Project
GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for PITX1
Z-value: 0.12
Motif logo
Transcription factors associated with PITX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PITX1 | hg19_v2_chr5_-_134369973_134369988 | -0.12 | 8.7e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_1077393 Show fit | 28.02 |
ENST00000590577.1
|
histocompatibility (minor) HA-1 |
|
| chr7_+_73623717 Show fit | 22.67 |
ENST00000344995.5
ENST00000460943.1 |
linker for activation of T cells family, member 2 |
|
| chr22_-_17680472 Show fit | 19.98 |
ENST00000330232.4
|
cat eye syndrome chromosome region, candidate 1 |
|
| chr22_-_43036607 Show fit | 18.82 |
ENST00000505920.1
|
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G2 |
|
| chr14_+_35747825 Show fit | 16.93 |
ENST00000540871.1
|
proteasome (prosome, macropain) subunit, alpha type, 6 |
|
| chr12_-_54691668 Show fit | 16.92 |
ENST00000553198.1
|
nuclear factor, erythroid 2 |
|
| chr7_+_73624327 Show fit | 16.00 |
ENST00000361082.3
ENST00000275635.7 ENST00000470709.1 |
linker for activation of T cells family, member 2 |
|
| chr13_+_43597269 Show fit | 15.92 |
ENST00000379221.2
|
DnaJ (Hsp40) homolog, subfamily C, member 15 |
|
| chr19_-_39826639 Show fit | 15.88 |
ENST00000602185.1
ENST00000598034.1 ENST00000601387.1 ENST00000595636.1 ENST00000253054.8 ENST00000594700.1 ENST00000597595.1 |
glia maturation factor, gamma |
|
| chr2_+_234104079 Show fit | 15.60 |
ENST00000417661.1
|
inositol polyphosphate-5-phosphatase, 145kDa |
Network of associatons between targets according to the STRING database.
First level regulatory network of PITX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 77.1 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.2 | 57.0 | GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 0.6 | 53.2 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 1.1 | 51.9 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 0.8 | 44.0 | GO:0050434 | positive regulation of viral transcription(GO:0050434) |
| 0.7 | 42.7 | GO:0002279 | mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303) |
| 1.4 | 41.8 | GO:0034035 | purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) |
| 1.5 | 37.2 | GO:0006337 | nucleosome disassembly(GO:0006337) |
| 2.8 | 36.4 | GO:0045059 | positive thymic T cell selection(GO:0045059) |
| 4.9 | 34.3 | GO:0098989 | NMDA selective glutamate receptor signaling pathway(GO:0098989) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 65.9 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.6 | 63.4 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 4.2 | 46.0 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 1.1 | 38.9 | GO:0042629 | mast cell granule(GO:0042629) |
| 1.3 | 37.5 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 2.7 | 35.7 | GO:0000243 | commitment complex(GO:0000243) |
| 0.2 | 31.1 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 1.4 | 28.9 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453) |
| 2.3 | 28.1 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 1.4 | 26.0 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 113.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.5 | 47.5 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 2.7 | 45.8 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.8 | 45.6 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.1 | 39.9 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 5.7 | 34.3 | GO:0047685 | amine sulfotransferase activity(GO:0047685) |
| 1.5 | 31.9 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 0.7 | 30.5 | GO:0017069 | snRNA binding(GO:0017069) |
| 2.6 | 28.9 | GO:0004931 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.6 | 28.3 | GO:0050699 | WW domain binding(GO:0050699) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 39.1 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.5 | 37.2 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.7 | 30.4 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.6 | 27.2 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.6 | 25.9 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.7 | 24.3 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.3 | 20.1 | PID ATR PATHWAY | ATR signaling pathway |
| 0.5 | 17.4 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.2 | 15.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 14.6 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 86.1 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 0.6 | 85.7 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 2.9 | 80.1 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.8 | 71.9 | REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C | Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C |
| 0.9 | 70.6 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.5 | 43.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.2 | 41.0 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 1.7 | 39.9 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.9 | 32.9 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 1.3 | 31.1 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |