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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for PPARA
Z-value: 0.31
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Transcription factors associated with PPARA
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PPARA | hg19_v2_chr22_+_46546494_46546525 | -0.27 | 4.1e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_176046391 Show fit | 24.25 |
ENST00000392541.3
ENST00000409194.1 |
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9) |
|
| chr22_+_23264766 Show fit | 15.49 |
ENST00000390331.2
|
immunoglobulin lambda constant 7 |
|
| chr1_+_169075554 Show fit | 14.72 |
ENST00000367815.4
|
ATPase, Na+/K+ transporting, beta 1 polypeptide |
|
| chr7_-_72936531 Show fit | 14.52 |
ENST00000339594.4
|
bromodomain adjacent to zinc finger domain, 1B |
|
| chr1_-_26233423 Show fit | 13.56 |
ENST00000357865.2
|
stathmin 1 |
|
| chr1_+_46769303 Show fit | 12.36 |
ENST00000311672.5
|
ubiquinol-cytochrome c reductase hinge protein |
|
| chr13_-_41635512 Show fit | 11.35 |
ENST00000405737.2
|
E74-like factor 1 (ets domain transcription factor) |
|
| chr7_-_10979750 Show fit | 10.72 |
ENST00000339600.5
|
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa |
|
| chr3_-_18480260 Show fit | 10.60 |
ENST00000454909.2
|
SATB homeobox 1 |
|
| chr14_-_104387888 Show fit | 10.37 |
ENST00000286953.3
|
chromosome 14 open reading frame 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of PPARA
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 126.1 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 2.5 | 79.4 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 0.4 | 38.5 | GO:0006415 | translational termination(GO:0006415) |
| 1.9 | 24.9 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 6.0 | 24.0 | GO:0044861 | protein transport into plasma membrane raft(GO:0044861) positive regulation of potassium ion import(GO:1903288) |
| 0.7 | 21.9 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) |
| 0.2 | 20.6 | GO:0050871 | positive regulation of B cell activation(GO:0050871) |
| 1.2 | 20.0 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.3 | 18.9 | GO:0000380 | alternative mRNA splicing, via spliceosome(GO:0000380) |
| 1.1 | 17.9 | GO:0090361 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 98.5 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 3.2 | 57.3 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.2 | 40.3 | GO:0043209 | myelin sheath(GO:0043209) |
| 1.7 | 34.9 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 3.1 | 34.2 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.2 | 32.0 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.7 | 28.7 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 2.1 | 25.3 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 1.7 | 24.3 | GO:0005753 | mitochondrial proton-transporting ATP synthase complex(GO:0005753) |
| 0.1 | 21.9 | GO:0000922 | spindle pole(GO:0000922) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 114.1 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 1.7 | 39.2 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 2.2 | 35.1 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 0.1 | 25.5 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.4 | 24.2 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 23.1 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.4 | 22.5 | GO:0015078 | hydrogen ion transmembrane transporter activity(GO:0015078) |
| 0.7 | 20.0 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.7 | 18.2 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.1 | 18.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.9 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.2 | 16.6 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.2 | 16.1 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 1.1 | 15.5 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.2 | 15.3 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.2 | 14.4 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.8 | 13.6 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.4 | 13.1 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.2 | 12.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 11.6 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 183.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 48.0 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 1.5 | 35.2 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.6 | 35.1 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.5 | 23.3 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.5 | 17.7 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.2 | 17.2 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.6 | 15.5 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.3 | 13.9 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.3 | 12.2 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |