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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for POU6F1

Z-value: 0.52

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Transcription factors associated with POU6F1

Gene Symbol Gene ID Gene Info
POU6F1
ENSG00000184271.11 POU class 6 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU6F1hg19_v2_chr12_-_51611477_51611612-0.432.4e-11Click!

Activity profile of POU6F1 motif

Sorted Z-values of POU6F1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_+_98612446 14.14 ENST00000496368.1
ENST00000421861.2
ENST00000357602.3
IPO5
importin 5
chrX_-_122756660 10.90 ENST00000441692.1
THOC2
THO complex 2
chr2_+_242289502 8.73 ENST00000451310.1
SEPT2
septin 2
chr1_-_197115818 8.49 ENST00000367409.4
ENST00000294732.7
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr15_-_85259294 8.47 ENST00000558217.1
ENST00000558196.1
ENST00000558134.1
SEC11A
SEC11 homolog A (S. cerevisiae)
chr15_-_85259330 7.76 ENST00000560266.1
SEC11A
SEC11 homolog A (S. cerevisiae)
chr15_-_85259384 7.70 ENST00000455959.3
SEC11A
SEC11 homolog A (S. cerevisiae)
chr6_-_74231444 7.62 ENST00000331523.2
ENST00000356303.2
EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chrX_+_119737806 7.53 ENST00000371317.5
MCTS1
malignant T cell amplified sequence 1
chr5_+_115177178 7.47 ENST00000316788.7
AP3S1
adaptor-related protein complex 3, sigma 1 subunit
chr15_+_80351910 7.14 ENST00000261749.6
ENST00000561060.1
ZFAND6
zinc finger, AN1-type domain 6
chr12_-_30887948 6.93 ENST00000433722.2
CAPRIN2
caprin family member 2
chr1_-_153538292 6.84 ENST00000497140.1
ENST00000368708.3
S100A2
S100 calcium binding protein A2
chr5_+_162864575 6.64 ENST00000512163.1
ENST00000393929.1
ENST00000340828.2
ENST00000511683.2
ENST00000510097.1
ENST00000511490.2
ENST00000510664.1
CCNG1
cyclin G1
chr1_-_151431647 6.21 ENST00000368863.2
ENST00000409503.1
ENST00000491586.1
ENST00000533351.1
ENST00000540984.1
POGZ
pogo transposable element with ZNF domain
chr15_-_85259360 6.20 ENST00000559729.1
SEC11A
SEC11 homolog A (S. cerevisiae)
chr15_+_80351977 6.18 ENST00000559157.1
ENST00000561012.1
ENST00000564367.1
ENST00000558494.1
ZFAND6
zinc finger, AN1-type domain 6
chr6_+_151646800 5.99 ENST00000354675.6
AKAP12
A kinase (PRKA) anchor protein 12
chr6_-_111804905 5.34 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr11_+_85339623 5.12 ENST00000358867.6
ENST00000534341.1
ENST00000393375.1
ENST00000531274.1
TMEM126B
transmembrane protein 126B
chr11_-_107729887 4.82 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr20_+_34129770 4.58 ENST00000348547.2
ENST00000357394.4
ENST00000447986.1
ENST00000279052.6
ENST00000416206.1
ENST00000411577.1
ENST00000413587.1
ERGIC3
ERGIC and golgi 3
chr7_+_80267973 4.54 ENST00000394788.3
ENST00000447544.2
CD36
CD36 molecule (thrombospondin receptor)
chr10_-_43904235 3.72 ENST00000356053.3
HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr1_-_151431909 3.03 ENST00000361398.3
ENST00000271715.2
POGZ
pogo transposable element with ZNF domain
chr13_-_52027134 2.88 ENST00000311234.4
ENST00000425000.1
ENST00000463928.1
ENST00000442263.3
ENST00000398119.2
INTS6
integrator complex subunit 6
chr5_+_67586465 2.83 ENST00000336483.5
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr1_-_47655686 2.68 ENST00000294338.2
PDZK1IP1
PDZK1 interacting protein 1
chr9_+_128509624 2.49 ENST00000342287.5
ENST00000373487.4
PBX3
pre-B-cell leukemia homeobox 3
chr22_+_31518938 2.43 ENST00000412985.1
ENST00000331075.5
ENST00000412277.2
ENST00000420017.1
ENST00000400294.2
ENST00000405300.1
ENST00000404390.3
INPP5J
inositol polyphosphate-5-phosphatase J
chr17_-_26972126 2.28 ENST00000528896.2
KIAA0100
KIAA0100
chr12_-_91546926 2.28 ENST00000550758.1
DCN
decorin
chr10_-_94257512 2.15 ENST00000371581.5
IDE
insulin-degrading enzyme
chr1_-_21377383 2.06 ENST00000374935.3
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr12_-_108954933 1.47 ENST00000431469.2
ENST00000546815.1
SART3
squamous cell carcinoma antigen recognized by T cells 3
chr12_+_102513950 1.43 ENST00000378128.3
ENST00000327680.2
ENST00000541394.1
ENST00000543784.1
PARPBP
PARP1 binding protein
chr18_+_9475001 1.41 ENST00000019317.4
RALBP1
ralA binding protein 1
chr16_+_15744078 1.37 ENST00000396354.1
ENST00000570727.1
NDE1
nudE neurodevelopment protein 1
chr11_-_65381643 1.28 ENST00000309100.3
ENST00000529839.1
ENST00000526293.1
MAP3K11
mitogen-activated protein kinase kinase kinase 11
chr2_+_128403439 1.28 ENST00000544369.1
GPR17
G protein-coupled receptor 17
chr8_-_146176199 1.24 ENST00000532351.1
ENST00000276816.4
ENST00000394909.2
ZNF16
zinc finger protein 16
chr2_+_128403720 1.19 ENST00000272644.3
GPR17
G protein-coupled receptor 17
chr2_+_102721023 1.18 ENST00000409589.1
ENST00000409329.1
IL1R1
interleukin 1 receptor, type I
chr6_+_26183958 1.15 ENST00000356530.3
HIST1H2BE
histone cluster 1, H2be
chr3_-_108248169 1.13 ENST00000273353.3
MYH15
myosin, heavy chain 15
chr9_-_13165457 1.11 ENST00000542239.1
ENST00000538841.1
ENST00000433359.2
MPDZ
multiple PDZ domain protein
chr16_-_87351022 1.07 ENST00000253461.4
C16orf95
chromosome 16 open reading frame 95
chr11_-_4414880 1.03 ENST00000254436.7
ENST00000543625.1
TRIM21
tripartite motif containing 21
chr10_+_97803151 0.95 ENST00000403870.3
ENST00000265992.5
ENST00000465148.2
ENST00000534974.1
CCNJ
cyclin J
chr16_-_87350970 0.88 ENST00000567970.1
C16orf95
chromosome 16 open reading frame 95
chr2_+_207220463 0.86 ENST00000598562.1
AC017081.1
Uncharacterized protein
chr12_+_15699286 0.82 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
PTPRO
protein tyrosine phosphatase, receptor type, O
chr17_-_39677971 0.80 ENST00000393976.2
KRT15
keratin 15
chr6_+_110501344 0.67 ENST00000368932.1
CDC40
cell division cycle 40
chr3_+_46395219 0.54 ENST00000445132.2
ENST00000292301.4
CCR2
chemokine (C-C motif) receptor 2
chr9_-_118687405 0.50 ENST00000374014.3
LINC00474
long intergenic non-protein coding RNA 474
chr7_-_38407770 0.43 ENST00000390348.2
TRGV1
T cell receptor gamma variable 1 (non-functional)
chr12_+_54892550 0.41 ENST00000545638.2
NCKAP1L
NCK-associated protein 1-like
chr11_-_89223883 0.29 ENST00000528341.1
NOX4
NADPH oxidase 4
chr3_-_114343768 0.16 ENST00000393785.2
ZBTB20
zinc finger and BTB domain containing 20
chr12_-_108955070 0.14 ENST00000228284.3
ENST00000546611.1
SART3
squamous cell carcinoma antigen recognized by T cells 3
chr22_-_22307199 0.13 ENST00000397495.4
ENST00000263212.5
PPM1F
protein phosphatase, Mg2+/Mn2+ dependent, 1F
chr17_-_40337470 0.10 ENST00000293330.1
HCRT
hypocretin (orexin) neuropeptide precursor
chr12_+_10460417 0.10 ENST00000381908.3
ENST00000336164.4
ENST00000350274.5
KLRD1
killer cell lectin-like receptor subfamily D, member 1
chr6_-_111136513 0.09 ENST00000368911.3
CDK19
cyclin-dependent kinase 19
chr2_-_217560248 0.08 ENST00000233813.4
IGFBP5
insulin-like growth factor binding protein 5
chr20_-_58515344 0.07 ENST00000370996.3
PPP1R3D
protein phosphatase 1, regulatory subunit 3D
chr14_-_70883708 0.06 ENST00000256366.4
SYNJ2BP
synaptojanin 2 binding protein
chr19_+_52076425 0.06 ENST00000436511.2
ZNF175
zinc finger protein 175
chr1_+_113010056 0.00 ENST00000369686.5
WNT2B
wingless-type MMTV integration site family, member 2B

Network of associatons between targets according to the STRING database.

First level regulatory network of POU6F1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.5 GO:0002188 translation reinitiation(GO:0002188)
1.4 8.5 GO:0051661 maintenance of centrosome location(GO:0051661)
1.4 30.1 GO:0006465 signal peptide processing(GO:0006465)
1.1 10.9 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.9 14.1 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.7 2.1 GO:1901143 insulin catabolic process(GO:1901143)
0.7 9.2 GO:0051382 kinetochore assembly(GO:0051382)
0.6 4.5 GO:2000332 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.5 13.3 GO:0072662 protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.5 7.5 GO:0099514 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.4 2.5 GO:0007386 compartment pattern specification(GO:0007386)
0.4 7.6 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.4 6.0 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.4 1.2 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.3 0.8 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.3 0.5 GO:0002436 immune complex clearance(GO:0002434) immune complex clearance by monocytes and macrophages(GO:0002436) regulation of immune complex clearance by monocytes and macrophages(GO:0090264)
0.3 1.0 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.2 6.9 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.2 2.3 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.2 2.5 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.2 1.3 GO:0007256 activation of JNKK activity(GO:0007256)
0.2 5.3 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.2 2.8 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.1 2.9 GO:0016180 snRNA processing(GO:0016180)
0.1 2.4 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.1 1.6 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.1 1.2 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.1 0.4 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376) actin polymerization-dependent cell motility(GO:0070358)
0.1 1.4 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.1 5.1 GO:0010257 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1 6.6 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.1 7.9 GO:0007224 smoothened signaling pathway(GO:0007224)
0.0 0.1 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.0 3.7 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.0 6.9 GO:0043542 endothelial cell migration(GO:0043542)
0.0 2.1 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.1 GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 30.1 GO:0005787 signal peptidase complex(GO:0005787)
1.6 10.9 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
1.2 8.5 GO:0036449 microtubule minus-end(GO:0036449)
0.8 7.6 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.7 2.8 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.7 7.5 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.6 8.7 GO:0097227 sperm annulus(GO:0097227)
0.4 1.6 GO:0071001 U4/U6 snRNP(GO:0071001)
0.4 5.3 GO:0042575 DNA polymerase complex(GO:0042575)
0.3 2.9 GO:0032039 integrator complex(GO:0032039)
0.2 2.3 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 4.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 2.1 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 14.1 GO:0005643 nuclear pore(GO:0005643)
0.1 2.1 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.1 7.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 1.4 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 1.1 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.0 4.6 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 2.4 GO:0043198 dendritic shaft(GO:0043198)
0.0 1.1 GO:0032982 myosin filament(GO:0032982)
0.0 3.6 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 8.0 GO:0000790 nuclear chromatin(GO:0000790)
0.0 1.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 5.5 GO:0005938 cell cortex(GO:0005938)
0.0 8.2 GO:0005813 centrosome(GO:0005813)
0.0 0.8 GO:0016328 lateral plasma membrane(GO:0016328)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.5 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.6 14.1 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.6 5.0 GO:0043559 insulin binding(GO:0043559)
0.4 6.0 GO:0008179 adenylate cyclase binding(GO:0008179)
0.3 1.3 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.3 1.2 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.3 13.3 GO:0031593 polyubiquitin binding(GO:0031593)
0.3 7.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.2 2.4 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445) phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.2 1.6 GO:0030621 U4 snRNA binding(GO:0030621)
0.2 5.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.2 0.5 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 9.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 30.1 GO:0008236 serine-type peptidase activity(GO:0008236)
0.1 3.7 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 1.4 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 2.5 GO:0001637 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.1 7.5 GO:0008565 protein transporter activity(GO:0008565)
0.0 2.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 9.4 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 9.1 GO:0005516 calmodulin binding(GO:0005516)
0.0 2.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.1 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.8 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 8.7 GO:0045296 cadherin binding(GO:0045296)
0.0 0.1 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.8 GO:0097110 scaffold protein binding(GO:0097110)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 PID IL5 PATHWAY IL5-mediated signaling events
0.1 6.6 PID P53 REGULATION PATHWAY p53 pathway
0.1 10.0 PID CDC42 PATHWAY CDC42 signaling events
0.1 6.8 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 2.3 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.4 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 1.2 PID IL1 PATHWAY IL1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 30.1 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
1.3 7.6 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 2.5 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.1 2.8 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 7.5 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 2.3 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.1 14.1 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.1 2.4 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 0.5 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 4.6 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 5.3 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 3.6 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 1.2 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 2.1 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 1.2 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling