ISMARA results: POU4F2

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for POU4F2

Z-value: 0.75

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Transcription factors associated with POU4F2

Gene Symbol	Gene ID	Gene Info
POU4F2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000151615.3	POU class 4 homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
POU4F2	hg19_v2_chr4_+_147560042_147560046	0.04	5.3e-01	Click!

Activity profile of POU4F2 motif

Sorted Z-values of POU4F2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr18_+_74240610 Show fit	9.97	ENST00000578092.1 ENST00000578613.1 ENST00000583578.1	LINC00908 Ensembl NCBI GeneCards UniProt NextProt Show fit	long intergenic non-protein coding RNA 908
chr3_-_58613323 Show fit	9.75	ENST00000474531.1 ENST00000465970.1	FAM107A Ensembl NCBI GeneCards UniProt NextProt Show fit	family with sequence similarity 107, member A
chr5_-_134914673 Show fit	8.05	ENST00000512158.1	CXCL14 Ensembl NCBI GeneCards UniProt NextProt Show fit	chemokine (C-X-C motif) ligand 14
chr6_+_151042224 Show fit	6.95	ENST00000358517.2	PLEKHG1 Ensembl NCBI GeneCards UniProt NextProt Show fit	pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr10_-_73848086 Show fit	5.09	ENST00000536168.1	SPOCK2 Ensembl NCBI GeneCards UniProt NextProt Show fit	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr17_-_9929581 Show fit	4.45	ENST00000437099.2 ENST00000396115.2	GAS7 Ensembl NCBI GeneCards UniProt NextProt Show fit	growth arrest-specific 7
chr8_-_18541603 Show fit	4.05	ENST00000428502.2	PSD3 Ensembl NCBI GeneCards UniProt NextProt Show fit	pleckstrin and Sec7 domain containing 3
chr6_+_39760129 Show fit	3.88	ENST00000274867.4	DAAM2 Ensembl NCBI GeneCards UniProt NextProt Show fit	dishevelled associated activator of morphogenesis 2
chr5_-_140998481 Show fit	3.87	ENST00000518047.1	DIAPH1 Ensembl NCBI GeneCards UniProt NextProt Show fit	diaphanous-related formin 1
chr3_+_115342349 Show fit	3.76	ENST00000393780.3	GAP43 Ensembl NCBI GeneCards UniProt NextProt Show fit	growth associated protein 43

Showing 1 to 10 of 70 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of POU4F2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	9.0	GO:0001558	regulation of cell growth(GO:0001558)
0.4	8.7	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
1.2	8.1	GO:2000503	positive regulation of natural killer cell chemotaxis(GO:2000503)
0.0	6.9	GO:0035023	regulation of Rho protein signal transduction(GO:0035023)
0.5	6.1	GO:0035372	protein localization to microtubule(GO:0035372)
0.0	4.6	GO:0007050	cell cycle arrest(GO:0007050)
0.2	4.0	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	3.9	GO:0007368	determination of left/right symmetry(GO:0007368)
0.4	3.6	GO:0016198	axon choice point recognition(GO:0016198)
0.2	3.5	GO:0071985	multivesicular body sorting pathway(GO:0071985)

Showing 1 to 10 of 42 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	9.8	GO:0016607	nuclear speck(GO:0016607)
0.0	8.7	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.1	6.1	GO:0072686	mitotic spindle(GO:0072686)
0.5	3.8	GO:0032584	growth cone membrane(GO:0032584)
0.1	3.5	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.1	3.5	GO:0031526	brush border membrane(GO:0031526)
0.0	3.3	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.2	2.7	GO:0033093	Weibel-Palade body(GO:0033093)
0.0	2.7	GO:0032587	ruffle membrane(GO:0032587)
0.0	2.4	GO:0031093	platelet alpha granule lumen(GO:0031093)

Showing 1 to 10 of 21 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	10.0	GO:0017048	Rho GTPase binding(GO:0017048)
0.3	8.7	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.2	8.1	GO:0008009	chemokine activity(GO:0008009)
0.1	6.9	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2	4.0	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.4	3.8	GO:0035727	lysophosphatidic acid binding(GO:0035727)
0.3	3.5	GO:0042043	neurexin family protein binding(GO:0042043)
0.1	3.4	GO:0017091	AU-rich element binding(GO:0017091)
0.4	3.3	GO:0070181	small ribosomal subunit rRNA binding(GO:0070181)
0.1	3.0	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)

Showing 1 to 10 of 39 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	8.7	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.1	8.5	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.0	8.0	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	3.8	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.0	3.5	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.1	3.0	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.0	2.7	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	2.2	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	1.8	PID RHODOPSIN PATHWAY	Visual signal transduction: Rods
0.0	1.5	PID CXCR3 PATHWAY	CXCR3-mediated signaling events

Showing 1 to 10 of 13 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.9	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.2	2.7	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.1	2.4	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.2	2.2	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.1	1.5	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.0	1.5	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.0	1.5	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	1.5	REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	Genes involved in Phase 1 - Functionalization of compounds
0.0	1.3	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0	1.2	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle

Showing 1 to 10 of 17 entries

Results for POU4F2

Z-value: 0.75

Motif logo

Transcription factors associated with POU4F2

Activity-expression correlation:

Activity profile of POU4F2 motif

Sorted Z-values of POU4F2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of POU4F2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: