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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for PITX3
Z-value: 1.36
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Transcription factors associated with PITX3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PITX3 | hg19_v2_chr10_-_104001231_104001274 | -0.69 | 5.7e-32 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_159848807 Show fit | 53.83 |
ENST00000352433.5
|
pituitary tumor-transforming 1 |
|
| chr12_+_104682496 Show fit | 51.89 |
ENST00000378070.4
|
thioredoxin reductase 1 |
|
| chr6_+_24775153 Show fit | 50.91 |
ENST00000356509.3
ENST00000230056.3 |
geminin, DNA replication inhibitor |
|
| chr4_-_120988229 Show fit | 48.51 |
ENST00000296509.6
|
MAD2 mitotic arrest deficient-like 1 (yeast) |
|
| chr5_+_159848854 Show fit | 47.17 |
ENST00000517480.1
ENST00000520452.1 ENST00000393964.1 |
pituitary tumor-transforming 1 |
|
| chr17_-_4852332 Show fit | 42.93 |
ENST00000572383.1
|
profilin 1 |
|
| chr13_-_31191642 Show fit | 41.86 |
ENST00000405805.1
|
high mobility group box 1 |
|
| chr9_+_75766652 Show fit | 39.35 |
ENST00000257497.6
|
annexin A1 |
|
| chr7_+_141438393 Show fit | 37.08 |
ENST00000484178.1
ENST00000473783.1 ENST00000481508.1 |
single-stranded DNA binding protein 1, mitochondrial |
|
| chr8_-_101718991 Show fit | 36.36 |
ENST00000517990.1
|
poly(A) binding protein, cytoplasmic 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of PITX3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 158.4 | GO:0010257 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 3.8 | 144.1 | GO:2000816 | negative regulation of mitotic sister chromatid separation(GO:2000816) |
| 1.6 | 141.5 | GO:1904667 | negative regulation of ubiquitin protein ligase activity(GO:1904667) |
| 2.1 | 99.5 | GO:0006370 | 7-methylguanosine mRNA capping(GO:0006370) |
| 2.6 | 97.8 | GO:0060261 | positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) |
| 1.9 | 87.6 | GO:0006409 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 1.2 | 84.3 | GO:0070125 | mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126) |
| 6.3 | 81.3 | GO:1904869 | regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) |
| 7.7 | 76.8 | GO:1900029 | positive regulation of ruffle assembly(GO:1900029) |
| 15.2 | 76.0 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 109.9 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 5.9 | 94.4 | GO:0019774 | proteasome core complex, beta-subunit complex(GO:0019774) |
| 0.9 | 90.4 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 1.5 | 89.4 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 6.3 | 81.3 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 2.5 | 74.9 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 1.0 | 74.9 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 4.6 | 73.8 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.7 | 70.7 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 2.7 | 68.2 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 168.4 | GO:0003723 | RNA binding(GO:0003723) |
| 0.8 | 155.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.6 | 135.3 | GO:0051015 | actin filament binding(GO:0051015) |
| 3.7 | 110.6 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 2.6 | 100.6 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 1.8 | 92.9 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 1.2 | 91.4 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 0.9 | 90.0 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 1.0 | 74.5 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 6.1 | 72.9 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 153.3 | PID AURORA B PATHWAY | Aurora B signaling |
| 1.6 | 85.3 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 1.6 | 80.0 | PID MYC PATHWAY | C-MYC pathway |
| 1.0 | 75.2 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.8 | 53.8 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.6 | 51.1 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.6 | 44.4 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.7 | 38.7 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.5 | 38.6 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.4 | 37.4 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 382.1 | REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS | Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins |
| 2.0 | 173.1 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 5.1 | 158.7 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.9 | 152.9 | REACTOME TRANSLATION | Genes involved in Translation |
| 2.0 | 152.3 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.8 | 125.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 3.1 | 119.5 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 3.8 | 99.5 | REACTOME KINESINS | Genes involved in Kinesins |
| 2.0 | 97.1 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 1.4 | 85.4 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |