ISMARA results: POU1F1

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for POU1F1

Z-value: 0.21

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Transcription factors associated with POU1F1

Gene Symbol	Gene ID	Gene Info
POU1F1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000064835.6	POU class 1 homeobox 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
POU1F1	hg19_v2_chr3_-_87325612_87325654	0.27	6.8e-05	Click!

Activity profile of POU1F1 motif

Sorted Z-values of POU1F1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_+_140762268 Show fit	18.09	ENST00000518325.1	PCDHGA7 Ensembl NCBI GeneCards UniProt NextProt Show fit	protocadherin gamma subfamily A, 7
chr6_-_52859046 Show fit	14.49	ENST00000457564.1 ENST00000541324.1 ENST00000370960.1	GSTA4 Ensembl NCBI GeneCards UniProt NextProt Show fit	glutathione S-transferase alpha 4
chrX_-_13835147 Show fit	12.75	ENST00000493677.1 ENST00000355135.2	GPM6B Ensembl NCBI GeneCards UniProt NextProt Show fit	glycoprotein M6B
chr17_+_1674982 Show fit	11.73	ENST00000572048.1 ENST00000573763.1	SERPINF1 Ensembl NCBI GeneCards UniProt NextProt Show fit	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr6_-_52859968 Show fit	10.29	ENST00000370959.1	GSTA4 Ensembl NCBI GeneCards UniProt NextProt Show fit	glutathione S-transferase alpha 4
chr12_-_15038779 Show fit	8.79	ENST00000228938.5 ENST00000539261.1	MGP Ensembl NCBI GeneCards UniProt NextProt Show fit	matrix Gla protein
chr21_-_27423339 Show fit	8.09	ENST00000415997.1	APP Ensembl NCBI GeneCards UniProt NextProt Show fit	amyloid beta (A4) precursor protein
chr19_+_54466179 Show fit	8.06	ENST00000270458.2	CACNG8 Ensembl NCBI GeneCards UniProt NextProt Show fit	calcium channel, voltage-dependent, gamma subunit 8
chr8_+_30244580 Show fit	7.17	ENST00000523115.1 ENST00000519647.1	RBPMS Ensembl NCBI GeneCards UniProt NextProt Show fit	RNA binding protein with multiple splicing
chr15_+_84115868 Show fit	6.81	ENST00000427482.2	SH3GL3 Ensembl NCBI GeneCards UniProt NextProt Show fit	SH3-domain GRB2-like 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of POU1F1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	24.8	GO:1901685	glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.2	23.9	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.3	12.7	GO:0051581	negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
2.3	11.7	GO:0071279	cellular response to cobalt ion(GO:0071279)
0.3	9.6	GO:0043968	histone H2A acetylation(GO:0043968)
0.1	9.3	GO:0007498	mesoderm development(GO:0007498)
0.3	9.1	GO:0001502	cartilage condensation(GO:0001502)
1.6	8.1	GO:0071874	cellular response to norepinephrine stimulus(GO:0071874)
0.4	7.7	GO:0009312	oligosaccharide biosynthetic process(GO:0009312)
0.4	7.6	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)

Showing 1 to 10 of 133 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	21.4	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.0	12.7	GO:0045121	membrane raft(GO:0045121)
1.0	11.7	GO:0043203	axon hillock(GO:0043203)
0.0	11.4	GO:0000139	Golgi membrane(GO:0000139)
0.3	9.6	GO:0035267	NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.9	8.1	GO:1990761	growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.3	8.1	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.1	8.0	GO:0097014	axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0	7.9	GO:0044309	dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.2	7.2	GO:0005685	U1 snRNP(GO:0005685)

Showing 1 to 10 of 73 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	32.7	GO:0005509	calcium ion binding(GO:0005509)
0.5	24.8	GO:0004364	glutathione transferase activity(GO:0004364)
1.1	12.9	GO:1990459	transferrin receptor binding(GO:1990459)
0.1	12.8	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.1	11.7	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	10.9	GO:0005096	GTPase activator activity(GO:0005096)
0.8	8.1	GO:0051425	PTB domain binding(GO:0051425)
0.2	7.8	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.5	7.6	GO:0005132	type I interferon receptor binding(GO:0005132)
0.0	7.6	GO:0003779	actin binding(GO:0003779)

Showing 1 to 10 of 94 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	19.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	9.1	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.1	8.8	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1	8.1	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.1	7.7	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.1	6.6	PID ILK PATHWAY	Integrin-linked kinase signaling
0.1	6.5	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	6.1	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.1	5.5	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.0	5.2	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins

Showing 1 to 10 of 34 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	24.8	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.4	8.1	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.2	8.1	REACTOME TRAFFICKING OF AMPA RECEPTORS	Genes involved in Trafficking of AMPA receptors
0.2	7.6	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.2	6.6	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.2	6.5	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	6.3	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.3	5.4	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.1	5.1	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.1	4.8	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction

Showing 1 to 10 of 47 entries

Results for POU1F1

Z-value: 0.21

Motif logo

Transcription factors associated with POU1F1

Activity-expression correlation:

Activity profile of POU1F1 motif

Sorted Z-values of POU1F1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of POU1F1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: