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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for PKNOX2
Z-value: 0.74
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Transcription factors associated with PKNOX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PKNOX2 | hg19_v2_chr11_+_125034586_125034604 | -0.41 | 3.4e-10 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PKNOX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.1 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 1.6 | 14.3 | GO:0030091 | protein repair(GO:0030091) |
| 4.5 | 13.4 | GO:0006597 | spermine biosynthetic process(GO:0006597) |
| 2.6 | 13.0 | GO:0008204 | ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204) |
| 1.5 | 10.5 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
| 1.5 | 10.3 | GO:0006307 | DNA dealkylation involved in DNA repair(GO:0006307) |
| 0.0 | 10.0 | GO:0042493 | response to drug(GO:0042493) |
| 0.5 | 9.9 | GO:0006465 | signal peptide processing(GO:0006465) |
| 0.1 | 9.7 | GO:0071392 | cellular response to estradiol stimulus(GO:0071392) |
| 2.4 | 9.6 | GO:0016259 | selenocysteine metabolic process(GO:0016259) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 26.6 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.2 | 19.1 | GO:0000502 | proteasome complex(GO:0000502) |
| 0.1 | 12.0 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.9 | 10.5 | GO:0005642 | annulate lamellae(GO:0005642) |
| 1.4 | 9.9 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 1.6 | 9.7 | GO:0001740 | Barr body(GO:0001740) |
| 0.6 | 9.4 | GO:0045120 | pronucleus(GO:0045120) |
| 0.2 | 8.1 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.3 | 6.8 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.0 | 6.3 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 19.1 | GO:0047134 | protein-disulfide reductase activity(GO:0047134) |
| 0.6 | 16.0 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 4.8 | 14.3 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
| 0.2 | 13.4 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 3.3 | 13.0 | GO:0004310 | farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996) |
| 0.1 | 12.6 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 1.0 | 10.5 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.2 | 9.7 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.4 | 9.6 | GO:0005161 | platelet-derived growth factor receptor binding(GO:0005161) |
| 1.0 | 9.4 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 20.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 13.1 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 9.7 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 8.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.4 | 6.6 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.2 | 6.3 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 3.2 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.0 | 3.0 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.0 | 2.6 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 1.4 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 16.0 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.5 | 13.5 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.5 | 13.4 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.4 | 13.0 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.2 | 12.2 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.6 | 9.9 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.5 | 9.6 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.4 | 9.6 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 8.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.3 | 7.7 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |