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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for PBX3
Z-value: 0.56
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Transcription factors associated with PBX3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PBX3 | hg19_v2_chr9_+_128509624_128509658 | -0.17 | 1.4e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PBX3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 37.2 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
| 0.7 | 30.1 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.5 | 28.5 | GO:0042417 | dopamine metabolic process(GO:0042417) |
| 0.0 | 24.9 | GO:0007417 | central nervous system development(GO:0007417) |
| 2.0 | 24.3 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 2.7 | 21.4 | GO:0060075 | regulation of resting membrane potential(GO:0060075) |
| 0.5 | 21.2 | GO:0045022 | early endosome to late endosome transport(GO:0045022) |
| 1.9 | 20.9 | GO:0010529 | regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) |
| 0.3 | 19.8 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.6 | 18.2 | GO:0009083 | branched-chain amino acid catabolic process(GO:0009083) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 77.5 | GO:0043209 | myelin sheath(GO:0043209) |
| 1.7 | 24.3 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 3.1 | 21.4 | GO:0044326 | dendritic spine neck(GO:0044326) |
| 5.0 | 20.1 | GO:0070695 | FHF complex(GO:0070695) |
| 0.2 | 20.1 | GO:0016234 | inclusion body(GO:0016234) |
| 1.2 | 17.4 | GO:0033179 | proton-transporting V-type ATPase, V0 domain(GO:0033179) |
| 2.5 | 15.2 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 1.1 | 14.7 | GO:0034992 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 3.5 | 14.2 | GO:1990246 | uniplex complex(GO:1990246) |
| 0.2 | 13.6 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 261.9 | GO:0046872 | metal ion binding(GO:0046872) |
| 0.2 | 45.9 | GO:0051015 | actin filament binding(GO:0051015) |
| 2.9 | 34.4 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.4 | 29.6 | GO:0030276 | clathrin binding(GO:0030276) |
| 2.0 | 28.7 | GO:1903136 | cuprous ion binding(GO:1903136) |
| 0.1 | 28.2 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.2 | 26.6 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.3 | 22.2 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 1.5 | 21.4 | GO:1990239 | steroid hormone binding(GO:1990239) |
| 0.6 | 17.4 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 24.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 16.6 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.6 | 15.4 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.2 | 12.4 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.5 | 11.6 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.3 | 10.4 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.1 | 10.3 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.3 | 9.2 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.3 | 7.9 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.3 | 6.9 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 113.0 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.3 | 29.2 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.5 | 26.8 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.9 | 24.3 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.5 | 12.4 | REACTOME ACYL CHAIN REMODELLING OF PE | Genes involved in Acyl chain remodelling of PE |
| 0.4 | 11.6 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.4 | 10.8 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.3 | 10.8 | REACTOME CIRCADIAN CLOCK | Genes involved in Circadian Clock |
| 0.3 | 10.5 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.3 | 10.1 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |