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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for PLAG1
Z-value: 1.05
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Transcription factors associated with PLAG1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PLAG1 | hg19_v2_chr8_-_57123815_57123867 | 0.30 | 4.9e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PLAG1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.0 | 36.1 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 1.7 | 29.8 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 3.1 | 25.1 | GO:0034587 | piRNA metabolic process(GO:0034587) |
| 0.4 | 21.2 | GO:0034260 | negative regulation of GTPase activity(GO:0034260) |
| 0.9 | 17.3 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.2 | 15.8 | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) |
| 2.5 | 15.1 | GO:0070560 | protein secretion by platelet(GO:0070560) |
| 1.2 | 14.7 | GO:0030210 | heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210) |
| 4.7 | 14.0 | GO:1905167 | positive regulation of lysosomal protein catabolic process(GO:1905167) |
| 0.2 | 13.8 | GO:0007528 | neuromuscular junction development(GO:0007528) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.2 | 36.1 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.1 | 28.7 | GO:0098793 | presynapse(GO:0098793) |
| 0.3 | 27.6 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.8 | 25.1 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.3 | 22.3 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.5 | 17.3 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.9 | 15.1 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.3 | 15.1 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 13.1 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 11.9 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.2 | 36.1 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 7.4 | 29.8 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
| 0.9 | 25.3 | GO:0005527 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.8 | 22.3 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 2.2 | 17.3 | GO:1904315 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
| 0.3 | 15.1 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.5 | 15.0 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 3.7 | 14.7 | GO:0050119 | N-acetylglucosamine deacetylase activity(GO:0050119) |
| 0.5 | 14.7 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 3.5 | 14.0 | GO:0042954 | apolipoprotein receptor activity(GO:0030226) lipoprotein transporter activity(GO:0042954) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 39.5 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.5 | 15.0 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.2 | 14.5 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.3 | 14.0 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.4 | 13.1 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.3 | 11.3 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.0 | 11.2 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 7.6 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 5.9 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 5.4 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 36.1 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.3 | 25.1 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.6 | 17.3 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.4 | 14.7 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.4 | 11.5 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.2 | 11.3 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.5 | 9.7 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.3 | 9.3 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.2 | 7.7 | REACTOME G PROTEIN ACTIVATION | Genes involved in G-protein activation |
| 0.3 | 7.2 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |