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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for POU4F2

Z-value: 0.75

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Transcription factors associated with POU4F2

Gene Symbol Gene ID Gene Info
ENSG00000151615.3 POU class 4 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU4F2hg19_v2_chr4_+_147560042_1475600460.045.3e-01Click!

Activity profile of POU4F2 motif

Sorted Z-values of POU4F2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr18_+_74240610 9.97 ENST00000578092.1
ENST00000578613.1
ENST00000583578.1
long intergenic non-protein coding RNA 908
chr3_-_58613323 9.75 ENST00000474531.1
ENST00000465970.1
family with sequence similarity 107, member A
chr5_-_134914673 8.05 ENST00000512158.1
chemokine (C-X-C motif) ligand 14
chr6_+_151042224 6.95 ENST00000358517.2
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr10_-_73848086 5.09 ENST00000536168.1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr17_-_9929581 4.45 ENST00000437099.2
ENST00000396115.2
growth arrest-specific 7
chr8_-_18541603 4.05 ENST00000428502.2
pleckstrin and Sec7 domain containing 3
chr6_+_39760129 3.88 ENST00000274867.4
dishevelled associated activator of morphogenesis 2
chr5_-_140998481 3.87 ENST00000518047.1
diaphanous-related formin 1
chr3_+_115342349 3.76 ENST00000393780.3
growth associated protein 43
chr10_-_73848531 3.62 ENST00000373109.2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chrX_-_99987088 3.52 ENST00000372981.1
ENST00000263033.5
synaptotagmin-like 4
chr1_+_50574585 3.40 ENST00000371824.1
ENST00000371823.4
ELAV like neuron-specific RNA binding protein 4
chr19_+_1269324 3.33 ENST00000589710.1
ENST00000588230.1
ENST00000413636.2
ENST00000586472.1
ENST00000589686.1
ENST00000444172.2
ENST00000587323.1
ENST00000320936.5
ENST00000587896.1
ENST00000589235.1
ENST00000591659.1
cold inducible RNA binding protein
chr9_-_79520989 3.15 ENST00000376713.3
ENST00000376718.3
ENST00000428286.1
prune homolog 2 (Drosophila)
chr12_-_6233828 2.71 ENST00000572068.1
ENST00000261405.5
von Willebrand factor
chr16_-_4852915 2.39 ENST00000322048.7
rogdi homolog (Drosophila)
chr12_-_118796910 2.32 ENST00000541186.1
ENST00000539872.1
TAO kinase 3
chr5_-_140998616 2.24 ENST00000389054.3
ENST00000398562.2
ENST00000389057.5
ENST00000398566.3
ENST00000398557.4
ENST00000253811.6
diaphanous-related formin 1
chr20_+_56136136 2.17 ENST00000319441.4
ENST00000543666.1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr6_-_25874440 2.02 ENST00000361703.6
ENST00000397060.4
solute carrier family 17 (organic anion transporter), member 3
chr1_+_198608146 1.79 ENST00000367376.2
ENST00000352140.3
ENST00000594404.1
ENST00000598951.1
ENST00000530727.1
ENST00000442510.2
ENST00000367367.4
ENST00000348564.6
ENST00000367364.1
ENST00000413409.2
protein tyrosine phosphatase, receptor type, C
chr5_+_66300446 1.57 ENST00000261569.7
microtubule associated serine/threonine kinase family member 4
chr12_-_52779433 1.50 ENST00000257951.3
keratin 84
chr4_+_78432907 1.47 ENST00000286758.4
chemokine (C-X-C motif) ligand 13
chr2_+_44502597 1.47 ENST00000260649.6
ENST00000409387.1
solute carrier family 3 (amino acid transporter heavy chain), member 1
chr4_-_47983519 1.45 ENST00000358519.4
ENST00000544810.1
ENST00000402813.3
cyclic nucleotide gated channel alpha 1
chr9_+_125132803 1.36 ENST00000540753.1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr12_+_109577202 1.28 ENST00000377848.3
ENST00000377854.5
acetyl-CoA carboxylase beta
chr2_+_191792376 1.22 ENST00000409428.1
ENST00000409215.1
glutaminase
chr11_+_118175132 1.16 ENST00000361763.4
CD3e molecule, epsilon (CD3-TCR complex)
chr1_+_229440129 1.15 ENST00000366688.3
S-phase response (cyclin related)
chr19_-_36304201 1.09 ENST00000301175.3
proline dehydrogenase (oxidase) 2
chr10_+_18549645 1.01 ENST00000396576.2
calcium channel, voltage-dependent, beta 2 subunit
chr8_+_22857048 0.98 ENST00000251822.6
Rho-related BTB domain containing 2
chr7_-_81399329 0.94 ENST00000453411.1
ENST00000444829.2
hepatocyte growth factor (hepapoietin A; scatter factor)
chr5_-_58295712 0.93 ENST00000317118.8
phosphodiesterase 4D, cAMP-specific
chr4_-_10686475 0.90 ENST00000226951.6
cytokine-dependent hematopoietic cell linker
chr7_-_81399411 0.86 ENST00000423064.2
hepatocyte growth factor (hepapoietin A; scatter factor)
chr15_-_43877062 0.83 ENST00000381885.1
ENST00000396923.3
diphosphoinositol pentakisphosphate kinase 1
chr3_+_108541545 0.80 ENST00000295756.6
T cell receptor associated transmembrane adaptor 1
chr17_-_7832753 0.75 ENST00000303790.2
potassium voltage-gated channel, shaker-related subfamily, beta member 3
chr9_-_14308004 0.75 ENST00000493697.1
nuclear factor I/B
chr3_+_108541608 0.71 ENST00000426646.1
T cell receptor associated transmembrane adaptor 1
chrX_+_68835911 0.66 ENST00000525810.1
ENST00000527388.1
ENST00000374553.2
ENST00000374552.4
ENST00000338901.3
ENST00000524573.1
ectodysplasin A
chr12_-_118797475 0.65 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAO kinase 3
chr6_+_10521574 0.64 ENST00000495262.1
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr10_+_95372289 0.63 ENST00000371447.3
phosphodiesterase 6C, cGMP-specific, cone, alpha prime
chr2_-_158300556 0.61 ENST00000264192.3
cytohesin 1 interacting protein
chr6_-_111136513 0.58 ENST00000368911.3
cyclin-dependent kinase 19
chr7_-_81399438 0.55 ENST00000222390.5
hepatocyte growth factor (hepapoietin A; scatter factor)
chr3_+_121774202 0.55 ENST00000469710.1
ENST00000493101.1
ENST00000330540.2
ENST00000264468.5
CD86 molecule
chr12_-_89746173 0.52 ENST00000308385.6
dual specificity phosphatase 6
chr6_-_109777128 0.49 ENST00000358807.3
ENST00000358577.3
microtubule associated monooxygenase, calponin and LIM domain containing 1
chr3_+_159557637 0.46 ENST00000445224.2
schwannomin interacting protein 1
chr17_+_68100989 0.44 ENST00000585558.1
ENST00000392670.1
potassium inwardly-rectifying channel, subfamily J, member 16
chr1_-_47655686 0.39 ENST00000294338.2
PDZK1 interacting protein 1
chr4_+_169418255 0.36 ENST00000505667.1
ENST00000511948.1
palladin, cytoskeletal associated protein
chr8_+_50824233 0.34 ENST00000522124.1
syntrophin, gamma 1
chr4_-_123542224 0.32 ENST00000264497.3
interleukin 21
chr17_-_79623597 0.32 ENST00000574024.1
ENST00000331056.5
phosphodiesterase 6G, cGMP-specific, rod, gamma
chr14_+_55221541 0.29 ENST00000555192.1
sterile alpha motif domain containing 4A
chr6_+_118869452 0.22 ENST00000357525.5
phospholamban
chr9_+_125133315 0.18 ENST00000223423.4
ENST00000362012.2
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr1_-_190446759 0.15 ENST00000367462.3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr15_+_45544426 0.15 ENST00000347644.3
ENST00000560438.1
solute carrier family 28 (concentrative nucleoside transporter), member 2
chr11_-_125550764 0.14 ENST00000527795.1
acrosomal vesicle protein 1
chr14_-_70883708 0.09 ENST00000256366.4
synaptojanin 2 binding protein
chr7_-_81399355 0.09 ENST00000457544.2
hepatocyte growth factor (hepapoietin A; scatter factor)
chr1_+_40506392 0.03 ENST00000414893.1
ENST00000414281.1
ENST00000420216.1
ENST00000372792.2
ENST00000372798.1
ENST00000340450.3
ENST00000372805.3
ENST00000435719.1
ENST00000427843.1
ENST00000417287.1
ENST00000424977.1
ENST00000446031.1
CAP, adenylate cyclase-associated protein 1 (yeast)

Network of associatons between targets according to the STRING database.

First level regulatory network of POU4F2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 8.1 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.5 2.2 GO:0006114 glycerol biosynthetic process(GO:0006114) response to methionine(GO:1904640)
0.5 1.5 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.5 6.1 GO:0035372 protein localization to microtubule(GO:0035372)
0.4 8.7 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.4 1.8 GO:0048539 immunoglobulin biosynthetic process(GO:0002378) bone marrow development(GO:0048539)
0.4 3.6 GO:0016198 axon choice point recognition(GO:0016198)
0.3 1.3 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
0.3 2.4 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.3 2.0 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.2 1.5 GO:1990822 L-cystine transport(GO:0015811) basic amino acid transmembrane transport(GO:1990822)
0.2 1.2 GO:0006543 glutamine catabolic process(GO:0006543)
0.2 1.2 GO:0002913 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.2 4.0 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.2 3.3 GO:0034063 stress granule assembly(GO:0034063)
0.2 3.5 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.2 1.5 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.2 0.5 GO:0042109 negative regulation of tolerance induction(GO:0002644) lymphotoxin A production(GO:0032641) interleukin-4 biosynthetic process(GO:0042097) lymphotoxin A biosynthetic process(GO:0042109) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.2 1.1 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.2 1.0 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.2 0.5 GO:0019417 sulfur oxidation(GO:0019417)
0.1 0.5 GO:1903224 regulation of endodermal cell differentiation(GO:1903224)
0.1 1.4 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.1 2.9 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 1.5 GO:0035878 nail development(GO:0035878)
0.1 0.9 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 0.6 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 1.5 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 0.2 GO:0086092 regulation of the force of heart contraction by cardiac conduction(GO:0086092) regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877) regulation of calcium ion import into sarcoplasmic reticulum(GO:1902080) negative regulation of calcium ion import into sarcoplasmic reticulum(GO:1902081)
0.0 1.8 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 0.8 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.4 GO:0007603 phototransduction, visible light(GO:0007603)
0.0 1.0 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.0 6.9 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.3 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 3.9 GO:0007368 determination of left/right symmetry(GO:0007368)
0.0 2.4 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.0 0.1 GO:0015860 purine nucleoside transmembrane transport(GO:0015860)
0.0 9.0 GO:0001558 regulation of cell growth(GO:0001558)
0.0 0.1 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 4.6 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.4 GO:0010107 potassium ion import(GO:0010107)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.8 GO:0032584 growth cone membrane(GO:0032584)
0.2 2.7 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 3.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 1.2 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 1.5 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 1.0 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 1.5 GO:0042101 T cell receptor complex(GO:0042101)
0.1 0.7 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 6.1 GO:0072686 mitotic spindle(GO:0072686)
0.1 3.5 GO:0031526 brush border membrane(GO:0031526)
0.0 3.3 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.3 GO:0016013 syntrophin complex(GO:0016013)
0.0 1.5 GO:0045095 keratin filament(GO:0045095)
0.0 1.9 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 9.8 GO:0016607 nuclear speck(GO:0016607)
0.0 8.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.7 GO:0005581 collagen trimer(GO:0005581)
0.0 2.4 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 2.7 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.6 GO:0016592 mediator complex(GO:0016592)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.4 3.3 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.4 1.5 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.4 3.8 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.4 1.5 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
0.3 8.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.3 1.3 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.3 2.0 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.3 1.1 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.3 3.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.2 1.5 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.2 1.2 GO:0004359 glutaminase activity(GO:0004359)
0.2 8.1 GO:0008009 chemokine activity(GO:0008009)
0.2 0.8 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.2 4.0 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 1.0 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.1 1.5 GO:0043855 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.1 1.5 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 3.4 GO:0017091 AU-rich element binding(GO:0017091)
0.1 0.6 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 1.2 GO:0042608 T cell receptor binding(GO:0042608)
0.1 3.0 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 2.7 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 10.0 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 6.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 1.5 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 1.8 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 2.4 GO:0042056 chemoattractant activity(GO:0042056)
0.1 0.2 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.1 0.3 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.9 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.9 GO:0030553 cGMP binding(GO:0030553)
0.0 0.1 GO:0005415 nucleoside:sodium symporter activity(GO:0005415)
0.0 0.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.5 GO:0071949 FAD binding(GO:0071949)
0.0 0.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.3 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.5 GO:0015026 coreceptor activity(GO:0015026)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 8.5 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 3.8 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 3.0 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 0.6 PID CONE PATHWAY Visual signal transduction: Cones
0.1 1.8 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 3.5 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 2.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.5 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 8.0 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.5 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 2.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.7 PID HNF3A PATHWAY FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.2 2.7 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 2.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 2.9 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1 1.5 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 1.2 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 1.3 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 1.5 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.5 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 1.0 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.5 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.7 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 1.5 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.4 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.9 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 1.5 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.7 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels