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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for PITX2
Z-value: 0.96
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Transcription factors associated with PITX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PITX2 | hg19_v2_chr4_-_111544254_111544270, hg19_v2_chr4_-_111563076_111563172, hg19_v2_chr4_-_111558135_111558198 | 0.15 | 2.5e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PITX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.3 | 17.1 | GO:0030185 | nitric oxide transport(GO:0030185) |
| 1.9 | 11.2 | GO:0061517 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.3 | 8.3 | GO:0021952 | central nervous system projection neuron axonogenesis(GO:0021952) |
| 1.2 | 4.7 | GO:2000686 | regulation of rubidium ion transmembrane transporter activity(GO:2000686) |
| 1.5 | 4.4 | GO:0003383 | apical constriction(GO:0003383) mesoderm migration involved in gastrulation(GO:0007509) |
| 0.1 | 3.7 | GO:0006730 | one-carbon metabolic process(GO:0006730) bicarbonate transport(GO:0015701) |
| 0.3 | 3.3 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
| 0.0 | 2.5 | GO:0008203 | cholesterol metabolic process(GO:0008203) |
| 0.1 | 2.2 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.5 | 1.9 | GO:1900827 | positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.3 | 17.1 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.7 | 11.2 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418) |
| 0.0 | 9.8 | GO:0099572 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.0 | 4.7 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 4.4 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.1 | 3.9 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.1 | 1.9 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.2 | 1.3 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.0 | 1.2 | GO:0097381 | photoreceptor disc membrane(GO:0097381) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 17.1 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.6 | 11.2 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.0 | 8.3 | GO:0005057 | receptor signaling protein activity(GO:0005057) |
| 0.0 | 6.2 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.4 | 4.7 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 0.2 | 3.7 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.0 | 3.5 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 2.3 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.1 | 1.9 | GO:0036041 | long-chain fatty acid binding(GO:0036041) |
| 0.0 | 1.7 | GO:0042826 | histone deacetylase binding(GO:0042826) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.0 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 3.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 2.6 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 2.2 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 1.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.1 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 11.2 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 3.7 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.0 | 2.6 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 1.9 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 1.2 | REACTOME OPSINS | Genes involved in Opsins |
| 0.1 | 1.1 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 0.8 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.0 | 0.6 | REACTOME HORMONE LIGAND BINDING RECEPTORS | Genes involved in Hormone ligand-binding receptors |
| 0.0 | 0.2 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |