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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for POU2F2_POU3F1

Z-value: 0.81

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Transcription factors associated with POU2F2_POU3F1

Gene Symbol Gene ID Gene Info
POU2F2
ENSG00000028277.16 POU class 2 homeobox 2
POU3F1
ENSG00000185668.5 POU class 3 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU2F2hg19_v2_chr19_-_42636543_426366070.503.6e-15Click!
POU3F1hg19_v2_chr1_-_38512450_385124740.312.8e-06Click!

Activity profile of POU2F2_POU3F1 motif

Sorted Z-values of POU2F2_POU3F1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_33605231 85.76 ENST00000570121.2
IGHV3OR16-12
immunoglobulin heavy variable 3/OR16-12 (non-functional)
chr14_-_106573756 75.03 ENST00000390601.2
IGHV3-11
immunoglobulin heavy variable 3-11 (gene/pseudogene)
chr14_-_106994333 74.28 ENST00000390624.2
IGHV3-48
immunoglobulin heavy variable 3-48
chr2_-_89399845 71.07 ENST00000479981.1
IGKV1-16
immunoglobulin kappa variable 1-16
chr14_-_107114267 68.34 ENST00000454421.2
IGHV3-64
immunoglobulin heavy variable 3-64
chr14_-_106692191 68.04 ENST00000390607.2
IGHV3-21
immunoglobulin heavy variable 3-21
chr14_-_106926724 67.27 ENST00000434710.1
IGHV3-43
immunoglobulin heavy variable 3-43
chr16_+_32077386 66.96 ENST00000354689.6
IGHV3OR16-9
immunoglobulin heavy variable 3/OR16-9 (non-functional)
chr2_+_90248739 64.54 ENST00000468879.1
IGKV1D-43
immunoglobulin kappa variable 1D-43
chr14_-_106552755 59.97 ENST00000390600.2
IGHV3-9
immunoglobulin heavy variable 3-9
chr2_-_89340242 52.91 ENST00000480492.1
IGKV1-12
immunoglobulin kappa variable 1-12
chr16_+_33020496 52.82 ENST00000565407.2
IGHV3OR16-8
immunoglobulin heavy variable 3/OR16-8 (non-functional)
chr21_+_10862622 52.58 ENST00000302092.5
ENST00000559480.1
IGHV1OR21-1
immunoglobulin heavy variable 1/OR21-1 (non-functional)
chr2_+_90121477 51.49 ENST00000483379.1
IGKV1D-17
immunoglobulin kappa variable 1D-17
chr14_-_106845789 50.27 ENST00000390617.2
IGHV3-35
immunoglobulin heavy variable 3-35 (non-functional)
chr15_-_20193370 47.45 ENST00000558565.2
IGHV3OR15-7
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr1_+_149822620 47.13 ENST00000369159.2
HIST2H2AA4
histone cluster 2, H2aa4
chr16_-_33647696 45.84 ENST00000558425.1
ENST00000569103.2
RP11-812E19.9
Uncharacterized protein
chr1_-_149814478 42.85 ENST00000369161.3
HIST2H2AA3
histone cluster 2, H2aa3
chr2_-_89459813 38.95 ENST00000390256.2
IGKV6-21
immunoglobulin kappa variable 6-21 (non-functional)
chr2_+_90060377 38.65 ENST00000436451.2
IGKV6D-21
immunoglobulin kappa variable 6D-21 (non-functional)
chr2_+_90108504 37.72 ENST00000390271.2
IGKV6D-41
immunoglobulin kappa variable 6D-41 (non-functional)
chr2_+_90139056 37.71 ENST00000492446.1
IGKV1D-16
immunoglobulin kappa variable 1D-16
chr14_-_107078851 37.49 ENST00000390628.2
IGHV1-58
immunoglobulin heavy variable 1-58
chr14_-_106610852 34.66 ENST00000390603.2
IGHV3-15
immunoglobulin heavy variable 3-15
chr2_+_90192768 34.12 ENST00000390275.2
IGKV1D-13
immunoglobulin kappa variable 1D-13
chr16_+_33006369 33.52 ENST00000425181.3
IGHV3OR16-10
immunoglobulin heavy variable 3/OR16-10 (non-functional)
chr6_+_27114861 32.82 ENST00000377459.1
HIST1H2AH
histone cluster 1, H2ah
chr22_+_22930626 32.82 ENST00000390302.2
IGLV2-33
immunoglobulin lambda variable 2-33 (non-functional)
chr2_-_89266286 32.27 ENST00000464162.1
IGKV1-6
immunoglobulin kappa variable 1-6
chr2_-_89619904 32.21 ENST00000498574.1
IGKV1-39
immunoglobulin kappa variable 1-39 (gene/pseudogene)
chr15_-_20170354 31.83 ENST00000338912.5
IGHV1OR15-9
immunoglobulin heavy variable 1/OR15-9 (non-functional)
chr14_-_106518922 31.81 ENST00000390598.2
IGHV3-7
immunoglobulin heavy variable 3-7
chr2_+_90198535 31.20 ENST00000390276.2
IGKV1D-12
immunoglobulin kappa variable 1D-12
chr1_-_149858227 30.68 ENST00000369155.2
HIST2H2BE
histone cluster 2, H2be
chr2_-_89247338 30.65 ENST00000496168.1
IGKV1-5
immunoglobulin kappa variable 1-5
chr2_+_89952792 30.46 ENST00000390265.2
IGKV1D-33
immunoglobulin kappa variable 1D-33
chr2_+_90273679 30.34 ENST00000423080.2
IGKV3D-7
immunoglobulin kappa variable 3D-7
chr22_+_23040274 29.87 ENST00000390306.2
IGLV2-23
immunoglobulin lambda variable 2-23
chr6_+_26124373 29.58 ENST00000377791.2
ENST00000602637.1
HIST1H2AC
histone cluster 1, H2ac
chr22_+_23165153 29.41 ENST00000390317.2
IGLV2-8
immunoglobulin lambda variable 2-8
chr16_+_23847339 29.23 ENST00000303531.7
PRKCB
protein kinase C, beta
chr22_+_23077065 28.94 ENST00000390310.2
IGLV2-18
immunoglobulin lambda variable 2-18
chr14_-_106622419 27.86 ENST00000390604.2
IGHV3-16
immunoglobulin heavy variable 3-16 (non-functional)
chr16_+_32063311 27.03 ENST00000426099.1
AC142381.1
AC142381.1
chr2_-_89417335 26.68 ENST00000490686.1
IGKV1-17
immunoglobulin kappa variable 1-17
chr2_+_90211643 26.63 ENST00000390277.2
IGKV3D-11
immunoglobulin kappa variable 3D-11
chr14_-_107049312 26.60 ENST00000390627.2
IGHV3-53
immunoglobulin heavy variable 3-53
chr2_-_89545079 26.36 ENST00000468494.1
IGKV2-30
immunoglobulin kappa variable 2-30
chr22_+_23046750 26.20 ENST00000390307.2
IGLV3-22
immunoglobulin lambda variable 3-22 (gene/pseudogene)
chr2_-_89568263 26.12 ENST00000473726.1
IGKV1-33
immunoglobulin kappa variable 1-33
chr16_+_33629600 25.96 ENST00000562905.2
IGHV3OR16-13
immunoglobulin heavy variable 3/OR16-13 (non-functional)
chr2_-_89327228 25.55 ENST00000483158.1
IGKV3-11
immunoglobulin kappa variable 3-11
chr1_+_149858461 25.51 ENST00000331380.2
HIST2H2AC
histone cluster 2, H2ac
chr14_-_106816253 25.18 ENST00000390615.2
IGHV3-33
immunoglobulin heavy variable 3-33
chr2_+_89923550 25.13 ENST00000509129.1
IGKV1D-37
immunoglobulin kappa variable 1D-37 (non-functional)
chr4_-_71532339 25.00 ENST00000254801.4
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr14_-_106539557 24.63 ENST00000390599.2
IGHV1-8
immunoglobulin heavy variable 1-8
chr6_+_37137939 24.49 ENST00000373509.5
PIM1
pim-1 oncogene
chr2_+_89901292 24.42 ENST00000448155.2
IGKV1D-39
immunoglobulin kappa variable 1D-39
chr8_+_56792355 23.66 ENST00000519728.1
LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr2_+_114163945 23.10 ENST00000453673.3
IGKV1OR2-108
immunoglobulin kappa variable 1/OR2-108 (non-functional)
chr14_-_106586656 22.43 ENST00000390602.2
IGHV3-13
immunoglobulin heavy variable 3-13
chr14_-_107283278 22.19 ENST00000390639.2
IGHV7-81
immunoglobulin heavy variable 7-81 (non-functional)
chr22_+_23089870 22.08 ENST00000390311.2
IGLV3-16
immunoglobulin lambda variable 3-16
chr14_-_106866934 22.04 ENST00000390618.2
IGHV3-38
immunoglobulin heavy variable 3-38 (non-functional)
chrX_-_106960285 21.81 ENST00000503515.1
ENST00000372397.2
TSC22D3
TSC22 domain family, member 3
chr14_-_107170409 21.59 ENST00000390633.2
IGHV1-69
immunoglobulin heavy variable 1-69
chr22_+_22712087 20.90 ENST00000390294.2
IGLV1-47
immunoglobulin lambda variable 1-47
chr8_+_56792377 20.71 ENST00000520220.2
LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr14_-_106725723 20.34 ENST00000390609.2
IGHV3-23
immunoglobulin heavy variable 3-23
chr2_+_90259593 19.70 ENST00000471857.1
IGKV1D-8
immunoglobulin kappa variable 1D-8
chr14_-_107013465 19.34 ENST00000390625.2
IGHV3-49
immunoglobulin heavy variable 3-49
chr16_+_23847267 18.96 ENST00000321728.7
PRKCB
protein kinase C, beta
chr14_-_107131560 18.65 ENST00000390632.2
IGHV3-66
immunoglobulin heavy variable 3-66
chr22_+_22735135 18.54 ENST00000390297.2
IGLV1-44
immunoglobulin lambda variable 1-44
chr8_-_134115118 18.19 ENST00000395352.3
ENST00000338087.5
SLA
Src-like-adaptor
chr2_+_89975669 17.75 ENST00000474213.1
IGKV2D-30
immunoglobulin kappa variable 2D-30
chr17_-_47841485 17.19 ENST00000506156.1
ENST00000240364.2
FAM117A
family with sequence similarity 117, member A
chr2_+_89998789 16.89 ENST00000453166.2
IGKV2D-28
immunoglobulin kappa variable 2D-28
chr1_-_149783914 16.07 ENST00000369167.1
ENST00000427880.2
ENST00000545683.1
HIST2H2BF
histone cluster 2, H2bf
chr11_-_5248294 15.87 ENST00000335295.4
HBB
hemoglobin, beta
chr6_-_27114577 15.07 ENST00000356950.1
ENST00000396891.4
HIST1H2BK
histone cluster 1, H2bk
chr18_-_53089723 14.99 ENST00000561992.1
ENST00000562512.2
TCF4
transcription factor 4
chr17_+_20059302 14.42 ENST00000395530.2
SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr18_-_52989217 14.37 ENST00000570287.2
TCF4
transcription factor 4
chr22_+_23161491 14.28 ENST00000390316.2
IGLV3-9
immunoglobulin lambda variable 3-9 (gene/pseudogene)
chr2_-_89597542 14.11 ENST00000465170.1
IGKV1-37
immunoglobulin kappa variable 1-37 (non-functional)
chr22_+_23154239 13.84 ENST00000390315.2
IGLV3-10
immunoglobulin lambda variable 3-10
chr14_-_107219365 12.95 ENST00000424969.2
IGHV3-74
immunoglobulin heavy variable 3-74
chr14_-_106791536 12.52 ENST00000390613.2
IGHV3-30
immunoglobulin heavy variable 3-30
chr22_+_22764088 12.52 ENST00000390299.2
IGLV1-40
immunoglobulin lambda variable 1-40
chr1_+_156119798 11.94 ENST00000355014.2
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr10_-_98031265 11.39 ENST00000224337.5
ENST00000371176.2
BLNK
B-cell linker
chr18_-_52989525 11.29 ENST00000457482.3
TCF4
transcription factor 4
chr6_-_27782548 11.28 ENST00000333151.3
HIST1H2AJ
histone cluster 1, H2aj
chrX_+_12993202 11.15 ENST00000451311.2
ENST00000380636.1
TMSB4X
thymosin beta 4, X-linked
chr19_-_17516449 10.97 ENST00000252593.6
BST2
bone marrow stromal cell antigen 2
chr10_-_98031310 10.91 ENST00000427367.2
ENST00000413476.2
BLNK
B-cell linker
chr22_+_23063100 10.25 ENST00000390309.2
IGLV3-19
immunoglobulin lambda variable 3-19
chr19_-_18392422 10.08 ENST00000252818.3
JUND
jun D proto-oncogene
chr7_-_100183742 9.87 ENST00000310300.6
LRCH4
leucine-rich repeats and calponin homology (CH) domain containing 4
chr6_+_6588902 9.64 ENST00000230568.4
LY86
lymphocyte antigen 86
chr6_-_26216872 9.51 ENST00000244601.3
HIST1H2BG
histone cluster 1, H2bg
chr1_+_117297007 9.39 ENST00000369478.3
ENST00000369477.1
CD2
CD2 molecule
chr4_-_25865159 9.18 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr11_-_129872712 9.06 ENST00000358825.5
ENST00000360871.3
ENST00000528746.1
PRDM10
PR domain containing 10
chr19_+_1269324 8.75 ENST00000589710.1
ENST00000588230.1
ENST00000413636.2
ENST00000586472.1
ENST00000589686.1
ENST00000444172.2
ENST00000587323.1
ENST00000320936.5
ENST00000587896.1
ENST00000589235.1
ENST00000591659.1
CIRBP
cold inducible RNA binding protein
chr22_+_23029188 8.60 ENST00000390305.2
IGLV3-25
immunoglobulin lambda variable 3-25
chr22_-_24096562 8.49 ENST00000398465.3
VPREB3
pre-B lymphocyte 3
chr6_+_27775899 8.39 ENST00000358739.3
HIST1H2AI
histone cluster 1, H2ai
chr2_+_90458201 8.36 ENST00000603238.1
CH17-132F21.1
Uncharacterized protein
chrX_-_48776292 8.29 ENST00000376509.4
PIM2
pim-2 oncogene
chr2_+_68962014 8.25 ENST00000467265.1
ARHGAP25
Rho GTPase activating protein 25
chr19_+_19144384 7.90 ENST00000392335.2
ENST00000535612.1
ENST00000537263.1
ENST00000540707.1
ENST00000541725.1
ENST00000269932.6
ENST00000546344.1
ENST00000540792.1
ENST00000536098.1
ENST00000541898.1
ENST00000543877.1
ARMC6
armadillo repeat containing 6
chr6_+_27782788 7.82 ENST00000359465.4
HIST1H2BM
histone cluster 1, H2bm
chr21_+_39644395 7.82 ENST00000398934.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr12_-_7245125 7.79 ENST00000542285.1
ENST00000540610.1
C1R
complement component 1, r subcomponent
chr21_+_39644305 7.73 ENST00000398930.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr6_-_27775694 7.72 ENST00000377401.2
HIST1H2BL
histone cluster 1, H2bl
chr17_-_19651654 7.42 ENST00000395555.3
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr7_+_26438187 7.42 ENST00000439120.1
ENST00000430548.1
ENST00000421862.1
ENST00000449537.1
ENST00000420774.1
ENST00000418758.2
AC004540.5
AC004540.5
chr6_-_34113856 7.38 ENST00000538487.2
GRM4
glutamate receptor, metabotropic 4
chr11_-_2906979 7.16 ENST00000380725.1
ENST00000313407.6
ENST00000430149.2
ENST00000440480.2
ENST00000414822.3
CDKN1C
cyclin-dependent kinase inhibitor 1C (p57, Kip2)
chr6_+_26158343 7.10 ENST00000377777.4
ENST00000289316.2
HIST1H2BD
histone cluster 1, H2bd
chr7_+_16793160 6.93 ENST00000262067.4
TSPAN13
tetraspanin 13
chr6_-_27100529 6.46 ENST00000607124.1
ENST00000339812.2
ENST00000541790.1
HIST1H2BJ
histone cluster 1, H2bj
chr17_+_73521763 6.41 ENST00000167462.5
ENST00000375227.4
ENST00000392550.3
ENST00000578363.1
ENST00000579392.1
LLGL2
lethal giant larvae homolog 2 (Drosophila)
chr19_-_1021113 6.40 ENST00000333175.5
ENST00000356663.3
TMEM259
transmembrane protein 259
chrX_+_12993336 6.29 ENST00000380635.1
TMSB4X
thymosin beta 4, X-linked
chr16_+_56969284 6.19 ENST00000568358.1
HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr19_+_55128576 6.09 ENST00000396331.1
LILRB1
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
chr19_+_35820064 6.07 ENST00000341773.6
ENST00000600131.1
ENST00000270311.6
ENST00000595780.1
ENST00000597916.1
ENST00000593867.1
ENST00000600424.1
ENST00000599811.1
ENST00000536635.2
ENST00000085219.5
ENST00000544992.2
ENST00000419549.2
CD22
CD22 molecule
chr1_+_66797687 5.80 ENST00000371045.5
ENST00000531025.1
ENST00000526197.1
PDE4B
phosphodiesterase 4B, cAMP-specific
chr17_-_19651668 5.71 ENST00000494157.2
ENST00000225740.6
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr9_-_127533582 5.70 ENST00000416460.2
NR6A1
nuclear receptor subfamily 6, group A, member 1
chr4_+_124320665 5.70 ENST00000394339.2
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr22_-_24096630 5.69 ENST00000248948.3
VPREB3
pre-B lymphocyte 3
chr6_-_82462425 5.48 ENST00000369754.3
ENST00000320172.6
ENST00000369756.3
FAM46A
family with sequence similarity 46, member A
chr6_-_53013620 5.36 ENST00000259803.7
GCM1
glial cells missing homolog 1 (Drosophila)
chr18_-_53253112 5.26 ENST00000568673.1
ENST00000562847.1
ENST00000568147.1
TCF4
transcription factor 4
chr7_+_100183927 4.90 ENST00000241071.6
ENST00000360609.2
FBXO24
F-box protein 24
chr1_+_152975488 4.89 ENST00000542696.1
SPRR3
small proline-rich protein 3
chr4_-_40517984 4.86 ENST00000381795.6
RBM47
RNA binding motif protein 47
chr6_+_27833034 4.73 ENST00000357320.2
HIST1H2AL
histone cluster 1, H2al
chr12_+_62654119 4.68 ENST00000353364.3
ENST00000549523.1
ENST00000280377.5
USP15
ubiquitin specific peptidase 15
chr7_-_130080818 4.66 ENST00000343969.5
ENST00000541543.1
ENST00000489512.1
CEP41
centrosomal protein 41kDa
chr11_-_62369291 4.59 ENST00000278823.2
MTA2
metastasis associated 1 family, member 2
chr1_+_104198377 4.54 ENST00000370083.4
AMY1A
amylase, alpha 1A (salivary)
chr2_-_175462934 4.49 ENST00000392546.2
ENST00000436221.1
WIPF1
WAS/WASL interacting protein family, member 1
chr11_-_118305921 4.47 ENST00000532619.1
RP11-770J1.4
RP11-770J1.4
chr11_-_62359027 4.39 ENST00000494385.1
ENST00000308436.7
TUT1
terminal uridylyl transferase 1, U6 snRNA-specific
chr9_-_84303269 4.27 ENST00000418319.1
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr12_+_62654155 4.25 ENST00000312635.6
ENST00000393654.3
ENST00000549237.1
USP15
ubiquitin specific peptidase 15
chr7_-_73038822 4.25 ENST00000414749.2
ENST00000429400.2
ENST00000434326.1
MLXIPL
MLX interacting protein-like
chr6_-_52628271 4.24 ENST00000493422.1
GSTA2
glutathione S-transferase alpha 2
chr7_-_73038867 4.23 ENST00000313375.3
ENST00000354613.1
ENST00000395189.1
ENST00000453275.1
MLXIPL
MLX interacting protein-like
chr11_+_74699703 4.17 ENST00000529024.1
ENST00000544263.1
NEU3
sialidase 3 (membrane sialidase)
chr9_+_136325089 4.14 ENST00000291722.7
ENST00000316948.4
ENST00000540581.1
CACFD1
calcium channel flower domain containing 1
chr17_+_43213004 4.13 ENST00000586346.1
ENST00000398322.3
ENST00000592162.1
ENST00000376955.4
ENST00000321854.8
ACBD4
acyl-CoA binding domain containing 4
chr17_+_38497640 4.11 ENST00000394086.3
RARA
retinoic acid receptor, alpha
chrX_-_130037198 3.98 ENST00000370935.1
ENST00000338144.3
ENST00000394363.1
ENOX2
ecto-NOX disulfide-thiol exchanger 2
chr6_+_27861190 3.94 ENST00000303806.4
HIST1H2BO
histone cluster 1, H2bo
chr17_-_73127778 3.94 ENST00000578407.1
NT5C
5', 3'-nucleotidase, cytosolic
chr1_+_207669495 3.87 ENST00000367052.1
ENST00000367051.1
ENST00000367053.1
CR1
complement component (3b/4b) receptor 1 (Knops blood group)
chr6_+_26273144 3.87 ENST00000377733.2
HIST1H2BI
histone cluster 1, H2bi
chr6_-_52668605 3.83 ENST00000334575.5
GSTA1
glutathione S-transferase alpha 1
chr6_+_27100811 3.82 ENST00000359193.2
HIST1H2AG
histone cluster 1, H2ag
chr22_-_43010928 3.64 ENST00000348657.2
ENST00000252115.5
POLDIP3
polymerase (DNA-directed), delta interacting protein 3
chr8_+_19796381 3.62 ENST00000524029.1
ENST00000522701.1
ENST00000311322.8
LPL
lipoprotein lipase
chr10_-_115904361 3.53 ENST00000428953.1
ENST00000543782.1
C10orf118
chromosome 10 open reading frame 118
chr6_-_35656712 3.47 ENST00000357266.4
ENST00000542713.1
FKBP5
FK506 binding protein 5
chr15_-_45406385 3.44 ENST00000389039.6
DUOX2
dual oxidase 2
chr6_-_11232891 3.44 ENST00000379433.5
ENST00000379446.5
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr19_-_50169064 3.42 ENST00000593337.1
ENST00000598808.1
ENST00000600453.1
ENST00000593818.1
ENST00000597198.1
ENST00000601809.1
ENST00000377139.3
IRF3
interferon regulatory factor 3
chr19_-_40791302 3.40 ENST00000392038.2
ENST00000578123.1
AKT2
v-akt murine thymoma viral oncogene homolog 2
chr11_-_75917569 3.39 ENST00000322563.3
WNT11
wingless-type MMTV integration site family, member 11
chr19_+_35862192 3.39 ENST00000597214.1
GPR42
G protein-coupled receptor 42 (gene/pseudogene)
chr18_-_45457478 3.37 ENST00000402690.2
ENST00000356825.4
SMAD2
SMAD family member 2
chr14_+_22293618 3.36 ENST00000390432.2
TRAV10
T cell receptor alpha variable 10
chr2_+_241938255 3.35 ENST00000401884.1
ENST00000405547.3
ENST00000310397.8
ENST00000342631.6
SNED1
sushi, nidogen and EGF-like domains 1
chr8_-_57123815 3.34 ENST00000316981.3
ENST00000423799.2
ENST00000429357.2
PLAG1
pleiomorphic adenoma gene 1
chr9_+_92219919 3.30 ENST00000252506.6
ENST00000375769.1
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr5_-_64777733 3.28 ENST00000381055.3
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr12_+_72080253 3.23 ENST00000549735.1
TMEM19
transmembrane protein 19
chr19_+_35861831 3.13 ENST00000454971.1
GPR42
G protein-coupled receptor 42 (gene/pseudogene)
chr6_+_26217159 3.10 ENST00000303910.2
HIST1H2AE
histone cluster 1, H2ae
chr7_+_50348268 3.09 ENST00000438033.1
ENST00000439701.1
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr19_-_50168962 3.06 ENST00000599223.1
ENST00000593922.1
ENST00000600022.1
ENST00000596765.1
ENST00000599144.1
ENST00000596822.1
ENST00000598108.1
ENST00000601373.1
ENST00000595034.1
ENST00000601291.1
IRF3
interferon regulatory factor 3
chr22_+_22550113 3.01 ENST00000390285.3
IGLV6-57
immunoglobulin lambda variable 6-57
chr19_+_17337406 2.97 ENST00000597836.1
OCEL1
occludin/ELL domain containing 1
chr15_-_58357932 2.97 ENST00000347587.3
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr17_-_7307358 2.92 ENST00000576017.1
ENST00000302422.3
ENST00000535512.1
TMEM256
TMEM256-PLSCR3
transmembrane protein 256
TMEM256-PLSCR3 readthrough (NMD candidate)
chr3_+_186435065 2.85 ENST00000287611.2
ENST00000265023.4
KNG1
kininogen 1
chr4_+_94750014 2.80 ENST00000306011.3
ATOH1
atonal homolog 1 (Drosophila)
chr12_+_81110684 2.70 ENST00000228644.3
MYF5
myogenic factor 5
chr19_-_3971050 2.63 ENST00000545797.2
ENST00000596311.1
DAPK3
death-associated protein kinase 3
chr19_-_47164386 2.59 ENST00000391916.2
ENST00000410105.2
DACT3
dishevelled-binding antagonist of beta-catenin 3
chr12_-_99038732 2.58 ENST00000393042.3
ENST00000420861.1
ENST00000299157.4
ENST00000342502.2
IKBIP
IKBKB interacting protein
chr15_-_58357866 2.57 ENST00000537372.1
ALDH1A2
aldehyde dehydrogenase 1 family, member A2

Network of associatons between targets according to the STRING database.

First level regulatory network of POU2F2_POU3F1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
16.1 48.2 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
14.8 44.4 GO:0070666 positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
11.7 1750.0 GO:0006958 complement activation, classical pathway(GO:0006958)
4.0 15.9 GO:0030185 nitric oxide transport(GO:0030185)
3.7 11.0 GO:1901253 negative regulation of dendritic cell cytokine production(GO:0002731) negative regulation of intracellular transport of viral material(GO:1901253)
3.3 565.1 GO:0002377 immunoglobulin production(GO:0002377)
2.7 21.8 GO:0070235 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
2.5 17.4 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
2.2 8.9 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
2.2 24.5 GO:0070561 vitamin D receptor signaling pathway(GO:0070561)
1.9 5.7 GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940)
1.9 34.0 GO:0002227 innate immune response in mucosa(GO:0002227)
1.9 9.4 GO:0030885 regulation of myeloid dendritic cell activation(GO:0030885)
1.8 5.4 GO:0060018 astrocyte fate commitment(GO:0060018)
1.5 6.1 GO:2001193 gamma-delta T cell activation involved in immune response(GO:0002290) negative regulation of interferon-beta secretion(GO:0035548) regulation of gamma-delta T cell activation involved in immune response(GO:2001191) positive regulation of gamma-delta T cell activation involved in immune response(GO:2001193)
1.4 5.6 GO:0042335 cuticle development(GO:0042335)
1.4 127.5 GO:0006342 chromatin silencing(GO:0006342)
1.3 8.9 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
1.1 3.4 GO:0060775 mediolateral intercalation(GO:0060031) planar cell polarity pathway involved in gastrula mediolateral intercalation(GO:0060775)
1.1 3.4 GO:1900224 positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
1.0 4.1 GO:0060010 Sertoli cell fate commitment(GO:0060010)
1.0 4.1 GO:0072396 response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423)
1.0 4.9 GO:0016554 cytidine to uridine editing(GO:0016554)
0.8 2.5 GO:0060168 positive regulation of adenosine receptor signaling pathway(GO:0060168)
0.8 0.8 GO:2000317 negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.8 4.0 GO:0048511 rhythmic process(GO:0048511)
0.8 7.8 GO:0060340 positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
0.8 4.7 GO:0018095 protein polyglutamylation(GO:0018095)
0.7 6.0 GO:0006689 ganglioside catabolic process(GO:0006689)
0.7 2.2 GO:0060535 trachea cartilage morphogenesis(GO:0060535)
0.7 8.5 GO:0090324 negative regulation of oxidative phosphorylation(GO:0090324)
0.7 2.1 GO:0003099 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) baroreceptor response to increased systemic arterial blood pressure(GO:0001983) positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.7 2.0 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619) positive regulation of sarcomere organization(GO:0060298)
0.6 2.5 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.6 5.5 GO:0035799 ureter maturation(GO:0035799)
0.6 1.7 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.6 3.4 GO:0010746 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.5 9.9 GO:0045199 maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.5 12.6 GO:1904294 positive regulation of ERAD pathway(GO:1904294)
0.5 2.6 GO:0051946 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.5 3.6 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890) lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
0.5 2.1 GO:0036269 swimming behavior(GO:0036269)
0.5 2.6 GO:0010165 response to X-ray(GO:0010165)
0.5 8.8 GO:0034063 stress granule assembly(GO:0034063)
0.5 2.6 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.5 1.5 GO:0071676 negative regulation of mononuclear cell migration(GO:0071676)
0.5 2.0 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.5 7.4 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.5 5.8 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.5 1.4 GO:0060370 susceptibility to T cell mediated cytotoxicity(GO:0060370)
0.5 2.8 GO:0045631 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.4 1.7 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.4 11.3 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.4 8.0 GO:0046135 pyrimidine deoxyribonucleotide catabolic process(GO:0009223) pyrimidine nucleoside catabolic process(GO:0046135)
0.4 4.4 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.4 0.8 GO:0061110 dense core granule biogenesis(GO:0061110) regulation of dense core granule biogenesis(GO:2000705)
0.4 2.5 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.3 15.1 GO:0010107 potassium ion import(GO:0010107)
0.3 2.5 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.3 0.9 GO:0005989 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.3 4.3 GO:2000811 negative regulation of anoikis(GO:2000811)
0.3 1.1 GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.3 5.3 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.3 2.5 GO:0015889 cobalamin transport(GO:0015889)
0.2 2.7 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.2 2.6 GO:0033004 negative regulation of mast cell activation(GO:0033004)
0.2 3.8 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.2 2.1 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.2 3.3 GO:0060252 positive regulation of glial cell proliferation(GO:0060252)
0.2 1.0 GO:0046985 positive regulation of hemoglobin biosynthetic process(GO:0046985)
0.2 1.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 18.2 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.2 49.4 GO:0065004 protein-DNA complex assembly(GO:0065004)
0.2 1.5 GO:0070995 NADPH oxidation(GO:0070995)
0.2 6.4 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.2 3.6 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.2 0.7 GO:0035990 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.2 0.5 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.2 4.6 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.2 1.3 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.2 2.6 GO:0031033 myosin filament organization(GO:0031033)
0.2 23.6 GO:0051591 response to cAMP(GO:0051591)
0.1 8.3 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.1 6.9 GO:0018149 peptide cross-linking(GO:0018149)
0.1 1.7 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.1 0.4 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320)
0.1 10.0 GO:0030183 B cell differentiation(GO:0030183)
0.1 2.6 GO:0010719 negative regulation of epithelial to mesenchymal transition(GO:0010719)
0.1 4.0 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 2.4 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.1 5.6 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)
0.1 0.3 GO:0048867 stem cell fate determination(GO:0048867)
0.1 1.4 GO:0060271 cilium morphogenesis(GO:0060271)
0.1 2.0 GO:0015012 heparan sulfate proteoglycan biosynthetic process(GO:0015012)
0.1 0.8 GO:0070327 thyroid hormone transport(GO:0070327)
0.1 2.0 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.1 1.1 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.1 0.5 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.1 5.5 GO:0030193 regulation of blood coagulation(GO:0030193) regulation of hemostasis(GO:1900046)
0.1 3.3 GO:0007160 cell-matrix adhesion(GO:0007160)
0.1 6.9 GO:1903169 regulation of calcium ion transmembrane transport(GO:1903169)
0.1 1.9 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.1 0.5 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 3.8 GO:0038096 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.0 2.5 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 1.3 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.7 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 3.3 GO:0003279 cardiac septum development(GO:0003279)
0.0 1.0 GO:0060711 labyrinthine layer development(GO:0060711)
0.0 1.3 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.6 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 4.2 GO:0007586 digestion(GO:0007586)
0.0 0.2 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0 4.8 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 2.9 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 1.0 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 0.5 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.1 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.0 1.0 GO:0071349 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.0 0.2 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518)
0.0 5.6 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.0 0.4 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.5 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.4 GO:0007507 heart development(GO:0007507)
0.0 0.5 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
16.0 801.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
8.9 44.4 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
4.0 15.9 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
3.5 198.1 GO:0000786 nucleosome(GO:0000786)
1.8 315.7 GO:0072562 blood microparticle(GO:0072562)
1.3 10.1 GO:0035976 AP1 complex(GO:0035976)
1.0 6.2 GO:1990037 Lewy body core(GO:1990037)
1.0 4.1 GO:0043293 apoptosome(GO:0043293)
0.6 3.4 GO:0032444 activin responsive factor complex(GO:0032444)
0.6 2.2 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.5 17.4 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.4 2.4 GO:0098560 cytoplasmic side of late endosome membrane(GO:0098560)
0.4 621.9 GO:0005615 extracellular space(GO:0005615)
0.4 9.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.4 1.5 GO:1990031 pinceau fiber(GO:1990031)
0.4 4.4 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.3 41.0 GO:0032993 protein-DNA complex(GO:0032993)
0.2 3.6 GO:0000346 transcription export complex(GO:0000346)
0.2 3.1 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.2 5.8 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 1.3 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.2 11.0 GO:0035577 azurophil granule membrane(GO:0035577)
0.2 4.6 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 1.9 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 6.3 GO:0001533 cornified envelope(GO:0001533)
0.1 8.8 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 7.8 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.1 2.6 GO:0042629 mast cell granule(GO:0042629)
0.1 14.8 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 0.7 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 9.5 GO:0016605 PML body(GO:0016605)
0.1 288.3 GO:0005576 extracellular region(GO:0005576)
0.0 3.5 GO:0036064 ciliary basal body(GO:0036064)
0.0 2.3 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 2.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 2.1 GO:0005901 caveola(GO:0005901)
0.0 2.2 GO:0030667 secretory granule membrane(GO:0030667)
0.0 1.6 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 1.6 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 1.8 GO:0043204 perikaryon(GO:0043204)
0.0 1.2 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.6 GO:0016592 mediator complex(GO:0016592)
0.0 0.5 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 1.0 GO:0031252 cell leading edge(GO:0031252)
0.0 1.0 GO:0005884 actin filament(GO:0005884)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
16.1 48.2 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
14.6 801.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
7.4 1385.5 GO:0003823 antigen binding(GO:0003823)
6.2 43.3 GO:0043208 glycosphingolipid binding(GO:0043208)
3.5 45.9 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
2.6 15.9 GO:0030492 hemoglobin binding(GO:0030492)
2.6 7.8 GO:0001861 complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877)
2.4 21.8 GO:0043426 MRF binding(GO:0043426)
2.0 6.1 GO:0030107 HLA-A specific inhibitory MHC class I receptor activity(GO:0030107)
1.7 24.5 GO:0043024 ribosomal small subunit binding(GO:0043024)
1.5 6.0 GO:0052795 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
1.5 8.9 GO:0061649 ubiquitinated histone binding(GO:0061649)
1.3 18.7 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
1.2 3.6 GO:0017129 triglyceride binding(GO:0017129)
1.2 22.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
1.1 4.5 GO:0016160 amylase activity(GO:0016160)
1.1 4.4 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
1.1 8.8 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
1.0 10.6 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.8 15.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.7 2.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.6 9.6 GO:0038191 neuropilin binding(GO:0038191)
0.5 2.6 GO:0070097 delta-catenin binding(GO:0070097)
0.5 4.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.5 1.5 GO:0005137 interleukin-5 receptor binding(GO:0005137)
0.4 11.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.4 12.0 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.4 7.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.4 5.6 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.4 2.5 GO:0050682 AF-2 domain binding(GO:0050682)
0.3 2.0 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.3 1.8 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.3 2.1 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.3 2.3 GO:0070324 thyroid hormone binding(GO:0070324)
0.3 0.6 GO:0010861 thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375)
0.3 3.4 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.2 4.5 GO:0005522 profilin binding(GO:0005522)
0.2 2.5 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.2 0.9 GO:0004461 lactose synthase activity(GO:0004461)
0.2 2.5 GO:0031419 cobalamin binding(GO:0031419)
0.2 4.1 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.2 0.9 GO:0019826 oxygen sensor activity(GO:0019826)
0.2 18.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2 6.5 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.2 5.8 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 2.6 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.2 120.7 GO:0046982 protein heterodimerization activity(GO:0046982)
0.2 0.6 GO:0004594 pantothenate kinase activity(GO:0004594)
0.2 4.0 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 1.5 GO:0070700 BMP receptor binding(GO:0070700)
0.1 4.0 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.1 1.9 GO:0005221 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.1 3.8 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 1.0 GO:0030274 LIM domain binding(GO:0030274)
0.1 2.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 4.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 2.5 GO:0001671 ATPase activator activity(GO:0001671)
0.1 1.3 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 1.6 GO:0005537 mannose binding(GO:0005537)
0.1 0.4 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 4.1 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 5.7 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 1.7 GO:0005123 death receptor binding(GO:0005123)
0.1 5.3 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 2.2 GO:0008066 glutamate receptor activity(GO:0008066)
0.1 1.5 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.1 2.4 GO:0050699 WW domain binding(GO:0050699)
0.1 2.5 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 1.6 GO:0003785 actin monomer binding(GO:0003785)
0.0 7.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.3 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0 0.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.8 GO:0032813 tumor necrosis factor receptor superfamily binding(GO:0032813)
0.0 0.7 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.4 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.5 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.1 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 0.4 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.2 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.5 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.4 GO:0071855 neuropeptide receptor binding(GO:0071855)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 70.4 PID IL5 PATHWAY IL5-mediated signaling events
2.2 47.5 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.9 22.3 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.4 15.5 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.3 39.7 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 3.4 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.2 10.1 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.2 4.1 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 5.6 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 5.3 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.1 6.1 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.1 2.6 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 3.1 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 2.6 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 3.4 PID GLYPICAN 1PATHWAY Glypican 1 network
0.1 4.5 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 2.4 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.1 3.6 PID MTOR 4PATHWAY mTOR signaling pathway
0.1 9.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.1 ST GA12 PATHWAY G alpha 12 Pathway
0.1 3.4 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 3.7 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 2.1 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 2.2 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 1.0 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.5 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.7 PID PDGFRB PATHWAY PDGFR-beta signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 210.1 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
2.6 44.4 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
1.5 43.1 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.9 48.6 REACTOME MYOGENESIS Genes involved in Myogenesis
0.7 8.0 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.7 22.3 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.5 11.9 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.5 7.4 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.4 15.1 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.4 4.5 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.4 7.8 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.4 3.4 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.4 5.3 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.3 7.8 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.3 5.7 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.2 8.1 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.2 2.6 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.2 3.6 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.2 13.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 4.5 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.1 2.2 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 6.0 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 17.4 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 5.8 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 4.1 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 10.5 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.1 3.4 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 2.6 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 6.1 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 6.3 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.1 6.3 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.0 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 4.7 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.6 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 1.7 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 6.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.7 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.6 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.8 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.4 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.5 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.5 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 1.1 REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane