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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for POU3F3_POU3F4

Z-value: 0.91

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Transcription factors associated with POU3F3_POU3F4

Gene Symbol Gene ID Gene Info
ENSG00000198914.2 POU class 3 homeobox 3
ENSG00000196767.4 POU class 3 homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU3F3hg19_v2_chr2_+_105471969_1054719690.387.2e-09Click!
POU3F4hg19_v2_chrX_+_82763265_827632830.351.2e-07Click!

Activity profile of POU3F3_POU3F4 motif

Sorted Z-values of POU3F3_POU3F4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_158142750 71.76 ENST00000505888.1
ENST00000449365.1
glutamate receptor, ionotropic, AMPA 2
chr4_+_158141899 66.41 ENST00000264426.9
ENST00000506284.1
glutamate receptor, ionotropic, AMPA 2
chr15_-_45670924 66.02 ENST00000396659.3
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr3_-_58613323 50.77 ENST00000474531.1
ENST00000465970.1
family with sequence similarity 107, member A
chr5_+_140762268 44.45 ENST00000518325.1
protocadherin gamma subfamily A, 7
chr6_-_46459675 40.38 ENST00000306764.7
regulator of calcineurin 2
chr14_-_60097297 34.73 ENST00000395090.1
reticulon 1
chr14_-_21270561 32.56 ENST00000412779.2
ribonuclease, RNase A family, 1 (pancreatic)
chr14_-_21270995 29.58 ENST00000555698.1
ENST00000397970.4
ENST00000340900.3
ribonuclease, RNase A family, 1 (pancreatic)
chr5_-_11588907 28.42 ENST00000513598.1
ENST00000503622.1
catenin (cadherin-associated protein), delta 2
chr3_+_35722487 28.38 ENST00000441454.1
cAMP-regulated phosphoprotein, 21kDa
chr3_+_158787041 26.61 ENST00000471575.1
ENST00000476809.1
ENST00000485419.1
IQCJ-SCHIP1 readthrough
chr16_-_21314360 24.61 ENST00000219599.3
ENST00000576703.1
crystallin, mu
chr14_+_101297740 24.54 ENST00000555928.1
maternally expressed 3 (non-protein coding)
chr4_+_158141843 23.19 ENST00000509417.1
ENST00000296526.7
glutamate receptor, ionotropic, AMPA 2
chr5_+_140753444 22.24 ENST00000517434.1
protocadherin gamma subfamily A, 6
chr5_-_42811986 21.97 ENST00000511224.1
ENST00000507920.1
ENST00000510965.1
selenoprotein P, plasma, 1
chr5_-_11589131 21.88 ENST00000511377.1
catenin (cadherin-associated protein), delta 2
chr17_-_66951474 21.38 ENST00000269080.2
ATP-binding cassette, sub-family A (ABC1), member 8
chr5_-_42812143 21.07 ENST00000514985.1
selenoprotein P, plasma, 1
chr17_+_3379284 20.03 ENST00000263080.2
aspartoacylase
chr5_+_36608422 18.54 ENST00000381918.3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr9_+_137967366 17.77 ENST00000252854.4
olfactomedin 1
chr18_-_52989217 17.10 ENST00000570287.2
transcription factor 4
chr10_-_75226166 17.06 ENST00000544628.1
protein phosphatase 3, catalytic subunit, beta isozyme
chr4_-_87281224 16.01 ENST00000395169.3
ENST00000395161.2
mitogen-activated protein kinase 10
chr11_-_2906979 15.50 ENST00000380725.1
ENST00000313407.6
ENST00000430149.2
ENST00000440480.2
ENST00000414822.3
cyclin-dependent kinase inhibitor 1C (p57, Kip2)
chr2_-_101034070 14.39 ENST00000264249.3
carbohydrate sulfotransferase 10
chr7_-_100026280 14.31 ENST00000360951.4
ENST00000398027.2
ENST00000324725.6
ENST00000472716.1
zinc finger, CW type with PWWP domain 1
chr8_-_120685608 13.45 ENST00000427067.2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr2_-_175711133 13.41 ENST00000409597.1
ENST00000413882.1
chimerin 1
chr5_-_146461027 12.93 ENST00000394410.2
ENST00000508267.1
ENST00000504198.1
protein phosphatase 2, regulatory subunit B, beta
chr1_+_28099683 12.81 ENST00000373943.4
syntaxin 12
chr5_+_125758813 12.78 ENST00000285689.3
ENST00000515200.1
GRAM domain containing 3
chr2_-_55237484 11.84 ENST00000394609.2
reticulon 4
chr6_-_52859046 11.42 ENST00000457564.1
ENST00000541324.1
ENST00000370960.1
glutathione S-transferase alpha 4
chr5_+_125758865 11.22 ENST00000542322.1
ENST00000544396.1
GRAM domain containing 3
chr8_-_91095099 10.89 ENST00000265431.3
calbindin 1, 28kDa
chr12_-_111926342 10.34 ENST00000389154.3
ataxin 2
chr7_-_14880892 10.24 ENST00000406247.3
ENST00000399322.3
ENST00000258767.5
diacylglycerol kinase, beta 90kDa
chr3_-_127455200 9.99 ENST00000398101.3
monoglyceride lipase
chr2_+_239335449 9.73 ENST00000264607.4
ankyrin repeat and SOCS box containing 1
chr19_-_18632861 9.28 ENST00000262809.4
elongation factor RNA polymerase II
chr3_-_33686743 9.24 ENST00000333778.6
ENST00000539981.1
cytoplasmic linker associated protein 2
chr18_-_52989525 9.19 ENST00000457482.3
transcription factor 4
chr5_-_160279207 8.99 ENST00000327245.5
ATPase, class V, type 10B
chr22_-_37213554 8.47 ENST00000443735.1
parvalbumin
chr19_-_44123734 8.30 ENST00000598676.1
zinc finger protein 428
chr17_+_66255310 8.16 ENST00000448504.2
arylsulfatase G
chr12_-_91574142 8.00 ENST00000547937.1
decorin
chr1_+_19923454 7.84 ENST00000602662.1
ENST00000602293.1
ENST00000322753.6
MINOS1-NBL1 readthrough
mitochondrial inner membrane organizing system 1
chr5_+_140710061 7.83 ENST00000517417.1
ENST00000378105.3
protocadherin gamma subfamily A, 1
chr1_+_104198377 7.78 ENST00000370083.4
amylase, alpha 1A (salivary)
chr2_-_166930131 7.78 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
sodium channel, voltage-gated, type I, alpha subunit
chr12_-_91573249 7.63 ENST00000550099.1
ENST00000546391.1
ENST00000551354.1
decorin
chr9_+_137967268 7.56 ENST00000371799.4
ENST00000277415.11
olfactomedin 1
chr17_-_50236039 7.39 ENST00000451037.2
carbonic anhydrase X
chr15_-_90892669 7.19 ENST00000412799.2
GABA(A) receptors associated protein like 3, pseudogene
chr3_-_185826855 7.16 ENST00000306376.5
ets variant 5
chr5_+_141488070 6.69 ENST00000253814.4
Nedd4 family interacting protein 1
chr17_-_37844267 6.67 ENST00000579146.1
ENST00000378011.4
ENST00000429199.2
ENST00000300658.4
post-GPI attachment to proteins 3
chr12_-_91573316 6.43 ENST00000393155.1
decorin
chr19_-_44124019 6.31 ENST00000300811.3
zinc finger protein 428
chr5_+_129083772 6.14 ENST00000564719.1
KIAA1024-like
chr1_-_1297157 6.09 ENST00000477278.2
matrix-remodelling associated 8
chr2_+_189839046 6.03 ENST00000304636.3
ENST00000317840.5
collagen, type III, alpha 1
chr12_-_91573132 6.03 ENST00000550563.1
ENST00000546370.1
decorin
chr1_+_50574585 5.95 ENST00000371824.1
ENST00000371823.4
ELAV like neuron-specific RNA binding protein 4
chr11_-_57004658 5.80 ENST00000606794.1
apelin receptor
chr3_+_53528659 5.55 ENST00000350061.5
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr7_+_116593433 5.53 ENST00000323984.3
ENST00000393449.1
suppression of tumorigenicity 7
chr5_-_78809950 5.41 ENST00000334082.6
homer homolog 1 (Drosophila)
chr11_+_2405833 5.22 ENST00000527343.1
ENST00000464784.2
CD81 molecule
chrX_+_65382433 5.12 ENST00000374727.3
hephaestin
chr2_+_166095898 5.06 ENST00000424833.1
ENST00000375437.2
ENST00000357398.3
sodium channel, voltage-gated, type II, alpha subunit
chr8_-_67090825 4.81 ENST00000276571.3
corticotropin releasing hormone
chr17_-_61996136 4.77 ENST00000342364.4
growth hormone 1
chr5_+_140782351 4.74 ENST00000573521.1
protocadherin gamma subfamily A, 9
chr4_+_62067860 4.74 ENST00000514591.1
latrophilin 3
chr15_+_74422585 4.74 ENST00000561740.1
ENST00000435464.1
ENST00000453268.2
immunoglobulin superfamily containing leucine-rich repeat 2
chrX_+_57618269 4.60 ENST00000374888.1
zinc finger, X-linked, duplicated B
chr10_-_90712520 4.56 ENST00000224784.6
actin, alpha 2, smooth muscle, aorta
chr13_+_52586517 4.33 ENST00000523764.1
ENST00000521508.1
ALG11, alpha-1,2-mannosyltransferase
chr18_-_33647487 4.31 ENST00000590898.1
ENST00000357384.4
ENST00000319040.6
ENST00000588737.1
ENST00000399022.4
regulation of nuclear pre-mRNA domain containing 1A
chr11_-_95657231 4.20 ENST00000409459.1
ENST00000352297.7
ENST00000393223.3
ENST00000346299.5
myotubularin related protein 2
chr11_+_8040739 4.18 ENST00000534099.1
tubby bipartite transcription factor
chr13_-_26795840 4.17 ENST00000381570.3
ENST00000399762.2
ENST00000346166.3
ring finger protein (C3H2C3 type) 6
chr1_+_101702417 4.09 ENST00000305352.6
sphingosine-1-phosphate receptor 1
chr16_-_70835034 4.05 ENST00000261776.5
Vac14 homolog (S. cerevisiae)
chr12_+_41086297 4.00 ENST00000551295.2
contactin 1
chr4_+_88754113 3.90 ENST00000560249.1
ENST00000540395.1
ENST00000511670.1
ENST00000361056.3
matrix extracellular phosphoglycoprotein
chr9_-_15472730 3.88 ENST00000481862.1
PC4 and SFRS1 interacting protein 1
chr21_-_27423339 3.73 ENST00000415997.1
amyloid beta (A4) precursor protein
chr19_+_36486078 3.61 ENST00000378887.2
succinate dehydrogenase complex assembly factor 1
chrX_+_134975858 3.61 ENST00000537770.1
sarcoma antigen 1
chrX_+_134975753 3.55 ENST00000535938.1
sarcoma antigen 1
chr4_-_102268484 3.51 ENST00000394853.4
protein phosphatase 3, catalytic subunit, alpha isozyme
chr6_-_11779403 3.50 ENST00000414691.3
androgen-dependent TFPI-regulating protein
chr15_-_30113676 3.40 ENST00000400011.2
tight junction protein 1
chr1_-_216978709 3.32 ENST00000360012.3
estrogen-related receptor gamma
chr7_+_119913688 3.28 ENST00000331113.4
potassium voltage-gated channel, Shal-related subfamily, member 2
chr17_-_26220366 3.26 ENST00000460380.2
ENST00000508862.1
ENST00000379102.3
ENST00000582441.1
LYR motif containing 9
Uncharacterized protein
chr12_+_110011571 3.11 ENST00000539696.1
ENST00000228510.3
ENST00000392727.3
mevalonate kinase
chr12_-_102224457 3.09 ENST00000549165.1
ENST00000549940.1
ENST00000392919.4
N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
chr7_+_29237354 3.07 ENST00000546235.1
chimerin 2
chr1_-_104238912 3.06 ENST00000330330.5
amylase, alpha 1B (salivary)
chr14_+_100485712 3.06 ENST00000544450.2
Enah/Vasp-like
chr1_-_193155729 2.98 ENST00000367434.4
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr2_-_183387430 2.95 ENST00000410103.1
phosphodiesterase 1A, calmodulin-dependent
chr14_+_70918874 2.94 ENST00000603540.1
ADAM metallopeptidase domain 21
chr6_+_29429217 2.93 ENST00000396792.2
olfactory receptor, family 2, subfamily H, member 1
chr15_-_74658519 2.90 ENST00000450547.1
ENST00000358632.4
cytochrome P450, family 11, subfamily A, polypeptide 1
chr10_-_49813090 2.90 ENST00000249601.4
Rho GTPase activating protein 22
chr4_+_186990298 2.84 ENST00000296795.3
ENST00000513189.1
toll-like receptor 3
chr4_-_102268628 2.84 ENST00000323055.6
ENST00000512215.1
ENST00000394854.3
protein phosphatase 3, catalytic subunit, alpha isozyme
chr16_+_31128978 2.82 ENST00000448516.2
ENST00000219797.4
K(lysine) acetyltransferase 8
chr15_-_74658493 2.82 ENST00000419019.2
ENST00000569662.1
cytochrome P450, family 11, subfamily A, polypeptide 1
chrX_-_55020511 2.82 ENST00000375006.3
ENST00000374992.2
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr7_+_134528635 2.80 ENST00000445569.2
caldesmon 1
chr9_+_21967137 2.77 ENST00000441769.2
chromosome 9 open reading frame 53
chr1_-_104239076 2.73 ENST00000370080.3
amylase, alpha 1B (salivary)
chr5_+_74807886 2.68 ENST00000514296.1
polymerase (DNA directed) kappa
chr1_-_62190793 2.64 ENST00000371177.2
ENST00000606498.1
TM2 domain containing 1
chrX_-_112084043 2.61 ENST00000304758.1
angiomotin
chr6_-_49712147 2.61 ENST00000433368.2
ENST00000354620.4
cysteine-rich secretory protein 3
chr16_-_279405 2.60 ENST00000430864.1
ENST00000293872.8
ENST00000337351.4
ENST00000397783.1
LUC7-like (S. cerevisiae)
chr2_-_183387064 2.56 ENST00000536095.1
ENST00000331935.6
ENST00000358139.2
ENST00000456212.1
phosphodiesterase 1A, calmodulin-dependent
chr13_+_109248500 2.55 ENST00000356711.2
myosin XVI
chr9_-_14180778 2.51 ENST00000380924.1
ENST00000543693.1
nuclear factor I/B
chr17_-_61996160 2.50 ENST00000458650.2
ENST00000351388.4
ENST00000323322.5
growth hormone 1
chr3_+_148508845 2.47 ENST00000491148.1
carboxypeptidase B1 (tissue)
chr1_-_48866517 2.46 ENST00000371841.1
spermatogenesis associated 6
chr6_+_44355257 2.41 ENST00000371477.3
cell division cycle 5-like
chrX_+_54834004 2.41 ENST00000375068.1
melanoma antigen family D, 2
chr19_-_18508396 2.40 ENST00000595840.1
ENST00000339007.3
leucine rich repeat containing 25
chr12_-_42631529 2.40 ENST00000548917.1
YY1 associated factor 2
chr4_+_175839551 2.36 ENST00000404450.4
ENST00000514159.1
ADAM metallopeptidase domain 29
chr1_+_104293028 2.35 ENST00000370079.3
amylase, alpha 1C (salivary)
chr1_-_67142710 2.27 ENST00000502413.2
Uncharacterized protein
chr12_-_71148357 2.26 ENST00000378778.1
protein tyrosine phosphatase, receptor type, R
chr17_-_61996192 2.23 ENST00000392824.4
chorionic somatomammotropin hormone-like 1
chr5_+_140474181 2.16 ENST00000194155.4
protocadherin beta 2
chr5_+_36152179 2.15 ENST00000508514.1
ENST00000513151.1
ENST00000546211.1
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr14_-_80697396 2.11 ENST00000557010.1
deiodinase, iodothyronine, type II
chr2_+_210444142 2.11 ENST00000360351.4
ENST00000361559.4
microtubule-associated protein 2
chr11_+_55029628 2.11 ENST00000417545.2
tripartite motif containing 48
chr2_-_228244013 2.10 ENST00000304568.3
transmembrane 4 L six family member 20
chr5_-_160973649 2.09 ENST00000393959.1
ENST00000517547.1
gamma-aminobutyric acid (GABA) A receptor, beta 2
chr4_-_70826725 2.01 ENST00000353151.3
casein beta
chr1_-_152332480 2.00 ENST00000388718.5
filaggrin family member 2
chr7_-_140482926 2.00 ENST00000496384.2
v-raf murine sarcoma viral oncogene homolog B
chr15_+_63569785 1.97 ENST00000380343.4
ENST00000560353.1
APH1B gamma secretase subunit
chr11_+_28129795 1.92 ENST00000406787.3
ENST00000342303.5
ENST00000403099.1
ENST00000407364.3
methyltransferase like 15
chr6_+_131894284 1.91 ENST00000368087.3
ENST00000356962.2
arginase 1
chr22_-_41032668 1.87 ENST00000355630.3
ENST00000396617.3
ENST00000402042.1
megakaryoblastic leukemia (translocation) 1
chr11_-_62369291 1.83 ENST00000278823.2
metastasis associated 1 family, member 2
chr12_-_56753858 1.82 ENST00000314128.4
ENST00000557235.1
ENST00000418572.2
signal transducer and activator of transcription 2, 113kDa
chr7_+_106505912 1.82 ENST00000359195.3
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
chr1_-_89664595 1.82 ENST00000355754.6
guanylate binding protein 4
chr14_+_22337014 1.78 ENST00000390436.2
T cell receptor alpha variable 13-1
chr6_+_158733692 1.77 ENST00000367094.2
ENST00000367097.3
tubby like protein 4
chr3_-_52931557 1.77 ENST00000504329.1
ENST00000355083.5
TMEM110-MUSTN1 readthrough
transmembrane protein 110
chr9_+_34458771 1.77 ENST00000437363.1
ENST00000242317.4
dynein, axonemal, intermediate chain 1
chrX_-_32173579 1.75 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
dystrophin
chr10_+_114710425 1.75 ENST00000352065.5
ENST00000369395.1
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr8_-_17942432 1.74 ENST00000381733.4
ENST00000314146.10
N-acylsphingosine amidohydrolase (acid ceramidase) 1
chr17_-_39093672 1.73 ENST00000209718.3
ENST00000436344.3
ENST00000485751.1
keratin 23 (histone deacetylase inducible)
chr6_-_11779014 1.73 ENST00000229583.5
androgen-dependent TFPI-regulating protein
chr1_-_179112189 1.72 ENST00000512653.1
ENST00000344730.3
c-abl oncogene 2, non-receptor tyrosine kinase
chr12_-_10324716 1.69 ENST00000545927.1
ENST00000432556.2
ENST00000309539.3
ENST00000544577.1
oxidized low density lipoprotein (lectin-like) receptor 1
chr12_-_71148413 1.69 ENST00000440835.2
ENST00000549308.1
ENST00000550661.1
protein tyrosine phosphatase, receptor type, R
chr17_-_61951090 1.68 ENST00000345366.7
ENST00000392886.2
ENST00000336844.5
ENST00000560142.1
chorionic somatomammotropin hormone 2
chr2_-_113993020 1.66 ENST00000465084.1
paired box 8
chr15_+_71228826 1.65 ENST00000558456.1
ENST00000560158.2
ENST00000558808.1
ENST00000559806.1
ENST00000559069.1
leucine rich repeat containing 49
chr6_-_49712123 1.64 ENST00000263045.4
cysteine-rich secretory protein 3
chr8_-_93029865 1.63 ENST00000422361.2
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr3_+_189507523 1.58 ENST00000437221.1
ENST00000392463.2
ENST00000392461.3
ENST00000449992.1
ENST00000456148.1
tumor protein p63
chr17_-_3301704 1.53 ENST00000322608.2
olfactory receptor, family 1, subfamily E, member 1
chr7_-_36406750 1.49 ENST00000453212.1
ENST00000415803.2
ENST00000440378.1
ENST00000431396.1
ENST00000317020.6
ENST00000436884.1
KIAA0895
chr1_+_160336851 1.48 ENST00000302101.5
nescient helix loop helix 1
chr17_+_17206635 1.47 ENST00000389022.4
5',3'-nucleotidase, mitochondrial
chr8_-_38008783 1.45 ENST00000276449.4
steroidogenic acute regulatory protein
chr8_-_41166953 1.43 ENST00000220772.3
secreted frizzled-related protein 1
chr12_-_91505608 1.42 ENST00000266718.4
lumican
chr5_-_133702761 1.38 ENST00000521118.1
ENST00000265334.4
ENST00000435211.1
cyclin-dependent kinase-like 3
chr5_-_111312622 1.37 ENST00000395634.3
neuronal regeneration related protein
chr1_+_104159999 1.37 ENST00000414303.2
ENST00000423678.1
amylase, alpha 2A (pancreatic)
chrX_+_23352133 1.36 ENST00000379361.4
patched domain containing 1
chr4_+_175839506 1.34 ENST00000505141.1
ENST00000359240.3
ENST00000445694.1
ADAM metallopeptidase domain 29
chr12_-_102874416 1.29 ENST00000392904.1
ENST00000337514.6
insulin-like growth factor 1 (somatomedin C)
chrX_+_96138907 1.28 ENST00000373040.3
replication protein A4, 30kDa
chr19_-_8373173 1.27 ENST00000537716.2
ENST00000301458.5
CD320 molecule
chr22_-_39268308 1.25 ENST00000407418.3
chromobox homolog 6
chr5_+_175288631 1.24 ENST00000509837.1
complexin 2
chr11_+_124824000 1.21 ENST00000529051.1
ENST00000344762.5
coiled-coil domain containing 15
chr12_-_7848364 1.21 ENST00000329913.3
growth differentiation factor 3
chr1_-_100231349 1.21 ENST00000287474.5
ENST00000414213.1
ferric-chelate reductase 1
chr3_+_121902511 1.20 ENST00000490131.1
calcium-sensing receptor
chr15_+_59279851 1.17 ENST00000348370.4
ENST00000434298.1
ENST00000559160.1
ring finger protein 111
chr2_+_201170596 1.16 ENST00000439084.1
ENST00000409718.1
spermatogenesis associated, serine-rich 2-like

Network of associatons between targets according to the STRING database.

First level regulatory network of POU3F3_POU3F4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.7 20.0 GO:0006533 aspartate catabolic process(GO:0006533)
6.0 66.0 GO:0006600 creatine metabolic process(GO:0006600)
3.4 165.1 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
2.8 25.3 GO:0003190 atrioventricular valve formation(GO:0003190)
2.6 18.5 GO:0006537 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
2.3 28.1 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
2.3 9.3 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
2.2 24.6 GO:0006554 lysine catabolic process(GO:0006554)
2.2 6.7 GO:0048294 negative regulation of isotype switching to IgE isotypes(GO:0048294)
2.2 15.5 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
2.1 6.3 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
2.0 4.1 GO:0003241 growth involved in heart morphogenesis(GO:0003241)
2.0 16.0 GO:0007258 JUN phosphorylation(GO:0007258)
1.9 21.4 GO:0042908 xenobiotic transport(GO:0042908)
1.8 5.4 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
1.6 4.8 GO:0043400 cortisol secretion(GO:0043400) positive regulation of corticotropin secretion(GO:0051461) regulation of cortisol secretion(GO:0051462) negative regulation of glucagon secretion(GO:0070093) positive regulation of corticosterone secretion(GO:2000854)
1.4 4.3 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
1.4 7.2 GO:0042078 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
1.4 10.0 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
1.4 17.1 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
1.4 4.2 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
1.3 11.8 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
1.3 5.2 GO:0043126 regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043126) positive regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043128)
1.3 12.5 GO:0072221 distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221)
1.2 14.5 GO:0002091 negative regulation of receptor internalization(GO:0002091)
1.2 9.2 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
1.1 3.4 GO:1901350 cell-cell signaling involved in cell-cell junction organization(GO:1901350)
1.0 3.1 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
1.0 2.9 GO:1990637 response to prolactin(GO:1990637)
0.9 7.3 GO:0010536 positive regulation of activation of Janus kinase activity(GO:0010536)
0.9 13.4 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.8 56.3 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.8 5.6 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.8 3.9 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.8 8.4 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.8 4.6 GO:0090131 mesenchyme migration(GO:0090131)
0.8 6.0 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.7 50.0 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.7 2.8 GO:0034344 microglial cell activation involved in immune response(GO:0002282) type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.7 2.0 GO:1903487 regulation of lactation(GO:1903487)
0.6 1.2 GO:0048859 formation of anatomical boundary(GO:0048859)
0.6 1.8 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.6 12.9 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.5 1.0 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.5 5.8 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.5 1.4 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894)
0.5 76.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.5 1.4 GO:0090244 Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.5 2.8 GO:0033133 fructose 2,6-bisphosphate metabolic process(GO:0006003) positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.5 2.3 GO:0033299 secretion of lysosomal enzymes(GO:0033299)
0.5 20.3 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.4 7.5 GO:0046069 cGMP catabolic process(GO:0046069)
0.4 6.1 GO:0060856 establishment of blood-brain barrier(GO:0060856)
0.4 3.9 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.4 7.2 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.4 5.1 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.4 4.2 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500) protein localization to photoreceptor outer segment(GO:1903546)
0.4 13.4 GO:0008045 motor neuron axon guidance(GO:0008045)
0.4 2.0 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.4 9.7 GO:0030539 male genitalia development(GO:0030539)
0.4 1.9 GO:1902023 L-arginine import(GO:0043091) arginine import(GO:0090467) L-arginine transport(GO:1902023)
0.4 2.5 GO:2000795 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.3 9.0 GO:0045332 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.3 2.4 GO:0070294 renal sodium ion absorption(GO:0070294)
0.3 11.4 GO:1901687 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.3 3.0 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.3 1.8 GO:0010897 negative regulation of triglyceride catabolic process(GO:0010897) secretory granule localization(GO:0032252)
0.3 12.8 GO:0033344 cholesterol efflux(GO:0033344)
0.3 10.2 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.3 1.9 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.3 4.3 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.2 1.9 GO:0070475 rRNA base methylation(GO:0070475)
0.2 3.3 GO:0045475 locomotor rhythm(GO:0045475)
0.2 1.8 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.2 0.4 GO:2001180 negative regulation of interleukin-10 secretion(GO:2001180)
0.2 5.7 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
0.2 1.4 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.2 2.6 GO:0042074 cell migration involved in gastrulation(GO:0042074)
0.2 1.4 GO:0044245 polysaccharide digestion(GO:0044245)
0.2 2.1 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.2 0.6 GO:0061743 motor learning(GO:0061743)
0.2 2.8 GO:0043982 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.2 0.5 GO:2000768 positive regulation of epithelial cell differentiation involved in kidney development(GO:2000698) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
0.2 3.3 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.2 0.7 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.2 0.9 GO:0032096 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
0.2 4.3 GO:0006825 copper ion transport(GO:0006825)
0.1 0.9 GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.1 1.8 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 1.5 GO:0046078 dUMP metabolic process(GO:0046078)
0.1 1.2 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 0.7 GO:0051006 positive regulation of lipoprotein lipase activity(GO:0051006)
0.1 1.3 GO:0015889 cobalamin transport(GO:0015889)
0.1 24.7 GO:0034605 cellular response to heat(GO:0034605)
0.1 1.1 GO:0048505 positive regulation of activin receptor signaling pathway(GO:0032927) regulation of development, heterochronic(GO:0040034) regulation of timing of cell differentiation(GO:0048505)
0.1 1.4 GO:0021794 thalamus development(GO:0021794)
0.1 2.5 GO:0044458 motile cilium assembly(GO:0044458)
0.1 56.9 GO:0001558 regulation of cell growth(GO:0001558)
0.1 1.2 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.1 2.2 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.1 0.5 GO:1902774 late endosome to lysosome transport(GO:1902774)
0.1 1.1 GO:0010265 SCF complex assembly(GO:0010265)
0.1 2.7 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.1 2.1 GO:0071420 cellular response to histamine(GO:0071420)
0.1 8.5 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.1 2.6 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 0.8 GO:0070995 NADPH oxidation(GO:0070995)
0.1 0.6 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 1.8 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.1 1.7 GO:0061436 regulation of water loss via skin(GO:0033561) establishment of skin barrier(GO:0061436)
0.1 23.3 GO:0045666 positive regulation of neuron differentiation(GO:0045666)
0.1 4.1 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.1 0.8 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 1.2 GO:0005513 detection of calcium ion(GO:0005513)
0.1 2.9 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.1 2.1 GO:0050770 regulation of axonogenesis(GO:0050770)
0.1 1.0 GO:0007220 Notch receptor processing(GO:0007220)
0.1 0.5 GO:2001300 lipoxin metabolic process(GO:2001300)
0.1 3.1 GO:0010633 negative regulation of epithelial cell migration(GO:0010633)
0.1 0.9 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.1 0.2 GO:0060423 foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492) positive regulation of branching involved in lung morphogenesis(GO:0061047)
0.1 1.8 GO:0010762 regulation of fibroblast migration(GO:0010762)
0.1 1.0 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.1 1.8 GO:0061512 protein localization to cilium(GO:0061512)
0.1 2.6 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 1.1 GO:0032026 response to magnesium ion(GO:0032026)
0.0 0.3 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.0 3.6 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.0 0.7 GO:0097242 beta-amyloid clearance(GO:0097242)
0.0 6.5 GO:0016051 carbohydrate biosynthetic process(GO:0016051)
0.0 0.4 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.0 1.3 GO:0033260 DNA replication initiation(GO:0006270) nuclear DNA replication(GO:0033260)
0.0 3.8 GO:0007586 digestion(GO:0007586)
0.0 1.0 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 1.4 GO:0021549 cerebellum development(GO:0021549)
0.0 0.4 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.1 GO:0001865 NK T cell differentiation(GO:0001865)
0.0 0.2 GO:0046602 regulation of mitotic centrosome separation(GO:0046602) negative regulation of centrosome cycle(GO:0046606)
0.0 0.1 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.2 GO:0034142 toll-like receptor 4 signaling pathway(GO:0034142)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
32.3 161.3 GO:0098843 postsynaptic endocytic zone(GO:0098843)
2.6 23.4 GO:0005955 calcineurin complex(GO:0005955)
2.4 7.3 GO:0070195 growth hormone receptor complex(GO:0070195)
2.0 28.1 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
1.2 25.3 GO:0044295 axonal growth cone(GO:0044295)
1.1 4.6 GO:0030485 smooth muscle contractile fiber(GO:0030485)
1.1 7.8 GO:0061617 MICOS complex(GO:0061617)
0.9 9.2 GO:0045180 basal cortex(GO:0045180)
0.8 12.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.7 67.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.7 12.8 GO:0031083 BLOC-1 complex(GO:0031083)
0.7 13.6 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.6 7.5 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.6 2.5 GO:0097224 sperm connecting piece(GO:0097224)
0.6 1.8 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.6 4.8 GO:0043196 varicosity(GO:0043196)
0.6 4.1 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.5 13.2 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.4 5.6 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.4 23.4 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.4 3.7 GO:0097449 astrocyte projection(GO:0097449) growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.4 12.9 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.4 2.8 GO:0072487 MSL complex(GO:0072487)
0.4 2.1 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.3 52.3 GO:0043204 perikaryon(GO:0043204)
0.3 41.4 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.2 3.7 GO:0005662 DNA replication factor A complex(GO:0005662)
0.2 20.6 GO:0043195 terminal bouton(GO:0043195)
0.2 1.8 GO:0036157 outer dynein arm(GO:0036157)
0.2 2.5 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.2 0.8 GO:1990031 pinceau fiber(GO:1990031)
0.2 1.8 GO:0016013 syntrophin complex(GO:0016013)
0.2 2.8 GO:0030478 actin cap(GO:0030478)
0.2 10.3 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 2.8 GO:0036020 endolysosome membrane(GO:0036020)
0.1 5.4 GO:0043034 costamere(GO:0043034)
0.1 1.1 GO:0031467 Cul7-RING ubiquitin ligase complex(GO:0031467)
0.1 3.4 GO:0005921 gap junction(GO:0005921)
0.1 2.6 GO:0071004 U2-type prespliceosome(GO:0071004)
0.1 0.5 GO:0071439 CORVET complex(GO:0033263) clathrin complex(GO:0071439)
0.1 43.0 GO:0016607 nuclear speck(GO:0016607)
0.1 1.0 GO:0070765 gamma-secretase complex(GO:0070765)
0.1 7.7 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 2.1 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 29.8 GO:0043025 neuronal cell body(GO:0043025)
0.1 13.9 GO:0032993 protein-DNA complex(GO:0032993)
0.1 1.8 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 0.6 GO:0043194 axon initial segment(GO:0043194)
0.1 0.7 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.1 1.7 GO:0005882 intermediate filament(GO:0005882)
0.0 1.6 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.5 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 2.0 GO:0044297 cell body(GO:0044297)
0.0 8.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 4.2 GO:0030424 axon(GO:0030424)
0.0 3.9 GO:0043197 dendritic spine(GO:0043197)
0.0 3.7 GO:0016591 DNA-directed RNA polymerase II, holoenzyme(GO:0016591)
0.0 0.9 GO:0012505 endomembrane system(GO:0012505)
0.0 1.6 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.7 GO:0042627 chylomicron(GO:0042627)
0.0 1.6 GO:0016363 nuclear matrix(GO:0016363)
0.0 2.8 GO:0061695 transferase complex, transferring phosphorus-containing groups(GO:0061695)
0.0 0.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.1 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.0 GO:0031904 endosome lumen(GO:0031904)
0.0 6.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 6.7 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 1.1 GO:0005604 basement membrane(GO:0005604)
0.0 9.2 GO:0000139 Golgi membrane(GO:0000139)
0.0 2.3 GO:0030027 lamellipodium(GO:0030027)
0.0 2.7 GO:0043005 neuron projection(GO:0043005)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
13.4 161.3 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
10.4 62.1 GO:0004522 ribonuclease A activity(GO:0004522)
6.7 40.4 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
6.2 24.6 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
3.4 13.4 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
2.9 20.0 GO:0004046 aminoacylase activity(GO:0004046)
2.7 21.4 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
2.7 16.0 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
2.6 18.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
2.6 66.0 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
2.4 7.3 GO:0005148 prolactin receptor binding(GO:0005148)
2.3 23.4 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
2.3 9.1 GO:0016160 amylase activity(GO:0016160)
2.0 26.3 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
1.9 5.7 GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386)
1.8 10.9 GO:0005499 vitamin D binding(GO:0005499)
1.4 4.3 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
1.1 7.5 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
1.0 3.0 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.9 15.5 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.8 3.9 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.8 2.3 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.8 10.0 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.6 1.9 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.6 1.3 GO:0015235 cobalamin transporter activity(GO:0015235)
0.6 2.4 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.6 8.2 GO:0004065 arylsulfatase activity(GO:0004065)
0.6 10.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.6 2.8 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.6 5.6 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.5 13.1 GO:0002162 dystroglycan binding(GO:0002162)
0.5 12.9 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.5 4.3 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.5 3.3 GO:0050682 AF-2 domain binding(GO:0050682)
0.4 4.8 GO:0051430 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.4 2.6 GO:0043532 angiostatin binding(GO:0043532)
0.4 5.2 GO:1990459 transferrin receptor binding(GO:1990459)
0.4 1.7 GO:0017040 ceramidase activity(GO:0017040)
0.4 6.0 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.4 3.3 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.4 28.1 GO:0050840 extracellular matrix binding(GO:0050840)
0.4 1.2 GO:0032184 SUMO polymer binding(GO:0032184)
0.4 9.0 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.4 3.7 GO:0051425 PTB domain binding(GO:0051425)
0.4 2.6 GO:0050733 RS domain binding(GO:0050733)
0.4 5.4 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.4 2.1 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.3 4.1 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036) sphingolipid binding(GO:0046625)
0.3 15.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.3 39.0 GO:0008013 beta-catenin binding(GO:0008013)
0.3 4.2 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.3 3.9 GO:0097100 supercoiled DNA binding(GO:0097100)
0.3 2.1 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.3 12.8 GO:0005484 SNAP receptor activity(GO:0005484)
0.2 1.7 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.2 2.8 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.2 11.4 GO:0004364 glutathione transferase activity(GO:0004364)
0.2 14.4 GO:0008146 sulfotransferase activity(GO:0008146)
0.2 1.1 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.2 2.5 GO:0032027 myosin light chain binding(GO:0032027)
0.2 1.2 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.2 6.1 GO:0017091 AU-rich element binding(GO:0017091)
0.2 3.9 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.2 0.9 GO:0008430 selenium binding(GO:0008430)
0.1 0.7 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.1 6.4 GO:0050699 WW domain binding(GO:0050699)
0.1 0.7 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.1 1.9 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 0.5 GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404)
0.1 1.5 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 12.9 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 30.1 GO:0005516 calmodulin binding(GO:0005516)
0.1 1.9 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 0.8 GO:0070492 oligosaccharide binding(GO:0070492)
0.1 2.7 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 1.8 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 1.4 GO:0017127 cholesterol transporter activity(GO:0017127)
0.1 0.6 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 1.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 2.5 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 52.1 GO:0005509 calcium ion binding(GO:0005509)
0.1 1.2 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 0.9 GO:0005522 profilin binding(GO:0005522)
0.1 2.6 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 1.0 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 1.1 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 1.8 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 3.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.2 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0 1.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 5.9 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 1.4 GO:0005518 collagen binding(GO:0005518)
0.0 1.4 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.4 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 1.2 GO:0030145 manganese ion binding(GO:0030145)
0.0 1.2 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.6 GO:0005504 fatty acid binding(GO:0005504)
0.0 1.1 GO:0050681 androgen receptor binding(GO:0050681)
0.0 0.2 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.9 GO:0003774 motor activity(GO:0003774)
0.0 0.4 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 1.3 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 1.3 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.5 GO:0042805 actinin binding(GO:0042805)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 161.3 PID NCADHERIN PATHWAY N-cadherin signaling events
0.9 49.5 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.5 25.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.4 17.7 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.2 16.5 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.2 24.4 PID AR PATHWAY Coregulation of Androgen receptor activity
0.2 12.9 PID ATR PATHWAY ATR signaling pathway
0.2 17.7 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.2 4.1 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 1.8 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 2.0 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 1.2 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.1 4.0 PID NOTCH PATHWAY Notch signaling pathway
0.1 3.4 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 5.1 PID ENDOTHELIN PATHWAY Endothelins
0.1 5.2 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.1 1.8 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.1 2.8 PID P53 REGULATION PATHWAY p53 pathway
0.1 1.4 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 1.1 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.5 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 1.1 PID CONE PATHWAY Visual signal transduction: Cones
0.0 1.9 PID RHOA PATHWAY RhoA signaling pathway
0.0 2.5 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 2.1 PID LKB1 PATHWAY LKB1 signaling events
0.0 3.0 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 1.9 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 1.2 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 3.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
6.7 161.3 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
1.6 17.3 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
1.0 28.1 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.8 8.2 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.8 16.0 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.7 8.2 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.6 21.4 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.5 26.3 REACTOME MYOGENESIS Genes involved in Myogenesis
0.5 2.0 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.5 20.2 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.5 12.8 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.4 3.9 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.4 7.3 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.4 20.4 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.3 11.4 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.3 18.5 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.3 6.1 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.3 7.5 REACTOME DAG AND IP3 SIGNALING Genes involved in DAG and IP3 signaling
0.2 2.8 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.2 2.6 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.2 3.4 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.2 8.7 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.2 3.7 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.2 51.4 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.2 4.3 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.2 5.8 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 4.3 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.2 2.0 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 5.0 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 7.2 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 15.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 5.7 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 7.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.8 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 11.8 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.1 2.5 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 1.5 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 6.0 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.1 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.1 1.1 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.1 4.1 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 4.4 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 2.1 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 1.4 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.1 1.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 1.8 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.1 1.7 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 1.0 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.1 1.8 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.1 5.2 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 5.1 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.5 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 1.4 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 1.8 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.0 2.8 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism
0.0 5.6 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 1.3 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 0.4 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix