359303.2
|
histone cluster 1, H3j |
|
| chr2_+_90248739 Show fit | 6.52 |
ENST00000468879.1
|
immunoglobulin kappa variable 1D-43 |
|
| chr11_-_58343319 Show fit | 6.12 |
ENST00000395074.2
|
leupaxin |
|
| chr2_+_90198535 Show fit | 5.31 |
ENST00000390276.2
|
immunoglobulin kappa variable 1D-12 |
|
| chr2_-_211179883 Show fit | 5.19 |
ENST00000352451.3
|
myosin, light chain 1, alkali; skeletal, fast |
|
| chr22_+_22707260 Show fit | 5.11 |
ENST00000390293.1
|
immunoglobulin lambda variable 5-48 (non-functional) |
Network of associatons between targets according to the STRING database.
First level regulatory network of PAX8
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.4 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 1.2 | 14.7 | GO:0048298 | positive regulation of isotype switching to IgA isotypes(GO:0048298) |
| 0.1 | 12.9 | GO:0070268 | cornification(GO:0070268) |
| 0.5 | 11.1 | GO:1902236 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236) |
| 0.1 | 10.8 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.1 | 10.4 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 0.5 | 10.1 | GO:0033008 | positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306) |
| 2.7 | 8.2 | GO:0044278 | cell wall disruption in other organism(GO:0044278) |
| 0.8 | 7.7 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
| 1.0 | 7.1 | GO:0048241 | epinephrine transport(GO:0048241) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 31.1 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 18.4 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 17.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 15.7 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 13.4 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 12.1 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 10.1 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.3 | 9.8 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.2 | 8.4 | GO:0002102 | podosome(GO:0002102) |
| 2.5 | 7.6 | GO:0071745 | IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 25.9 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 16.2 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.3 | 15.6 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.3 | 12.8 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.7 | 12.1 | GO:0019864 | IgG binding(GO:0019864) |
| 0.9 | 11.1 | GO:0089720 | caspase binding(GO:0089720) |
| 0.1 | 11.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 10.9 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.1 | 10.4 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 2.5 | 10.1 | GO:0034988 | Fc-gamma receptor I complex binding(GO:0034988) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 17.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 12.2 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.2 | 10.1 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.1 | 9.1 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 5.3 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 4.3 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.1 | 4.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 3.9 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.1 | 3.8 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.7 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| 0.1 | 10.4 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.4 | 10.1 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |
| 0.5 | 7.1 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.0 | 7.1 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.0 | 6.2 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.1 | 5.7 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.3 | 5.5 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.1 | 5.0 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 4.8 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |