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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for POU4F1_POU4F3

Z-value: 0.84

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Transcription factors associated with POU4F1_POU4F3

Gene Symbol Gene ID Gene Info
ENSG00000152192.6 POU class 4 homeobox 1
ENSG00000091010.4 POU class 4 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU4F1hg19_v2_chr13_-_79177673_791777010.305.7e-06Click!
POU4F3hg19_v2_chr5_+_145718587_1457186070.101.5e-01Click!

Activity profile of POU4F1_POU4F3 motif

Sorted Z-values of POU4F1_POU4F3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_130554803 25.48 ENST00000535487.1
RP11-474D1.2
chr12_-_91574142 23.94 ENST00000547937.1
decorin
chr2_-_88285309 15.12 ENST00000420840.2
RANBP2-like and GRIP domain containing 2
chr19_-_18632861 14.89 ENST00000262809.4
elongation factor RNA polymerase II
chr7_-_100026280 13.15 ENST00000360951.4
ENST00000398027.2
ENST00000324725.6
ENST00000472716.1
zinc finger, CW type with PWWP domain 1
chr2_+_87135076 13.07 ENST00000409776.2
RANBP2-like and GRIP domain containing 1
chr22_+_41777927 10.33 ENST00000266304.4
thyrotrophic embryonic factor
chr15_+_74422585 10.07 ENST00000561740.1
ENST00000435464.1
ENST00000453268.2
immunoglobulin superfamily containing leucine-rich repeat 2
chr12_-_6798616 9.16 ENST00000355772.4
ENST00000417772.3
ENST00000396801.3
ENST00000396799.2
zinc finger protein 384
chr12_-_42631529 8.85 ENST00000548917.1
YY1 associated factor 2
chr12_-_6798410 8.05 ENST00000361959.3
ENST00000436774.2
ENST00000544482.1
zinc finger protein 384
chr12_-_6798523 8.04 ENST00000319770.3
zinc finger protein 384
chr18_-_52989217 8.04 ENST00000570287.2
transcription factor 4
chr14_+_22977587 7.50 ENST00000390504.1
T cell receptor alpha joining 33
chr14_+_101297740 6.87 ENST00000555928.1
maternally expressed 3 (non-protein coding)
chr5_+_129083772 6.27 ENST00000564719.1
KIAA1024-like
chr12_-_91546926 5.83 ENST00000550758.1
decorin
chr14_-_21270995 5.73 ENST00000555698.1
ENST00000397970.4
ENST00000340900.3
ribonuclease, RNase A family, 1 (pancreatic)
chr16_+_15596123 5.00 ENST00000452191.2
chromosome 16 open reading frame 45
chr9_+_34458771 4.93 ENST00000437363.1
ENST00000242317.4
dynein, axonemal, intermediate chain 1
chr14_-_21270561 4.71 ENST00000412779.2
ribonuclease, RNase A family, 1 (pancreatic)
chrX_-_138724994 4.30 ENST00000536274.1
MCF.2 cell line derived transforming sequence
chr6_-_52859046 4.09 ENST00000457564.1
ENST00000541324.1
ENST00000370960.1
glutathione S-transferase alpha 4
chr4_-_16085314 3.95 ENST00000510224.1
prominin 1
chr17_-_40540484 3.77 ENST00000588969.1
signal transducer and activator of transcription 3 (acute-phase response factor)
chr7_-_100425112 3.75 ENST00000358173.3
EPH receptor B4
chr4_+_102711764 3.72 ENST00000322953.4
ENST00000428908.1
B-cell scaffold protein with ankyrin repeats 1
chr2_+_87144738 3.68 ENST00000559485.1
RANBP2-like and GRIP domain containing 1
chr4_+_106631966 3.60 ENST00000360505.5
ENST00000510865.1
ENST00000509336.1
glutathione S-transferase, C-terminal domain containing
chr5_-_134871639 3.39 ENST00000314744.4
neurogenin 1
chr4_+_89513574 3.38 ENST00000402738.1
ENST00000431413.1
ENST00000422770.1
ENST00000407637.1
HECT and RLD domain containing E3 ubiquitin protein ligase 3
chr1_+_160336851 3.31 ENST00000302101.5
nescient helix loop helix 1
chr10_+_104613980 3.28 ENST00000339834.5
chromosome 10 open reading frame 32
chr4_-_25032501 3.26 ENST00000382114.4
leucine-rich repeat LGI family, member 2
chr2_-_183387283 3.25 ENST00000435564.1
phosphodiesterase 1A, calmodulin-dependent
chr4_+_74269956 3.08 ENST00000295897.4
ENST00000415165.2
ENST00000503124.1
ENST00000509063.1
ENST00000401494.3
albumin
chr3_-_194072019 3.07 ENST00000429275.1
ENST00000323830.3
carboxypeptidase N, polypeptide 2
chr6_+_126102292 3.06 ENST00000368357.3
nuclear receptor coactivator 7
chr14_-_101036119 2.95 ENST00000355173.2
brain-enriched guanylate kinase-associated
chr2_-_183387064 2.84 ENST00000536095.1
ENST00000331935.6
ENST00000358139.2
ENST00000456212.1
phosphodiesterase 1A, calmodulin-dependent
chr4_-_16085340 2.82 ENST00000508167.1
prominin 1
chr6_-_136847099 2.82 ENST00000438100.2
microtubule-associated protein 7
chr22_+_40322623 2.78 ENST00000399090.2
GRB2-related adaptor protein 2
chr3_+_35722487 2.72 ENST00000441454.1
cAMP-regulated phosphoprotein, 21kDa
chr2_-_183387430 2.70 ENST00000410103.1
phosphodiesterase 1A, calmodulin-dependent
chr1_-_95538492 2.69 ENST00000370205.5
ALG14, UDP-N-acetylglucosaminyltransferase subunit
chr17_-_29641084 2.66 ENST00000544462.1
ecotropic viral integration site 2B
chr22_+_40322595 2.66 ENST00000420971.1
ENST00000544756.1
GRB2-related adaptor protein 2
chr22_-_43010928 2.62 ENST00000348657.2
ENST00000252115.5
polymerase (DNA-directed), delta interacting protein 3
chrX_+_41583408 2.61 ENST00000302548.4
G protein-coupled receptor 82
chr5_-_41261540 2.60 ENST00000263413.3
complement component 6
chr1_-_33430286 2.57 ENST00000373456.7
ENST00000356990.5
ENST00000235150.4
ring finger protein 19B
chr7_-_140482926 2.56 ENST00000496384.2
v-raf murine sarcoma viral oncogene homolog B
chr14_-_65409438 2.56 ENST00000557049.1
glutathione peroxidase 2 (gastrointestinal)
chr19_+_54466179 2.54 ENST00000270458.2
calcium channel, voltage-dependent, gamma subunit 8
chr18_+_29027696 2.52 ENST00000257189.4
desmoglein 3
chr3_-_149470229 2.42 ENST00000473414.1
COMM domain containing 2
chr6_-_44281043 2.41 ENST00000244571.4
alanyl-tRNA synthetase 2, mitochondrial
chr2_-_26781521 2.39 ENST00000403946.3
ENST00000272371.2
otoferlin
chr3_-_18480260 2.36 ENST00000454909.2
SATB homeobox 1
chr1_+_50574585 2.32 ENST00000371824.1
ENST00000371823.4
ELAV like neuron-specific RNA binding protein 4
chr1_-_160549235 2.32 ENST00000368054.3
ENST00000368048.3
ENST00000311224.4
ENST00000368051.3
ENST00000534968.1
CD84 molecule
chrX_-_138724677 2.32 ENST00000370573.4
ENST00000338585.6
ENST00000370576.4
MCF.2 cell line derived transforming sequence
chr9_-_123812542 2.31 ENST00000223642.1
complement component 5
chr1_+_198608146 2.28 ENST00000367376.2
ENST00000352140.3
ENST00000594404.1
ENST00000598951.1
ENST00000530727.1
ENST00000442510.2
ENST00000367367.4
ENST00000348564.6
ENST00000367364.1
ENST00000413409.2
protein tyrosine phosphatase, receptor type, C
chr1_+_145292806 2.24 ENST00000448873.2
neuroblastoma breakpoint family, member 10
chr19_-_53696587 2.22 ENST00000396424.3
ENST00000600412.1
zinc finger protein 665
chr13_+_52586517 2.18 ENST00000523764.1
ENST00000521508.1
ALG11, alpha-1,2-mannosyltransferase
chrX_+_135279179 2.16 ENST00000370676.3
four and a half LIM domains 1
chr16_+_33204980 2.10 ENST00000561509.1
TP53 target 3C
chr15_-_65426174 2.10 ENST00000204549.4
programmed cell death 7
chr1_+_66458072 2.01 ENST00000423207.2
phosphodiesterase 4B, cAMP-specific
chr16_+_6533380 1.98 ENST00000552089.1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr1_+_206808868 1.84 ENST00000367109.2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
chr1_+_206808918 1.82 ENST00000367108.3
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
chr17_+_29664830 1.82 ENST00000444181.2
ENST00000417592.2
neurofibromin 1
chr12_-_102224457 1.81 ENST00000549165.1
ENST00000549940.1
ENST00000392919.4
N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
chr12_+_49740700 1.80 ENST00000549441.2
ENST00000395069.3
DnaJ (Hsp40) homolog, subfamily C, member 22
chr19_-_36304201 1.79 ENST00000301175.3
proline dehydrogenase (oxidase) 2
chr1_-_216978709 1.72 ENST00000360012.3
estrogen-related receptor gamma
chr21_-_37914898 1.71 ENST00000399136.1
claudin 14
chrX_+_135278908 1.71 ENST00000539015.1
ENST00000370683.1
four and a half LIM domains 1
chr15_-_20193370 1.63 ENST00000558565.2
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr3_-_52860850 1.61 ENST00000441637.2
inter-alpha-trypsin inhibitor heavy chain family, member 4
chrX_-_32173579 1.60 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
dystrophin
chr16_+_48278178 1.55 ENST00000285737.4
ENST00000535754.1
lon peptidase 2, peroxisomal
chr7_+_100026406 1.54 ENST00000414441.1
methylphosphate capping enzyme
chr9_-_95298314 1.54 ENST00000344604.5
ENST00000375540.1
extracellular matrix protein 2, female organ and adipocyte specific
chr12_+_110011571 1.48 ENST00000539696.1
ENST00000228510.3
ENST00000392727.3
mevalonate kinase
chr17_+_18012020 1.40 ENST00000205890.5
myosin XVA
chr7_+_134528635 1.40 ENST00000445569.2
caldesmon 1
chr2_+_204732487 1.39 ENST00000302823.3
cytotoxic T-lymphocyte-associated protein 4
chr9_-_215744 1.36 ENST00000382387.2
chromosome 9 open reading frame 66
chrX_-_65253506 1.34 ENST00000427538.1
V-set and immunoglobulin domain containing 4
chr2_-_183106641 1.34 ENST00000346717.4
phosphodiesterase 1A, calmodulin-dependent
chr1_-_156470515 1.28 ENST00000340875.5
ENST00000368240.2
ENST00000353795.3
myocyte enhancer factor 2D
chr3_-_58613323 1.28 ENST00000474531.1
ENST00000465970.1
family with sequence similarity 107, member A
chr2_-_101034070 1.24 ENST00000264249.3
carbohydrate sulfotransferase 10
chr1_+_67773044 1.23 ENST00000262345.1
ENST00000371000.1
interleukin 12 receptor, beta 2
chr10_+_135207598 1.22 ENST00000477902.2
mitochondrial ribosome-associated GTPase 1
chr5_-_135290705 1.22 ENST00000274507.1
leukocyte cell-derived chemotaxin 2
chr7_-_115670792 1.21 ENST00000265440.7
ENST00000393485.1
transcription factor EC
chr17_-_56492989 1.15 ENST00000583753.1
ring finger protein 43
chr5_+_112227311 1.15 ENST00000391338.1
zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 1
chr14_-_107049312 1.14 ENST00000390627.2
immunoglobulin heavy variable 3-53
chr5_-_58295712 1.10 ENST00000317118.8
phosphodiesterase 4D, cAMP-specific
chr6_-_146057144 1.09 ENST00000367519.3
epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
chr2_+_29336855 1.07 ENST00000404424.1
CAP-GLY domain containing linker protein family, member 4
chr4_+_154622652 1.06 ENST00000260010.6
toll-like receptor 2
chr18_+_61575200 1.04 ENST00000238508.3
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr7_-_115670804 1.02 ENST00000320239.7
transcription factor EC
chr12_-_51611477 1.01 ENST00000389243.4
POU class 6 homeobox 1
chrX_-_107975917 1.00 ENST00000563887.1
Uncharacterized protein
chr13_-_46756351 1.00 ENST00000323076.2
lymphocyte cytosolic protein 1 (L-plastin)
chr2_+_29320571 0.98 ENST00000401605.1
ENST00000401617.2
CAP-GLY domain containing linker protein family, member 4
chr7_+_150725510 0.98 ENST00000461373.1
ENST00000358849.4
ENST00000297504.6
ENST00000542328.1
ENST00000498578.1
ENST00000356058.4
ENST00000477719.1
ENST00000477092.1
ATP-binding cassette, sub-family B (MDR/TAP), member 8
chr10_+_135207623 0.97 ENST00000317502.6
ENST00000432508.3
mitochondrial ribosome-associated GTPase 1
chr19_+_16940198 0.93 ENST00000248054.5
ENST00000596802.1
ENST00000379803.1
SIN3 transcription regulator family member B
chr6_-_136847610 0.92 ENST00000454590.1
ENST00000432797.2
microtubule-associated protein 7
chr10_-_112678692 0.90 ENST00000605742.1
BBSome interacting protein 1
chr2_-_70475730 0.87 ENST00000445587.1
ENST00000433529.2
ENST00000415783.2
TIA1 cytotoxic granule-associated RNA binding protein
chr14_+_21249200 0.85 ENST00000304677.2
ribonuclease, RNase A family, k6
chr10_-_6104253 0.84 ENST00000256876.6
ENST00000379954.1
ENST00000379959.3
interleukin 2 receptor, alpha
chr16_+_31366536 0.83 ENST00000562522.1
integrin, alpha X (complement component 3 receptor 4 subunit)
chr12_-_23737534 0.82 ENST00000396007.2
SRY (sex determining region Y)-box 5
chr20_+_30063067 0.80 ENST00000201979.2
RAS (RAD and GEM)-like GTP-binding 1
chr10_-_112678904 0.77 ENST00000423273.1
ENST00000436562.1
ENST00000447005.1
ENST00000454061.1
BBSome interacting protein 1
chr3_+_70048881 0.76 ENST00000483525.1
RP11-460N16.1
chr5_+_140501581 0.75 ENST00000194152.1
protocadherin beta 4
chrX_+_65382381 0.71 ENST00000519389.1
hephaestin
chr10_-_115904361 0.71 ENST00000428953.1
ENST00000543782.1
chromosome 10 open reading frame 118
chr8_-_110986918 0.67 ENST00000297404.1
potassium channel, subfamily V, member 1
chr10_-_11574274 0.66 ENST00000277575.5
USP6 N-terminal like
chr4_-_68749699 0.65 ENST00000545541.1
transmembrane protease, serine 11D
chr6_-_27880174 0.64 ENST00000303324.2
olfactory receptor, family 2, subfamily B, member 2
chr5_-_39270725 0.64 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYN binding protein
chr1_+_73771844 0.64 ENST00000440762.1
ENST00000444827.1
ENST00000415686.1
ENST00000411903.1
RP4-598G3.1
chr16_+_31366455 0.64 ENST00000268296.4
integrin, alpha X (complement component 3 receptor 4 subunit)
chr8_-_125577940 0.64 ENST00000519168.1
ENST00000395508.2
metastasis suppressor 1
chr20_+_57875758 0.59 ENST00000395654.3
endothelin 3
chr6_-_127840453 0.59 ENST00000556132.1
SOGA family member 3
chr1_+_22979474 0.58 ENST00000509305.1
complement component 1, q subcomponent, B chain
chr15_+_58724184 0.57 ENST00000433326.2
lipase, hepatic
chr14_+_31494841 0.55 ENST00000556232.1
ENST00000216366.4
ENST00000334725.4
ENST00000554609.1
ENST00000554345.1
adaptor-related protein complex 4, sigma 1 subunit
chr5_-_59481406 0.53 ENST00000546160.1
phosphodiesterase 4D, cAMP-specific
chr12_+_54366894 0.53 ENST00000546378.1
ENST00000243082.4
homeobox C11
chr14_-_106668095 0.50 ENST00000390606.2
immunoglobulin heavy variable 3-20
chr4_-_122085469 0.49 ENST00000057513.3
TNFAIP3 interacting protein 3
chr11_-_35441597 0.48 ENST00000395753.1
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr5_-_88119580 0.47 ENST00000539796.1
myocyte enhancer factor 2C
chr8_+_70404996 0.47 ENST00000402687.4
ENST00000419716.3
sulfatase 1
chr10_-_22292613 0.46 ENST00000376980.3
DnaJ (Hsp40) homolog, subfamily C, member 1
chr17_-_40540586 0.45 ENST00000264657.5
signal transducer and activator of transcription 3 (acute-phase response factor)
chr10_-_112678976 0.43 ENST00000448814.1
BBSome interacting protein 1
chrX_-_15288154 0.42 ENST00000380483.3
ENST00000380485.3
ENST00000380488.4
ankyrin repeat and SOCS box containing 9
chr15_+_25068773 0.41 ENST00000400100.1
ENST00000400098.1
small nuclear ribonucleoprotein polypeptide N
chr16_+_619931 0.41 ENST00000321878.5
ENST00000439574.1
ENST00000026218.5
ENST00000470411.2
phosphatidylinositol glycan anchor biosynthesis, class Q
chr5_+_140767452 0.40 ENST00000519479.1
protocadherin gamma subfamily B, 4
chr18_-_31803435 0.39 ENST00000589544.1
ENST00000269185.4
ENST00000261592.5
nucleolar protein 4
chr2_+_169757750 0.39 ENST00000375363.3
ENST00000429379.2
ENST00000421979.1
glucose-6-phosphatase, catalytic, 2
chr16_-_11363178 0.35 ENST00000312693.3
transition protein 2 (during histone to protamine replacement)
chr1_+_63063152 0.35 ENST00000371129.3
angiopoietin-like 3
chr6_-_76782371 0.33 ENST00000369950.3
ENST00000369963.3
interphotoreceptor matrix proteoglycan 1
chr14_-_65409502 0.32 ENST00000389614.5
glutathione peroxidase 2 (gastrointestinal)
chr2_+_202047843 0.28 ENST00000272879.5
ENST00000374650.3
ENST00000346817.5
ENST00000313728.7
ENST00000448480.1
caspase 10, apoptosis-related cysteine peptidase
chr11_-_8290263 0.26 ENST00000428101.2
LIM domain only 1 (rhombotin 1)
chr14_+_39703112 0.23 ENST00000555143.1
ENST00000280082.3
melanoma inhibitory activity 2
chr11_+_86085778 0.23 ENST00000354755.1
ENST00000278487.3
ENST00000531271.1
ENST00000445632.2
coiled-coil domain containing 81
chr12_+_51985001 0.21 ENST00000354534.6
sodium channel, voltage gated, type VIII, alpha subunit
chr11_-_35441524 0.20 ENST00000395750.1
ENST00000449068.1
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr3_-_169587621 0.19 ENST00000523069.1
ENST00000316428.5
ENST00000264676.5
leucine rich repeat containing 31
chr14_+_31494672 0.18 ENST00000542754.2
ENST00000313566.6
adaptor-related protein complex 4, sigma 1 subunit
chr5_-_11589131 0.18 ENST00000511377.1
catenin (cadherin-associated protein), delta 2
chr17_+_7155819 0.17 ENST00000570322.1
ENST00000576496.1
ENST00000574841.2
elongator acetyltransferase complex subunit 5
chr7_-_20256965 0.16 ENST00000400331.5
ENST00000332878.4
metastasis associated in colon cancer 1
chr3_-_185826855 0.12 ENST00000306376.5
ets variant 5
chr4_+_68424434 0.10 ENST00000265404.2
ENST00000396225.1
signal transducing adaptor family member 1
chr5_-_77844974 0.10 ENST00000515007.2
lipoma HMGIC fusion partner-like 2
chr12_+_26164645 0.10 ENST00000542004.1
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr9_+_35673853 0.09 ENST00000378357.4
carbonic anhydrase IX
chr20_-_23731893 0.09 ENST00000398402.1
cystatin SN
chr7_-_107880508 0.07 ENST00000425651.2
neuronal cell adhesion molecule
chr5_-_132200477 0.04 ENST00000296875.2
growth differentiation factor 9
chr19_-_23941639 0.02 ENST00000395385.3
ENST00000531570.1
ENST00000528059.1
zinc finger protein 681

Network of associatons between targets according to the STRING database.

First level regulatory network of POU4F1_POU4F3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 14.9 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
2.5 29.8 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
1.7 6.8 GO:2000768 glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
1.2 2.3 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
1.1 3.4 GO:0021650 vestibulocochlear nerve formation(GO:0021650)
1.1 31.9 GO:0000042 protein targeting to Golgi(GO:0000042)
1.0 3.1 GO:0044179 hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
1.0 5.1 GO:1903976 negative regulation of glial cell migration(GO:1903976)
1.0 4.0 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
0.8 2.4 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.7 3.7 GO:0035617 stress granule disassembly(GO:0035617)
0.7 3.4 GO:0032661 regulation of interleukin-18 production(GO:0032661)
0.6 2.6 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
0.6 1.8 GO:0061534 gamma-aminobutyric acid secretion, neurotransmission(GO:0061534)
0.6 10.1 GO:0046069 cGMP catabolic process(GO:0046069)
0.5 2.6 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.5 1.5 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.5 2.3 GO:0002378 immunoglobulin biosynthetic process(GO:0002378) bone marrow development(GO:0048539)
0.4 4.9 GO:0036158 outer dynein arm assembly(GO:0036158)
0.4 3.7 GO:1900165 negative regulation of interleukin-6 secretion(GO:1900165)
0.3 3.7 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.3 1.8 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.3 4.7 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.3 1.2 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.3 4.9 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.3 1.4 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.3 1.1 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.3 0.8 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.3 1.5 GO:0040031 snRNA modification(GO:0040031)
0.2 2.1 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.2 2.2 GO:0070129 regulation of mitochondrial translation(GO:0070129)
0.2 2.4 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.2 10.4 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.1 0.6 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.1 10.1 GO:0045773 positive regulation of axon extension(GO:0045773)
0.1 2.6 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.1 3.0 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.1 0.8 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.1 4.1 GO:1901685 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.1 0.6 GO:0030035 microspike assembly(GO:0030035)
0.1 1.6 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998)
0.1 1.3 GO:0007512 adult heart development(GO:0007512)
0.1 0.7 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1 3.8 GO:0002042 cell migration involved in sprouting angiogenesis(GO:0002042)
0.1 0.9 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.1 1.3 GO:0001558 regulation of cell growth(GO:0001558)
0.1 3.9 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.1 0.7 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.1 1.3 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 1.0 GO:0051639 actin filament network formation(GO:0051639)
0.1 0.4 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.1 1.7 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 0.4 GO:0010519 negative regulation of phospholipase activity(GO:0010519)
0.1 5.4 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 0.5 GO:0060686 negative regulation of prostatic bud formation(GO:0060686)
0.0 2.1 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.5 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.0 4.8 GO:0030449 regulation of complement activation(GO:0030449)
0.0 0.6 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372) phosphatidylcholine catabolic process(GO:0034638)
0.0 6.1 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 3.7 GO:0006970 response to osmotic stress(GO:0006970)
0.0 2.0 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 2.1 GO:0051384 response to glucocorticoid(GO:0051384)
0.0 0.1 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0 1.1 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.4 GO:0009725 response to hormone(GO:0009725)
0.0 0.5 GO:0034142 toll-like receptor 4 signaling pathway(GO:0034142)
0.0 10.4 GO:0048511 rhythmic process(GO:0048511)
0.0 1.6 GO:0006953 acute-phase response(GO:0006953)
0.0 5.9 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 2.4 GO:0016079 synaptic vesicle exocytosis(GO:0016079)
0.0 3.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.2 GO:0032729 positive regulation of interferon-gamma production(GO:0032729)
0.0 0.4 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.8 GO:0019731 antibacterial humoral response(GO:0019731)
0.0 0.1 GO:0034334 adherens junction maintenance(GO:0034334)
0.0 1.4 GO:0042472 inner ear morphogenesis(GO:0042472)
0.0 1.0 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.1 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 1.5 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 0.6 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 1.5 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.3 GO:0097194 execution phase of apoptosis(GO:0097194)
0.0 2.6 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 0.7 GO:0007585 respiratory gaseous exchange(GO:0007585)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 29.8 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.6 4.9 GO:0036157 outer dynein arm(GO:0036157)
0.5 4.9 GO:0005579 membrane attack complex(GO:0005579)
0.5 14.9 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.4 6.8 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.4 1.1 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.3 0.9 GO:0000806 Y chromosome(GO:0000806)
0.3 2.6 GO:0044194 cytolytic granule(GO:0044194)
0.2 2.1 GO:0034464 BBSome(GO:0034464)
0.2 1.1 GO:0089701 U2AF(GO:0089701)
0.2 1.6 GO:0016013 syntrophin complex(GO:0016013)
0.2 2.6 GO:0000346 transcription export complex(GO:0000346)
0.1 1.5 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.9 GO:0097165 nuclear stress granule(GO:0097165)
0.1 0.6 GO:0005602 complement component C1 complex(GO:0005602)
0.1 6.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 1.8 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 1.4 GO:0030478 actin cap(GO:0030478)
0.1 1.6 GO:0031089 platelet dense granule lumen(GO:0031089)
0.1 1.0 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.1 1.0 GO:0001891 phagocytic cup(GO:0001891)
0.1 2.4 GO:0005720 nuclear heterochromatin(GO:0005720)
0.1 2.9 GO:0098636 protein complex involved in cell adhesion(GO:0098636)
0.0 2.5 GO:0001533 cornified envelope(GO:0001533)
0.0 2.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 2.1 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 8.4 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 1.4 GO:0032420 stereocilium(GO:0032420)
0.0 5.9 GO:0072562 blood microparticle(GO:0072562)
0.0 2.2 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.0 0.4 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.4 GO:0005687 U4 snRNP(GO:0005687)
0.0 5.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.6 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 2.4 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.7 GO:0030673 axolemma(GO:0030673)
0.0 0.6 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 3.7 GO:0005875 microtubule associated complex(GO:0005875)
0.0 3.0 GO:0043204 perikaryon(GO:0043204)
0.0 0.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.3 GO:0043194 axon initial segment(GO:0043194)
0.0 1.0 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 3.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.3 GO:0031265 CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
0.0 1.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 5.8 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 1.7 GO:0005923 bicellular tight junction(GO:0005923)
0.0 7.0 GO:0009986 cell surface(GO:0009986)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 10.4 GO:0004522 ribonuclease A activity(GO:0004522)
1.4 10.1 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.8 2.4 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.7 2.2 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.6 8.0 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.5 1.5 GO:0070052 collagen V binding(GO:0070052)
0.4 1.8 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.4 29.8 GO:0050840 extracellular matrix binding(GO:0050840)
0.4 4.0 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.3 3.1 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.2 4.9 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 1.7 GO:0050682 AF-2 domain binding(GO:0050682)
0.2 1.1 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.2 0.8 GO:0004911 interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
0.2 1.6 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.2 3.1 GO:0015643 toxic substance binding(GO:0015643)
0.2 3.8 GO:0005003 ephrin receptor activity(GO:0005003)
0.1 1.8 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.1 0.6 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 3.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 1.1 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.1 0.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 4.1 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 6.8 GO:0042805 actinin binding(GO:0042805)
0.1 3.1 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.4 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1 0.7 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 2.9 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 3.2 GO:0017091 AU-rich element binding(GO:0017091)
0.1 2.6 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.1 2.3 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 2.6 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 1.6 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.1 3.4 GO:0070888 E-box binding(GO:0070888)
0.1 6.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 2.5 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 3.7 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 5.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 0.3 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.1 11.3 GO:0019902 phosphatase binding(GO:0019902)
0.1 2.3 GO:0008009 chemokine activity(GO:0008009)
0.0 1.4 GO:0005523 tropomyosin binding(GO:0005523)
0.0 2.1 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.4 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 14.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.6 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 1.7 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 1.5 GO:0008173 RNA methyltransferase activity(GO:0008173)
0.0 1.2 GO:0005109 frizzled binding(GO:0005109)
0.0 2.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.7 GO:0016248 ion channel inhibitor activity(GO:0008200) channel inhibitor activity(GO:0016248)
0.0 0.1 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.0 0.6 GO:0003785 actin monomer binding(GO:0003785)
0.0 3.8 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.9 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 0.5 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 3.4 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.5 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.4 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 0.6 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 2.7 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.2 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 9.5 GO:0008270 zinc ion binding(GO:0008270)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 30.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.2 5.4 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.2 4.0 ST STAT3 PATHWAY STAT3 Pathway
0.1 2.6 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 6.6 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 11.4 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 3.8 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.1 4.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 3.7 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 1.2 PID IL27 PATHWAY IL27-mediated signaling events
0.0 1.5 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 2.9 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.3 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 1.1 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 2.6 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 3.4 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.8 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 1.6 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 2.0 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 4.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.1 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.6 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.6 PID ENDOTHELIN PATHWAY Endothelins
0.0 2.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.5 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 29.8 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.5 2.3 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.3 14.9 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.3 10.1 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.2 4.0 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.2 4.9 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.2 9.8 REACTOME MYOGENESIS Genes involved in Myogenesis
0.2 2.5 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 2.5 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 4.1 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 2.6 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.1 6.6 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 6.1 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 2.4 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 5.5 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.1 1.1 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 2.5 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 1.6 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.7 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 1.4 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 1.4 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 3.0 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.0 0.6 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 1.7 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.3 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0 0.8 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 1.7 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.4 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 1.5 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.0 0.7 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.7 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.6 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway