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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for PKNOX2

Z-value: 0.74

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Transcription factors associated with PKNOX2

Gene Symbol Gene ID Gene Info
PKNOX2
ENSG00000165495.11 PBX/knotted 1 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PKNOX2hg19_v2_chr11_+_125034586_125034604-0.413.4e-10Click!

Activity profile of PKNOX2 motif

Sorted Z-values of PKNOX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_111195973 13.37 ENST00000368885.3
ENST00000368882.3
ENST00000451850.2
ENST00000368877.5
AMD1
adenosylmethionine decarboxylase 1
chr8_+_11666649 13.03 ENST00000528643.1
ENST00000525777.1
FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr2_-_61765315 10.51 ENST00000406957.1
ENST00000401558.2
XPO1
exportin 1 (CRM1 homolog, yeast)
chr11_+_74660278 9.90 ENST00000263672.6
ENST00000530257.1
ENST00000526361.1
ENST00000532972.1
SPCS2
signal peptidase complex subunit 2 homolog (S. cerevisiae)
chr4_-_100871506 9.65 ENST00000296417.5
H2AFZ
H2A histone family, member Z
chr12_+_49621658 9.61 ENST00000541364.1
TUBA1C
tubulin, alpha 1c
chr18_-_54318353 9.59 ENST00000590954.1
ENST00000540155.1
TXNL1
thioredoxin-like 1
chr4_-_157892498 9.58 ENST00000502773.1
PDGFC
platelet derived growth factor C
chr18_-_54305658 9.55 ENST00000586262.1
ENST00000217515.6
TXNL1
thioredoxin-like 1
chr7_-_148580563 9.42 ENST00000476773.1
EZH2
enhancer of zeste homolog 2 (Drosophila)
chr18_+_3449695 9.15 ENST00000343820.5
TGIF1
TGFB-induced factor homeobox 1
chr11_-_64013288 8.60 ENST00000542235.1
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr3_+_52719936 8.33 ENST00000418458.1
ENST00000394799.2
GNL3
guanine nucleotide binding protein-like 3 (nucleolar)
chr1_+_181057638 8.08 ENST00000367577.4
IER5
immediate early response 5
chr19_+_36142147 8.02 ENST00000590618.1
COX6B1
cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
chr6_+_150070831 8.00 ENST00000367380.5
PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr6_-_101329191 7.43 ENST00000324723.6
ENST00000369162.2
ENST00000522650.1
ASCC3
activating signal cointegrator 1 complex subunit 3
chr17_-_29151794 7.27 ENST00000324238.6
CRLF3
cytokine receptor-like factor 3
chr3_-_33481835 7.05 ENST00000283629.3
UBP1
upstream binding protein 1 (LBP-1a)
chr6_-_32140886 7.04 ENST00000395496.1
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1
chr16_-_30457048 6.96 ENST00000500504.2
ENST00000542752.1
SEPHS2
selenophosphate synthetase 2
chrX_-_77225135 6.84 ENST00000458128.1
PGAM4
phosphoglycerate mutase family member 4
chr18_+_3449821 6.83 ENST00000407501.2
ENST00000405385.3
ENST00000546979.1
TGIF1
TGFB-induced factor homeobox 1
chr20_+_43514320 6.35 ENST00000372839.3
ENST00000428262.1
ENST00000445830.1
YWHAB
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
chr6_+_150070857 6.31 ENST00000544496.1
PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chrX_-_153775426 5.89 ENST00000393562.2
G6PD
glucose-6-phosphate dehydrogenase
chr1_-_35658736 5.69 ENST00000357214.5
SFPQ
splicing factor proline/glutamine-rich
chr2_+_219081817 5.23 ENST00000315717.5
ENST00000420104.1
ENST00000295685.10
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr5_-_52405564 5.23 ENST00000510818.2
ENST00000396954.3
ENST00000508922.1
ENST00000361377.4
ENST00000582677.1
ENST00000584946.1
ENST00000450852.3
MOCS2
molybdenum cofactor synthesis 2
chr2_+_219524473 5.22 ENST00000439945.1
ENST00000431802.1
BCS1L
BC1 (ubiquinol-cytochrome c reductase) synthesis-like
chr20_-_61847586 4.92 ENST00000370339.3
YTHDF1
YTH domain family, member 1
chr11_-_46867780 4.48 ENST00000529230.1
ENST00000415402.1
ENST00000312055.5
CKAP5
cytoskeleton associated protein 5
chr10_+_51565188 4.47 ENST00000430396.2
ENST00000374087.4
ENST00000414907.2
NCOA4
nuclear receptor coactivator 4
chr11_-_111741994 4.20 ENST00000398006.2
ALG9
ALG9, alpha-1,2-mannosyltransferase
chr4_+_140222609 3.78 ENST00000296543.5
ENST00000398947.1
NAA15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr15_-_37392086 3.51 ENST00000561208.1
MEIS2
Meis homeobox 2
chr17_-_27405875 3.39 ENST00000359450.6
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr6_+_29910301 3.17 ENST00000376809.5
ENST00000376802.2
HLA-A
major histocompatibility complex, class I, A
chr16_-_3030407 3.04 ENST00000431515.2
ENST00000574385.1
ENST00000576268.1
ENST00000574730.1
ENST00000575632.1
ENST00000573944.1
ENST00000262300.8
PKMYT1
protein kinase, membrane associated tyrosine/threonine 1
chr5_+_125758865 2.96 ENST00000542322.1
ENST00000544396.1
GRAMD3
GRAM domain containing 3
chr22_-_30234218 2.88 ENST00000307790.3
ENST00000542393.1
ENST00000397771.2
ASCC2
activating signal cointegrator 1 complex subunit 2
chr10_+_70661014 2.76 ENST00000373585.3
DDX50
DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
chr14_-_21994525 2.71 ENST00000538754.1
SALL2
spalt-like transcription factor 2
chr16_+_57481382 2.71 ENST00000564655.1
ENST00000567072.1
ENST00000567933.1
ENST00000563166.1
COQ9
coenzyme Q9
chr3_-_127541194 2.63 ENST00000453507.2
MGLL
monoglyceride lipase
chr1_+_161736072 2.62 ENST00000367942.3
ATF6
activating transcription factor 6
chr1_+_74701062 2.62 ENST00000326637.3
TNNI3K
TNNI3 interacting kinase
chr1_+_109756523 2.60 ENST00000234677.2
ENST00000369923.4
SARS
seryl-tRNA synthetase
chr6_+_26124373 2.58 ENST00000377791.2
ENST00000602637.1
HIST1H2AC
histone cluster 1, H2ac
chr5_+_125758813 2.57 ENST00000285689.3
ENST00000515200.1
GRAMD3
GRAM domain containing 3
chr9_-_132805430 2.51 ENST00000446176.2
ENST00000355681.3
ENST00000420781.1
FNBP1
formin binding protein 1
chr22_-_31885514 2.46 ENST00000397525.1
EIF4ENIF1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr16_+_57481349 2.37 ENST00000262507.6
ENST00000565964.1
COQ9
coenzyme Q9
chr4_+_169418195 2.32 ENST00000261509.6
ENST00000335742.7
PALLD
palladin, cytoskeletal associated protein
chr2_-_202316260 2.20 ENST00000332624.3
TRAK2
trafficking protein, kinesin binding 2
chr8_+_57124245 2.05 ENST00000521831.1
ENST00000355315.3
ENST00000303759.3
ENST00000517636.1
ENST00000517933.1
ENST00000518801.1
ENST00000523975.1
ENST00000396723.5
ENST00000523061.1
ENST00000521524.1
CHCHD7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr11_-_842509 2.05 ENST00000322028.4
POLR2L
polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
chr16_-_57481278 1.98 ENST00000567751.1
ENST00000568940.1
ENST00000563341.1
ENST00000565961.1
ENST00000569370.1
ENST00000567518.1
ENST00000565786.1
ENST00000394391.4
CIAPIN1
cytokine induced apoptosis inhibitor 1
chr6_-_116575226 1.98 ENST00000420283.1
TSPYL4
TSPY-like 4
chr6_+_17600576 1.96 ENST00000259963.3
FAM8A1
family with sequence similarity 8, member A1
chr4_-_46391805 1.95 ENST00000540012.1
GABRA2
gamma-aminobutyric acid (GABA) A receptor, alpha 2
chr7_-_104909435 1.94 ENST00000357311.3
SRPK2
SRSF protein kinase 2
chr11_+_842808 1.73 ENST00000397397.2
ENST00000397411.2
ENST00000397396.1
TSPAN4
tetraspanin 4
chr5_-_94620239 1.70 ENST00000515393.1
MCTP1
multiple C2 domains, transmembrane 1
chr6_+_31674639 1.64 ENST00000556581.1
ENST00000375832.4
ENST00000503322.1
LY6G6F
MEGT1
lymphocyte antigen 6 complex, locus G6F
HCG43720, isoform CRA_a; Lymphocyte antigen 6 complex locus protein G6f; Megakaryocyte-enhanced gene transcript 1 protein; Uncharacterized protein
chr12_-_121734489 1.56 ENST00000412367.2
ENST00000402834.4
ENST00000404169.3
CAMKK2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr3_-_127541679 1.54 ENST00000265052.5
MGLL
monoglyceride lipase
chr5_-_81046922 1.40 ENST00000514493.1
ENST00000320672.4
SSBP2
single-stranded DNA binding protein 2
chr5_-_81046841 1.38 ENST00000509013.2
ENST00000505980.1
ENST00000509053.1
SSBP2
single-stranded DNA binding protein 2
chr11_+_842928 1.37 ENST00000397408.1
TSPAN4
tetraspanin 4
chr6_-_87804815 1.36 ENST00000369582.2
CGA
glycoprotein hormones, alpha polypeptide
chr3_-_3221358 1.27 ENST00000424814.1
ENST00000450014.1
ENST00000231948.4
ENST00000432408.2
CRBN
cereblon
chr8_+_133787586 1.22 ENST00000395379.1
ENST00000395386.2
ENST00000337920.4
PHF20L1
PHD finger protein 20-like 1
chr2_+_191208196 1.18 ENST00000392329.2
ENST00000322522.4
ENST00000430311.1
ENST00000541441.1
INPP1
inositol polyphosphate-1-phosphatase
chr19_+_10828724 1.16 ENST00000585892.1
ENST00000314646.5
ENST00000359692.6
DNM2
dynamin 2
chr12_+_62654119 1.12 ENST00000353364.3
ENST00000549523.1
ENST00000280377.5
USP15
ubiquitin specific peptidase 15
chr3_+_52828805 1.00 ENST00000416872.2
ENST00000449956.2
ITIH3
inter-alpha-trypsin inhibitor heavy chain 3
chr21_-_34185944 0.98 ENST00000479548.1
C21orf62
chromosome 21 open reading frame 62
chr11_+_12132117 0.87 ENST00000256194.4
MICAL2
microtubule associated monooxygenase, calponin and LIM domain containing 2
chr13_+_33160553 0.74 ENST00000315596.10
PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr19_+_41281060 0.69 ENST00000594436.1
ENST00000597784.1
MIA
melanoma inhibitory activity
chr3_+_32147997 0.65 ENST00000282541.5
GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr7_-_137028498 0.59 ENST00000393083.2
PTN
pleiotrophin
chr12_+_62654155 0.58 ENST00000312635.6
ENST00000393654.3
ENST00000549237.1
USP15
ubiquitin specific peptidase 15
chr19_+_41281282 0.46 ENST00000263369.3
MIA
melanoma inhibitory activity
chr1_-_179112173 0.41 ENST00000408940.3
ENST00000504405.1
ABL2
c-abl oncogene 2, non-receptor tyrosine kinase
chr12_-_91398796 0.41 ENST00000261172.3
ENST00000551767.1
EPYC
epiphycan
chr5_+_118407053 0.37 ENST00000311085.8
ENST00000539542.1
DMXL1
Dmx-like 1
chr18_+_54318616 0.32 ENST00000254442.3
WDR7
WD repeat domain 7
chr19_+_7733929 0.29 ENST00000221515.2
RETN
resistin
chr19_+_41281416 0.28 ENST00000597140.1
MIA
melanoma inhibitory activity
chr6_+_138188551 0.27 ENST00000237289.4
ENST00000433680.1
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr19_+_10828795 0.23 ENST00000389253.4
ENST00000355667.6
ENST00000408974.4
DNM2
dynamin 2
chr2_+_64681103 0.20 ENST00000464281.1
LGALSL
lectin, galactoside-binding-like
chr5_-_81046904 0.20 ENST00000515395.1
SSBP2
single-stranded DNA binding protein 2
chr6_+_108881012 0.19 ENST00000343882.6
FOXO3
forkhead box O3
chr17_+_68071389 0.05 ENST00000283936.1
ENST00000392671.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr19_-_6424783 0.04 ENST00000398148.3
KHSRP
KH-type splicing regulatory protein

Network of associatons between targets according to the STRING database.

First level regulatory network of PKNOX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 13.4 GO:0006597 spermine biosynthetic process(GO:0006597)
3.1 9.4 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
2.6 13.0 GO:0008204 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
2.4 9.6 GO:0016259 selenocysteine metabolic process(GO:0016259)
2.0 5.9 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
1.7 6.8 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
1.6 14.3 GO:0030091 protein repair(GO:0030091)
1.5 10.5 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
1.5 10.3 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.9 5.7 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.7 2.2 GO:0098935 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937)
0.7 5.2 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.7 5.2 GO:0097033 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.6 3.8 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.6 4.2 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.5 7.9 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.5 2.6 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.5 7.0 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.5 1.4 GO:1903526 negative regulation of membrane tubulation(GO:1903526)
0.5 9.9 GO:0006465 signal peptide processing(GO:0006465)
0.4 4.5 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.4 1.7 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.4 1.6 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
0.4 1.9 GO:0035063 nuclear speck organization(GO:0035063)
0.4 8.0 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.3 3.2 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.3 7.7 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.3 0.9 GO:0019417 sulfur oxidation(GO:0019417)
0.3 0.3 GO:0090291 negative regulation of osteoclast proliferation(GO:0090291)
0.3 5.1 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.2 5.2 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.2 4.2 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.2 19.1 GO:0045454 cell redox homeostasis(GO:0045454)
0.2 0.6 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072) negative regulation of protein kinase C signaling(GO:0090038)
0.1 9.7 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.1 4.9 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.1 0.4 GO:1904395 retinal rod cell differentiation(GO:0060221) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.1 4.5 GO:0006622 protein targeting to lysosome(GO:0006622)
0.1 6.3 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.1 2.6 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.1 1.3 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.1 2.0 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 0.3 GO:2000870 positive regulation of female gonad development(GO:2000196) regulation of progesterone secretion(GO:2000870)
0.1 1.9 GO:0003334 keratinocyte development(GO:0003334)
0.1 7.3 GO:0046427 positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894)
0.1 8.1 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.1 0.2 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.1 2.8 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 3.5 GO:0008542 visual learning(GO:0008542)
0.0 2.0 GO:0006356 regulation of transcription from RNA polymerase I promoter(GO:0006356)
0.0 0.7 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 7.0 GO:0019079 viral genome replication(GO:0019079)
0.0 3.0 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.4 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 2.6 GO:0006342 chromatin silencing(GO:0006342)
0.0 3.9 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
0.0 10.0 GO:0042493 response to drug(GO:0042493)
0.0 0.7 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 2.0 GO:0006334 nucleosome assembly(GO:0006334)
0.0 2.5 GO:0019827 stem cell population maintenance(GO:0019827) maintenance of cell number(GO:0098727)
0.0 1.2 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.0 1.4 GO:0030335 positive regulation of cell migration(GO:0030335)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.2 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
1.7 5.2 GO:0019008 molybdopterin synthase complex(GO:0019008)
1.6 9.7 GO:0001740 Barr body(GO:0001740)
1.4 9.9 GO:0005787 signal peptidase complex(GO:0005787)
0.9 10.5 GO:0005642 annulate lamellae(GO:0005642)
0.7 5.7 GO:0042382 paraspeckles(GO:0042382)
0.6 9.4 GO:0045120 pronucleus(GO:0045120)
0.5 3.8 GO:0031415 NatA complex(GO:0031415)
0.5 5.2 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.3 4.5 GO:0044754 autolysosome(GO:0044754)
0.3 3.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.3 6.8 GO:0097228 sperm principal piece(GO:0097228)
0.2 8.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 19.1 GO:0000502 proteasome complex(GO:0000502)
0.1 4.5 GO:0035371 microtubule plus-end(GO:0035371)
0.1 12.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 0.4 GO:0043291 RAVE complex(GO:0043291)
0.1 2.0 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 0.6 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 1.3 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.1 2.7 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 2.2 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 1.4 GO:0001891 phagocytic cup(GO:0001891)
0.1 1.0 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 2.6 GO:0000786 nucleosome(GO:0000786)
0.0 1.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.9 GO:0002102 podosome(GO:0002102)
0.0 6.3 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 26.6 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 2.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 4.4 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 3.2 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 5.7 GO:0005874 microtubule(GO:0005874)
0.0 5.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 1.4 GO:0005796 Golgi lumen(GO:0005796)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 14.3 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
3.3 13.0 GO:0004310 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
2.7 19.1 GO:0047134 protein-disulfide reductase activity(GO:0047134)
2.3 7.0 GO:0004756 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
2.0 5.9 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
1.7 5.2 GO:0030366 molybdopterin synthase activity(GO:0030366)
1.7 6.8 GO:0004619 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
1.4 4.2 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
1.0 9.4 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
1.0 10.5 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.9 7.4 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.9 6.3 GO:0050815 phosphoserine binding(GO:0050815)
0.9 2.6 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.6 16.0 GO:0070410 co-SMAD binding(GO:0070410)
0.4 9.6 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.4 4.9 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.3 4.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.3 7.0 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.3 3.8 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.3 1.7 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.3 8.0 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 13.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.2 2.6 GO:0031013 troponin I binding(GO:0031013)
0.2 9.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 9.0 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.2 3.2 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.2 6.5 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.2 4.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 2.6 GO:0035497 cAMP response element binding(GO:0035497)
0.1 1.4 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1 1.9 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 1.2 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.1 2.0 GO:0001054 RNA polymerase I activity(GO:0001054)
0.1 2.2 GO:0050811 GABA receptor binding(GO:0050811)
0.1 2.0 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 12.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 5.7 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1 0.7 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.1 4.1 GO:0050681 androgen receptor binding(GO:0050681)
0.0 2.8 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 1.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 1.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.9 GO:0071949 FAD binding(GO:0071949)
0.0 2.5 GO:0008565 protein transporter activity(GO:0008565)
0.0 1.9 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.4 GO:0005539 glycosaminoglycan binding(GO:0005539)
0.0 0.3 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 3.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 2.1 GO:0005178 integrin binding(GO:0005178)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 6.6 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.2 6.3 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.2 20.5 PID AR PATHWAY Coregulation of Androgen receptor activity
0.2 13.1 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 9.7 PID CMYB PATHWAY C-MYB transcription factor network
0.0 2.6 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 3.2 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 3.0 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 8.4 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.4 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.3 PID CD40 PATHWAY CD40/CD40L signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 9.9 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.5 13.4 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.5 6.3 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.5 9.6 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.5 13.5 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.4 13.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.4 9.6 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.3 16.0 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.3 3.2 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.3 7.7 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.2 12.2 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.2 2.6 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.2 4.2 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 4.2 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.4 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 8.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 5.2 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 2.0 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.1 1.4 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.1 5.2 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 2.6 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 4.5 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.7 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 3.5 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates