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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for POU1F1

Z-value: 0.21

Motif logo

Transcription factors associated with POU1F1

Gene Symbol Gene ID Gene Info
ENSG00000064835.6 POU class 1 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU1F1hg19_v2_chr3_-_87325612_873256540.276.8e-05Click!

Activity profile of POU1F1 motif

Sorted Z-values of POU1F1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_140762268 18.09 ENST00000518325.1
protocadherin gamma subfamily A, 7
chr6_-_52859046 14.49 ENST00000457564.1
ENST00000541324.1
ENST00000370960.1
glutathione S-transferase alpha 4
chrX_-_13835147 12.75 ENST00000493677.1
ENST00000355135.2
glycoprotein M6B
chr17_+_1674982 11.73 ENST00000572048.1
ENST00000573763.1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr6_-_52859968 10.29 ENST00000370959.1
glutathione S-transferase alpha 4
chr12_-_15038779 8.79 ENST00000228938.5
ENST00000539261.1
matrix Gla protein
chr21_-_27423339 8.09 ENST00000415997.1
amyloid beta (A4) precursor protein
chr19_+_54466179 8.06 ENST00000270458.2
calcium channel, voltage-dependent, gamma subunit 8
chr8_+_30244580 7.17 ENST00000523115.1
ENST00000519647.1
RNA binding protein with multiple splicing
chr15_+_84115868 6.81 ENST00000427482.2
SH3-domain GRB2-like 3
chr11_+_12399071 6.59 ENST00000539723.1
ENST00000550549.1
parvin, alpha
chr11_-_117186946 6.51 ENST00000313005.6
ENST00000528053.1
beta-site APP-cleaving enzyme 1
chr7_-_45960850 6.50 ENST00000381083.4
ENST00000381086.5
ENST00000275521.6
insulin-like growth factor binding protein 3
chr11_-_128894053 6.19 ENST00000392657.3
Rho GTPase activating protein 32
chr9_-_21351377 6.16 ENST00000380210.1
interferon, alpha 6
chr11_+_2405833 5.74 ENST00000527343.1
ENST00000464784.2
CD81 molecule
chr19_-_51920952 5.66 ENST00000356298.5
ENST00000339313.5
ENST00000529627.1
ENST00000439889.2
ENST00000353836.5
ENST00000432469.2
sialic acid binding Ig-like lectin 10
chr4_-_46911248 5.51 ENST00000355591.3
ENST00000505102.1
cytochrome c oxidase subunit VIIb2
chr8_-_30670384 5.35 ENST00000221138.4
ENST00000518243.1
protein phosphatase 2, catalytic subunit, beta isozyme
chr1_+_233086326 5.23 ENST00000366628.5
ENST00000366627.4
nucleoside-triphosphatase, cancer-related
chr6_-_110501200 5.14 ENST00000392586.1
ENST00000419252.1
ENST00000392589.1
ENST00000392588.1
ENST00000359451.2
WAS protein family, member 1
chr5_+_173472607 5.11 ENST00000303177.3
ENST00000519867.1
Neuron-specific protein family member 2
chr1_-_13390765 5.03 ENST00000357367.2
PRAME family member 8
chr5_+_129083772 4.96 ENST00000564719.1
KIAA1024-like
chr10_+_64133934 4.89 ENST00000395254.3
ENST00000395255.3
ENST00000410046.3
zinc finger protein 365
chr7_+_134528635 4.81 ENST00000445569.2
caldesmon 1
chr2_-_152118352 4.81 ENST00000331426.5
RNA binding motif protein 43
chr7_+_130126012 4.64 ENST00000341441.5
mesoderm specific transcript
chr7_+_130126165 4.63 ENST00000427521.1
ENST00000416162.2
ENST00000378576.4
mesoderm specific transcript
chr4_+_48833234 4.56 ENST00000510824.1
ENST00000425583.2
OCIA domain containing 1
chr8_+_98900132 4.45 ENST00000520016.1
matrilin 2
chr3_-_48130707 4.32 ENST00000360240.6
ENST00000383737.4
microtubule-associated protein 4
chr4_-_153601136 4.22 ENST00000504064.1
ENST00000304385.3
transmembrane protein 154
chr5_+_81575281 4.19 ENST00000380167.4
ATPase, H+ transporting, lysosomal accessory protein 1-like
chrX_-_102941596 3.99 ENST00000441076.2
ENST00000422355.1
ENST00000442614.1
ENST00000422154.2
ENST00000451301.1
mortality factor 4 like 2
chr5_+_95066823 3.98 ENST00000506817.1
ENST00000379982.3
Rho-related BTB domain containing 3
chr5_-_125930929 3.84 ENST00000553117.1
ENST00000447989.2
ENST00000409134.3
aldehyde dehydrogenase 7 family, member A1
chr12_-_25150373 3.82 ENST00000549828.1
chromosome 12 open reading frame 77
chr6_+_26087509 3.82 ENST00000397022.3
ENST00000353147.5
ENST00000352392.4
ENST00000349999.4
ENST00000317896.7
ENST00000357618.5
ENST00000470149.1
ENST00000336625.8
ENST00000461397.1
ENST00000488199.1
hemochromatosis
chr4_-_185275104 3.69 ENST00000317596.3
RP11-290F5.2
chr15_-_56757329 3.66 ENST00000260453.3
meiosis-specific nuclear structural 1
chr5_-_55412774 3.65 ENST00000434982.2
ankyrin repeat domain 55
chr16_-_66764119 3.62 ENST00000569320.1
dynein, cytoplasmic 1, light intermediate chain 2
chr10_-_28571015 3.61 ENST00000375719.3
ENST00000375732.1
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chrX_+_43515467 3.61 ENST00000338702.3
ENST00000542639.1
monoamine oxidase A
chr12_-_118796910 3.60 ENST00000541186.1
ENST00000539872.1
TAO kinase 3
chr1_-_182921119 3.49 ENST00000423786.1
SHC SH2-domain binding protein 1-like
chr2_-_190044480 3.38 ENST00000374866.3
collagen, type V, alpha 2
chrX_-_102942961 3.31 ENST00000434230.1
ENST00000418819.1
ENST00000360458.1
mortality factor 4 like 2
chr8_-_38008783 3.19 ENST00000276449.4
steroidogenic acute regulatory protein
chr3_+_38537960 3.17 ENST00000453767.1
endo/exonuclease (5'-3'), endonuclease G-like
chr19_+_19144384 3.16 ENST00000392335.2
ENST00000535612.1
ENST00000537263.1
ENST00000540707.1
ENST00000541725.1
ENST00000269932.6
ENST00000546344.1
ENST00000540792.1
ENST00000536098.1
ENST00000541898.1
ENST00000543877.1
armadillo repeat containing 6
chr10_+_91152303 3.11 ENST00000371804.3
interferon-induced protein with tetratricopeptide repeats 1
chrX_-_102943022 3.10 ENST00000433176.2
mortality factor 4 like 2
chr21_-_43735628 3.07 ENST00000291525.10
ENST00000518498.1
trefoil factor 3 (intestinal)
chr3_-_194072019 3.03 ENST00000429275.1
ENST00000323830.3
carboxypeptidase N, polypeptide 2
chr9_-_215744 3.02 ENST00000382387.2
chromosome 9 open reading frame 66
chr6_+_26087646 2.99 ENST00000309234.6
hemochromatosis
chr4_+_169552748 2.97 ENST00000504519.1
ENST00000512127.1
palladin, cytoskeletal associated protein
chr10_+_18549645 2.96 ENST00000396576.2
calcium channel, voltage-dependent, beta 2 subunit
chr16_+_16434185 2.96 ENST00000524823.2
Protein PKD1P1
chr16_-_66584059 2.89 ENST00000417693.3
ENST00000544898.1
ENST00000569718.1
ENST00000527284.1
ENST00000299697.7
ENST00000451102.2
thymidine kinase 2, mitochondrial
chr11_-_327537 2.89 ENST00000602735.1
interferon induced transmembrane protein 3
chr4_+_3344141 2.89 ENST00000306648.7
regulator of G-protein signaling 12
chr1_+_77333117 2.87 ENST00000477717.1
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr18_+_21269404 2.82 ENST00000313654.9
laminin, alpha 3
chr8_-_141774467 2.81 ENST00000520151.1
ENST00000519024.1
ENST00000519465.1
protein tyrosine kinase 2
chr6_+_114178512 2.73 ENST00000368635.4
myristoylated alanine-rich protein kinase C substrate
chr5_+_140588269 2.73 ENST00000541609.1
ENST00000239450.2
protocadherin beta 12
chr4_-_122854612 2.66 ENST00000264811.5
transient receptor potential cation channel, subfamily C, member 3
chr16_-_28937027 2.65 ENST00000358201.4
rabaptin, RAB GTPase binding effector protein 2
chr18_-_52989217 2.65 ENST00000570287.2
transcription factor 4
chr7_-_140482926 2.56 ENST00000496384.2
v-raf murine sarcoma viral oncogene homolog B
chr2_+_210517895 2.55 ENST00000447185.1
microtubule-associated protein 2
chr3_-_160823158 2.54 ENST00000392779.2
ENST00000392780.1
ENST00000494173.1
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
chr4_+_88754113 2.51 ENST00000560249.1
ENST00000540395.1
ENST00000511670.1
ENST00000361056.3
matrix extracellular phosphoglycoprotein
chr14_-_90420862 2.47 ENST00000556005.1
ENST00000555872.1
EF-hand calcium binding domain 11
chr10_+_53806501 2.47 ENST00000373975.2
protein kinase, cGMP-dependent, type I
chr22_-_32767017 2.46 ENST00000400234.1
RFPL3 antisense
chr3_+_195447738 2.45 ENST00000447234.2
ENST00000320736.6
ENST00000436408.1
mucin 20, cell surface associated
chr7_+_129932974 2.44 ENST00000445470.2
ENST00000222482.4
ENST00000492072.1
ENST00000473956.1
ENST00000493259.1
ENST00000486598.1
carboxypeptidase A4
chr11_-_63376013 2.42 ENST00000540943.1
phospholipase A2, group XVI
chr8_-_110986918 2.42 ENST00000297404.1
potassium channel, subfamily V, member 1
chr14_-_80697396 2.41 ENST00000557010.1
deiodinase, iodothyronine, type II
chr8_+_70404996 2.39 ENST00000402687.4
ENST00000419716.3
sulfatase 1
chr16_-_18462221 2.37 ENST00000528301.1
LOC339047 protein; Nuclear pore complex-interacting protein family member A3; Nuclear pore complex-interacting protein family member A5; Protein PKD1P1
chr6_+_29555683 2.33 ENST00000383640.2
olfactory receptor, family 2, subfamily H, member 2
chr1_+_117963209 2.32 ENST00000449370.2
mannosidase, alpha, class 1A, member 2
chr19_-_56826157 2.31 ENST00000592509.1
ENST00000592679.1
ENST00000588442.1
ENST00000593106.1
ENST00000587492.1
ENST00000254165.3
zinc finger and SCAN domain containing 5A
chr12_-_71148357 2.31 ENST00000378778.1
protein tyrosine phosphatase, receptor type, R
chr3_-_160823040 2.30 ENST00000484127.1
ENST00000492353.1
ENST00000473142.1
ENST00000468268.1
ENST00000460353.1
ENST00000320474.4
ENST00000392781.2
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
chr18_+_21269556 2.25 ENST00000399516.3
laminin, alpha 3
chr7_+_138943265 2.24 ENST00000483726.1
ubinuclein 2
chr2_-_166930131 2.23 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
sodium channel, voltage-gated, type I, alpha subunit
chr5_+_140552218 2.14 ENST00000231137.3
protocadherin beta 7
chr8_-_49833978 2.13 ENST00000020945.1
snail family zinc finger 2
chr11_+_122753391 2.11 ENST00000307257.6
ENST00000227349.2
chromosome 11 open reading frame 63
chr10_+_17270214 2.09 ENST00000544301.1
vimentin
chr6_+_29429217 2.09 ENST00000396792.2
olfactory receptor, family 2, subfamily H, member 1
chr1_-_109584608 2.05 ENST00000400794.3
ENST00000528747.1
ENST00000369962.3
ENST00000361054.3
WD repeat domain 47
chr5_-_111754948 2.05 ENST00000261486.5
erythrocyte membrane protein band 4.1 like 4A
chr9_+_111624577 2.04 ENST00000333999.3
actin-like 7A
chr5_+_119867159 2.01 ENST00000505123.1
proline rich 16
chr17_+_66255310 1.98 ENST00000448504.2
arylsulfatase G
chr12_+_26348246 1.97 ENST00000422622.2
sarcospan
chr17_+_29664830 1.97 ENST00000444181.2
ENST00000417592.2
neurofibromin 1
chr1_+_119957554 1.96 ENST00000543831.1
ENST00000433745.1
ENST00000369416.3
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chr12_-_71148413 1.92 ENST00000440835.2
ENST00000549308.1
ENST00000550661.1
protein tyrosine phosphatase, receptor type, R
chr19_-_4535233 1.91 ENST00000381848.3
ENST00000588887.1
ENST00000586133.1
perilipin 5
chr1_+_197237352 1.89 ENST00000538660.1
ENST00000367400.3
ENST00000367399.2
crumbs homolog 1 (Drosophila)
chr18_-_64271363 1.88 ENST00000262150.2
cadherin 19, type 2
chr4_+_186990298 1.86 ENST00000296795.3
ENST00000513189.1
toll-like receptor 3
chr17_-_4938712 1.85 ENST00000254853.5
ENST00000424747.1
solute carrier family 52 (riboflavin transporter), member 1
chr2_+_11696464 1.84 ENST00000234142.5
growth regulation by estrogen in breast cancer 1
chr3_+_130650738 1.79 ENST00000504612.1
ATPase, Ca++ transporting, type 2C, member 1
chrX_+_154113317 1.77 ENST00000354461.2
H2A histone family, member B1
chr1_+_81771806 1.77 ENST00000370721.1
ENST00000370727.1
ENST00000370725.1
ENST00000370723.1
ENST00000370728.1
ENST00000370730.1
latrophilin 2
chrX_+_153533275 1.76 ENST00000426989.1
ENST00000426203.1
ENST00000369912.2
transketolase-like 1
chr17_+_25799008 1.72 ENST00000583370.1
ENST00000398988.3
ENST00000268763.6
kinase suppressor of ras 1
chr8_-_91095099 1.71 ENST00000265431.3
calbindin 1, 28kDa
chr2_+_161993465 1.71 ENST00000457476.1
TRAF family member-associated NFKB activator
chr16_+_19535235 1.70 ENST00000565376.2
ENST00000396208.2
centriolar coiled coil protein 110kDa
chr4_+_71263599 1.69 ENST00000399575.2
proline rich, lacrimal 1
chr16_-_66583701 1.68 ENST00000527800.1
ENST00000525974.1
ENST00000563369.2
thymidine kinase 2, mitochondrial
chr4_+_37455536 1.65 ENST00000381980.4
ENST00000508175.1
chromosome 4 open reading frame 19
chr12_+_26348429 1.65 ENST00000242729.2
sarcospan
chr22_+_23487513 1.65 ENST00000263116.2
ENST00000341989.4
RAB36, member RAS oncogene family
chr12_-_112123524 1.60 ENST00000327551.6
BRCA1 associated protein
chr7_-_138666053 1.59 ENST00000440172.1
ENST00000422774.1
KIAA1549
chr19_-_22193731 1.58 ENST00000601773.1
ENST00000397126.4
ENST00000601993.1
ENST00000599916.1
zinc finger protein 208
chr14_-_36990354 1.57 ENST00000518149.1
NK2 homeobox 1
chr8_-_49834299 1.57 ENST00000396822.1
snail family zinc finger 2
chr9_-_33473882 1.57 ENST00000455041.2
ENST00000353159.2
ENST00000297990.4
ENST00000379471.2
nucleolar protein 6 (RNA-associated)
chr19_+_9296279 1.55 ENST00000344248.2
olfactory receptor, family 7, subfamily D, member 2
chr17_-_2996290 1.53 ENST00000331459.1
olfactory receptor, family 1, subfamily D, member 2
chr1_-_67266939 1.51 ENST00000304526.2
insulin-like 5
chr2_-_26700900 1.50 ENST00000338581.6
ENST00000339598.3
ENST00000402415.3
otoferlin
chr15_+_75970672 1.49 ENST00000435356.1
Uncharacterized protein; cDNA FLJ12988 fis, clone NT2RP3000080
chr7_+_107224364 1.49 ENST00000491150.1
B-cell receptor-associated protein 29
chr9_-_21239978 1.42 ENST00000380222.2
interferon, alpha 14
chr20_+_55904815 1.41 ENST00000371263.3
ENST00000345868.4
ENST00000371260.4
ENST00000418127.1
SPO11 meiotic protein covalently bound to DSB
chr7_-_16872932 1.37 ENST00000419572.2
ENST00000412973.1
anterior gradient 2
chr2_+_103035102 1.37 ENST00000264260.2
interleukin 18 receptor accessory protein
chr4_+_175839551 1.37 ENST00000404450.4
ENST00000514159.1
ADAM metallopeptidase domain 29
chrX_-_71458802 1.37 ENST00000373657.1
ENST00000334463.3
excision repair cross-complementing rodent repair deficiency, complementation group 6-like
chr2_-_169887827 1.37 ENST00000263817.6
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr1_+_162039558 1.35 ENST00000530878.1
ENST00000361897.5
nitric oxide synthase 1 (neuronal) adaptor protein
chr18_-_52989525 1.32 ENST00000457482.3
transcription factor 4
chr20_-_43589109 1.31 ENST00000372813.3
translocase of outer mitochondrial membrane 34
chr12_-_58220078 1.29 ENST00000549039.1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chrX_+_84258832 1.27 ENST00000373173.2
apolipoprotein O-like
chr6_-_136788001 1.26 ENST00000544465.1
microtubule-associated protein 7
chr11_-_13517565 1.25 ENST00000282091.1
ENST00000529816.1
parathyroid hormone
chr2_+_67624430 1.21 ENST00000272342.5
Ewing tumor-associated antigen 1
chr1_-_211307404 1.20 ENST00000367007.4
potassium voltage-gated channel, subfamily H (eag-related), member 1
chr4_+_5527117 1.18 ENST00000505296.1
chromosome 4 open reading frame 6
chr6_-_146057144 1.15 ENST00000367519.3
epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
chr9_+_103947311 1.14 ENST00000395056.2
Lipid phosphate phosphatase-related protein type 1
chr4_+_175839506 1.13 ENST00000505141.1
ENST00000359240.3
ENST00000445694.1
ADAM metallopeptidase domain 29
chr14_+_61654271 1.11 ENST00000555185.1
ENST00000557294.1
ENST00000556778.1
protein kinase C, eta
chrX_-_11308598 1.09 ENST00000380717.3
Rho GTPase activating protein 6
chr1_-_45988542 1.08 ENST00000424390.1
peroxiredoxin 1
chr5_+_140593509 1.08 ENST00000341948.4
protocadherin beta 13
chr10_-_52645379 1.03 ENST00000395489.2
APOBEC1 complementation factor
chr9_-_99540328 1.03 ENST00000223428.4
ENST00000375231.1
ENST00000374641.3
zinc finger protein 510
chr3_+_52245458 1.03 ENST00000459884.1
aminolevulinate, delta-, synthase 1
chr11_-_102651343 1.00 ENST00000279441.4
ENST00000539681.1
matrix metallopeptidase 10 (stromelysin 2)
chr1_-_53608289 0.98 ENST00000371491.4
solute carrier family 1 (glutamate transporter), member 7
chr22_-_43010928 0.95 ENST00000348657.2
ENST00000252115.5
polymerase (DNA-directed), delta interacting protein 3
chr1_+_87012753 0.95 ENST00000370563.3
chloride channel accessory 4
chr10_+_57358750 0.95 ENST00000512524.2
MT-RNR2-like 5
chr4_+_5526883 0.91 ENST00000195455.2
chromosome 4 open reading frame 6
chr1_-_53608249 0.90 ENST00000371494.4
solute carrier family 1 (glutamate transporter), member 7
chr12_+_26164645 0.89 ENST00000542004.1
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr12_-_52761262 0.87 ENST00000257901.3
keratin 85
chr5_+_137225158 0.87 ENST00000290431.5
polycystic kidney disease 2-like 2
chr16_-_70835034 0.86 ENST00000261776.5
Vac14 homolog (S. cerevisiae)
chr4_-_46996424 0.84 ENST00000264318.3
gamma-aminobutyric acid (GABA) A receptor, alpha 4
chr17_-_40950698 0.82 ENST00000328434.7
cytochrome c oxidase assembly factor 3
chr2_+_152214098 0.80 ENST00000243347.3
tumor necrosis factor, alpha-induced protein 6
chrX_+_83116142 0.78 ENST00000329312.4
cylicin, basic protein of sperm head cytoskeleton 1
chr9_-_100684845 0.77 ENST00000375119.3
chromosome 9 open reading frame 156
chr2_-_109605663 0.76 ENST00000409271.1
ENST00000258443.2
ENST00000376651.1
ectodysplasin A receptor
chr15_+_67418047 0.76 ENST00000540846.2
SMAD family member 3
chr7_+_99425633 0.74 ENST00000354829.2
ENST00000421837.2
ENST00000417625.1
ENST00000342499.4
ENST00000444905.1
ENST00000415413.1
ENST00000312017.5
ENST00000222382.5
cytochrome P450, family 3, subfamily A, polypeptide 43
chrX_-_154689596 0.72 ENST00000369444.2
H2A histone family, member B3
chr16_+_48278178 0.72 ENST00000285737.4
ENST00000535754.1
lon peptidase 2, peroxisomal
chr19_-_43969796 0.71 ENST00000244333.3
LY6/PLAUR domain containing 3
chr12_-_10978957 0.67 ENST00000240619.2
taste receptor, type 2, member 10
chr5_-_78809950 0.66 ENST00000334082.6
homer homolog 1 (Drosophila)
chrY_-_6740649 0.66 ENST00000383036.1
ENST00000383037.4
amelogenin, Y-linked
chr1_+_11333245 0.65 ENST00000376810.5
UbiA prenyltransferase domain containing 1
chr3_-_46759314 0.62 ENST00000315170.7
protease, serine, 50
chr6_-_49712147 0.60 ENST00000433368.2
ENST00000354620.4
cysteine-rich secretory protein 3
chr3_+_193310918 0.60 ENST00000361908.3
ENST00000392438.3
ENST00000361510.2
ENST00000361715.2
ENST00000361828.2
ENST00000361150.2
optic atrophy 1 (autosomal dominant)
chr4_-_120243545 0.59 ENST00000274024.3
fatty acid binding protein 2, intestinal
chr18_-_13915530 0.58 ENST00000327606.3
melanocortin 2 receptor (adrenocorticotropic hormone)
chr6_-_25874440 0.56 ENST00000361703.6
ENST00000397060.4
solute carrier family 17 (organic anion transporter), member 3
chr8_+_67687413 0.53 ENST00000521960.1
ENST00000522398.1
ENST00000522629.1
ENST00000520976.1
ENST00000396596.1
serum/glucocorticoid regulated kinase family, member 3
chr8_-_59412717 0.49 ENST00000301645.3
cytochrome P450, family 7, subfamily A, polypeptide 1

Network of associatons between targets according to the STRING database.

First level regulatory network of POU1F1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 11.7 GO:0071279 cellular response to cobalt ion(GO:0071279)
2.3 6.8 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) regulation of T cell antigen processing and presentation(GO:0002625) positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440) response to iron ion starvation(GO:1990641)
1.6 8.1 GO:0071874 cellular response to norepinephrine stimulus(GO:0071874)
1.4 5.7 GO:0043128 regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043126) positive regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043128)
1.3 12.7 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
1.2 3.7 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
1.1 4.6 GO:0046104 thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
1.1 3.2 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894)
1.0 3.1 GO:0051097 negative regulation of helicase activity(GO:0051097)
1.0 3.8 GO:0032053 ciliary basal body organization(GO:0032053)
0.8 3.4 GO:1903224 regulation of endodermal cell differentiation(GO:1903224)
0.7 24.8 GO:1901685 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.7 4.3 GO:0051012 microtubule sliding(GO:0051012)
0.7 4.2 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.7 2.0 GO:0061534 gamma-aminobutyric acid secretion, neurotransmission(GO:0061534)
0.6 1.9 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.6 5.1 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.5 3.8 GO:0042426 choline catabolic process(GO:0042426)
0.5 4.3 GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.5 3.6 GO:0071896 protein localization to adherens junction(GO:0071896)
0.5 2.6 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.5 6.6 GO:0071670 smooth muscle cell chemotaxis(GO:0071670)
0.5 1.5 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.5 1.9 GO:0034343 microglial cell activation involved in immune response(GO:0002282) type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.5 1.9 GO:0032218 riboflavin transport(GO:0032218)
0.4 2.7 GO:0010615 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.4 1.3 GO:1900158 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.4 2.4 GO:0060686 negative regulation of prostatic bud formation(GO:0060686)
0.4 2.3 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.4 7.6 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.4 7.2 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.4 7.7 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.3 9.1 GO:0001502 cartilage condensation(GO:0001502)
0.3 2.4 GO:0046485 ether lipid metabolic process(GO:0046485)
0.3 9.6 GO:0043968 histone H2A acetylation(GO:0043968)
0.3 1.6 GO:0021759 globus pallidus development(GO:0021759)
0.3 2.8 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.3 6.5 GO:0044342 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) type B pancreatic cell proliferation(GO:0044342)
0.3 1.8 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.3 1.4 GO:0015722 canalicular bile acid transport(GO:0015722)
0.3 3.0 GO:0050821 protein stabilization(GO:0050821)
0.2 1.7 GO:0072205 metanephric collecting duct development(GO:0072205)
0.2 3.6 GO:0042420 dopamine catabolic process(GO:0042420)
0.2 0.7 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.2 2.4 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.2 4.6 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.2 2.2 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.2 1.4 GO:0060480 lung goblet cell differentiation(GO:0060480)
0.2 1.4 GO:0070301 cellular response to hydrogen peroxide(GO:0070301)
0.2 2.1 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.2 0.9 GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.2 0.9 GO:0034334 adherens junction maintenance(GO:0034334)
0.2 0.4 GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness(GO:0010841)
0.2 5.1 GO:0031581 hemidesmosome assembly(GO:0031581)
0.2 1.0 GO:0016554 cytidine to uridine editing(GO:0016554)
0.2 1.2 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.2 5.1 GO:0048268 clathrin coat assembly(GO:0048268)
0.2 2.5 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.2 0.8 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.2 2.0 GO:0070986 left/right axis specification(GO:0070986)
0.2 23.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 0.8 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.1 1.5 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 2.0 GO:0045793 positive regulation of cell size(GO:0045793)
0.1 1.1 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.1 6.8 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 6.5 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509) beta-amyloid metabolic process(GO:0050435)
0.1 2.0 GO:0006705 mineralocorticoid biosynthetic process(GO:0006705) mineralocorticoid metabolic process(GO:0008212)
0.1 0.7 GO:0009233 menaquinone metabolic process(GO:0009233)
0.1 2.7 GO:0051764 actin crosslink formation(GO:0051764)
0.1 3.0 GO:0003334 keratinocyte development(GO:0003334)
0.1 1.2 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.1 0.6 GO:0014042 positive regulation of neuron maturation(GO:0014042)
0.1 2.5 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.1 4.2 GO:0015988 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991)
0.1 1.4 GO:0090220 meiotic telomere clustering(GO:0045141) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.1 2.9 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.1 0.8 GO:2001023 regulation of response to drug(GO:2001023)
0.1 3.6 GO:0051642 centrosome localization(GO:0051642)
0.1 0.5 GO:0050955 thermoception(GO:0050955)
0.1 4.4 GO:0031102 neuron projection regeneration(GO:0031102)
0.1 1.9 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.1 5.4 GO:0051058 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.1 2.4 GO:0048012 hepatocyte growth factor receptor signaling pathway(GO:0048012)
0.1 0.6 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.1 0.8 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.1 9.3 GO:0007498 mesoderm development(GO:0007498)
0.1 0.5 GO:0070857 regulation of bile acid biosynthetic process(GO:0070857)
0.1 0.4 GO:1901529 regulation of anion channel activity(GO:0010359) positive regulation of anion channel activity(GO:1901529)
0.1 4.4 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.1 1.2 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 1.0 GO:0019216 regulation of lipid metabolic process(GO:0019216)
0.1 1.9 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.1 1.0 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.7 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998)
0.0 0.3 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.0 1.1 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895)
0.0 0.1 GO:0006711 estrogen catabolic process(GO:0006711)
0.0 0.2 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
0.0 1.3 GO:0006626 protein targeting to mitochondrion(GO:0006626)
0.0 2.5 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 1.3 GO:0042407 cristae formation(GO:0042407)
0.0 0.4 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.0 1.1 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 0.7 GO:0034505 tooth mineralization(GO:0034505)
0.0 1.8 GO:0006007 glucose catabolic process(GO:0006007)
0.0 0.2 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.2 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.0 0.9 GO:0050982 detection of mechanical stimulus(GO:0050982)
0.0 1.7 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.0 0.2 GO:1904322 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.0 1.7 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 0.3 GO:0048007 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0 2.0 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.0 3.7 GO:0007586 digestion(GO:0007586)
0.0 0.9 GO:0046329 negative regulation of JNK cascade(GO:0046329)
0.0 0.9 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.0 2.4 GO:0016573 histone acetylation(GO:0016573)
0.0 5.4 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.0 4.5 GO:0065004 protein-DNA complex assembly(GO:0065004)
0.0 1.5 GO:0016079 synaptic vesicle exocytosis(GO:0016079)
0.0 0.4 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 1.9 GO:2001252 positive regulation of chromosome organization(GO:2001252)
0.0 6.1 GO:0006936 muscle contraction(GO:0006936)
0.0 1.3 GO:0006970 response to osmotic stress(GO:0006970)
0.0 0.2 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 1.0 GO:0030574 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.0 1.5 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 1.6 GO:0007265 Ras protein signal transduction(GO:0007265)
0.0 0.5 GO:0032411 positive regulation of transporter activity(GO:0032411)
0.0 0.4 GO:0061512 protein localization to cilium(GO:0061512)
0.0 1.5 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 0.7 GO:0006501 C-terminal protein lipidation(GO:0006501)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 6.8 GO:1990357 terminal web(GO:1990357)
1.1 3.4 GO:0005588 collagen type V trimer(GO:0005588)
1.0 11.7 GO:0043203 axon hillock(GO:0043203)
0.9 8.1 GO:1990761 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.7 6.5 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.6 5.1 GO:0005610 laminin-5 complex(GO:0005610)
0.5 3.8 GO:0030061 mitochondrial crista(GO:0030061)
0.4 3.5 GO:0072687 meiotic spindle(GO:0072687)
0.4 2.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.4 5.1 GO:0031209 SCAR complex(GO:0031209)
0.3 1.0 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.3 4.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.3 5.5 GO:0045277 respiratory chain complex IV(GO:0045277)
0.3 4.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.3 4.8 GO:0030478 actin cap(GO:0030478)
0.3 4.8 GO:0043073 germ cell nucleus(GO:0043073)
0.3 3.6 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.3 9.6 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.3 8.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.3 0.8 GO:0043159 perinuclear theca(GO:0033011) cytoskeletal calyx(GO:0033150) acrosomal matrix(GO:0043159)
0.2 5.1 GO:0032585 multivesicular body membrane(GO:0032585)
0.2 7.2 GO:0005685 U1 snRNP(GO:0005685)
0.2 2.0 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.2 1.4 GO:0046581 intercellular canaliculus(GO:0046581)
0.2 1.3 GO:0061617 MICOS complex(GO:0061617)
0.2 5.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 2.2 GO:0043194 axon initial segment(GO:0043194)
0.1 4.0 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 1.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.9 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.1 3.9 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 4.6 GO:0005771 multivesicular body(GO:0005771)
0.1 2.0 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 5.7 GO:0001772 immunological synapse(GO:0001772)
0.1 0.3 GO:0097679 other organism cytoplasm(GO:0097679)
0.1 1.9 GO:0036020 endolysosome membrane(GO:0036020)
0.1 0.8 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 2.4 GO:0031528 microvillus membrane(GO:0031528)
0.1 8.0 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.1 0.4 GO:0030905 retromer, tubulation complex(GO:0030905)
0.1 1.0 GO:0000346 transcription export complex(GO:0000346)
0.1 3.0 GO:0002102 podosome(GO:0002102)
0.1 4.5 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 21.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 4.0 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 6.9 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.9 GO:0005902 microvillus(GO:0005902)
0.0 7.9 GO:0044309 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 0.8 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 2.9 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.7 GO:0043034 costamere(GO:0043034)
0.0 12.7 GO:0045121 membrane raft(GO:0045121)
0.0 0.3 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 2.6 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.7 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 3.1 GO:0030018 Z disc(GO:0030018)
0.0 3.0 GO:0005882 intermediate filament(GO:0005882)
0.0 1.9 GO:0005811 lipid particle(GO:0005811)
0.0 2.3 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.2 GO:0043596 nuclear replication fork(GO:0043596)
0.0 1.6 GO:0005884 actin filament(GO:0005884)
0.0 1.5 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 1.7 GO:0032587 ruffle membrane(GO:0032587)
0.0 3.0 GO:0032993 protein-DNA complex(GO:0032993)
0.0 2.8 GO:0005769 early endosome(GO:0005769)
0.0 1.4 GO:0000228 nuclear chromosome(GO:0000228)
0.0 11.4 GO:0000139 Golgi membrane(GO:0000139)
0.0 2.6 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 1.5 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 1.7 GO:0005814 centriole(GO:0005814)
0.0 0.6 GO:0031526 brush border membrane(GO:0031526)
0.0 0.8 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 1.6 GO:0031965 nuclear membrane(GO:0031965)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.5 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
1.7 5.2 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
1.6 4.8 GO:0047273 galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273)
1.5 4.6 GO:0004137 deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797)
1.1 12.9 GO:1990459 transferrin receptor binding(GO:1990459)
1.0 7.2 GO:0035614 snRNA stem-loop binding(GO:0035614)
1.0 2.9 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.9 6.5 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.8 8.1 GO:0051425 PTB domain binding(GO:0051425)
0.7 2.0 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854) steroid delta-isomerase activity(GO:0004769)
0.6 2.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.6 1.8 GO:0004802 transketolase activity(GO:0004802)
0.6 5.1 GO:0032051 clathrin light chain binding(GO:0032051)
0.5 7.6 GO:0005132 type I interferon receptor binding(GO:0005132)
0.5 2.5 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.5 24.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.5 2.5 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.5 2.4 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.5 1.9 GO:0035473 lipase binding(GO:0035473)
0.5 1.4 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.5 1.9 GO:0032217 riboflavin transporter activity(GO:0032217)
0.5 3.6 GO:0008131 primary amine oxidase activity(GO:0008131)
0.4 2.4 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.4 3.0 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.3 2.1 GO:1990254 keratin filament binding(GO:1990254)
0.3 4.0 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.3 1.7 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.3 1.7 GO:0005499 vitamin D binding(GO:0005499)
0.3 1.3 GO:0008420 CTD phosphatase activity(GO:0008420)
0.2 1.1 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.2 7.8 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.2 2.3 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.2 2.7 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.2 4.0 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 1.2 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.2 2.8 GO:0008432 JUN kinase binding(GO:0008432)
0.2 5.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 3.2 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.2 4.2 GO:0002162 dystroglycan binding(GO:0002162)
0.2 4.8 GO:0005523 tropomyosin binding(GO:0005523)
0.2 1.9 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.2 2.0 GO:0004065 arylsulfatase activity(GO:0004065)
0.2 3.8 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.2 4.2 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.2 4.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 3.2 GO:0017127 cholesterol transporter activity(GO:0017127)
0.2 2.0 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.2 0.8 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.1 6.8 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 1.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 3.0 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.7 GO:0016209 antioxidant activity(GO:0016209)
0.1 12.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 11.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 2.2 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.1 0.4 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.1 1.6 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.1 3.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.7 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.1 1.3 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.1 0.8 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.1 0.6 GO:0004977 melanocortin receptor activity(GO:0004977)
0.1 2.3 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.6 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.1 5.4 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 1.8 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 0.6 GO:1901612 cardiolipin binding(GO:1901612)
0.1 0.3 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.1 1.0 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 1.4 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 2.4 GO:0008200 ion channel inhibitor activity(GO:0008200)
0.1 1.3 GO:0048018 receptor agonist activity(GO:0048018)
0.0 2.7 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.7 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.0 0.7 GO:0070330 aromatase activity(GO:0070330)
0.0 32.7 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.5 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.4 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 1.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 3.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 10.9 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.7 GO:0043236 laminin binding(GO:0043236)
0.0 2.9 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.3 GO:0030882 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.0 4.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.6 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.5 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 5.6 GO:0003924 GTPase activity(GO:0003924)
0.0 7.6 GO:0003779 actin binding(GO:0003779)
0.0 1.0 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.6 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.5 GO:0005262 calcium channel activity(GO:0005262)
0.0 0.2 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.1 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 8.8 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 8.1 PID GLYPICAN 1PATHWAY Glypican 1 network
0.1 9.1 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.1 2.6 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 5.5 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 6.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 5.1 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 2.5 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.1 2.8 ST GA12 PATHWAY G alpha 12 Pathway
0.1 6.6 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 2.7 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 6.1 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 19.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.0 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.1 7.7 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 1.9 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 1.4 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 4.0 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 2.5 PID LKB1 PATHWAY LKB1 signaling events
0.0 3.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.9 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 2.1 PID AURORA B PATHWAY Aurora B signaling
0.0 1.6 PID BMP PATHWAY BMP receptor signaling
0.0 1.1 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.0 1.7 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 5.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.1 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 1.8 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.5 PID IL27 PATHWAY IL27-mediated signaling events
0.0 1.0 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.4 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 0.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.0 PID RHOA REG PATHWAY Regulation of RhoA activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 24.8 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.4 8.1 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.3 5.4 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.2 6.5 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 2.7 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.2 6.6 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.2 7.6 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.2 2.7 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.2 3.6 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.2 2.0 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.2 1.9 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.2 8.1 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.2 1.9 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.2 2.4 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.2 2.6 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 2.0 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 3.2 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.1 4.6 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.1 2.8 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 6.3 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.9 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.1 4.5 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 0.9 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 4.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 2.6 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 3.6 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.1 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 1.5 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 2.5 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 5.1 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 3.7 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 2.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 2.2 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.4 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 1.8 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.1 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 1.0 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.8 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.8 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.7 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.3 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 1.3 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 4.1 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.7 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.3 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.9 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors