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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for PBX2

Z-value: 0.87

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Transcription factors associated with PBX2

Gene Symbol Gene ID Gene Info
PBX2
ENSG00000204304.7 PBX homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PBX2hg19_v2_chr6_-_32157947_32157992-0.338.4e-07Click!

Activity profile of PBX2 motif

Sorted Z-values of PBX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_+_119737806 13.72 ENST00000371317.5
MCTS1
malignant T cell amplified sequence 1
chr14_-_55658252 13.03 ENST00000395425.2
DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr14_-_55658323 11.52 ENST00000554067.1
ENST00000247191.2
DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr12_+_53835383 10.37 ENST00000429243.2
PRR13
proline rich 13
chr12_+_53835539 9.72 ENST00000547368.1
ENST00000379786.4
ENST00000551945.1
PRR13
proline rich 13
chrX_+_56590002 7.51 ENST00000338222.5
UBQLN2
ubiquilin 2
chr3_-_129158676 6.72 ENST00000393278.2
MBD4
methyl-CpG binding domain protein 4
chr3_-_129158850 6.70 ENST00000503197.1
ENST00000249910.1
ENST00000429544.2
ENST00000507208.1
MBD4
methyl-CpG binding domain protein 4
chr12_+_53835508 6.01 ENST00000551003.1
ENST00000549068.1
ENST00000549740.1
ENST00000546581.1
ENST00000549581.1
ENST00000541275.1
PRR13
PCBP2
proline rich 13
poly(rC) binding protein 2
chr22_+_42017987 5.84 ENST00000405506.1
XRCC6
X-ray repair complementing defective repair in Chinese hamster cells 6
chr2_-_190044480 5.67 ENST00000374866.3
COL5A2
collagen, type V, alpha 2
chr17_-_29151794 5.30 ENST00000324238.6
CRLF3
cytokine receptor-like factor 3
chr2_+_12857015 4.77 ENST00000155926.4
TRIB2
tribbles pseudokinase 2
chr9_-_128246769 4.22 ENST00000444226.1
MAPKAP1
mitogen-activated protein kinase associated protein 1
chr11_-_62432641 3.33 ENST00000528405.1
ENST00000524958.1
ENST00000525675.1
RP11-831H9.11
C11orf48
Uncharacterized protein
chromosome 11 open reading frame 48
chr2_+_12857043 3.17 ENST00000381465.2
TRIB2
tribbles pseudokinase 2
chr17_+_8191815 3.11 ENST00000226105.6
ENST00000407006.4
ENST00000580434.1
ENST00000439238.3
RANGRF
RAN guanine nucleotide release factor
chr6_+_160211481 3.07 ENST00000367034.4
MRPL18
mitochondrial ribosomal protein L18
chr2_+_44396000 3.06 ENST00000409895.4
ENST00000409432.3
ENST00000282412.4
ENST00000378551.2
ENST00000345249.4
PPM1B
protein phosphatase, Mg2+/Mn2+ dependent, 1B
chr1_-_39339777 2.75 ENST00000397572.2
MYCBP
MYC binding protein
chr11_+_69455855 2.69 ENST00000227507.2
ENST00000536559.1
CCND1
cyclin D1
chr14_+_64854958 2.63 ENST00000555709.2
ENST00000554739.1
ENST00000554768.1
ENST00000216605.8
MTHFD1
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
chr4_+_37962018 2.50 ENST00000504686.1
PTTG2
pituitary tumor-transforming 2
chr10_+_47894572 2.44 ENST00000355876.5
FAM21B
family with sequence similarity 21, member B
chr12_-_28124903 2.02 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
PTHLH
parathyroid hormone-like hormone
chr7_-_32529973 1.99 ENST00000410044.1
ENST00000409987.1
ENST00000409782.1
ENST00000450169.2
LSM5
LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr2_+_234104079 1.91 ENST00000417661.1
INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr2_+_234601512 1.56 ENST00000305139.6
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr15_+_67418047 1.54 ENST00000540846.2
SMAD3
SMAD family member 3
chr2_+_27255806 1.31 ENST00000238788.9
ENST00000404032.3
TMEM214
transmembrane protein 214
chr8_-_6420930 1.03 ENST00000325203.5
ANGPT2
angiopoietin 2
chr1_+_101702417 0.85 ENST00000305352.6
S1PR1
sphingosine-1-phosphate receptor 1
chrX_+_46696372 0.64 ENST00000218340.3
RP2
retinitis pigmentosa 2 (X-linked recessive)
chr2_+_234602305 0.62 ENST00000406651.1
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr12_-_28125638 0.58 ENST00000545234.1
PTHLH
parathyroid hormone-like hormone
chr8_+_110098850 0.47 ENST00000518632.1
TRHR
thyrotropin-releasing hormone receptor
chr14_-_23624511 0.18 ENST00000529705.2
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8

Network of associatons between targets according to the STRING database.

First level regulatory network of PBX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 13.7 GO:0002188 translation reinitiation(GO:0002188)
4.1 24.5 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
1.9 7.5 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186)
1.6 7.9 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
1.4 5.7 GO:1903224 regulation of endodermal cell differentiation(GO:1903224)
1.0 13.4 GO:0045008 depyrimidination(GO:0045008)
1.0 3.1 GO:0035928 rRNA import into mitochondrion(GO:0035928)
1.0 5.8 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
0.8 3.1 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
0.7 4.2 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.6 1.9 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.5 2.6 GO:0009256 10-formyltetrahydrofolate metabolic process(GO:0009256)
0.5 3.1 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.4 6.0 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.3 1.5 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.3 0.8 GO:0003241 growth involved in heart morphogenesis(GO:0003241)
0.3 2.7 GO:0070141 response to UV-A(GO:0070141)
0.3 1.0 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
0.2 2.2 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.1 0.6 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.1 2.6 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.1 2.0 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.1 5.3 GO:1904894 positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894)
0.1 2.5 GO:0045143 homologous chromosome segregation(GO:0045143)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.7 GO:0005588 collagen type V trimer(GO:0005588)
1.4 24.1 GO:0031616 spindle pole centrosome(GO:0031616)
1.2 5.8 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.3 2.0 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.2 4.2 GO:0031932 TORC2 complex(GO:0031932)
0.2 1.5 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.2 13.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 0.6 GO:1990075 periciliary membrane compartment(GO:1990075)
0.1 3.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 7.5 GO:0005776 autophagosome(GO:0005776)
0.0 2.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 3.1 GO:0014704 intercalated disc(GO:0014704)
0.0 13.4 GO:0016607 nuclear speck(GO:0016607)
0.0 1.3 GO:0005881 cytoplasmic microtubule(GO:0005881)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 13.4 GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
1.0 6.0 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.9 2.6 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.6 1.9 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.6 5.8 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.5 7.9 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.4 3.1 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.3 1.5 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.2 3.1 GO:0008097 5S rRNA binding(GO:0008097)
0.2 4.2 GO:0070300 phosphatidic acid binding(GO:0070300)
0.2 13.7 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 27.6 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.1 2.6 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 2.7 GO:0070064 proline-rich region binding(GO:0070064)
0.1 0.8 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036) sphingolipid binding(GO:0046625)
0.1 2.2 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 5.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 2.5 GO:0017124 SH3 domain binding(GO:0017124)
0.0 1.0 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.2 GO:0019534 toxin transporter activity(GO:0019534)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 24.5 PID AURORA A PATHWAY Aurora A signaling
0.2 5.8 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 2.7 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 5.7 NABA COLLAGENS Genes encoding collagen proteins
0.1 2.6 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 4.2 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.1 1.9 PID IL3 PATHWAY IL3-mediated signaling events
0.0 1.5 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 2.8 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.8 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 1.0 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 4.1 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 13.4 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.3 5.8 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.1 2.0 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 2.7 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 6.0 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 4.2 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.1 5.7 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.2 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.5 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 2.6 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.0 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 3.1 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 2.6 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)